HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

EMBO Journal

Volumn 35, Issue 13, 2016, Pages 1385-1399

  Christensen, Maria H ^a   Jensen, Søren B ^a   Miettinen, Juho J ^b   Luecke, Stefanie ^a   Prabakaran, Thaneas ^a   Reinert, Line S ^a   Mettenleiter, Thomas ^c   Chen, Zhijian J ^d   Knipe, David M ^e   Sandri Goldin, Rozanne M ^f   Enquist, Lynn W ^g   Hartmann, Rune ^a   Mogensen, Trine H ^a,h   Rice, Stephen A ⁱ   Nyman, Tuula A ^b   Matikainen, Sampsa ^j   Paludan, Søren R ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF HELSINKI   (Finland)

^c FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g PRINCETON UNIVERSITY   (United States)

^h AARHUS UNIVERSITY HOSPITAL   (Denmark)

ⁱ UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^j FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

more..

Author keywords

herpes simplex virus; immune evasion; innate immunity; type I IFN

Indexed keywords

ACICLOVIR; ALPHA INTERFERON; BETA INTERFERON; ICP27 PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; PROTEIN; STING PROTEIN; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ALPHAHERPESVIRINAE; ARTICLE; CELL LYSATE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; GENE EXPRESSION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; IMMUNE EVASION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MACROPHAGE; NUCLEAR EXPORT SIGNAL; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SUPERNATANT; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; WESTERN BLOTTING;

EID: 85027918711     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201593458     Document Type: Article

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