Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Clinical Science

Volumn 129, Issue 10, 2015, Pages 875-883

  Pereira, Thiago A ^a,b   Syn, Wing Kin ^c,d   Machado, Mariana V ^a   Vidigal, Paula V ^e   Resende, Vivian ^e   Voieta, Izabela ^e   Xie, Guanhua ^a   Otoni, Alba ^e   Souza, Márcia M ^b   Santos, Elisângela T ^b   Chan, Isaac S ^a   Trindade, Guilherme V M ^e   Choi, Steve S ^a   Witek, Rafal P ^f   Pereira, Fausto E ^g   Secor, William E ^h   Andrade, Zilton A ^b   Lambertucci, José Roberto ^e   Diehl, Anna Mae ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c INSTITUTE OF HEPATOLOGY   (United Kingdom)

^d LOYOLA UNIVERSITY CHICAGO   (United States)

^e FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^f Life Technologies Inc   (United States)

^g FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^h CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Cholangiocyte; Ductular proliferation; Osteopontin; Portal hypertension; Schistosomiasis mansoni; Symmers' fibrosis

Indexed keywords

ANTIGEN; BROXURIDINE; OSTEOPONTIN; SOLUBLE EGG ANTIGEN; UNCLASSIFIED DRUG; PARASITE ANTIGEN;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CELL PROLIFERATION; CELL STIMULATION; CELLS BY BODY ANATOMY; CHILD; CHOLANGIOCYTE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EGG PARASITOID; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; LIVER FIBROSIS; LYMPHATIC PARAMETERS; MAJOR CLINICAL STUDY; MOUSE; MYOFIBROBLAST; NONHUMAN; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SCHOOL CHILD; SPLENIC VEIN PRESSURE; STAGING; STELLATE CELL; UPREGULATION; VENOUS PRESSURE; ANIMAL; BLOOD; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; HOST PARASITE INTERACTION; LIVER CIRRHOSIS; MALE; METABOLISM; MIDDLE AGED; PARASITOLOGY; PHYSIOLOGY; RAT; SCHISTOSOMA; SECRETION (PROCESS); YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; ANTIGENS, HELMINTH; BILE DUCTS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HEPATIC STELLATE CELLS; HOST-PARASITE INTERACTIONS; HUMANS; HYPERTENSION, PORTAL; IMMUNOHISTOCHEMISTRY; KUPFFER CELLS; LIVER CIRRHOSIS; MALE; MICE; MIDDLE AGED; OSTEOPONTIN; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHISTOSOMA; SCHISTOSOMIASIS MANSONI; YOUNG ADULT;

EID: 84951994157     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150117     Document Type: Article

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