Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections

Journal of Virology

Volumn 92, Issue 4, 2018, Pages

  Xiong, Xiaoli ^a   Tortorici, M Alejandra ^b,c   Snijder, Joost ^a   Yoshioka, Craig ^d   Walls, Alexandra C ^a   Li, Wentao ^e   McGuire, Andrew T ^f   Rey, Félix A ^b,c   Bosch, Berend Jan ^e   Veesler, David ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b INSTITUT PASTEUR   (France)

^c Institut Pasteur   (France)

^d Oregon Health and Science University Department of Biomedical Engineering   (United States)

^e UTRECHT UNIVERSITY   (Netherlands)

^f Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Coronaviruses; Cryo EM; Fusion proteins

Indexed keywords

AMINO ACID; GLYCAN; NEUTRALIZING ANTIBODY; PROTEINASE; VIRUS FUSION PROTEIN; VIRUS SPIKE PROTEIN; CORONAVIRUS SPIKE GLYCOPROTEIN; POLYSACCHARIDE;

ANIMAL CELL; ARTICLE; BETACORONAVIRUS; CONTROLLED STUDY; CORONAVIRINAE; CRYOELECTRON MICROSCOPY; HUMAN; HUMAN CELL; HUMAN CORONAVIRUS NL63; IMMUNE RESPONSE; INTESTINE INFECTION; MEMBRANE FUSION; NONHUMAN; PORCINE DELTACORONAVIRUS; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRAIN DIFFERENCE; SURFACE AREA; VIRUS CELL INTERACTION; ANIMAL; CHEMISTRY; CLASSIFICATION; CORONAVIRIDAE; CORONAVIRIDAE INFECTION; DROSOPHILA MELANOGASTER; METABOLISM; PATHOLOGY; PHYSIOLOGY; PIG; PROTEIN CONFORMATION; SWINE DISEASE; VIROLOGY; VIRUS ATTACHMENT;

ANIMALS; CORONAVIRIDAE; CORONAVIRIDAE INFECTIONS; DROSOPHILA MELANOGASTER; HUMANS; MEMBRANE FUSION; POLYSACCHARIDES; PROTEIN CONFORMATION; SPIKE GLYCOPROTEIN, CORONAVIRUS; SWINE; SWINE DISEASES; VIRUS ATTACHMENT;

EID: 85041238304     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01628-17     Document Type: Article

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