Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis

Pathology International

Volumn 53, Issue 1, 2003, Pages 8-17

  Harada, Kenichi ^a   Ozaki, Satoru ^a   Sudo, Yoshiko ^a   Tsuneyama, Koichi ^a   Ohta, Hajime ^b   Nakanuma, Yasuni ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b Tsuruga City Hospital   (Japan)

Author keywords

Bile duct; Granuloma; Osteopontin; Plasma cells; Primary biliary cirrhosis

Indexed keywords

AUTOANTIBODY; CD68 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; OSTEOPONTIN;

ADULT; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE DIFFERENTIATION; BILE DUCT INJURY; CELL INFILTRATION; CONTROLLED STUDY; EPITHELIOID CELL; FEMALE; GRANULOMA; HISTIOCYTE; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN PRODUCING CELL; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MONONUCLEAR CELL; PLASMA CELL; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BILE DUCTS, INTRAHEPATIC; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL COUNT; EPITHELIOID CELLS; FEMALE; GRANULOMA; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; LEUKOCYTES, MONONUCLEAR; LIVER CIRRHOSIS, BILIARY; MALE; MIDDLE AGED; OSTEOPONTIN; PLASMA CELLS; RNA, MESSENGER; SIALOGLYCOPROTEINS;

EID: 0037286311     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2003.01426.x     Document Type: Article

References (46)

