Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation

World Journal of Gastroenterology

Volumn 20, Issue 36, 2014, Pages 13088-13104

  Seth, Devanshi ^a,c   Duly, Alastair ^b   Kuo, Paul C ^d   McCaughan, Geoffrey W ^e   Haber, Paul S ^a,c  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^e RPAH   (Australia)

Author keywords

Fibrogenesis; Hepatic stellate cells; Liver cirrhosis; Osteopontin isoform; Plasmin; Steatosis; Transforming growth factor

Indexed keywords

HERMES ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; NEUTRALIZING ANTIBODY; OSTEOPONTIN; PLASMIN; PROTEIN KINASE B; SMALL INTERFERING RNA; VITRONECTIN RECEPTOR; CD44 PROTEIN, HUMAN; CD44 PROTEIN, MOUSE; MESSENGER RNA; SPP1 PROTEIN, HUMAN; SPP1 PROTEIN, MOUSE;

ADULT; ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; DISEASE COURSE; DOWNSTREAM PROCESSING; EXTRACELLULAR MATRIX; FEMALE; FIBRINOLYSIS; FIBROGENESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEATOSIS; STELLATE CELL; ALCOHOL LIVER CIRRHOSIS; ALCOHOLIC FATTY LIVER; ANIMAL; C57BL MOUSE; CASE CONTROL STUDY; CELL CULTURE; CELL MOTION; DEFICIENCY; DISEASE MODEL; GENETIC TRANSFECTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SEVERITY OF ILLNESS INDEX; TIME; UPREGULATION;

ANIMALS; ANTIGENS, CD44; CASE-CONTROL STUDIES; CELL MOVEMENT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FATTY LIVER, ALCOHOLIC; FEMALE; FIBRINOLYSIN; FIBRINOLYSIS; HEPATIC STELLATE CELLS; HUMANS; INTEGRIN ALPHAVBETA3; LIVER CIRRHOSIS, ALCOHOLIC; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOPONTIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84928385086     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i36.13088     Document Type: Article

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