메뉴 건너뛰기




Volumn 19, Issue 1, 2018, Pages

Is osteopontin a friend or foe of cell apoptosis in inflammatory gastrointestinal and liver diseases?

Author keywords

Apoptosis; Cacinogenesis; Gastrointestinal; Inflammation; Liver; Osteopontin

Indexed keywords

ALPHA4 INTEGRIN; HERMES ANTIGEN; MYELOID DIFFERENTIATION FACTOR 88; OSTEOPONTIN;

EID: 85039707563     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms19010007     Document Type: Review
Times cited : (31)

References (130)
  • 1
    • 1542292358 scopus 로고    scopus 로고
    • World Health Organization and International Union against Cancer: Geneva, Switzerland
    • Global Action against Cancer-Updated Version; World Health Organization and International Union against Cancer: Geneva, Switzerland, 2005; p. 12.
    • (2005) Global Action against Cancer-Updated Version , pp. 12
  • 3
    • 84928077532 scopus 로고    scopus 로고
    • Macrophages and therapeutic resistance in cancer
    • Ruffel, B.; Coussens, L.M. Macrophages and therapeutic resistance in cancer. Cancer Cell 2015, 27, 462-472.
    • (2015) Cancer Cell , vol.27 , pp. 462-472
    • Ruffel, B.1    Coussens, L.M.2
  • 4
    • 84941660341 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer: An eternal fight between good and evil
    • Shalapour, S.; Karin, M. Immunity, inflammation, and cancer: An eternal fight between good and evil. J. Clin. Investig. 2015, 125, 3347-3355.
    • (2015) J. Clin. Investig. , vol.125 , pp. 3347-3355
    • Shalapour, S.1    Karin, M.2
  • 5
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S.I.; Greten, F.R.; Karin, M. Immunity, inflammation, and cancer. Cell 2010, 140, 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 7
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB-dependent manner
    • Erez, N.; Truitt, M.; Olson, P.; Arron, S.T.; Hanahan, D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB-dependent manner. Cancer Cell 2010, 17, 135-147.
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 8
    • 0022354869 scopus 로고
    • Isolation and characterization of two sialoproteins present only in bone calcified matrix
    • Franzen, A.; Heinegard, D. Isolation and characterization of two sialoproteins present only in bone calcified matrix. Biochem. J. 1985, 232, 715-724.
    • (1985) Biochem. J. , vol.232 , pp. 715-724
    • Franzen, A.1    Heinegard, D.2
  • 12
    • 35648934023 scopus 로고    scopus 로고
    • Control of osteopontin signaling and function by post-translational phosphorylation and protein folding
    • Kazanecki, C.C.; Uzwiak, D.J.; Denhardt, D.T. Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. J. Cell. Biochem. 2007, 102, 912-924.
    • (2007) J. Cell. Biochem. , vol.102 , pp. 912-924
    • Kazanecki, C.C.1    Uzwiak, D.J.2    Denhardt, D.T.3
  • 13
    • 84908268897 scopus 로고    scopus 로고
    • Role of osteopontin in the pathophysiology of cancer
    • Shevde, L.A.; Samant, R.S. Role of osteopontin in the pathophysiology of cancer. Matrix Biol. 2014, 37, 131-141.
    • (2014) Matrix Biol. , vol.37 , pp. 131-141
    • Shevde, L.A.1    Samant, R.S.2
  • 14
    • 0035021027 scopus 로고    scopus 로고
    • Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival
    • Denhardt, D.T.; Noda, M.; O’Regan, A.W.; Pavlin, D.; Berman, J.S. Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival. J. Clin. Investig. 2001, 107, 1055-1061.
    • (2001) J. Clin. Investig. , vol.107 , pp. 1055-1061
    • Denhardt, D.T.1    Noda, M.2    O’Regan, A.W.3    Pavlin, D.4    Berman, J.S.5
  • 15
    • 44449131554 scopus 로고    scopus 로고
    • Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells
    • Shinohara, M.L.; Kim, H.J.; Kim, J.H.; Garcia, V.A.; Cantor, H. Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. Proc. Natl. Acad. Sci. USA 2008, 105, 7235-7239.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 7235-7239
    • Shinohara, M.L.1    Kim, H.J.2    Kim, J.H.3    Garcia, V.A.4    Cantor, H.5
  • 16
    • 57049166456 scopus 로고    scopus 로고
    • Osteopontin: Role in immuneregulation and stress responses
    • Wang, K.X.; Denhardt, D.T. Osteopontin: Role in immuneregulation and stress responses. Cytokine Growth Factor Rev. 2008, 19, 333-345.
    • (2008) Cytokine Growth Factor Rev. , vol.19 , pp. 333-345
    • Wang, K.X.1    Denhardt, D.T.2
  • 17
    • 42149085600 scopus 로고    scopus 로고
    • Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer
    • Ramaiah, S.K.; Rittling, S. Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. Toxicol. Sci. 2008, 103, 4-13.
    • (2008) Toxicol. Sci. , vol.103 , pp. 4-13
    • Ramaiah, S.K.1    Rittling, S.2
  • 18
    • 2942511574 scopus 로고    scopus 로고
    • Role of osteopontin in tumour progression
    • Rittling, S.R.; Chambers, A.F. Role of osteopontin in tumour progression. Br. J. Cancer 2004, 90, 1877-1881.
    • (2004) Br. J. Cancer , vol.90 , pp. 1877-1881
    • Rittling, S.R.1    Chambers, A.F.2
  • 21
    • 84897361955 scopus 로고    scopus 로고
    • Osteopontin knockdown inhibits αv, β3 integrin-induced cell migration and invasion and promotes apoptosis of breast cancer cells by inducing autophagy and inactivating the PI3K/Akt/mTOR pathway
    • Zhang, H.; Guo, M.; Chen, J.H.; Wang, Z.; Du, X.F.; Liu, P.X.; Li, W.H. Osteopontin knockdown inhibits αv, β3 integrin-induced cell migration and invasion and promotes apoptosis of breast cancer cells by inducing autophagy and inactivating the PI3K/Akt/mTOR pathway. Cell Physiol. Biochem. 2014, 33, 991-1002.
