Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

EMBO Journal

Volumn 37, Issue 8, 2018, Pages

  Prabakaran, Thaneas ^a   Bodda, Chiranjeevi ^a,b   Krapp, Christian ^a   Zhang, Bao Cun ^a   Christensen, Maria H ^a   Sun, Chenglong ^a   Reinert, Line ^a   Cai, Yujia ^a   Jensen, Søren B ^a   Skouboe, Morten K ^a   Nyengaard, Jens R ^a   Thompson, Craig B ^c   Lebbink, Robert Jan ^d   Sen, Ganes C ^e   van Loo, Geert ^f,g   Nielsen, Rikke ^a   Komatsu, Masaaki ^h   Nejsum, Lene N ^a   Jakobsen, Martin R ^a   Gyrd Hansen, Mads ^b   Paludan, Søren R ^a   more..

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e LERNER RESEARCH INSTITUTE   (United States)

^f DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^g GHENT UNIVERSITY   (Belgium)

^h NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

autophagy; DNA sensing; innate immunity; p62 SQSTM1; STING

Indexed keywords

ADAPTOR PROTEIN; CYCLIC GMP AMP SYNTHASE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 3; PROTEIN KINASE; SEQUESTOSOME 1; STIMULATOR OF INTERFERON GENE; SYNTHETASE; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; DNA; MB21D1 PROTEIN, HUMAN; MB21D1 PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE; PROTEIN SERINE THREONINE KINASE; SQSTM1 PROTEIN, HUMAN; SQSTM1 PROTEIN, MOUSE; TBK1 PROTEIN, HUMAN; TBK1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELLULAR DISTRIBUTION; CGAS STING SIGNALING; CONTROLLED STUDY; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTERFERON PRODUCTION; LISTERIA MONOCYTOGENES; LYSOSOME; MACROPHAGE; MEF CELL LINE; MONOCYTE DERIVED MACROPHAGE; MOUSE; MURINE CYTOMEGALOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THP-1 CELL LINE; UBIQUITINATION; ANIMAL; C57BL MOUSE; CELL LINE; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; CELL LINE; DNA; HUMANS; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEOTIDYLTRANSFERASES; PROTEIN-SERINE-THREONINE KINASES; SEQUESTOSOME-1 PROTEIN; SIGNAL TRANSDUCTION;

EID: 85042600965     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201797858     Document Type: Article

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