SCOPUS 정보 검색 플랫폼

Volumn 214, Issue 3, 2017, Pages 597-607

Soluble TREM2 induces inflammatory responses and enhances microglial survival

(19) Zhong, Li a Chen, Xiao Fen a Wang, Tingting a Wang, Zhe a Liao, Chunyan a Wang, Zongqi a Huang, Ruizhi a Wang, Daxin a Li, Xinxiu a Wu, Linbei a Jia, Lin a Zheng, Honghua a Painter, Meghan b Atagi, Yuka b Liu, Chia Chen b Zhang, Yun Wu a Fryer, John D b,c Xu, Huaxi a,d Bu, Guojun a,b,c

a XIAMEN UNIVERSITY (China)

b MAYO GRADUATE SCHOOL (United States)

c MAYO CLINIC (United States)

d BURNHAM INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TREM2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL; C57BL MOUSE; CELL SURVIVAL; GENETICS; HEK293 CELL LINE; HUMAN; INFLAMMATION; MICROGLIA; MOUSE; MUTATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; ANIMALS; BETA CATENIN; CELL SURVIVAL; GLYCOGEN SYNTHASE KINASE 3 BETA; HEK293 CELLS; HUMANS; INFLAMMATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROGLIA; MUTATION; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 85020604923 PISSN: 00221007 EISSN: 15409538 Source Type: Journal
DOI: 10.1084/jem.20160844 Document Type: Article

Times cited : (243)

References (31)

1
- 84944937240
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- Atagi,Y., C.C. Liu, M.M. Painter, X.F. Chen, C.Verbeeck, H. Zheng, X. Li, R. Rademakers, S.S. Kang, H. Xu, et al. 2015. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J. Biol. Chem. 290:26043–26050. http://dx.doi.org/10.1074/jbc.M115.679043
- (2015) J. Biol. Chem , vol.290 , pp. 26043-26050
- Atagi, Y.¹ Liu, C.C.² Painter, M.M.³ Chen, X.F.⁴ Verbeeck, C.⁵ Zheng, H.⁶ Li, X.⁷ Rademakers, R.⁸ Kang, S.S.⁹ Xu, H.¹⁰

2
- 84944937159
- The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
- Bailey, C.C., L.B. DeVaux, and M. Farzan. 2015. The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E. J. Biol. Chem. 290:26033–26042. http://dx.doi.org/10.1074/jbc.M115.677286
- (2015) J. Biol. Chem , vol.290 , pp. 26033-26042
- Bailey, C.C.¹ DeVaux, L.B.² Farzan, M.³

3
- 85058205970
- Heterozygous TREM2 mutations in frontotemporal dementia
- 934
- Borroni, B., F. Ferrari, D. Galimberti, B. Nacmias, C. Barone, S. Bagnoli, C. Fenoglio, I. Piaceri, S. Archetti, C. Bonvicini, et al. 2014. Heterozygous TREM2 mutations in frontotemporal dementia.Neurobiol.Aging. 35:934. e7–934.e10. http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.017
- (2014) Neurobiol.Aging , vol.35 , pp. e7-934e10
- Borroni, B.¹ Ferrari, F.² Galimberti, D.³ Nacmias, B.⁴ Barone, C.⁵ Bagnoli, S.⁶ Fenoglio, C.⁷ Piaceri, I.⁸ Archetti, S.⁹ Bonvicini, C.¹⁰

4
- 0034657890
- Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
- Bouchon,A., J. Dietrich, and M. Colonna. 2000. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J. Immunol. 164:4991–4995. http://dx.doi.org/10.4049/jimmunol.164.10.4991
- (2000) J. Immunol , vol.164 , pp. 4991-4995
- Bouchon, A.¹ Dietrich, J.² Colonna, M.³