    • (2014) Cell Physiol. Biochem. , vol.33 , pp. 991-1002
    • Zhang, H.1    Guo, M.2    Chen, J.H.3    Wang, Z.4    Du, X.F.5    Liu, P.X.6    Li, W.H.7
  • 22
    • 0028855585 scopus 로고
    • The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro
    • Liaw, L.; Skinner, M.P.; Raines, E.W.; Ross, R.; Cheresh, D.A.; Schwartz, S.M.; Giachelli, C.M. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro. J. Clin. Investig. 1995, 95, 713-724.
    • (1995) J. Clin. Investig. , vol.95 , pp. 713-724
    • Liaw, L.1    Skinner, M.P.2    Raines, E.W.3    Ross, R.4    Cheresh, D.A.5    Schwartz, S.M.6    Giachelli, C.M.7
  • 23
    • 28844482875 scopus 로고    scopus 로고
    • Distinct structural requirements for binding of the integrins αvβ6, αvβ3, αvβ5, α5β1 and α9β1 to osteopontin
    • Yokosaki, Y.; Tanaka, K.; Higashikawa, F.; Yamashita, K.; Eboshida, A. Distinct structural requirements for binding of the integrins αvβ6, αvβ3, αvβ5, α5β1 and α9β1 to osteopontin. Matrix Biol. 2005, 24, 418-427.
    • (2005) Matrix Biol. , vol.24 , pp. 418-427
    • Yokosaki, Y.1    Tanaka, K.2    Higashikawa, F.3    Yamashita, K.4    Eboshida, A.5
  • 24
    • 0035839024 scopus 로고    scopus 로고
    • Structural elements of the osteopontin SVVYGLR motif important for the interaction with α(4) integrins
    • Green, P.M.; Ludbrook, S.B.; Miller, D.D.; Horgan, C.M.; Barry, S.T. Structural elements of the osteopontin SVVYGLR motif important for the interaction with α(4) integrins. FEBS Lett. 2001, 503, 75-79.
    • (2001) FEBS Lett. , vol.503 , pp. 75-79
    • Green, P.M.1    Ludbrook, S.B.2    Miller, D.D.3    Horgan, C.M.4    Barry, S.T.5
  • 25
    • 55049109753 scopus 로고    scopus 로고
    • In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression
    • Marcondes, M.C.; Poling, M.; Watry, D.D.; Hall, D.; Fox, H.S. In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression. Cell. Immunol. 2008, 254, 56-62.
    • (2008) Cell. Immunol. , vol.254 , pp. 56-62
    • Marcondes, M.C.1    Poling, M.2    Watry, D.D.3    Hall, D.4    Fox, H.S.5
  • 26
    • 84875178124 scopus 로고    scopus 로고
    • Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin
    • Lund, S.A.; Wilson, C.L.; Raines, E.W.; Tang, J.; Giachelli, C.M.; Scatena, M. Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin. J. Cell. Biochem. 2013, 114, 1194-1202.
    • (2013) J. Cell. Biochem. , vol.114 , pp. 1194-1202
    • Lund, S.A.1    Wilson, C.L.2    Raines, E.W.3    Tang, J.4    Giachelli, C.M.5    Scatena, M.6
  • 27
    • 23044455714 scopus 로고    scopus 로고
    • Osteopontin: It’s role in regulation of cell motility and nuclear factor κB-mediated urokinase type plasminogen activator expression
    • Das, R.; Philip, S.; Mahabeleshwar, G.H.; Bulbule, A.; Kundu, G.C. Osteopontin: It’s role in regulation of cell motility and nuclear factor κB-mediated urokinase type plasminogen activator expression. IUBMB Life 2005, 57, 441-447.
    • (2005) IUBMB Life , vol.57 , pp. 441-447
    • Das, R.1    Philip, S.2    Mahabeleshwar, G.H.3    Bulbule, A.4    Kundu, G.C.5
  • 28
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB and IκB proteins: Implications in cancer and inflammation
    • Viatour, P.; Merville, M.P.; Bours, V.; Chariot, A. Phosphorylation of NF-κB and IκB proteins: Implications in cancer and inflammation. Trends Biochem. Sci. 2005, 30, 43-52.
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 29
    • 23044431647 scopus 로고    scopus 로고
    • Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype
    • Renkl, A.C.; Wussler, J.; Ahrens, T.; Thoma, K.; Kon, S.; Uede, T.; Martin, S.F.; Simon, J.C.; Weiss, J.M. Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype. Blood 2005, 106, 946-955.
    • (2005) Blood , vol.106 , pp. 946-955
    • Renkl, A.C.1    Wussler, J.2    Ahrens, T.3    Thoma, K.4    Kon, S.5    Uede, T.6    Martin, S.F.7    Simon, J.C.8    Weiss, J.M.9
  • 31
    • 0035167115 scopus 로고    scopus 로고
    • Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing Langerhans and dendritic cell migration to lymph nodes
    • Weiss, J.M.; Renkl, A.C.; Maier, C.S.; Kimmig, M.; Liaw, L.; Ahrens, T.; Kon, S.; Maeda, M.; Hotta, H.; Uede, T.; et al. Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing Langerhans and dendritic cell migration to lymph nodes. J. Exp. Med. 2001, 194, 1219-1229.
    • (2001) J. Exp. Med. , vol.194 , pp. 1219-1229
    • Weiss, J.M.1    Renkl, A.C.2    Maier, C.S.3    Kimmig, M.4    Liaw, L.5    Ahrens, T.6    Kon, S.7    Maeda, M.8    Hotta, H.9    Uede, T.10
  • 32
    • 84924258751 scopus 로고    scopus 로고
    • Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury
    • Hirano, Y.; Azi, M.; Yang, W.L.; Wang, Z.; Zhou, M.; Ochani, M.; Khader, A.; Wang, P. Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury. Crit. Care 2015, 19, 53.
