Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 47, 2009, Pages 19970-19974

  Wu, Kailang ^a   Li, Weikai ^b   Peng, Guiqing ^a   Li, Fang ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Receptor protein; SARS coronavirus; Spike protein receptor binding domain; Virus binding hotspots

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; VIRUS PROTEIN; VIRUS RECEPTOR;

ARTICLE; BETA SHEET; CONTROLLED STUDY; CORONAVIRUS; CRYSTAL STRUCTURE; GENETIC CONSERVATION; MOLECULAR RECOGNITION; NL63 CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; RECEPTOR BINDING; SARS CORONAVIRUS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; CORONAVIRUS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDYL-DIPEPTIDASE A; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; VIRAL ENVELOPE PROTEINS;

CORONAVIRUS; SARS CORONAVIRUS;

EID: 73949110051     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908837106     Document Type: Article

References (31)

1. Baranowski E, Ruiz-Jarabo CM, Domingo E (2001) Evolution of cell recognition by viruses. Science 292:1102-1105.
2. Bewley MC, Springer K, Zhang YB, Freimuth P, Flanagan JM (1999) Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science 286:1579-1583.
3. Carfi A, et al. (2001) Herpes simplex virus glycoprotein D bound to the human receptor HveA. Mol Cell 8:169-179.
4. Kwong PD, et al. (1998) Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393:648-659.
5. Li F, Li WH, Farzan M, Harrison SC (2005) Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science 309:1864-1868.
6. Xu K, et al. (2008) Host cell recognition by the henipaviruses: Crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3. Proc Natl Acad Sci USA 105:9953-9958.
7. van der Hoek L, et al. (2004) Identification of a new human coronavirus. Nature Medicine 10:368-373.
8. Fouchier RAM, et al. (2004) A previously undescribed coronavirus associated with respiratory disease in humans. Proc Natl Acad Sci USA 101:6212-6216.
9. Hofmann H, et al. (2005) Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad Sci USA 102:7988-7993.
10. Lai MMC, Holmes KV (2001) Coronaviridae: The viruses and their replication. Fields' Virology, Knipe DM, Howley PM, eds (Lippincott, Williams & Wilkins, Philadelphia), pp 1163-1186.
11. Delmas B, et al. (1992) Aminopeptidase-N is amajor receptor for the enteropathogenic coronavirus TGEV. Nature 357:417-420.
12. Yeager CL, et al. (1992) Human aminopeptidase-N is a receptor for human coronavirus-229e. Nature 357:420-422.
13. Li WH, et al. (2003) Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426:450-454.
14. Ksiazek TG, et al. (2003) A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 348:1953-1966.
15. Peiris JSM, et al. (2003) Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361:1319-1325.
16. Zheng Q, et al. (2006) Core structure of S2 from the human coronavirus NL63 spike glycoprotein. Biochemistry 45:15205-15215.
17. Xu YH, et al. (2004) Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core. J Biol Chem 279:49414-49419.
18. Babcock GJ, Esshaki DJ, Thomas WD, Ambrosino DM (2004) Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor. J Virol 78:4552-4560.
19. Hofmann H, et al. (2006) Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors. J Virol 80:8639-8652.
20. Li WH, et al. (2007) The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2. Virology 367:367-374.
21. Lin HX, et al. (2008) Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction. J Gen Virol 89:1015-1024.
22. Wong SK, Li WH, Moore MJ, Choe H, Farzan M (2004) A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J Biol Chem 279:3197-3201.
23. Li WH, et al. (2006) Animal origins of the severe acute respiratory syndrome coronavirus: Insight from ACE2-S-protein interactions. J Virol 80:4211-4219.
24. Towler P, et al. (2004) ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J Biol Chem 279:17996-18007.
25. Holm L, Sander C (1998) Touring protein fold space with Dali/FSSP. Nucleic Acids Res 26:316-319.
26. Li WH, et al. (2005) Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J 24:1634-1643.
27. Daopin S, Anderson DE, Baase WA, Dahlquist FW, Matthews BW (1991) Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme. Biochemistry 30:11521-11529.
28. Li F (2008) Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections. J Virol 82:6984-6991.
29. Tusell SM, Schittone SA, Holmes KV (2007) Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range. J Virol 81:1261-1273.
30. Li F, Li WH, Farzan M, Harrison SC (2006) Interactions between SARS coronavirus and its receptor. Adv Exp Med Biol 581:229-234.
31. Fenn TD, Ringe D, Petsko GA (2003) POVScript+: A program for model and data visualization using persistence of vision ray-tracing. J Appl Crystallogr 36:944-947.