5
- 84992068717
- Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer’s disease
- Gispert, J.D., M. Suárez-Calvet, G.C. Monté, A. Tucholka, C. Falcon, S. Rojas, L. Rami, R. Sánchez-Valle, A. Lladó, G. Kleinberger, et al. 2016. Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer’s disease. Alzheimers Dement. 12:1259–1272. http://dx.doi.org/10.1016/j.jalz .2016.06.005
- (2016) Alzheimers Dement , vol.12 , pp. 1259-1272
- Gispert, J.D.¹ Suárez-Calvet, M.² Monté, G.C.³ Tucholka, A.⁴ Falcon, C.⁵ Rojas, S.⁶ Rami, L.⁷ Sánchez-Valle, R.⁸ Lladó, A.⁹ Kleinberger, G.¹⁰

6
- 84885821412
- TREM2 and neurodegenerative disease
- Guerreiro, R., and J. Hardy. 2013. TREM2 and neurodegenerative disease. N. Engl. J. Med. 369:1569–1570. http://dx.doi.org/10.1056/ NEJMc1306509
- (2013) N. Engl. J. Med , vol.369 , pp. 1569-1570
- Guerreiro, R.¹ Hardy, J.²

7
- 84872586508
- Using exome sequencing to reveal mutations inTREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement
- Guerreiro, R.J., E. Lohmann, J.M. Brás, J.R. Gibbs, J.D. Rohrer, N. Gurunlian, B. Dursun, B. Bilgic, H. Hanagasi, H. Gurvit, et al. 2013b. Using exome sequencing to reveal mutations inTREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. JAMA Neurol. 70:78–84. http://dx.doi.org/10.1001/jamaneurol.2013.579
- (2013) JAMA Neurol , vol.70 , pp. 78-84
- Guerreiro, R.J.¹ Lohmann, E.² Brás, J.M.³ Gibbs, J.R.⁴ Rohrer, J.D.⁵ Gurunlian, N.⁶ Dursun, B.⁷ Bilgic, B.⁸ Hanagasi, H.⁹ Gurvit, H.¹⁰

8
- 84872057940
- TREM2 variants in Alzheimer’s disease
- Alzheimer Genetic Analysis Group. a
- Guerreiro, R., A. Wojtas, J. Bras, M. Carrasquillo, E. Rogaeva, E. Majounie, C. Cruchaga, C. Sassi, J.S. Kauwe, S.Younkin, et al. Alzheimer Genetic Analysis Group. 2013a. TREM2 variants in Alzheimer’s disease. N. Engl. J. Med. 368:117–127. http://dx.doi.org/10.1056/NEJMoa1211851
- (2013) N. Engl. J. Med , vol.368 , pp. 117-127
- Guerreiro, R.¹ Wojtas, A.² Bras, J.³ Carrasquillo, M.⁴ Rogaeva, E.⁵ Majounie, E.⁶ Cruchaga, C.⁷ Sassi, C.⁸ Kauwe, J.S.⁹ Younkin, S.¹⁰

9
- 84954101303
- Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
- Heslegrave, A., W. Heywood, R. Paterson, N. Magdalinou, J. Svensson, P. Johansson,A. Öhrfelt, K. Blennow, J. Hardy, J. Schott, et al. 2016. Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease. Mol. Neurodegener. 11:3. http://dx.doi.org/10.1186/s13024-016-0071-x
- (2016) Mol. Neurodegener , vol.11 , pp. 3
- Heslegrave, A.¹ Heywood, W.² Paterson, R.³ Magdalinou, N.⁴ Svensson, J.⁵ Johansson, P.⁶ Öhrfelt, A.⁷ Blennow, K.⁸ Hardy, J.⁹ Schott, J.¹⁰

