DNA methylation in cancer and aging

Cancer Research

Volumn 76, Issue 12, 2016, Pages 3446-3450

  Klutstein, Michael ^a,b   Nejman, Deborah ^a   Greenfield, Razi ^a   Cedar, Howard ^a  

^a HEBREW UNIVERSITY   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCOMB GROUP PROTEIN; TRANSCRIPTION FACTOR EZH2;

ACUTE MYELOBLASTIC LEUKEMIA; AGING; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL DIFFERENTIATION; COLON CANCER; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; GENE MUTATION; GENE REPRESSION; GENOME; HETEROCHROMATIN; HUMAN; MALIGNANT TRANSFORMATION; MYELODYSPLASTIC SYNDROME; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE; GENETICS; NEOPLASMS;

AGING; CARCINOGENESIS; CELL DIFFERENTIATION; CPG ISLANDS; DNA METHYLATION; HUMANS; NEOPLASMS;

EID: 84976869967     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-3278     Document Type: Review

References (34)

1. Shen H, Laird PW. Interplay between the cancer genome and epigenome. Cell 2013;153:38-55.
2. Cedar H, Bergman Y. Programming of DNA methylation patterns. Annu Rev Biochem 2012;81:97-117.
3. Straussman R, Nejman D, Roberts D, Steinfeld I, Blum B, Benvenisty N, et al. Developmental programming of CpG island methylation profiles in the human genome. Nature Struct Mol Biol 2009;16:564-71.
4. Fouse SD, Shen Y, Pellegrini M, Cole S, Meissner A, Van Neste L, et al. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell 2008;2:160-9.
5. Siegfried Z, Eden S, Mendelsohn M, Feng X, Tzubari B, Cedar H. DNA methylation represses transcription in vivo. Nat Genet 1999;22:203-6.
6. Kulis M, Merkel A, Heath S, Queiros AC, Schuyler RP, Castellano G, et al. Whole-genome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet 2015;47:746-56.
7. Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007;39:237-42.
8. Widschwendter M, Fiegl H, Egle D, Mueller-Holzner E, Spizzo G, Marth C, et al. Epigenetic stem cell signature in cancer. Nat Genet 2007;39:157-8.
9. Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, et al. Polycomb mediated histone H3(K27) methylation pre-marks genes for de novo methylation in cancer. Nat Genet 2007;39:232-6.
10. Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 2006;439:871-4.
11. Issa JP. Aging and epigenetic drift: A vicious cycle. J Clin Invest 2014;124:24-9.
12. Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, et al. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res 2010;20:440-6.
13. Maegawa S, Hinkal G, Kim HS, Shen L, Zhang L, Zhang J, et al. Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res 2010;20:332-40.
14. Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, et al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell 2014;14:673-88.
15. Raddatz G, Hagemann S, Aran D, Sohle J, Kulkarni PP, Kaderali L, et al. Aging is associated with highly defined epigenetic changes in the human epidermis. Epigenetics Chromatin 2013;6:36.
16. O'Hagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, et al. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell 2011;20:606-19.
17. Nejman D, Straussman R, Steinfeld I, Ruvolo M, Roberts D, Yakhini Z, et al. Molecular rules governing de novo methylation in cancer. Cancer Res 2013;74:1475-83.
18. Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2015;347:78-81.
19. Easwaran H, Tsai HC, Baylin SB. Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell 2014;54:716-27.
20. Niwa T, Ushijima T. Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis. Adv Genet 2010;71:41-56.
21. Rasmussen KD, Jia G, Johansen JV, Pedersen MT, Rapin N, Bagger FO, et al. Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis. Genes Dev 2015;29:910-22.
22. Aran D, Hellman A. DNA methylation of transcriptional enhancers and cancer predisposition. Cell 2013;154:11-3.
23. Nicot C. Tumor suppressor inactivation in the pathogenesis of adult T-cell leukemia. J Oncol 2015;2015:183590.
24. Keshet I, Schlesinger Y, Farkash S, Rand E, Hecht M, Segal E, et al. Evidence for an instructive mechanism of de novo methylation in cancer cells. Nat Genet 2006;38:149-53.
25. Fang M, Ou J, Hutchinson L, Green MR. The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG island methylator phenotype. Mol Cell 2014;55:904-15.
26. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006;441:349-53.
27. Ahuja N, Easwaran H, Baylin SB. Harnessing the potential of epigenetic therapy to target solid tumors. J Clin Invest 2014;124:56-63.
28. Easwaran H, Johnstone SE, Van Neste L, Ohm J, Mosbruger T, Wang Q, et al. A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res 2012;22:837-49.
29. Herman JG, Jen J, Merlo A, Baylin SB. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 1996;56:722-7.
30. Laird PW, Jackson-Grusby L, Fazeli A, Dickinson SL, Jung WE, Li E, et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 1995;81:197-205.
31. Lin H, Yamada Y, Nguyen S, Linhart H, Jackson-Grusby L, Meissner A, et al. Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol 2006;26:2976-83.
32. Shibata D. Inferring human stem cell behaviour from epigenetic drift. J Pathol 2009;217:199-205.
33. Belshaw NJ, Pal N, Tapp HS, Dainty JR, Lewis MP, Williams MR, et al. Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa. Carcinogenesis 2010;31:1158-63.
34. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ, et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A 2005;102:9194-9.