-
1
-
-
77952944052
-
Designing customized cell signalling circuits
-
Lim, W. A. Designing customized cell signalling circuits. Nat. Rev. Mol. Cell. Biol. 11, 393-403 (2010).
-
(2010)
Nat. Rev. Mol. Cell. Biol.
, vol.11
, pp. 393-403
-
-
Lim, W.A.1
-
2
-
-
84855799592
-
Diversity and modularity of G protein-coupled receptor structures
-
Katritch, V., Cherezov, V. & Stevens, R. C. Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol. Sci. 33, 17-27 (2012).
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 17-27
-
-
Katritch, V.1
Cherezov, V.2
Stevens, R.C.3
-
3
-
-
66249144426
-
The structure and function of G-protein-coupled receptors
-
Rosenbaum, D. M., Rasmussen, S. G. & Kobilka, B. K. The structure and function of G-protein-coupled receptors. Nature 459, 356-363 (2009).
-
(2009)
Nature
, vol.459
, pp. 356-363
-
-
Rosenbaum, D.M.1
Rasmussen, S.G.2
Kobilka, B.K.3
-
4
-
-
85026367955
-
How ligands illuminate GPCR molecular pharmacology
-
Wacker, D., Stevens, R. C. & Roth, B. L. How ligands illuminate GPCR molecular pharmacology. Cell 170, 414-427 (2017).
-
(2017)
Cell
, vol.170
, pp. 414-427
-
-
Wacker, D.1
Stevens, R.C.2
Roth, B.L.3
-
5
-
-
34247640671
-
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
-
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S. & Roth, B. L. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl. Acad. Sci. USA 104, 5163-5168 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 5163-5168
-
-
Armbruster, B.N.1
Li, X.2
Pausch, M.H.3
Herlitze, S.4
Roth, B.L.5
-
6
-
-
84930244375
-
A New DREADD facilitates the multiplexed chemogenetic interrogation of behavior
-
Vardy, E. et al. A New DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 86, 936-946 (2015).
-
(2015)
Neuron
, vol.86
, pp. 936-946
-
-
Vardy, E.1
-
7
-
-
38349092683
-
The genetic design of signaling cascades to record receptor activation
-
Barnea, G. et al. The genetic design of signaling cascades to record receptor activation. Proc. Natl. Acad. Sci. USA 105, 64-69 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 64-69
-
-
Barnea, G.1
-
8
-
-
84929285245
-
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
-
Kroeze, W. K. et al. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nat. Struct. Mol. Biol. 22, 362-369 (2015).
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 362-369
-
-
Kroeze, W.K.1
-
9
-
-
84876567971
-
RNA-programmed genome editing in human cells
-
Jinek, M. et al. RNA-programmed genome editing in human cells. Elife 2, e00471 (2013).
-
(2013)
Elife
, vol.2
, pp. e00471
-
-
Jinek, M.1
-
10
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
11
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
12
-
-
84880571335
-
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
-
Gilbert, L. A. et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154, 442-451 (2013).
-
(2013)
Cell
, vol.154
, pp. 442-451
-
-
Gilbert, L.A.1
-
13
-
-
84884160273
-
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
-
Mali, P. et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat. Biotechnol. 31, 833-838 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 833-838
-
-
Mali, P.1
-
14
-
-
84920992414
-
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds
-
Zalatan, J. G. et al. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell 160, 339-350 (2015).
-
(2015)
Cell
, vol.160
, pp. 339-350
-
-
Zalatan, J.G.1
-
15
-
-
84923096541
-
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
-
Konermann, S. et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517, 583-588 (2015).
-
(2015)
Nature
, vol.517
, pp. 583-588
-
-
Konermann, S.1
-
16
-
-
84929135130
-
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
-
Hilton, I. B. et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat. Biotechnol. 33, 510-517 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 510-517
-
-
Hilton, I.B.1
-
17
-
-
84949100864
-
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
-
Thakore, P. I. et al. Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. Nat. Methods 12, 1143-1149 (2015).
-
(2015)
Nat. Methods
, vol.12
, pp. 1143-1149
-
-
Thakore, P.I.1
-
18
-
-
84988592852
-
Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing
-
Amabile, A. et al. Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing. Cell 167, 219 (2016).
-
(2016)
Cell
, vol.167
, pp. 219
-
-
Amabile, A.1
-
19
-
-
85014514373
-
Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs
-
Ferry, Q. R., Lyutova, R. & Fulga, T. A. Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs. Nat. Commun. 8, 14633 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 14633
-
-
Ferry, Q.R.1
Lyutova, R.2
Fulga, T.A.3
-
20
-
-
85026446269
-
Cell-type-specific genome editing with a microRNAresponsive CRISPR-Cas9 switch
-
Hirosawa, M. et al. Cell-type-specific genome editing with a microRNAresponsive CRISPR-Cas9 switch. Nucleic Acids Res. 45, e118 (2017).
