Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment

Genome Biology

Volumn 18, Issue 1, 2017, Pages

  Müller, Sören ^a,b   Kohanbash, Gary ^d   Liu, S John ^a,b   Alvarado, Beatriz ^a,b   Carrera, Diego ^a,b   Bhaduri, Aparna ^a,b   Watchmaker, Payal B ^a,b   Yagnik, Garima ^a,b   Di Lullo, Elizabeth ^a,b   Malatesta, Martina ^a,b   Amankulor, Nduka M ^d   Kriegstein, Arnold R ^a,b   Lim, Daniel A ^a,b,c   Aghi, Manish ^a,b   Okada, Hideho ^a,b   Diaz, Aaron ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Glioma; Immunotherapy; Macrophage; Single cell sequencing

Indexed keywords

ALPHA4 INTEGRIN; CD11B ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; HLA DR ANTIGEN; INTERLEUKIN 10; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; PURINERGIC P2Y12 RECEPTOR; RNA; TOLL LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSCRIPTOME;

ADULT; ANIMAL CELL; ARTICLE; BRAIN SURGERY; CANCER GRADING; CANCER SURVIVAL; CANCER TISSUE; CELL INFILTRATION; CELL ISOLATION; CELL LINEAGE; CELL METABOLISM; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MODEL; DRUG TARGETING; FEMALE; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MIDDLE AGED; MOUSE; NONHUMAN; ONTOGENY; PERIVASCULAR SPACE; PHENOTYPE; PHENOTYPIC VARIATION; PROTEIN EXPRESSION; RNA SEQUENCE; TISSUE NECROSIS; TUMOR ASSOCIATED LEUKOCYTE; TUMOR BIOPSY; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; BIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ONTOLOGY; GENETICS; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGY; IMMUNOTHERAPY; MACROPHAGE; METABOLISM; PATHOLOGY; PROCEDURES; PROGNOSIS; SINGLE CELL ANALYSIS; SURVIVAL ANALYSIS;

ANIMALS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE ONTOLOGY; GLIOMA; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOTHERAPY; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; PROGNOSIS; SINGLE-CELL ANALYSIS; SURVIVAL ANALYSIS; TRANSCRIPTOME; TUMOR MICROENVIRONMENT;

EID: 85038614969     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-017-1362-4     Document Type: Article

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