Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations

Cancer Cell

Volumn 32, Issue 3, 2017, Pages 360-376.e6

  Vaz, Michelle ^a   Hwang, Stephen Y ^a   Kagiampakis, Ioannis ^a   Phallen, Jillian ^a   Patil, Ashwini ^b   O'Hagan, Heather M ^c,e   Murphy, Lauren ^a   Zahnow, Cynthia A ^a   Gabrielson, Edward ^d   Velculescu, Victor E ^a   Easwaran, Hariharan P ^a   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c Indiana University School of Medicine   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e INDIANA UNIVERSITY   (United States)

Author keywords

addiction; cigarette smoke exposure; DNA methylation; epigenetic; genetic; HBECs; human bronchial epithelial cells; Kras; lung cancer; oncogene; polycomb

Indexed keywords

CIGARETTE SMOKE; CIGARETTE SMOKE CONDENSATE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; TRANSFORMING GROWTH FACTOR BETA; CHROMATIN; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; EZH2 PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; PROTEIN P21; SIRTUIN 1; TRANSCRIPTION FACTOR EZH2;

ANIMAL EXPERIMENT; ARTICLE; BRONCHIOLE CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CPG ISLAND; DNA DAMAGE; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; LONG TERM EXPOSURE; LUNG ALVEOLUS EPITHELIUM CELL; LUNG CANCER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; ADVERSE EFFECTS; ANIMAL; BRONCHUS; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMATIN; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HUMAN GENOME; LUNG TUMOR; METABOLISM; MUTATION; NON SMALL CELL LUNG CANCER; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION; SMOKING;

ANIMALS; BRONCHI; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA DAMAGE; DNA METHYLATION; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; EPIGENOMICS; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; LUNG NEOPLASMS; MALE; MICE; MUTATION; PHENOTYPE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; SIRTUIN 1; SMOKING;

EID: 85030425782     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2017.08.006     Document Type: Article

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