1. Denhardt DT, Guo X. Osteopontin: A protein with diverse functions. FASEB J 1993; 7: 1475-82.
2. Franzen A, Heinegard D. Isolation and characterization of two sialoproteins present only in bone calcified matrix. Biochem J 1985; 232: 715-24.
3. Oldberg A, Franzen A, Heinegard D. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc Natl Acad Sci USA 1986; 83: 8819-23.
4. Patarca R, Saavedra RA, Cantor H. Molecular and cellular basis of genetic resistance to bacterial infection: The role of the early T-lymphocyte activation-1/osteopontin gene. Crit Rev Immunol 1993; 13: 225-46.
5. Carlson I, Tognazzi K, Manseau EJ, Dvorak HF, Brown LF. Osteopontin is strongly expressed by histiocytes in granulomas of diverse etiology. Lab Invest 1997; 77: 103-8.
6. Nau GJ, Guilfoile P, Chupp GL et al. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proc Natl Acad Sci USA 1997; 94; 6414-19.
7. O'Regan AW, Chupp GL, Lowry JA, Goetschkes M, Mulligan N, Berman JS. Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro. J Immunol 1999; 162: 1024-31.
8. Cantor H. T-cell receptor crossreactivity and autoimmune disease. Adv Immunol 2000; 75: 209-33.
9. Giachelli CM, Lombardi D, Johnson RJ, Murry CE, Almeida M. Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Am J Pathol 1998; 152: 353-8.
10. Uede T, Katagiri Y, Iizuka J, Murakami M. Osteopontin, a coordinator of host defense system: A cytokine or an extracellular adhesive protein? Microbiol Immunol 1997; 41: 641-8.
11. Kaplan MM. Primary biliary cirrhosis. N Engl J Med 1996; 335: 1570-80.
12. Nakanuma Y, Ohta G. Histometric and serial Section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology 1979; 76: 1326-32.
13. Nakanuma Y, Ohta G. Quantitation of hepatic granulomas and epithelioid cells in primary biliary cirrhosis. Hepatology 1983; 3: 423-7.
14. Ludwig J, Dickson ER, McDonald GS. Staging of chronic non-suppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Arch A Pathol Anat Histol 1978; 379: 103-12.
15. Nakanuma Y, Hoso M, Sanzen T, Sasaki M. Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply. Microsc Res Tech 1997; 38: 552-70.
16. Sebestyen A, Berczi L, Mihalik R, Paku S, Matolcsy A, Kopper L. Syndecan-1 (CD138) expression in human non-Hodgkin lymphomas. Br J Haematol 1999; 104: 412-19.
17. Craig AM, Smith JH, Denhardt DT. Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis. J Biol Chem 1989; 264: 9682-9.
18. Brown LF, Berse B, Van de Water L et al. Expression and distribution of osteopontin in human tissues: Widespread association with luminal epithelial surfaces. Mol Biol Cell 1992; 3: 1169-80.
19. Iizuka J, Katagiri Y, Tada N et al. Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies. Lab Invest 1998; 78: 1523-33.
20. O'Regan A, Berman JS. Osteopontin: A key cytokine in cell-mediated and granulomatous inflammation. Int J Exp Pathol 2000; 81: 373-90.
21. Brown LF, Papadopoulos-Sergiou A, Berse B et al. Osteopontin expression and distribution in human carcinomas. Am J Pathol 1994; 145: 610-23.
22. Lampe MA, Patarca R, Iregui MV, Cantor H. Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease. J Immunol 1991; 147: 2902-6.
23. Singh RP, Patarca R, Schwartz J, Singh P, Cantor H. Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo. J Exp Med 1990; 171: 1931-42.
24. Weber GF, Ashkar S, Glimcher MJ, Cantor H. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science 1996; 271: 509-12.
25. Patarca R, Freeman GJ, Singh RP et al. Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med 1989; 170: 145-61.
26. Kreisel W, Siegel A, Bahler A et al. High prevalence of antibodies to calreticulin of the IgA class in primary biliary cirrhosis: A possible role of gut-derived bacterial antigens in its aetiology? Scand J Gastroenterol 1999; 34: 623-8.
27. Harada K, Tsuneyama K, Sudo Y, Masuda S, Nakanuma Y. Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: Is Propionibacterium acnes involved in granuloma formation? Hepatology 2001; 33: 530-36.
28. Wang Y, Mochida S, Kawashima R et al. Increased expression of osteopontin in activated Kupffer cells and hepatic macrophages during macrophage migration in Propionibacterium acnes-treated rat liver. J Gastroenterol 2000; 35: 696-701.
29. Tsuneyama K, Yasoshima M, Harada K, Hiramatsu K, Gershwin ME, Nakanuma Y. Increased CD1d expression on small bile duct epithelium and epithelioid granuloma in livers in primary biliary cirrhosis. Hepatology 1998; 28: 620-23.
30. Tsuneyama K, Harada K, Yasoshima M et al. Monocyte chemotactic protein-1 -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: Implications for pathogenesis. J Pathol 2001; 193: 102-9.
31. Kawashima R, Mochida S, Matsui A et al. Expression of osteopontin in Kupffer cells and hepatic macrophages and stellate cells in rat liver after carbon tetrachloride intoxication: a possible factor for macrophage migration into hepatic necrotic areas. Biochem Biophys Res Commun 1999; 256: 527-31.
32. Guo H, Cai CQ, Schroeder RA, Kuo PC. Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. J Immunol 2001; 166: 1079-86.
33. Hogaboam CM, Chensue SW, Steinhauser ML et al. Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide. J Immunol 1997; 159: 5585-93.
34. Setoguchi K, Takeya M, Akaike T et al. Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats. Am J Pathol 1996; 149: 2005-22.
35. Tsuji M, Dimov VB, Yoshida T. In vivo expression of monokine and inducible nitric oxide synthase in experimentally induced pulmonary granulomatous inflammation. Evidence for sequential production of interleukin-1, inducible nitric oxide synthase, and tumor necrosis factor. Am J Pathol 1995; 147: 1001-15.
36. Chensue SW, Warmington K, Ruth J, Lincoln P, Kuo MC, Kunkel SL. Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor. Am J Pathol 1994; 145: 1105-13.
37. Harada K, Van de Water J, Leung PS et al. In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: Predominance of the Th1 subset. Hepatology 1997; 25: 791-6.
38. Ashkar S, Weber GF, Panoutsakopoulou V et al. Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity. Science 2000; 287: 860-64.
39. Murry CE, Giachelli CM, Schwartz SM, Vracko R. Macrophages express osteopontin during repair of myocardial necrosis. Am J Pathol 1994; 145: 1450-62.
40. Devoll RE, Pinero GJ, Appelbaum ER et al. Improved immunohistochemical staining of osteopontin (OPN) in paraffin-embedded archival bone specimens following antigen retrieval: Anti-human OPN antibody recognizes multiple molecular forms. Calcif Tissue Int 1997; 60: 380-86.
41. Kiefer MC, Bauer DM, Barr PJ. The cDNA and derived amino acid sequence for human osteopontin. Nucl Acids Res 1989; 17: 3306.
42. Sorensen ES, Rasmussen LK, Moller L, Jensen PH, Hojrup P, Petersen TE. Localization of transglutaminase-reactive glutamine residues in bovine osteopontin. Biochem J 1994; 304: 13-16.
43. Rudland PS, Platt-Higgins A, El-Tanani M et al. Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer. Cancer Res 2002; 62: 3417-27.
44. Mori K, Kobayashi S, Inobe M et al. In vivo cytokine gene expression in various T cell subsets of the autoimmune MRL/Mp-Ipr/Ipr mouse. Autoimmunity 1994; 17: 49-57.
45. Katagiri Y, Mori K, Hara T, Tanaka K, Murakami M, Uede T. Functional analysis of the osteopontin molecule. Ann NY Acad Sci 1995; 760: 371-4.
46. Hardy RR, Hayakawa K. CD5 B cells, a fetal B cell lineage. Adv Immunol 1994; 55: 297-339.