-
1
-
-
84861736119
-
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
-
Aghajanian C, Blank SV, Goff BA, Judson PL, Teneriello MG, Husain A et al. (2012). OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 30: 2039–2045.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2039-2045
-
-
Aghajanian, C.1
Blank, S.V.2
Goff, B.A.3
Judson, P.L.4
Teneriello, M.G.5
Husain, A.6
-
2
-
-
84949818216
-
The Concise Guide to PHARMACOLOGY 2015/16: Overview
-
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E et al. (2015a). The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol 172: 5729–5743.
-
(2015)
Br J Pharmacol
, vol.172
, pp. 5729-5743
-
-
Alexander, S.P.H.1
Kelly, E.2
Marrion, N.3
Peters, J.A.4
Benson, H.E.5
Faccenda, E.6
-
3
-
-
84949818215
-
The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors
-
Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE et al. (2015b). The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol 172: 5979–6023.
-
(2015)
Br J Pharmacol
, vol.172
, pp. 5979-6023
-
-
Alexander, S.P.H.1
Fabbro, D.2
Kelly, E.3
Marrion, N.4
Peters, J.A.5
Benson, H.E.6
-
4
-
-
84949844937
-
The Concise Guide to PHARMACOLOGY 2015/16: Enzymes
-
Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE et al. (2015c). The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol 172: 6024–6109.
-
(2015)
Br J Pharmacol
, vol.172
, pp. 6024-6109
-
-
Alexander, S.P.H.1
Fabbro, D.2
Kelly, E.3
Marrion, N.4
Peters, J.A.5
Benson, H.E.6
-
5
-
-
84949907904
-
The Concise Guide to PHARMACOLOGY 2015/16: Transporters
-
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E et al. (2015d). The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol 172: 6110–6202.
-
(2015)
Br J Pharmacol
, vol.172
, pp. 6110-6202
-
-
Alexander, S.P.H.1
Kelly, E.2
Marrion, N.3
Peters, J.A.4
Benson, H.E.5
Faccenda, E.6
-
6
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M et al. (2009). Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457: 608–611.
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
Ridgway, R.A.2
van Es, J.H.3
van de Wetering, M.4
Begthel, H.5
van den Born, M.6
-
7
-
-
0023223410
-
Localization of the gene for familial adenomatous polyposis on chromosome 5
-
Bodmer WF, Bailey CJ, Bodmer J, Bussey HJ, Ellis A, Gorman P et al. (1987). Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328: 614–616.
-
(1987)
Nature
, vol.328
, pp. 614-616
-
-
Bodmer, W.F.1
Bailey, C.J.2
Bodmer, J.3
Bussey, H.J.4
Ellis, A.5
Gorman, P.6
-
8
-
-
0035312290
-
All TCF HMG box transcription factors interact with Groucho-related co- repressors
-
Brantjes H, Roose J, van De Wetering M, Clevers H (2001). All TCF HMG box transcription factors interact with Groucho-related co- repressors. Nucleic Acids Res 29: 1410–1419.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 1410-1419
-
-
Brantjes, H.1
Roose, J.2
van De Wetering, M.3
Clevers, H.4
-
10
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network, Muzny DM, Bainbridge MN, Chang K, Dinh HH, Drummond JA et al. (2012). Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330–337.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
Muzny, D.M.1
Bainbridge, M.N.2
Chang, K.3
Dinh, H.H.4
Drummond, J.A.5
-
11
-
-
84898606032
-
Molecular functions of the TLE tetramerization domain in Wnt target gene repression
-
Chodaparambil JV, Pate KT, Hepler MRD, Tsai BP, Muthurajan UM, Luger K et al. (2014). Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J 33: 719–731.
-
(2014)
EMBO J
, vol.33
, pp. 719-731
-
-
Chodaparambil, J.V.1
Pate, K.T.2
Hepler, M.R.D.3
Tsai, B.P.4
Muthurajan, U.M.5
Luger, K.6
-
12
-
-
33644859739
-
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity
-
Choi H-J, Huber AH, Weis WI (2006). Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem 281: 1027–1038.
-
(2006)
J Biol Chem
, vol.281
, pp. 1027-1038
-
-
Choi, H.-J.1
Huber, A.H.2
Weis, W.I.3
-
14
-
-
85031700231
-
Assembly and architecture of the Wnt/β-catenin signalosome
-
DeBruine Z, Xu E, Melcher K (2017). Assembly and architecture of the Wnt/β-catenin signalosome. Br J Pharmacol.
-
(2017)
Br J Pharmacol
-
-
DeBruine, Z.1
Xu, E.2
Melcher, K.3
-
15
-
-
84857724447
-
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid
-
de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM et al. (2012). An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid. Nat Commun 3: 680.
-
(2012)
Nat Commun
, vol.3
, pp. 680
-
-
de la Roche, M.1
Rutherford, T.J.2
Gupta, D.3
Veprintsev, D.B.4
Saxty, B.5
Freund, S.M.6
-
16
-
-
85017356443
-
WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer
-
Driehuis E, Clevers H (2017). WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer. Br J Pharmacol 1–17.
