Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers

Cancer Research

Volumn 67, Issue 18, 2007, Pages 8468-8476

  Arena, Sabrina ^a   Isella, Claudio ^a   Martini, Miriam ^a   De Marco, Ario ^b   Medico, Enzo ^a   Bardelli, Alberto ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; K RAS PROTEIN; PARVOVIRUS VECTOR; PROTEIN K RAS G12D; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT CARCINOMA; CANCER CLASSIFICATION; CELL MOTILITY; CELL PROLIFERATION; CELL TRANSFORMATION; COLORECTAL CANCER; CONTROLLED STUDY; DNA FINGERPRINTING; GENE INSERTION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC MANIPULATION; GENETIC RECOMBINATION; HETEROZYGOSITY; HOMOLOGOUS RECOMBINATION; HUMAN; KNOCKIN MOUSE; KNOCKOUT MOUSE; LUNG ADENOCARCINOMA; MOLECULAR MECHANICS; MOUSE; NONHUMAN; ONCOGENE K RAS; ORTHOTOPIC TRANSPLANTATION; PANCREAS CANCER; PRIORITY JOURNAL; SOMATIC CELL; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENES, RAS; HUMANS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; POINT MUTATION; STEM CELLS; TRANS-ACTIVATION (GENETICS);

EID: 34548735435     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1126     Document Type: Article

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