Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells

Arthritis and Rheumatism

Volumn 58, Issue 7, 2008, Pages 2041-2052

  Fan, Kexing ^a   Dai, Jianxin ^a   Wang, Hao ^a   Wei, Huafeng ^a   Cao, Zhiguo ^a   Hou, Sheng ^a   Qian, Weizhu ^a   Wang, Huaqing ^a   Li, Bohua ^a   Zhao, Jian ^a   Xu, Huji ^b   Yang, Chengde ^c   Guo, Yajun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLTHREONYLTRYPTOPHYLLEUCYLASPARAGINYLPROLYLASPARTYLPROLYLSERYLGLUTAMINYLLYSYLGLUTAMINE; BIM PROTEIN; COLLAGEN ANTIBODY; COLLAGEN TYPE 2; EPITOPE; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 23C3; MONOCLONAL ANTIBODY F8E11; OSTEOPONTIN; PEPTIDE LIBRARY; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; APOPTOSIS; ARTHRITIS; ARTICLE; BIOPANNING; CD4+ T LYMPHOCYTE; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DBA 1 MOUSE; DISEASE SEVERITY; DRUG EFFECT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOBLOTTING; INHIBITION KINETICS; MALE; MONOCYTE; MOUSE; NICK END LABELING; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIOCYTE; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; ARTHRITIS; ARTHRITIS, RHEUMATOID; COLLAGEN; HUMANS; MALE; MICE; MICE, INBRED DBA; OSTEOPONTIN; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 47249145601     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23490     Document Type: Article

References (40)

1. Boers M. Rheumatoid arthritis: treatment of early disease. Rheum Dis Clin North Am 2001;27:405-14.
2. Holmdahl R, Brockermann R, Backlund J, Yamada H. The molecular pathogenesis of collagen-induced arthritis in mice: a model for rheumatoid arthritis [review]. Ageing Res Rev 2002;1: 135-47.
3. Salmon M, Gaston JS. The role of T-lymphocytes in rheumatoid arthritis. Br Med Bull 1995;51:332-45.
4. Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 2001;344:907-16.
5. Szekanecz Z, Kim J, Koch AE. Chemokines and chemokine receptors in rheumatoid arthritis. Semin Immunol 2003;15:15-21.
6. Genovese MC, Bathon JM, Martin RW, Fleischmann RM, Tesser JR, Schiff MH, et al. Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes. Arthritis Rheum 2002;46:1443-50.
7. Lipsky PE, van der Heijde DM, St. Clair EW, Furst DE, Breedveld FC, Kalden JR, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 2000;343:1594-602.
8. Campion GV, Lebsack ME, Lookabaugh J, Gordon G, Catalano M, and the IL-1Ra Arthritis Study Group. Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1092-101.
9. Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, et al. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science 2000;287: 860-4.
10. O'Regan AW, Nau GJ, Chupp GL, Berman JS. Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Immunol Today 2000;21:475-8.
11. Denhardt DT, Noda M. Osteopontin expression and function: role in bone remodeling. J Cell Biochem Suppl 1998;30-31:92-102.
12. Murry CE, Giachelli CM, Schwartz SM, Vracko R. Macrophages express osteopontin during repair of myocardial necrosis. Am J Pathol 1994;145:1450-62.
13. Gravallese EM. Osteopontin: a bridge between bone and the immune svstem. J Clin Invest 2003;112:147-9.
14. 6 binds and activates latent TGF ß1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999;96:319-28.
15. Ruoslahti E. RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol 1996;12:697-715.
16. Yamamoto N, Sakai F, Kon S, Morimoto J, Kimura C, Yamazaki H, et al. Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis. J Clin Invest 2003;112:181-8.
17. 1 binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem 1999;274:36328-34.
18. Petrow PK, Hummel KM, Schedel J, Franz JK, Klein CL, Muller-Ladner U, et al. Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts. Arthritis Rheum 2000;43:1597-605.
19. Xu G, Nie H, Li N, Zheng W, Zhang D, Feng G, et al. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J Clin Invest 2005;115:1060-7.
20. Ohshima S, Kobayashi H, Yamaguchi N, Nishioka K, Umeshita-Sasai M, Mima T, et al. Expression of osteopontin at sites of bone erosion in a murine experimental arthritis model of collagen-induced arthritis: possible involvement of osteopontin in bone destruction in arthritis. Arthritis Rheum 2002;46:1094-101.
21. Yoshitake H, Rittling SR, Denhardt DT, Noda M. Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci U S A 1999;96:8156-60.
22. Ishijima M, Rittling SR, Yamashita T, Tsuji K, Kurosawa H, Nifuji A, et al. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. J Exp Med 2001;193:399-404.
23. Yumoto K, Ishijima M, Rittling SR, Tsuji K, Tsuchiya Y, Kon S, et al. Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Proc Natl Acad Sci U S A 2002;99:4556-61.
24. Myers LK, Rosloniec EF, Cremer MA, Kang AH. Collagen induced arthritis, an animal model of autoimmunity. Life Sci 1997;61:1861-78.
25. Bautista DS, Xuan JW, Hota C, Chambers AF, Harris JF. Inhibition of Arg-Gly-Asp (RGD)-mediated cell adhesion to osteopontin by a monoclonal antibody against osteopontin. J Biol Chem 1994;269:23280-5.
26. Rosloniec EF, Cremer M, Kang A, Myers LK. Collagen-induced arthritis. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. New York: John Wiley & Sons; 2001. p. 15.5.1.
27. Mauri C, Mars LT, Londei M. Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process. Nat Med 2000;6:673-9.
28. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
29. Kon S, Yokosaki Y, Maeda M, Segawa T, Horikoshi Y, Tsukagoshi H, et al. Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. J Cell Biochem 2002;84:420-32.
30. Hur EM, Youssef S, Haws ME, Zhang SY, Sobel RA, Steinman L. Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol 2007;8:74-83.
31. Salmon M, Pilling D, Borthwick NJ, Viner N, Janossy G, Bacon PA, et al. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur J Immunol 1994;24:892-9.
32. Akbar AN, Borthwick NJ, Wickremasinghe RG, Panayoitidis P, Pilling D, Bofill M, et al. Interleukin-2 receptor common γ-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur J Immunol 1996;26:294-9.
33. Salmon M, Scheel-Toellner D, Huissoon AP, Pilling D, Shamsadeen N, Hyde H, et al. Inhibition of T cell apoptosis in the rheumatoid synovium. J Clin Invest 1997;99:439-46.
34. Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid-arthritis synovium. J Clin Invest 1995;96:1631-8.
35. Yu XQ, Fan JM, Nikolic-Paterson DJ, Yang N, Mu W, Pichler R, et al. IL-1 up-regulates osteopontin expression in experimental crescentic glomerulonephritis in the rat. Am J Pathol 1999;154: 833-41.
36. 3 integrin-induced endothelial cell survival. J Cell Biol 1998;141:1083-93.
37. Lin YH, Huang CJ, Chao JR, Chen ST, Lee SF, Yen JJ, et al. Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor [published erratum appears in Mol Cell Biol 2001;21:2248]. Mol Cell Biol 2000;20:2734-42.
38. Lin YH, Yang-Yen HF. The osteopontin-CD44 survival signal involves activation of the phosphatidylinositol 3-kinase/Akt signaling pathway. J Biol Chem 2001;276:46024-30.
39. Denhardt DT, Guo X. Osteopontin: a protein with diverse functions. FASEB J 1993;7:1475-82.
40. Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 2001;107:1055-61.