Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

Journal of Experimental Medicine

Volumn 215, Issue 3, 2018, Pages 745-760

  Song, Wilbur M ^a   Joshita, Satoru ^a,b   Zhou, Yingyue ^a   Ulland, Tyler K ^a   Gilfillan, Susan ^a   Colonna, Marco ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN PROTEIN; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; R47H PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN;

5XFAD MOUSE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BRAIN TISSUE; CONTROLLED STUDY; FEMALE; GLIOSIS; IN VITRO STUDY; IN VIVO STUDY; INTRINSIC ACTIVITY; MICROGLIA; MOUSE; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN POLYMORPHISM; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; BRAIN; CELL COUNT; GENETICS; HUMAN; METABOLISM; NERVE CELL; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SOLUBILITY;

ADAM17 PROTEIN; ANIMALS; BRAIN; CELL COUNT; GLIOSIS; HUMANS; MEMBRANE GLYCOPROTEINS; MICE, TRANSGENIC; MICROGLIA; MYELOID CELLS; NEURONS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, IMMUNOLOGIC; SOLUBILITY;

EID: 85042776769     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20171529     Document Type: Article

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