10
- 84911361303
- Coding variants inTREM2 increase risk for Alzheimer’s disease
- Jin, S.C., B.A. Benitez, C.M. Karch, B. Cooper,T. Skorupa, D. Carrell, J.B. Norton,S.Hsu,O.Harari,Y.Cai,et al.2014.Coding variants inTREM2 increase risk for Alzheimer’s disease. Hum. Mol. Genet. 23:5838–5846. http://dx.doi.org/10.1093/hmg/ddu277
- (2014) Hum. Mol. Genet , vol.23 , pp. 5838-5846
- Jin, S.C.¹ Benitez, B.A.² Karch, C.M.³ Cooper, B.⁴ Skorupa, T.⁵ Carrell, D.⁶ Norton, J.B.⁷ Hsu, S.⁸ Harari, O.⁹ Cai, Y.¹⁰

11
- 84929174352
- TREM2 is associated with increased risk for Alzheimer’s disease in African Americans
- Jin, S.C., M.M. Carrasquillo, B.A. Benitez,T. Skorupa, D. Carrell, D. Patel, S. Lincoln, S. Krishnan, M. Kachadoorian, C. Reitz, et al. 2015. TREM2 is associated with increased risk for Alzheimer’s disease in African Americans. Mol. Neurodegener. 10:19. http://dx.doi.org/10.1186/s13024 -015-0016-9
- (2015) Mol. Neurodegener , vol.10 , pp. 19
- Jin, S.C.¹ Carrasquillo, M.M.² Benitez, B.A.³ Skorupa, T.⁴ Carrell, D.⁵ Patel, D.⁶ Lincoln, S.⁷ Krishnan, S.⁸ Kachadoorian, M.⁹ Reitz, C.¹⁰

12
- 84872088087
- Variant of TREM2 associated with the risk of Alzheimer’s disease
- Jonsson,T., H. Stefansson, S. Steinberg, I. Jonsdottir, P.V. Jonsson, J. Snaedal, S. Bjornsson, J. Huttenlocher, A.I. Levey, J.J. Lah, et al. 2013.Variant of TREM2 associated with the risk of Alzheimer’s disease. N. Engl. J. Med. 368:107–116. http://dx.doi.org/10.1056/NEJMoa1211103
- (2013) N. Engl. J. Med , vol.368 , pp. 107-116
- Jonsson, T.¹ Stefansson, H.² Steinberg, S.³ Jonsdottir, I.⁴ Jonsson, P.V.⁵ Snaedal, J.⁶ Bjornsson, S.⁷ Huttenlocher, J.⁸ Levey, A.I.⁹ Lah, J.J.¹⁰

13
- 84904479732
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
- Kleinberger, G., Y. Yamanishi, M. Suárez-Calvet, E. Czirr, E. Lohmann, E. Cuyvers, H. Struyfs, N. Pettkus, A.Wenninger-Weinzierl, F. Mazaheri, et al. 2014.TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci.Transl. Med. 6:243ra86. http://dx.doi.org/10.1126/scitranslmed.3009093
- (2014) Sci.Transl. Med , vol.6 , pp. 243ra86
- Kleinberger, G.¹ Yamanishi, Y.² Suárez-Calvet, M.³ Czirr, E.⁴ Lohmann, E.⁵ Cuyvers, E.⁶ Struyfs, H.⁷ Pettkus, N.⁸ Wenninger-Weinzierl, A.⁹ Mazaheri, F.¹⁰

14
- 20944436901
- The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2
- Klünemann, H.H., B.H. Ridha, L. Magy, J.R. Wherrett, D.M. Hemelsoet, R.W. Keen, J.L. De Bleecker, M.N. Rossor, J. Marienhagen, H.E. Klein, et al. 2005. The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2. Neurology. 64:1502–1507. http://dx.doi.org/10.1212/01.WNL.0000160304.00003.CA
- (2005) Neurology , vol.64 , pp. 1502-1507
- Klünemann, H.H.¹ Ridha, B.H.² Magy, L.³ Wherrett, J.R.⁴ Hemelsoet, D.M.⁵ Keen, R.W.⁶ De Bleecker, J.L.⁷ Rossor, M.N.⁸ Marienhagen, J.⁹ Klein, H.E.¹⁰