-
(2017)
Nucleic Acids Res.
, vol.45
, pp. e118
-
-
Hirosawa, M.1
-
21
-
-
85021648932
-
Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation
-
Tang, W., Hu, J. H. & Liu, D. R. Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation. Nat. Commun. 8, 15939 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 15939
-
-
Tang, W.1
Hu, J.H.2
Liu, D.R.3
-
22
-
-
84991662130
-
Directing cellular information flow via CRISPR signal conductors
-
Liu, Y. et al. Directing cellular information flow via CRISPR signal conductors. Nat. Methods 13, 938-944 (2016).
-
(2016)
Nat. Methods
, vol.13
, pp. 938-944
-
-
Liu, Y.1
-
23
-
-
84926521955
-
Highly efficient Cas9-mediated transcriptional programming
-
Chavez, A. et al. Highly efficient Cas9-mediated transcriptional programming. Nat. Methods 12, 326-328 (2015).
-
(2015)
Nat. Methods
, vol.12
, pp. 326-328
-
-
Chavez, A.1
-
24
-
-
0003519552
-
-
Oxford University Press) New York, USA
-
Lauffenburger, D. A. & Linderman, J. J. Receptors: Models for Binding, Trafficking, and Signaling. (Oxford University Press, 1996) New York, USA.
-
(1996)
Receptors: Models for Binding, Trafficking, and Signaling
-
-
Lauffenburger, D.A.1
Linderman, J.J.2
-
25
-
-
0035983443
-
The P1' specificity of tobacco etch virus protease
-
Kapust, R. B., Tozser, J., Copeland, T. D. & Waugh, D. S. The P1' specificity of tobacco etch virus protease. Biochem. Biophys. Res. Commun. 294, 949-955 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.294
, pp. 949-955
-
-
Kapust, R.B.1
Tozser, J.2
Copeland, T.D.3
Waugh, D.S.4
-
26
-
-
84992405263
-
Complex transcriptional modulation with orthogonal and inducible dCas9 regulators
-
Gao, Y. et al. Complex transcriptional modulation with orthogonal and inducible dCas9 regulators. Nat. Methods 13, 1043-1049 (2016).
-
(2016)
Nat. Methods
, vol.13
, pp. 1043-1049
-
-
Gao, Y.1
-
27
-
-
0034595860
-
Differential affinities of visual arrestin, betaarrestin1, and beta arrestin2 for G proteincoupled receptors delineate two major classes of receptors
-
Oakley, R. H., Laporte, S. A., Holt, J. A., Caron, M. G. & Barak, L. S. Differential affinities of visual arrestin, betaarrestin1, and beta arrestin2 for G proteincoupled receptors delineate two major classes of receptors. J. Biol. Chem. 275, 17201-17210 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 17201-17210
-
-
Oakley, R.H.1
Laporte, S.A.2
Holt, J.A.3
Caron, M.G.4
Barak, L.S.5
-
28
-
-
0032568931
-
Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor
-
Sainz, E., Akeson, M., Mantey, S. A., Jensen, R. T. & Battey, J. F. Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. J. Biol. Chem. 273, 15927-15932 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15927-15932
-
-
Sainz, E.1
Akeson, M.2
Mantey, S.A.3
Jensen, R.T.4
Battey, J.F.5
-
29
-
-
84927514894
-
In vivo genome editing using Staphylococcus aureus Cas9
-
Ran, F. A. et al. In vivo genome editing using Staphylococcus aureus Cas9. Nature 520, 186-U198 (2015).
-
(2015)
Nature
, vol.520
, pp. U186-U198
-
-
Ran, F.A.1
-
30
-
-
85011072174
-
Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array
-
Zetsche, B. et al. Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array. Nat. Biotechnol. 35, 31-34 (2017).
-
(2017)
Nat. Biotechnol.
, vol.35
, pp. 31-34
-
-
Zetsche, B.1
-
31
-
-
84952639685
-
Beyond editing: Repurposing CRISPRCas9 for precision genome regulation and interrogation
-
Dominguez, A. A., Lim, W. A. & Qi, L. S. Beyond editing: repurposing CRISPRCas9 for precision genome regulation and interrogation. Nat. Rev. Mol. Cell. Biol. 17, 5-15 (2016).
