ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

Neuroscience Letters

Volumn 660, Issue , 2017, Pages 109-114

  Feuerbach, Dominik ^a   Schindler, Patrick ^a   Barske, Carmen ^a   Joller, Stefanie ^a   Beng Louka, Edwige ^a   Worringer, Katie A ^b   Kommineni, Sravya ^b   Kaykas, Ajamete ^b   Ho, Daniel J ^b   Ye, Chaoyang ^b   Welzenbach, Karl ^a   Elain, Gaelle ^a   Klein, Laurent ^a   Brzak, Irena ^a   Mir, Anis K ^a   Farady, Christopher J ^a   Aichholz, Reiner ^a   Popp, Simone ^a   George, Nathalie ^a   Neumann, Ulf ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Alzheimers disease; Macrophages; Neuroinflammation; Shedding

Indexed keywords

ADAM10 ENDOPEPTIDASE; HISTIDINE; HUMAN TRIGGERING RECEPTOR EXPRESSED IN MYELOID CELL PROTEIN; PROTEINASE; SERINE; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; ADAM10 PROTEIN, HUMAN; ADAM17 PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; SECRETASE; TREM2 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ARTICLE; BIOCHEMICAL ANALYSIS; CELL CLONE; CELL DIFFERENTIATION; CELL SURFACE; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LIVE CELL IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; STEADY STATE; SUPERNATANT; SURFACE PROPERTY; THP-1 CELL LINE; WESTERN BLOTTING; ANIMAL; CELL LINE; CHO CELL LINE; CRICETULUS; METABOLISM;

ADAM10 PROTEIN; ADAM17 PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; CHO CELLS; CRICETULUS; HISTIDINE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; RECEPTORS, IMMUNOLOGIC;

EID: 85029592100     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2017.09.034     Document Type: Article

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