    • (2015) Crit. Care , vol.19 , pp. 53
    • Hirano, Y.1    Azi, M.2    Yang, W.L.3    Wang, Z.4    Zhou, M.5    Ochani, M.6    Khader, A.7    Wang, P.8
  • 35
    • 84920969894 scopus 로고    scopus 로고
    • Intracellular osteopontin regulates homeostasis and function of natural killer cells
    • Leavenworth, J.W.; Verbinnen, B.; Wang, Q.; Shen, E.; Cantor, H. Intracellular osteopontin regulates homeostasis and function of natural killer cells. Proc. Natl. Acad. Sci. USA 2015, 112, 494-499.
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 494-499
    • Leavenworth, J.W.1    Verbinnen, B.2    Wang, Q.3    Shen, E.4    Cantor, H.5
  • 36
    • 77955493511 scopus 로고    scopus 로고
    • Osteopontin expressed in tubular epithelial cells regulates NK cell-mediated kidney ischemia reperfusion injury
    • Zhang, Z.X.; Shek, K.; Wang, S.; Huang, X.; Lau, A.; Yin, Z.; Sun, H.; Liu, W.; Garcia, B.; Rittling, S.; et al. Osteopontin expressed in tubular epithelial cells regulates NK cell-mediated kidney ischemia reperfusion injury. J. Immunol. 2010, 185, 967-973.
    • (2010) J. Immunol. , vol.185 , pp. 967-973
    • Zhang, Z.X.1    Shek, K.2    Wang, S.3    Huang, X.4    Lau, A.5    Yin, Z.6    Sun, H.7    Liu, W.8    Garcia, B.9    Rittling, S.10
  • 37
    • 84981243993 scopus 로고    scopus 로고
    • Osteopontin Blockade Attenuates Renal Injury After Ischemia Reperfusion by Inhibiting NK Cell Infiltration
    • Cen, C.; Aziz, M.; Yang, W.L.; Nicastro, J.M.; Coppa, G.F.; Wang, P. Osteopontin Blockade Attenuates Renal Injury After Ischemia Reperfusion by Inhibiting NK Cell Infiltration. Shock 2017, 47, 52-60.
    • (2017) Shock , vol.47 , pp. 52-60
    • Cen, C.1    Aziz, M.2    Yang, W.L.3    Nicastro, J.M.4    Coppa, G.F.5    Wang, P.6
  • 38
    • 84920671403 scopus 로고    scopus 로고
    • Intracellular osteopontin inhibits toll-like receptor signaling and impedes liver carcinogenesis
    • Fan, X.; He, C.; Jing, W.; Zhou, X.; Chen, R.; Cao, L.; Zhu, M.; Jia, R.; Wang, H.; Guo, Y.; et al. Intracellular osteopontin inhibits toll-like receptor signaling and impedes liver carcinogenesis. Cancer Res. 2015, 75, 86-97.
    • (2015) Cancer Res. , vol.75 , pp. 86-97
    • Fan, X.1    He, C.2    Jing, W.3    Zhou, X.4    Chen, R.5    Cao, L.6    Zhu, M.7    Jia, R.8    Wang, H.9    Guo, Y.10
  • 39
    • 84920956940 scopus 로고    scopus 로고
    • A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells
    • Leavenworth, J.W.; Verbinnen, B.; Yin, J.; Huang, H.; Cantor, H. A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells. Nat. Immunol. 2015, 16, 96-106.
    • (2015) Nat. Immunol. , vol.16 , pp. 96-106
    • Leavenworth, J.W.1    Verbinnen, B.2    Yin, J.3    Huang, H.4    Cantor, H.5
  • 40
    • 47249145601 scopus 로고    scopus 로고
    • Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells
    • Fan, K.; Dai, J.; Wang, H.; Wei, H.; Cao, Z.; Hou, S.; Qian, W.; Li, B.; Zhao, J.; Xu, H.; et al. Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells. Arthritis Rheum. 2008, 58, 2041-2052.
    • (2008) Arthritis Rheum. , vol.58 , pp. 2041-2052
    • Fan, K.1    Dai, J.2    Wang, H.3    Wei, H.4    Cao, Z.5    Hou, S.6    Qian, W.7    Li, B.8    Zhao, J.9    Xu, H.10
  • 41
    • 0025947139 scopus 로고
    • Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease
    • Lampe, M.A.; Patarca, R.; Iregui, M.V.; Cantor, H. Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease. J. Immunol. 1991, 147, 2902-2906.
    • (1991) J. Immunol. , vol.147 , pp. 2902-2906
    • Lampe, M.A.1    Patarca, R.2    Iregui, M.V.3    Cantor, H.4
  • 42
    • 0032407735 scopus 로고    scopus 로고
    • Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies
    • Iizuka, J.; Katagiri, Y.; Tada, N.; Murakami, M.; Ikeda, T.; Sato, M.; Hirokawa, K.; Okada, S.; Hatano, M.; Tokuhisa, T.; et al. Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies. Lab. Investig. 1998, 78, 1523-1533.
    • (1998) Lab. Investig. , vol.78 , pp. 1523-1533
    • Iizuka, J.1    Katagiri, Y.2    Tada, N.3    Murakami, M.4    Ikeda, T.5    Sato, M.6    Hirokawa, K.7    Okada, S.8    Hatano, M.9    Tokuhisa, T.10
  • 49
    • 0033580405 scopus 로고    scopus 로고
    • Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    • Lagergren, J.; Bergstrom, R.; Lindgren, A.; Nyren, O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N. Engl. J. Med. 1999, 340, 825-831.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 825-831
    • Lagergren, J.1    Bergstrom, R.2    Lindgren, A.3    Nyren, O.4
  • 50
    • 61349116213 scopus 로고    scopus 로고
    • Barrett’s oesophagus
    • Shaheen, N.J.; Richter, J.E. Barrett’s oesophagus. Lancet 2009, 373, 850-861.
