Two mutations were critical for bat-to-human transmission of middle east respiratory syndrome coronavirus

Journal of Virology

Volumn 89, Issue 17, 2015, Pages 9119-9123

  Yang, Yang ^a   Liu, Chang ^a   Du, Lanying ^b   Jiang, Shibo ^b,c   Shi, Zhengli ^d   Baric, Ralph S ^e   Li, Fang ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b NEW YORK BLOOD CENTER   (United States)

^c FUDAN UNIVERSITY   (China)

^d WUHAN INSTITUTE OF VIROLOGY   (China)

^e University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; DIPEPTIDYL PEPTIDASE IV; VIRAL PROTEIN; VIRUS RECEPTOR;

ARTICLE; BAT; CONTROLLED STUDY; HUMAN; HUMAN CELL; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; RNA VIRUS INFECTION; VIRUS ENTRY; VIRUS MUTATION; VIRUS STRAIN; VIRUS TRANSMISSION; ANIMAL; CELL LINE; CORONAVIRUS INFECTION; GENETICS; METABOLISM; MUTATION; TRANSMISSION; VIROLOGY;

CORONAVIRUS;

ANIMALS; CELL LINE; CHIROPTERA; CORONAVIRUS INFECTIONS; DIPEPTIDYL PEPTIDASE 4; HUMANS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUTATION; RECEPTORS, VIRUS; VIRAL STRUCTURAL PROTEINS;

EID: 84938933311     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01279-15     Document Type: Article

References (24)

1. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus A, Fouchier RAM. 2012. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 367:1814-1820. http://dx.doi.org/10.1056/NEJMoa1211721.
2. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, Fouchier RA, Galiano M, Gorbalenya AE, Memish ZA, Perlman S, Poon LL, Snijder EJ, Stephens GM, Woo PC, Zaki AM, Zambon M, Ziebuhr J. 2013. Middle East respiratory syndrome coronavirus (MERSCoV): announcement of the Coronavirus Study Group. J Virol 87:7790-7792. http://dx.doi.org/10.1128/JVI.01244-13.
3. Annan A, Baldwin HJ, Corman VM, Klose SM, Owusu M, Nkrumah EE, Badu EK, Anti P, Agbenyega O, Meyer B, Oppong S, Sarkodie YA, Kalko EK, Lina PH, Godlevska EV, Reusken C, Seebens A, Gloza-Rausch F, Vallo P, Tschapka M, Drosten C, Drexler JF. 2013. Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe. Emerg Infect Dis 19:456-459. http://dx.doi.org/10.3201/eid1903.121503.
4. Holmes KV, Dominguez SR. 2013. The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia. mBio 4:e00548-12. http://dx.doi.org/10.1128/mBio.00548-12.
5. Lau SK, Li KS, Tsang AK, Lam CS, Ahmed S, Chen H, Chan KH, Woo PC, Yuen KY. 2013. Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus. J Virol 87:8638-8650. http://dx.doi.org/10.1128/JVI.01055-13.
6. Perlman S, Netland J. 2009. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol 7:439-450. http://dx.doi.org/10.1038/nrmicro2147.
7. Li F. 2015. Receptor recognition mechanisms of coronaviruses: a decade of structural studies. J Virol 89:1954-1964. http://dx.doi.org/10.1128/JVI.02615-14.
8. Li WH, Wong SK, Li F, Kuhn JH, Huang IC, Choe H, Farzan M. 2006. Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions. J Virol 80:4211-4219. http://dx.doi.org/10.1128/JVI.80.9.4211-4219.2006.
9. Belouzard S, Millet JK, Licitra BN, Whittaker GR. 2012. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses 4:1011-1033. http://dx.doi.org/10.3390/v4061011.
10. Heald-Sargent T, Gallagher T. 2012. Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence. Viruses 4:557-580. http://dx.doi.org/10.3390/v4040557.
11. Simmons G, Zmora P, Gierer S, Heurich A, Pohlmann S. 2013. Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research. Antiviral Res 100:605-614. http://dx.doi.org/10.1016/j.antiviral.2013.09.028.
12. Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P. 2005. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A 102:11876-11881. http://dx.doi.org/10.1073/pnas.0505577102.
13. Simmons G, Reeves JD, Rennekamp AJ, Amberg SM, Piefer AJ, Bates P. 2004. Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry. Proc Natl Acad Sci U S A 101:4240-4245. http://dx.doi.org/10.1073/pnas.0306446101.
14. Yang Y, Du L, Liu C, Wang L, Ma C, Tang J, Baric RS, Jiang S, Li F. 2014. Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus. Proc Natl Acad Sci U S A 111:12516-12521. http://dx.doi.org/10.1073/pnas.1405889111.
15. Gierer S, Muller MA, Heurich A, Ritz D, Springstein BL, Karsten CB, Schendzielorz A, Gnirss K, Drosten C, Pohlmann S. 2015. Inhibition of proprotein convertases abrogates processing of the Middle Eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity. J Infect Dis 211:889-897. http://dx.doi.org/10.1093/infdis/jiu407.
16. Millet JK, Whittaker GR. 2014. Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proc Natl Acad Sci U S A 111:15214-15219. http://dx.doi.org/10.1073/pnas.1407087111.
17. Bosch BJ, Bartelink W, Rottier PJ. 2008. Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide. J Virol 82:8887-8890. http://dx.doi.org/10.1128/JVI.00415-08.
18. Biniossek ML, Nagler DK, Becker-Pauly C, Schilling O. 2011. Proteomic identification of protease cleavage sites characterizes prime and nonprime specificity of cysteine cathepsins B, L, and S. J Proteome Res 10: 5363-5373. http://dx.doi.org/10.1021/pr200621z.
19. Li F. 2013. Receptor recognition and cross-species infections of SARS coronavirus. Antiviral Res 100:246-254. http://dx.doi.org/10.1016/j.antiviral.2013.08.014.
20. Li F, Li WH, Farzan M, Harrison SC. 2005. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science 309:1864-1868. http://dx.doi.org/10.1126/science.1116480.
21. Li WH, Zhang CS, Sui JH, Kuhn JH, Moore MJ, Luo SW, Wong SK, Huang IC, Xu KM, Vasilieva N, Murakami A, He YQ, Marasco WA, Guan Y, Choe HY, Farzan M. 2005. Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J 24:1634-1643. http://dx.doi.org/10.1038/sj.emboj.7600640.
22. Li F. 2008. Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections. J Virol 82:6984-6991. http://dx.doi.org/10.1128/JVI.00442-08.
23. Wang Q, Qi J, Yuan Y, Xuan Y, Han P, Wan Y, Ji W, Li Y, Wu Y, Wang J, Iwamoto A, Woo PC, Yuen KY, Yan J, Lu G, Gao GF. 2014. Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26. Cell Host Microbe 16:328-337. http://dx.doi.org/10.1016/j.chom.2014.08.009.
24. Ge XY, Li JL, Yang XL, Chmura AA, Zhu G, Epstein JH, Mazet JK, Hu B, Zhang W, Peng C, Zhang YJ, Luo CM, Tan B, Wang N, Zhu Y, Crameri G, Zhang SY, Wang LF, Daszak P, Shi ZL. 2013. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature 503:535-538. http://dx.doi.org/10.1038/nature12711.