Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS

Nature Communications

Volumn 7, Issue , 2016, Pages

  Reinert, Line S ^a   Lopušná, Katarína ^a,b   Winther, Henriette ^a   Sun, Chenglong ^a   Thomsen, Martin K ^a   Nandakumar, Ramya ^a   Mogensen, Trine H ^a,c   Meyer, Morten ^d   Vægter, Christian ^a   Nyengaard, Jens R ^a   Fitzgerald, Katherine A ^e   Paludan, Søren R ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b INSTITUTE OF VIROLOGY   (Slovakia)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CYCLIC GMP; CYCLIC GMP AMP SYNTHASE; INTERFERON; STIMULATOR OF TYPE I INTERFERON GENE; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; MB21D1 PROTEIN, MOUSE; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE;

BRAIN; CELLS AND CELL COMPONENTS; ENCEPHALITIS; GENE EXPRESSION; NERVOUS SYSTEM; RODENT; VIRUS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENZYME DEFECT; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS 1; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICROGLIA; MOUSE; NERVE CELL; NONHUMAN; QUORUM SENSING; SIGNAL TRANSDUCTION; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DRUG EFFECT; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; HUMAN ALPHAHERPESVIRUS 1; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; VIROLOGY;

HUMAN HERPESVIRUS 1; MUS; SIMPLEXVIRUS;

ANIMALS; ANTIVIRAL AGENTS; ASTROCYTES; CELLS, CULTURED; ENCEPHALITIS, HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON TYPE I; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NUCLEOTIDYLTRANSFERASES; SIGNAL TRANSDUCTION;

EID: 84994908913     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13348     Document Type: Article

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