    • (2009) Lancet , vol.373 , pp. 850-861
    • Shaheen, N.J.1    Richter, J.E.2
  • 55
    • 85030154877 scopus 로고    scopus 로고
    • Metaplasia in the Stomach-Precursor of Gastric Cancer?
    • Kinoshita, H.; Hayakawa, Y.; Koike, K. Metaplasia in the Stomach-Precursor of Gastric Cancer? Int. J. Mol. Sci. 2017, 18, 2063.
    • (2017) Int. J. Mol. Sci. , vol.18 , pp. 2063
    • Kinoshita, H.1    Hayakawa, Y.2    Koike, K.3
  • 56
    • 0029790518 scopus 로고    scopus 로고
    • Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages
    • Rollo, E.E.; Laskin, D.L.; Denhardt, D.T. Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages. J. Leukoc. Biol. 1996, 60, 397-404.
    • (1996) J. Leukoc. Biol. , vol.60 , pp. 397-404
    • Rollo, E.E.1    Laskin, D.L.2    Denhardt, D.T.3
  • 57
    • 79956161639 scopus 로고    scopus 로고
    • Increased gastric osteopontin expression by Helicobacter pylori Infection can correlate with more severe gastric inflammation and intestinal metaplasia
    • Chang, W.L.; Yang, H.B.; Cheng, H.C.; Chuang, C.H.; Lu, P.J.; Sheu, B.S. Increased gastric osteopontin expression by Helicobacter pylori Infection can correlate with more severe gastric inflammation and intestinal metaplasia. Helicobacter 2011, 16, 217-224.
    • (2011) Helicobacter , vol.16 , pp. 217-224
    • Chang, W.L.1    Yang, H.B.2    Cheng, H.C.3    Chuang, C.H.4    Lu, P.J.5    Sheu, B.S.6
  • 58
    • 85026904603 scopus 로고    scopus 로고
    • Osteopontin polymorphism increases gastric precancerous intestinal metaplasia susceptibility in Helicobacter pylori infected male
    • Chang, W.L.; Lin, M.Y.; Kuo, H.Y.; Yang, H.B.; Cheng, H.C.; Lu, C.C.; Sheu, B.S. Osteopontin polymorphism increases gastric precancerous intestinal metaplasia susceptibility in Helicobacter pylori infected male. Future Oncol. 2017, 13, 1415-1425.
    • (2017) Future Oncol. , vol.13 , pp. 1415-1425
    • Chang, W.L.1    Lin, M.Y.2    Kuo, H.Y.3    Yang, H.B.4    Cheng, H.C.5    Lu, C.C.6    Sheu, B.S.7
  • 59
    • 58749094152 scopus 로고    scopus 로고
    • Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via αvβ3 integrins in human gastric cancer cells
    • Song, G.; Ming, Y.; Mao, Y.; Bao, S.; Ouyang, G. Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via αvβ3 integrins in human gastric cancer cells. Exp. Biol. Med. (Maywood) 2008, 233, 1537-1545.
    • (2008) Exp. Biol. Med. (Maywood) , vol.233 , pp. 1537-1545
    • Song, G.1    Ming, Y.2    Mao, Y.3    Bao, S.4    Ouyang, G.5
  • 60
    • 33947254565 scopus 로고    scopus 로고
    • Osteopontin promotes integrin activation through outsidein and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells
    • Lee, J.L.; Wang, M.J.; Sudhir, P.R.; Chen, G.D.; Chi, C.W.; Chen, J.Y. Osteopontin promotes integrin activation through outsidein and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells. Cancer Res. 2007, 67, 2089-2097.
    • (2007) Cancer Res. , vol.67 , pp. 2089-2097
    • Lee, J.L.1    Wang, M.J.2    Sudhir, P.R.3    Chen, G.D.4    Chi, C.W.5    Chen, J.Y.6
  • 61
    • 53949095412 scopus 로고    scopus 로고
    • A small interfering RNA targeting osteopontin as gastric cancer therapeutics
    • Gong, M.; Lu, Z.; Fang, G.; Bi, J.; Xue, X. A small interfering RNA targeting osteopontin as gastric cancer therapeutics. Cancer Lett. 2008, 272, 148-159.
    • (2008) Cancer Lett. , vol.272 , pp. 148-159
    • Gong, M.1    Lu, Z.2    Fang, G.3    Bi, J.4    Xue, X.5
  • 62
    • 84949762566 scopus 로고    scopus 로고
    • Ablation of osteopontin suppresses N-methyl-N-nitrosourea and Helicobacter pylori-induced gastric cancer development in mice
    • Lee, S.H.; Park, J.W.; Go, D.M.; Kim, H.K.; Kwon, H.J.; Han, S.U.; Kim, D.Y. Ablation of osteopontin suppresses N-methyl-N-nitrosourea and Helicobacter pylori-induced gastric cancer development in mice. Carcinogenesis 2015, 36, 1550-1560.
    • (2015) Carcinogenesis , vol.36 , pp. 1550-1560
    • Lee, S.H.1    Park, J.W.2    Go, D.M.3    Kim, H.K.4    Kwon, H.J.5    Han, S.U.6    Kim, D.Y.7
  • 63
    • 84925688608 scopus 로고    scopus 로고
    • Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial cells induced by TNF-α in inflammatory bowel disease
    • Tang, R.; Yang, G.; Zhang, S.; Wu, C.; Chen, M. Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial cells induced by TNF-α in inflammatory bowel disease. Inflamm. Bowel Dis. 2014, 20, 1950-1961.
    • (2014) Inflamm. Bowel Dis. , vol.20 , pp. 1950-1961
    • Tang, R.1    Yang, G.2    Zhang, S.3    Wu, C.4    Chen, M.5
  • 64
    • 84942904537 scopus 로고    scopus 로고
    • Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity
    • Toyonaga, T.; Nakase, H.; Ueno, S.; Matsuura, M.; Yoshino, T.; Honzawa, Y.; Itou, A.; Namba, K.; Minami, N.; Yamada, S.; et al. Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity. PLoS ONE 2015, 10, e0135552.