15
- 84938912653
- R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family: Clinical, genetic, and neuropathological study
- Korvatska, O., J.B. Leverenz, S. Jayadev, P. McMillan, I. Kurtz, X. Guo, M. Rumbaugh, M. Matsushita, S. Girirajan, M.O. Dorschner, et al. 2015. R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family: Clinical, genetic, and neuropathological study. JAMA Neurol. 72:920–927. http://dx.doi.org/10.1001/jamaneurol.2015.0979
- (2015) JAMA Neurol , vol.72 , pp. 920-927
- Korvatska, O.¹ Leverenz, J.B.² Jayadev, S.³ McMillan, P.⁴ Kurtz, I.⁵ Guo, X.⁶ Rumbaugh, M.⁷ Matsushita, M.⁸ Girirajan, S.⁹ Dorschner, M.O.¹⁰

16
- 84903776641
- HomozygousTREM2 mutation in a family with atypical frontotemporal dementia
- 2419.e23–2419.e25
- Le Ber, I., A. De Septenville, R. Guerreiro, J. Bras, A. Camuzat, P. Caroppo, S. Lattante, P. Couarch, E. Kabashi, K. Bouya-Ahmed, et al. 2014. HomozygousTREM2 mutation in a family with atypical frontotemporal dementia. Neurobiol.Aging. 35:2419.e23–2419.e25. http://dx.doi.org/10.1016/j.neurobiolaging.2014.04.010
- (2014) Neurobiol.Aging , vol.35
- Le Ber, I.¹ De Septenville, A.² Guerreiro, R.³ Bras, J.⁴ Camuzat, A.⁵ Caroppo, P.⁶ Lattante, S.⁷ Couarch, P.⁸ Kabashi, E.⁹ Bouya-Ahmed, K.¹⁰

17
- 0028675319
- GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures
- Lee, S.C.,W. Liu, C.F. Brosnan, and D.W. Dickson. 1994. GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia. 12:309–318. http://dx.doi.org/10.1002/glia.440120407
- (1994) Glia , vol.12 , pp. 309-318
- Lee, S.C.¹ Liu, W.² Brosnan, C.F.³ Dickson, D.W.⁴

18
- 80051587279
- Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family
- Numasawa,Y., C.Yamaura, S. Ishihara, S. Shintani, M.Yamazaki, H.Tabunoki, and J.I. Satoh. 2011. Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family. Eur. J. Neurol. 18:1179–1183. http://dx.doi.org/10.1111/j.1468-1331.2010.03311.x
- (2011) Eur. J. Neurol , vol.18 , pp. 1179-1183
- Numasawa, Y.¹ Yamaura, C.² Ishihara, S.³ Shintani, S.⁴ Yamazaki, M.⁵ Tabunoki, H.⁶ Satoh, J.I.⁷

19
- 84940731281
- TREM2 in CNS homeostasis and neurodegenerative disease
- Painter,M.M.,Y.Atagi,C.C.Liu,R.Rademakers,H.Xu,J.D.Fryer,and G.Bu. 2015.TREM2 in CNS homeostasis and neurodegenerative disease. Mol. Neurodegener. 10:43.http://dx.doi.org/10.1186/s13024-015-0040-9
- (2015) Mol. Neurodegener , vol.10 , pp. 43
- Painter, M.M.¹ Atagi, Y.² Liu, C.C.³ Rademakers, R.⁴ Xu, H.⁵ Fryer, J.D.⁶ Bu, G.⁷

