Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 42, 2014, Pages 15214-15219

  Mille, Jean Kaoru ^a   Whittaker, Gary R ^a  

^a Department of Microbiology and Immunology Cornell University ^*  (United States)

Author keywords

Furin; Middle East respiratory syndrome coronavirus; Proteolytic activation; Spike protein; Virus entry

Indexed keywords

FURIN; SMALL INTERFERING RNA; VIRUS SPIKE PROTEIN; CORONAVIRUS SPIKE GLYCOPROTEIN; PEPTIDE HYDROLASE; VIRUS RECEPTOR;

ARTICLE; CONTROLLED STUDY; CORONAVIRUS; ENZYME ASSAY; ENZYME METABOLISM; HOST CELL; HUMAN; HUMAN CELL; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; VIRUS ENTRY; ANIMAL; BIOLOGY; CHEMISTRY; CHLOROCEBUS AETHIOPS; GENE SILENCING; GENETIC PREDISPOSITION; HEK293 CELL LINE; METABOLISM; MUTATION; PHYSIOLOGY; TIME FACTOR; TUMOR CELL LINE; VERO CELL LINE;

ANIMALS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COMPUTATIONAL BIOLOGY; FURIN; GENE SILENCING; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HUMANS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUTATION; PEPTIDE HYDROLASES; RECEPTORS, VIRUS; RNA, SMALL INTERFERING; SPIKE GLYCOPROTEIN, CORONAVIRUS; TIME FACTORS; VERO CELLS; VIRUS INTERNALIZATION;

EID: 84908065761     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1407087111     Document Type: Article

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