    • (2015) PLoS ONE , vol.10
    • Toyonaga, T.1    Nakase, H.2    Ueno, S.3    Matsuura, M.4    Yoshino, T.5    Honzawa, Y.6    Itou, A.7    Namba, K.8    Minami, N.9    Yamada, S.10
  • 66
    • 33747383155 scopus 로고    scopus 로고
    • Osteopontin deficiency protects mice from Dextran sodium sulfate-induced colitis
    • Zhong, J.; Eckhardt, E.R.; Oz, H.S.; Bruemmer, D.; de Villiers, W.J. Osteopontin deficiency protects mice from Dextran sodium sulfate-induced colitis. Inflamm. Bowel Dis. 2006, 12, 790-796.
    • (2006) Inflamm. Bowel Dis. , vol.12 , pp. 790-796
    • Zhong, J.1    Eckhardt, E.R.2    Oz, H.S.3    Bruemmer, D.4    de Villiers, W.J.5
  • 72
    • 44849134814 scopus 로고    scopus 로고
    • Elevated plasma osteopontin level is predictive of cirrhosis in patients with hepatitis B infection
    • Zhao, L.; Li, T.; Wang, Y.; Pan, Y.; Ning, H.; Hui, X.; Xie, H.; Wang, J.; Han, Y.; Liu, Z.; et al. Elevated plasma osteopontin level is predictive of cirrhosis in patients with hepatitis B infection. Int. J. Clin. Pract. 2008, 62, 1056-1062.
    • (2008) Int. J. Clin. Pract. , vol.62 , pp. 1056-1062
    • Zhao, L.1    Li, T.2    Wang, Y.3    Pan, Y.4    Ning, H.5    Hui, X.6    Xie, H.7    Wang, J.8    Han, Y.9    Liu, Z.10
  • 73
    • 77950460585 scopus 로고    scopus 로고
    • Plasma osteopontin concentration correlates with the severity of hepatic fibrosis and inflammation in HCV-infected subjects
    • Huang, W.; Zhu, G.; Huang, M.; Lou, G.; Liu, Y.; Wang, S. Plasma osteopontin concentration correlates with the severity of hepatic fibrosis and inflammation in HCV-infected subjects. Clin. Chim. Acta 2010, 411, 675-678.
    • (2010) Clin. Chim. Acta , vol.411 , pp. 675-678
    • Huang, W.1    Zhu, G.2    Huang, M.3    Lou, G.4    Liu, Y.5    Wang, S.6
  • 74
    • 84924565105 scopus 로고    scopus 로고
    • Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus infection
    • Matsue, Y.; Tsutsumi, M.; Hayashi, N.; Saito, T.; Tsuchishima, M.; Toshikuni, N.; Arisawa, T.; George, J. Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus infection. PLoS ONE 2015, 10, e0118744.
    • (2015) PLoS ONE , vol.10
    • Matsue, Y.1    Tsutsumi, M.2    Hayashi, N.3    Saito, T.4    Tsuchishima, M.5    Toshikuni, N.6    Arisawa, T.7    George, J.8
  • 75
    • 0037286311 scopus 로고    scopus 로고
    • Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis
    • Harada, K.; Ozaki, S.; Sudo, Y.; Tsuneyama, K.; Ohta, H.; Nakanuma, Y. Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis. Pathol. Int. 2003, 53, 8-17.
    • (2003) Pathol. Int. , vol.53 , pp. 8-17
    • Harada, K.1    Ozaki, S.2    Sudo, Y.3    Tsuneyama, K.4    Ohta, H.5    Nakanuma, Y.6
  • 76
    • 84928385086 scopus 로고    scopus 로고
    • Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation
    • Seth, D.; Duly, A.; Kuo, P.C.; McCaughan, G.W.; Haber, P.S. Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation. World J. Gastroenterol. 2014, 20, 13088-13104.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 13088-13104
    • Seth, D.1    Duly, A.2    Kuo, P.C.3    McCaughan, G.W.4    Haber, P.S.5
  • 77
    • 84920997369 scopus 로고    scopus 로고
    • Emerging roles of Notch signaling in liver disease
    • Geisler, F.; Strazzabosco, M. Emerging roles of Notch signaling in liver disease. Hepatology 2015, 61, 382-392.
    • (2015) Hepatology , vol.61 , pp. 382-392
    • Geisler, F.1    Strazzabosco, M.2
  • 78
    • 84892753370 scopus 로고    scopus 로고
    • Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion
    • Williams, M.J.; Clouston, A.D.; Forbes, S.J. Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology 2014, 146, 349-356.
    • (2014) Gastroenterology , vol.146 , pp. 349-356
    • Williams, M.J.1    Clouston, A.D.2    Forbes, S.J.3
  • 80
    • 33748532813 scopus 로고    scopus 로고
    • The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: A potential biomarker
    • Banerjee, A.; Burghardt, R.C.; Johnson, G.A.; White, F.J.; Ramaiah, S.K. The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: A potential biomarker. Toxicol. Pathol. 2006, 34, 373-384.
    • (2006) Toxicol. Pathol. , vol.34 , pp. 373-384
    • Banerjee, A.1    Burghardt, R.C.2    Johnson, G.A.3    White, F.J.4    Ramaiah, S.K.5
  • 81
  • 82
    • 84896495748 scopus 로고    scopus 로고
    • Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice
    • Ge, X.; Leung, T.M.; Arriazu, E.; Lu, Y.; Urtasun, R.; Christensen, B.; Fiel, M.I.; Mochida, S.; Sørensen, E.S.; Nieto, N. Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice. Hepatology 2014, 59, 1600-1616.
    • (2014) Hepatology , vol.59 , pp. 1600-1616
    • Ge, X.1    Leung, T.M.2    Arriazu, E.3    Lu, Y.4    Urtasun, R.5    Christensen, B.6    Fiel, M.I.7    Mochida, S.8    Sørensen, E.S.9    Nieto, N.10
  • 83
    • 84982791075 scopus 로고    scopus 로고
    • Comparative analysis of gene expression profiles of OPN signaling pathway in four kinds of liver diseases
    • Wang, G.; Chen, S.; Zhao, C.; Li, X.; Zhao, W.; Yang, J.; Chang, C.; Xu, C. Comparative analysis of gene expression profiles of OPN signaling pathway in four kinds of liver diseases. J. Genet. 2016, 95, 741-750.