-
(2016)
Nat. Rev. Mol. Cell. Biol.
, vol.17
, pp. 5-15
-
-
Dominguez, A.A.1
Lim, W.A.2
Qi, L.S.3
-
32
-
-
85029363645
-
Engineering synthetic signaling pathways with programmable dCas9-Based chimeric receptors
-
Baeumler, T. A., Ahmed, A. A. & Fulga, T. A. Engineering synthetic signaling pathways with programmable dCas9-Based chimeric receptors. Cell. Rep. 20, 2639-2653 (2017).
-
(2017)
Cell. Rep.
, vol.20
, pp. 2639-2653
-
-
Baeumler, T.A.1
Ahmed, A.A.2
Fulga, T.A.3
-
33
-
-
84939864393
-
Model organisms in G protein-coupled receptor research
-
Langenhan, T. et al. Model organisms in G protein-coupled receptor research. Mol. Pharmacol. 88, 596-603 (2015).
-
(2015)
Mol. Pharmacol.
, vol.88
, pp. 596-603
-
-
Langenhan, T.1
-
34
-
-
1342281272
-
The identification of ligands at orphan G-protein coupled receptors
-
Wise, A., Jupe, S. C. & Rees, S. The identification of ligands at orphan G-protein coupled receptors. Annu. Rev. Pharmacol. Toxicol. 44, 43-66 (2004).
-
(2004)
Annu. Rev. Pharmacol. Toxicol.
, vol.44
, pp. 43-66
-
-
Wise, A.1
Jupe, S.C.2
Rees, S.3
-
35
-
-
84958230998
-
Engineering customized cell sensing and response behaviors using synthetic notch receptors
-
Morsut, L. et al. Engineering customized cell sensing and response behaviors using synthetic notch receptors. Cell 164, 780-791 (2016).
-
(2016)
Cell
, vol.164
, pp. 780-791
-
-
Morsut, L.1
-
36
-
-
85003955384
-
Rewiring human cellular input-output using modular extracellular sensors
-
Schwarz, K. A., Daringer, N. M., Dolberg, T. B. & Leonard, J. N. Rewiring human cellular input-output using modular extracellular sensors. Nat. Chem. Biol. 13, 202-209 (2017).
-
(2017)
Nat. Chem. Biol.
, vol.13
, pp. 202-209
-
-
Schwarz, K.A.1
Daringer, N.M.2
Dolberg, T.B.3
Leonard, J.N.4
-
37
-
-
84896335556
-
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
-
Davila, M. L. et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci. Transl. Med. 6, 224ra225 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 224ra225
-
-
Davila, M.L.1
-
38
-
-
0042887042
-
The emerging role of lysophosphatidic acid in cancer
-
Mills, G. B. & Moolenaar, W. H. The emerging role of lysophosphatidic acid in cancer. Nat. Rev. Cancer 3, 582-591 (2003).
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 582-591
-
-
Mills, G.B.1
Moolenaar, W.H.2
-
39
-
-
77949370572
-
The impact of GPCR structures on pharmacology and structure-based drug design
-
Congreve, M. & Marshall, F. The impact of GPCR structures on pharmacology and structure-based drug design. Br. J. Pharmacol. 159, 986-996 (2010).
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 986-996
-
-
Congreve, M.1
Marshall, F.2
-
40
-
-
84969791285
-
Comparison of Cas9 activators in multiple species
-
Chavez, A. et al. Comparison of Cas9 activators in multiple species. Nat. Methods 13, 563-567 (2016).
-
(2016)
Nat. Methods
, vol.13
, pp. 563-567
-
-
Chavez, A.1
-
41
-
-
0000917207
-
GPCRdb: An information system for G protein-coupled receptors
-
Isberg, V. et al. GPCRdb: an information system for G protein-coupled receptors. Nucleic Acids Res. 45, 2936 (2017).
-
(2017)
Nucleic Acids Res.
, vol.45
, pp. 2936
-
-
Isberg, V.1
-
42
-
-
0031803634
-
GPCRDB: An information system for G protein-coupled receptors
-
Horn, F. et al. GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res. 26, 275-279 (1998).
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 275-279
-
-
Horn, F.1
-
43
-
-
84864489995
-
T-REX: A web server for inferring, validating and visualizing phylogenetic trees and networks
-
Boc, A., Diallo, A. B. & Makarenkov, V. T-REX: a web server for inferring, validating and visualizing phylogenetic trees and networks. Nucleic Acids Res. 40, W573-W579 (2012).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. W573-W579
-
-
Boc, A.1
Diallo, A.B.2
Makarenkov, V.3
|