20
- 18544390923
- Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
- Paloneva, J., T. Manninen, G. Christman, K. Hovanes, J. Mandelin, R. Adolfsson, M. Bianchin, T. Bird, R. Miranda, A. Salmaggi, et al. 2002. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71:656–662. http://dx.doi.org/10.1086/342259
- (2002) Am. J. Hum. Genet , vol.71 , pp. 656-662
- Paloneva, J.¹ Manninen, T.² Christman, G.³ Hovanes, K.⁴ Mandelin, J.⁵ Adolfsson, R.⁶ Bianchin, M.⁷ Bird, T.⁸ Miranda, R.⁹ Salmaggi, A.¹⁰

21
- 55749094156
- Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
- II
- Piccio, L., C. Buonsanti, M. Cella, I. Tassi, R.E. Schmidt, C. Fenoglio, J. Rinker II, R.T. Naismith, P. Panina-Bordignon, N. Passini, et al. 2008. Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain. 131:3081–3091. http://dx.doi.org/10.1093/brain/awn217
- (2008) Brain , vol.131 , pp. 3081-3091
- Piccio, L.¹ Buonsanti, C.² Cella, M.³ Tassi, I.⁴ Schmidt, R.E.⁵ Fenoglio, C.⁶ Rinker, J.⁷ Naismith, R.T.⁸ Panina-Bordignon, P.⁹ Passini, N.¹⁰

22
- 84954193258
- Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
- Piccio, L., Y. Deming, J.L. Del-Águila, L. Ghezzi, D.M. Holtzman, A.M. Fagan, C. Fenoglio, D. Galimberti, B. Borroni, and C. Cruchaga. 2016. Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status. Acta Neuropathol. 131:925–933. http://dx.doi.org/10.1007/s00401-016-1533-5
- (2016) Acta Neuropathol , vol.131 , pp. 925-933
- Piccio, L.¹ Deming, Y.² Del-Águila, J.L.³ Ghezzi, L.⁴ Holtzman, D.M.⁵ Fagan, A.M.⁶ Fenoglio, C.⁷ Galimberti, D.⁸ Borroni, B.⁹ Cruchaga, C.¹⁰

23
- 17144395975
- The activation of Akt/PKB signaling pathway and cell survival
- Song, G., G. Ouyang, and S. Bao. 2005.The activation of Akt/PKB signaling pathway and cell survival. J. Cell. Mol. Med. 9:59–71. http://dx.doi.org/10.1111/j.1582-4934.2005.tb00337.x
- (2005) J. Cell. Mol. Med , vol.9 , pp. 59-71
- Song, G.¹ Ouyang, G.² Bao, S.³

24
- 84960155154
- sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers
- Suárez-Calvet, M., G. Kleinberger, M.A. Araque Caballero, M. Brendel, A. Rominger, D. Alcolea, J. Fortea, A. Lleó, R. Blesa, J.D. Gispert, et al. 2016. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers. EMBO Mol. Med. 8:466–476. http://dx.doi.org/10.15252/emmm.201506123
- (2016) EMBO Mol. Med , vol.8 , pp. 466-476
- Suárez-Calvet, M.¹ Kleinberger, G.² Araque Caballero, M.A.³ Brendel, M.⁴ Rominger, A.⁵ Alcolea, D.⁶ Fortea, J.⁷ Lleó, A.⁸ Blesa, R.⁹ Gispert, J.D.¹⁰

25
- 0029894624
- Apoptosis of cultured microglia by the deprivation of macrophage colony-stimulating factor
- Tomozawa, Y., T. Inoue, M. Takahashi, M. Adachi, and M. Satoh. 1996. Apoptosis of cultured microglia by the deprivation of macrophage colony-stimulating factor. Neurosci. Res. 25:7–15. http://dx.doi.org/10.1016/0168-0102(96)01021-8
- (1996) Neurosci. Res , vol.25 , pp. 7-15
- Tomozawa, Y.¹ Inoue, T.² Takahashi, M.³ Adachi, M.⁴ Satoh, M.⁵