    • (2016) J. Genet. , vol.95 , pp. 741-750
    • Wang, G.1    Chen, S.2    Zhao, C.3    Li, X.4    Zhao, W.5    Yang, J.6    Chang, C.7    Xu, C.8
  • 84
    • 84984858038 scopus 로고    scopus 로고
    • A preliminary in vivo study of the effects of OPN on rat liver regeneration induced by partial hepatectomy
    • Wang, G.; Zhao, C.; Chen, S.; Li, X.; Zhang, L.; Chang, C.; Xu, C. A preliminary in vivo study of the effects of OPN on rat liver regeneration induced by partial hepatectomy. Mol. Biol. Rep. 2016, 43, 1371-1382.
    • (2016) Mol. Biol. Rep. , vol.43 , pp. 1371-1382
    • Wang, G.1    Zhao, C.2    Chen, S.3    Li, X.4    Zhang, L.5    Chang, C.6    Xu, C.7
  • 85
    • 84891826248 scopus 로고    scopus 로고
    • Osteopontin: Versatile modulator of liver disease
    • Nagoshi, S. Osteopontin: Versatile modulator of liver disease. Hepatol. Res. 2014, 44, 22-30.
    • (2014) Hepatol. Res. , vol.44 , pp. 22-30
    • Nagoshi, S.1
  • 86
    • 0038340658 scopus 로고    scopus 로고
    • Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma
    • Pan, H.W.; Ou, Y.H.; Peng, S.Y.; Liu, S.H.; Lai, P.L.; Lee, P.H.; Sheu, J.C.; Chen, C.L.; Hsu, H.C. Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma. Cancer 2003, 98, 119-127.
    • (2003) Cancer , vol.98 , pp. 119-127
    • Pan, H.W.1    Ou, Y.H.2    Peng, S.Y.3    Liu, S.H.4    Lai, P.L.5    Lee, P.H.6    Sheu, J.C.7    Chen, C.L.8    Hsu, H.C.9
  • 87
    • 84864978576 scopus 로고    scopus 로고
    • Recurrence and poor prognosis following resection of small hepatitis B-related hepatocellular carcinoma lesions are associated with aberrant tumor expression profiles of glypican 3 and osteopontin
    • Yu, M.C.; Lee, Y.S.; Lin, S.E.; Wu, H.Y.; Chen, T.C.; Lee, W.C.; Chen, M.F.; Tsai, C.N. Recurrence and poor prognosis following resection of small hepatitis B-related hepatocellular carcinoma lesions are associated with aberrant tumor expression profiles of glypican 3 and osteopontin. Ann. Surg. Oncol. 2012, 19, S455-S463.
    • (2012) Ann. Surg. Oncol. , vol.19 , pp. S455-S463
    • Yu, M.C.1    Lee, Y.S.2    Lin, S.E.3    Wu, H.Y.4    Chen, T.C.5    Lee, W.C.6    Chen, M.F.7    Tsai, C.N.8
  • 88
    • 51249084799 scopus 로고    scopus 로고
    • Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis
    • Zhao, J.; Dong, L.; Lu, B.; Wu, G.; Xu, D.; Chen, J.; Li, K.; Tong, X.; Dai, J.; Yao, S.; et al. Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis. Gastroenterology 2008, 135, 956-968.
    • (2008) Gastroenterology , vol.135 , pp. 956-968
    • Zhao, J.1    Dong, L.2    Lu, B.3    Wu, G.4    Xu, D.5    Chen, J.6    Li, K.7    Tong, X.8    Dai, J.9    Yao, S.10
  • 89
    • 85007415627 scopus 로고    scopus 로고
    • Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice
    • Lee, S.H.; Park, J.W.; Woo, S.H.; Go, D.M.; Kwon, H.J.; Jang, J.J.; Kim, D.Y. Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice. Oncotarget 2016, 7, 87219-87231.
    • (2016) Oncotarget , vol.7 , pp. 87219-87231
    • Lee, S.H.1    Park, J.W.2    Woo, S.H.3    Go, D.M.4    Kwon, H.J.5    Jang, J.J.6    Kim, D.Y.7
  • 90
    • 0034794068 scopus 로고    scopus 로고
    • Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas
    • Lee, K.T.; Liu, T.S. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Dig. Dis. Sci. 2001, 46, 2166-2172.
    • (2001) Dig. Dis. Sci. , vol.46 , pp. 2166-2172
    • Lee, K.T.1    Liu, T.S.2
  • 91
    • 0023698699 scopus 로고    scopus 로고
    • Pathologic features of hepatolithiasis in Japan
    • Nakanuma, Y.; Yamaguchi, K.; Ohta, G.; Terada, T. Pathologic features of hepatolithiasis in Japan. Hum. Pathol. 1998, 19, 1181-1186.
    • (1998) Hum. Pathol. , vol.19 , pp. 1181-1186
    • Nakanuma, Y.1    Yamaguchi, K.2    Ohta, G.3    Terada, T.4
  • 92
  • 93
    • 0019976639 scopus 로고
    • Intrahepatic periductal glands and their significance in primary intrahepatic lithiasis
    • Yamamoto, K. Intrahepatic periductal glands and their significance in primary intrahepatic lithiasis. Jpn. J. Surg. 1982, 12, 163-170.
    • (1982) Jpn. J. Surg. , vol.12 , pp. 163-170
    • Yamamoto, K.1
  • 94
    • 84877670059 scopus 로고    scopus 로고
    • Osteopontin Expression in Patients with Hepatolith
    • Kim, B.S.; Joo, S.H.; Lim, S.J.; Joo, K.R. Osteopontin Expression in Patients with Hepatolith. Indian J. Surg. 2015, 77, 551-556.
