DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk

Cancer Cell

Volumn 33, Issue 2, 2018, Pages 309-321.e5

  Xie, Wenbing ^a   Kagiampakis, Ioannis ^a   Pan, Lixia ^b   Zhang, Yang W ^a   Murphy, Lauren ^a   Tao, Yong ^a   Kong, Xiangqian ^a   Kang, Byunghak ^a   Xia, Limin ^a   Carvalho, Filipe L F ^a   Sen, Subhojit ^c   Chiu Yen, Ray Whay ^a   Zahnow, Cynthia A ^a   Ahuja, Nita ^a   Baylin, Stephen B ^a   Easwaran, Hariharan ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF MUMBAI   (India)

Author keywords

aging; cancer; cancer risk; DNA methylation; epigenetic; malignant transformation; oncogene induced senescence; promoter CpG island; senescence

Indexed keywords

DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CELL AGING; CELL SELF-RENEWAL; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; CPG ISLAND; DEVELOPMENTAL GENE; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; MALIGNANT NEOPLASM; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; TUMOR XENOGRAFT; ANIMAL; GENETIC EPIGENESIS; GENETICS; NEOPLASM; RISK; SCID MOUSE;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLULAR SENESCENCE; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; MICE; MICE, SCID; NEOPLASMS; PROMOTER REGIONS, GENETIC; RISK;

EID: 85044335041     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2018.01.008     Document Type: Article

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