Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

Nature Genetics

Volumn 50, Issue 3, 2018, Pages 424-431

  Alasoo, Kaur ^a,c   Rodrigues, Julia ^a   Mukhopadhyay, Subhankar ^a   Knights, Andrew J ^a   Mann, Alice L ^a   Kundu, Kousik ^a,b   Hale, Christine ^a   Dougan, Gordon ^a   Gaffney, Daniel J ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STAT2 PROTEIN; TRANSCRIPTION FACTOR PU 1; PROTEIN BINDING; TRANSCRIPTION FACTOR;

ARTICLE; CHROMATIN; ENHANCER REGION; FEMALE; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; HEREDITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MACROPHAGE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE TRAIT LOCUS; SALMONELLA; CELL CULTURE; CELLULAR IMMUNITY; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS;

CELLS, CULTURED; CHROMATIN; ENHANCER ELEMENTS, GENETIC; FEMALE; GENE EXPRESSION; HUMANS; IMMUNITY, CELLULAR; MACROPHAGES; MALE; PROTEIN BINDING; QUANTITATIVE TRAIT LOCI; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; TRANSCRIPTION FACTORS;

EID: 85041133831     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0046-7     Document Type: Article

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