    • (2015) Indian J. Surg. , vol.77 , pp. 551-556
    • Kim, B.S.1    Joo, S.H.2    Lim, S.J.3    Joo, K.R.4
  • 98
    • 84933036440 scopus 로고    scopus 로고
    • miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
    • Zhang, J.; Jiao, J.; Cermelli, S.; Muir, K.; Jung, K.H.; Zou, R.; Rashid, A.; Gagea, M.; Zabludoff, S.; Kalluri, R.; et al. miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Res. 2015, 75, 1859-1867.
    • (2015) Cancer Res. , vol.75 , pp. 1859-1867
    • Zhang, J.1    Jiao, J.2    Cermelli, S.3    Muir, K.4    Jung, K.H.5    Zou, R.6    Rashid, A.7    Gagea, M.8    Zabludoff, S.9    Kalluri, R.10
  • 99
    • 84902786936 scopus 로고    scopus 로고
    • Cholangiocarcinoma
    • Razumilava, N.; Gores, G.J. Cholangiocarcinoma. Lancet 2014, 383, 2168-2179.
    • (2014) Lancet , vol.383 , pp. 2168-2179
    • Razumilava, N.1    Gores, G.J.2
  • 100
    • 84888250929 scopus 로고    scopus 로고
    • Pathogenesis, diagnosis, and management of cholangiocarcinoma
    • Rizvi, S.; Gores, G.J. Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology 2013, 145, 1215-1229.
    • (2013) Gastroenterology , vol.145 , pp. 1215-1229
    • Rizvi, S.1    Gores, G.J.2
  • 101
    • 77956637818 scopus 로고    scopus 로고
    • Risk factors for intrahepatic cholangiocarcinoma: A possible role of hepatitis B virus
    • Tanaka, M.; Tanaka, H.; Tsukuma, H.; Ioka, A.; Oshima, A.; Nakahara, T. Risk factors for intrahepatic cholangiocarcinoma: A possible role of hepatitis B virus. J. Viral Hepat. 2010, 17, 742-748.
    • (2010) J. Viral Hepat. , vol.17 , pp. 742-748
    • Tanaka, M.1    Tanaka, H.2    Tsukuma, H.3    Ioka, A.4    Oshima, A.5    Nakahara, T.6
  • 103
    • 84951994157 scopus 로고    scopus 로고
    • Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
    • Pereira, T.A.; Syn, W.K.; Machado, M.V.; Vidigal, P.V.; Resende, V.; Voieta, I.; Xie, G.; Otoni, A.; Souza, M.M.; Santos, E.T.; et al. Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Clin. Sci. 2015, 129, 875-883.
    • (2015) Clin. Sci. , vol.129 , pp. 875-883
    • Pereira, T.A.1    Syn, W.K.2    Machado, M.V.3    Vidigal, P.V.4    Resende, V.5    Voieta, I.6    Xie, G.7    Otoni, A.8    Souza, M.M.9    Santos, E.T.10
  • 105
    • 84896694682 scopus 로고    scopus 로고
    • Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma
    • Zheng, T.; Hong, X.; Wang, J.; Pie, T.; Liang, Y.; Yin, D.; Song, R.; Song, X.; Lu, Z.; Qi, S.; et al. Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma. Hepatology 2014, 59, 935-946.
    • (2014) Hepatology , vol.59 , pp. 935-946
    • Zheng, T.1    Hong, X.2    Wang, J.3    Pie, T.4    Liang, Y.5    Yin, D.6    Song, R.7    Song, X.8    Lu, Z.9    Qi, S.10
  • 107
    • 84880051262 scopus 로고    scopus 로고
    • 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins
    • Lu, D.; Han, C.; Wu, T. 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins. J. Biol. Chem. 2013, 288, 19484-19502.
    • (2013) J. Biol. Chem. , vol.288 , pp. 19484-19502
    • Lu, D.1    Han, C.2    Wu, T.3
  • 109
    • 84950266677 scopus 로고    scopus 로고
    • Screening of potential biomarkers for cholangiocarcinoma by integrated analysis of microarray data sets
    • Huang, Q.X.; Cui, J.Y.; Ma, H.; Jia, X.M.; Huang, F.L.; Jiang, L.X. Screening of potential biomarkers for cholangiocarcinoma by integrated analysis of microarray data sets. Cancer Gene Ther. 2016, 23, 48-53.
    • (2016) Cancer Gene Ther. , vol.23 , pp. 48-53
    • Huang, Q.X.1    Cui, J.Y.2    Ma, H.3    Jia, X.M.4    Huang, F.L.5    Jiang, L.X.6
  • 113
    • 32944479992 scopus 로고    scopus 로고
    • Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells
    • Isomoto, H.; Kobayashi, S.; Werneburg, N.W.; Bronk, S.F.; Guicciardi, M.E.; Frank, D.A.; Gores, G.J. Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology 2005, 42, 1329-1338.
    • (2005) Hepatology , vol.42 , pp. 1329-1338
    • Isomoto, H.1    Kobayashi, S.2    Werneburg, N.W.3    Bronk, S.F.4    Guicciardi, M.E.5    Frank, D.A.6    Gores, G.J.7
  • 115
    • 77953493495 scopus 로고    scopus 로고
    • Dipyridamole suppresses high glucose-induced osteopontin secretion and mRNA expression in rat aortic smooth muscle cells
    • Hsieh, M.S.; Zhong, W.B.; Yu, S.C.; Lin, J.Y.; Chi, W.M.; Lee, H.M. Dipyridamole suppresses high glucose-induced osteopontin secretion and mRNA expression in rat aortic smooth muscle cells. Circ. J. 2010, 74, 1242-1250.
