Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

Oncotarget

Volumn 6, Issue 17, 2015, Pages 15077-15094

  Feng, Xi ^a   Szulzewsky, Frank ^b   Yerevanian, Alexan ^a,c   Chen, Zhihong ^a   Heinzmann, David ^a,d   Rasmussen, Rikke Darling ^a   Alvarez Garcia, Virginia ^a   Kim, Yeonghwan ^e   Wang, Bingcheng ^c   Tamagno, Ilaria ^a   Zhou, Hao ^a   Li, Xiaoxia ^a   Kettenmann, Helmut ^b   Ransohoff, Richard M ^a   Hambardzumyan, Dolores ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e Department of Stem Cell Biology and Regenerative Medicine ^*  (United States)

Author keywords

CX3CR1 CX3CL1 signaling; Glioblastoma; Microglia; Monocyte

Indexed keywords

CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, HUMAN; CX3CR1 PROTEIN, MOUSE; IL1R1 PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL; BRAIN TUMOR; CANCER STEM CELL; CELL LINE; CONFOCAL MICROSCOPY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GLIOBLASTOMA; HUMAN; IMMUNOBLOTTING; KNOCKOUT MOUSE; MACROPHAGE; MALE; METABOLISM; MICROGLIA; MONOCYTE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TRANSGENIC MOUSE; TUMOR CELL CULTURE; TUMOR MICROENVIRONMENT;

ANIMALS; BRAIN NEOPLASMS; CELL LINE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-1BETA; MACROPHAGES; MALE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; MICROSCOPY, CONFOCAL; MONOCYTES; NEOPLASTIC STEM CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, CHEMOKINE; RECEPTORS, INTERLEUKIN-1 TYPE I; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TUMOR CELLS, CULTURED; TUMOR MICROENVIRONMENT;

EID: 84934300728     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3730     Document Type: Article

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