26
- 84925464993
- TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model
- Wang,Y., M. Cella, K. Mallinson, J.D. Ulrich, K.L.Young, M.L. Robinette, S. Gilfillan, G.M. Krishnan, S. Sudhakar, B.H. Zinselmeyer, et al. 2015. TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model. Cell. 160:1061–1071. http://dx.doi.org/10.1016/j.cell.2015.01.049
- (2015) Cell , vol.160 , pp. 1061-1071
- Wang, Y.¹ Cella, M.² Mallinson, K.³ Ulrich, J.D.⁴ Young, K.L.⁵ Robinette, M.L.⁶ Gilfillan, S.⁷ Krishnan, G.M.⁸ Sudhakar, S.⁹ Zinselmeyer, B.H.¹⁰

27
- 84940763775
- TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
- Wu, K., D.E. Byers, X. Jin, E.Agapov, J.Alexander-Brett,A.C. Patel, M. Cella, S. Gilfilan, M. Colonna, D.L. Kober, et al. 2015. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J. Exp. Med. 212:681–697. http://dx.doi.org/10.1084/jem.20141732
- (2015) J. Exp. Med , vol.212 , pp. 681-697
- Wu, K.¹ Byers, D.E.² Jin, X.³ Agapov, E.⁴ Alexander-Brett, J.⁵ Patel, A.C.⁶ Cella, M.⁷ Gilfilan, S.⁸ Colonna, M.⁹ Kober, D.L.¹⁰

28
- 84887853222
- Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage
- Wunderlich, P., K. Glebov, N. Kemmerling, N.T. Tien, H. Neumann, and J. Walter. 2013. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage. J. Biol. Chem. 288:33027–33036. http://dx.doi.org/10.1074/jbc.M113.517540
- (2013) J. Biol. Chem , vol.288 , pp. 33027-33036
- Wunderlich, P.¹ Glebov, K.² Kemmerling, N.³ Tien, N.T.⁴ Neumann, H.⁵ Walter, J.⁶

29
- 84940094599
- DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response
- Zhong, L., X.F. Chen, Z.L. Zhang, Z. Wang, X.Z. Shi, K. Xu, Y.W. Zhang, H. Xu, and G. Bu. 2015. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. J. Biol. Chem. 290:15866–15877. http://dx.doi.org/10.1074/jbc.M115.645986
- (2015) J. Biol. Chem , vol.290 , pp. 15866-15877
- Zhong, L.¹ Chen, X.F.² Zhang, Z.L.³ Wang, Z.⁴ Shi, X.Z.⁵ Xu, K.⁶ Zhang, Y.W.⁷ Xu, H.⁸ Bu, G.⁹

30
- 77953845018
- Excitotoxicity of TNFalpha derived from KA activated microglia on hippocampal neurons in vitro and in vivo
- Zhu,W., H. Zheng, X. Shao,W.Wang, Q.Yao, and Z. Li. 2010. Excitotoxicity of TNFalpha derived from KA activated microglia on hippocampal neurons in vitro and in vivo. J. Neurochem. 114:386–396. http://dx.doi.org/10.1111/j.1471-4159.2010.06763.x
- (2010) J. Neurochem , vol.114 , pp. 386-396
- Zhu, W.¹ Zheng, H.² Shao, X.³ Wang, W.⁴ Yao, Q.⁵ Li, Z.⁶

31
- 84904878925
- TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway
- Zhu, X., S.Wang, L.Yu, H.Yang, R.Tan, K.Yin, J. Jin, H. Zhao, D. Guan, andY. Xu.2014.TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway. Int. J. Neuropsychopharmacol. 17:1511–1519. http://dx.doi.org/10.1017/S1461145714000315
- (2014) Int. J. Neuropsychopharmacol , vol.17 , pp. 1511-1519
- Zhu, X.¹ Wang, S.² Yu, L.³ Yang, H.⁴ Tan, R.⁵ Yin, K.⁶ Jin, J.⁷ Zhao, H.⁸ Guan, D.⁹ Xu, andY.¹⁰

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.