    • (2010) Circ. J. , vol.74 , pp. 1242-1250
    • Hsieh, M.S.1    Zhong, W.B.2    Yu, S.C.3    Lin, J.Y.4    Chi, W.M.5    Lee, H.M.6
  • 116
    • 28044436717 scopus 로고    scopus 로고
    • Streptozotocin (STZ) mediates acute upregulation of serum and pancreatic osteopontin (OPN): A novel islet-protective effect of OPN through inhibition of STZ-induced nitric oxide production
    • Katakam, A.K.; Chipitsyna, G.; Gong, Q.; Vancha, A.R.; Gabβ, J.; Arafat, H.A. Streptozotocin (STZ) mediates acute upregulation of serum and pancreatic osteopontin (OPN): A novel islet-protective effect of OPN through inhibition of STZ-induced nitric oxide production. J. Endocrinol. 2005, 187, 237-247.
    • (2005) J. Endocrinol. , vol.187 , pp. 237-247
    • Katakam, A.K.1    Chipitsyna, G.2    Gong, Q.3    Vancha, A.R.4    Gab, J.5    Arafat, H.A.6
  • 117
    • 33846449547 scopus 로고    scopus 로고
    • Osteopontin protects the islets and β-cells from interleukin-1 β-mediated cytotoxicity through negative feedback regulation of nitric oxide
    • Arafat, H.A.; Katakam, A.K.; Chipitsyna, G.; Gong, Q.; Vancha, A.R.; Gabβ, J.; Dafoe, D.C. Osteopontin protects the islets and β-cells from interleukin-1 β-mediated cytotoxicity through negative feedback regulation of nitric oxide. Endocrinology 2007, 148, 575-584.
    • (2007) Endocrinology , vol.148 , pp. 575-584
    • Arafat, H.A.1    Katakam, A.K.2    Chipitsyna, G.3    Gong, Q.4    Vancha, A.R.5    Gab, J.6    Dafoe, D.C.7
  • 122
    • 25144492709 scopus 로고    scopus 로고
    • Friess, H. Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions
    • Kolb, A.; Kleeff, J.; Guweidhi, A.; Esposito, I.; Giese, N.A.; Adwan, H.; Giese, T.; Büchler, M.W.; Berger, M.R. Friess, H. Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions. Cancer Biol. Ther. 2005, 4, 740-746.
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 740-746
    • Kolb, A.1    Kleeff, J.2    Guweidhi, A.3    Esposito, I.4    Giese, N.A.5    Adwan, H.6    Giese, T.7    Büchler, M.W.8    Berger, M.R.9
  • 123
    • 84905642943 scopus 로고    scopus 로고
    • Diagnostic significance of serum osteopontin level for pancreatic cancer: A meta-analysis
    • Li, J.J.; Li, H.Y.; Gu, F. Diagnostic significance of serum osteopontin level for pancreatic cancer: A meta-analysis. Genet. Test. Mol. Biomark. 2014, 18, 580-586.
    • (2014) Genet. Test. Mol. Biomark. , vol.18 , pp. 580-586
    • Li, J.J.1    Li, H.Y.2    Gu, F.3
  • 124
    • 85018495441 scopus 로고    scopus 로고
    • High Glucose Accelerates Cell Proliferation and Increases the Secretion and mRNA Expression of Osteopontin in Human Pancreatic Duct Epithelial Cells
    • Ito, M.; Makino, N.; Matsuda, A.; Ikeda, Y.; Kakizaki, Y.; Saito, Y.; Ueno, Y.; Kawata, S. High Glucose Accelerates Cell Proliferation and Increases the Secretion and mRNA Expression of Osteopontin in Human Pancreatic Duct Epithelial Cells. Int. J. Mol. Sci. 2017, 18, 807.
    • (2017) Int. J. Mol. Sci. , vol.18 , pp. 807
    • Ito, M.1    Makino, N.2    Matsuda, A.3    Ikeda, Y.4    Kakizaki, Y.5    Saito, Y.6    Ueno, Y.7    Kawata, S.8
  • 125
    • 84864965633 scopus 로고    scopus 로고
    • Osteopontin expression is associated with improved survival in patients with pancreatic adenocarcinoma
    • Collins, A.L.; Rock, J.; Malhotra, L.; Frankel, W.L.; Bloomston, M. Osteopontin expression is associated with improved survival in patients with pancreatic adenocarcinoma. Ann. Surg. Oncol. 2012, 19, 2673-2678.
    • (2012) Ann. Surg. Oncol. , vol.19 , pp. 2673-2678
    • Collins, A.L.1    Rock, J.2    Malhotra, L.3    Frankel, W.L.4    Bloomston, M.5
  • 126
    • 84979562086 scopus 로고    scopus 로고
    • Pancreatic Cancer and Osteopontin: The Relationship Remains Unclear
    • Weber, C.E.; Erşahin, Ç.H.; Kuo, P.C.; Mi, Z. Pancreatic Cancer and Osteopontin: The Relationship Remains Unclear. Pancreas 2016, 45, e35-e36.
    • (2016) Pancreas , vol.45 , pp. e35-e36
    • Weber, C.E.1    Erşahin, Ç.H.2    Kuo, P.C.3    Mi, Z.4
  • 128
    • 84904498956 scopus 로고    scopus 로고
    • The biology of graft-versus-host disease: Experimental systems instructing clinical practice
    • Markey, K.A.; MacDonald, K.P.; Hill, G.R. The biology of graft-versus-host disease: Experimental systems instructing clinical practice. Blood 2014, 124, 354-362.
    • (2014) Blood , vol.124 , pp. 354-362
    • Markey, K.A.1    MacDonald, K.P.2    Hill, G.R.3
  • 129
    • 79551645767 scopus 로고    scopus 로고
    • Blockade of osteopontin reduces alloreactive CD8+T cell-mediated graft-versus-host disease
    • Zhao, F.; Zhang, Y.; Wang, H.; Jin, M.; He, S.; Shi, Y.; Guo, Y.; Zhang, Y. Blockade of osteopontin reduces alloreactive CD8+T cell-mediated graft-versus-host disease. Blood 2011, 117, 1723-1733.
    • (2011) Blood , vol.117 , pp. 1723-1733
    • Zhao, F.1    Zhang, Y.2    Wang, H.3    Jin, M.4    He, S.5    Shi, Y.6    Guo, Y.7    Zhang, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.