-
(2017)
Br J Pharmacol
, pp. 1-17
-
-
Driehuis, E.1
Clevers, H.2
-
18
-
-
84884194711
-
A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors
-
El-Khoueiry AB, Ning Y, Yang N, Cole S, Kahn M, Zoghbi M et al. (2013). A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors. J Clin Oncol 31 no pagination.
-
(2013)
J Clin Oncol
, vol.31
-
-
El-Khoueiry, A.B.1
Ning, Y.2
Yang, N.3
Cole, S.4
Kahn, M.5
Zoghbi, M.6
-
19
-
-
4344587136
-
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]
-
Emami KH, Nguyen C, Ma H, Kim DH, Jeong KW, Eguchi M et al. (2004). A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A 101: 12682–12687.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 12682-12687
-
-
Emami, K.H.1
Nguyen, C.2
Ma, H.3
Kim, D.H.4
Jeong, K.W.5
Eguchi, M.6
-
20
-
-
77955032181
-
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription
-
Ewan K, Pajak B, Stubbs M, Todd H, Barbeau O, Quevedo C et al. (2010). A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res 70: 5963–5973.
-
(2010)
Cancer Res
, vol.70
, pp. 5963-5973
-
-
Ewan, K.1
Pajak, B.2
Stubbs, M.3
Todd, H.4
Barbeau, O.5
Quevedo, C.6
-
21
-
-
84960438593
-
A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis
-
Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Weis WI et al. (2016). A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis. Cancer Res 76: 891–901.
-
(2016)
Cancer Res
, vol.76
, pp. 891-901
-
-
Fang, L.1
Zhu, Q.2
Neuenschwander, M.3
Specker, E.4
Wulf-Goldenberg, A.5
Weis, W.I.6
-
22
-
-
0037742533
-
Hot spots in Tcf4 for the interaction with ??-catenin
-
Fasolini M, Wu X, Flocco M, Trosset JY, Oppermann U, Knapp S (2003). Hot spots in Tcf4 for the interaction with ??-catenin. J Biol Chem 278: 21092–21098.
-
(2003)
J Biol Chem
, vol.278
, pp. 21092-21098
-
-
Fasolini, M.1
Wu, X.2
Flocco, M.3
Trosset, J.Y.4
Oppermann, U.5
Knapp, S.6
-
23
-
-
84941898988
-
An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP
-
Fiedler M, Graeb M, Mieszczanek J, Rutherford TJ, Johnson CM, Bienz M (2015). An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP. Elife 4: https://doi.org/10.7554/eLife.09073.
-
(2015)
Elife
, vol.4
-
-
Fiedler, M.1
Graeb, M.2
Mieszczanek, J.3
Rutherford, T.J.4
Johnson, C.M.5
Bienz, M.6
-
24
-
-
84922369296
-
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study
-
Finn RS, Crown JP, Lang I, Boer K, Bondarenko IM, Kulyk SO et al. (2015). The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol 16: 25–35.
-
(2015)
Lancet Oncol
, vol.16
, pp. 25-35
-
-
Finn, R.S.1
Crown, J.P.2
Lang, I.3
Boer, K.4
Bondarenko, I.M.5
Kulyk, S.O.6
-
25
-
-
84995633338
-
Palbociclib and letrozole in advanced breast cancer
-
Finn RS, Martin M, Rugo HS, Jones S, Im S-A, Gelmon K et al. (2016). Palbociclib and letrozole in advanced breast cancer. N Engl J Med 375: 1925–1936.
-
(2016)
N Engl J Med
, vol.375
, pp. 1925-1936
-
-
Finn, R.S.1
Martin, M.2
Rugo, H.S.3
Jones, S.4
Im, S.-A.5
Gelmon, K.6
-
26
-
-
85010005041
-
Cancer anabolic metabolism inhibitors move into clinic
-
Garber K (2016). Cancer anabolic metabolism inhibitors move into clinic. Nat Biotechnol 34: 794–795.
-
(2016)
Nat Biotechnol
, vol.34
, pp. 794-795
-
-
Garber, K.1
-
28
-
-
79955046668
-
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
-
Gonsalves FC, Klein K, Carson BB, Katz S, Ekas LA, Evans S (2011). An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A 108: 5954–5963.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 5954-5963
-
-
Gonsalves, F.C.1
Klein, K.2
Carson, B.B.3
Katz, S.4
Ekas, L.A.5
Evans, S.6
-
29
-
-
80054952442
-
Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3
-
Gore AV, Swift MR, Cha YR, Lo B, McKinney MC, Li W et al. (2011). Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3. Development 138: 4875–4886.
-
(2011)
Development
, vol.138
, pp. 4875-4886
-
-
Gore, A.V.1
Swift, M.R.2
Cha, Y.R.3
Lo, B.4
McKinney, M.C.5
Li, W.6
-
30
-
-
0033635606
-
Crystal structure of a beta-catenin/Tcf complex
-
Graham TA, Weaver C, Mao F, Kimelman D, Xu W (2000). Crystal structure of a beta-catenin/Tcf complex. Cell 103: 885–896.
-
(2000)
Cell
, vol.103
, pp. 885-896
-
-
Graham, T.A.1
Weaver, C.2
Mao, F.3
Kimelman, D.4
Xu, W.5
-
31
-
-
84946067038
-
Antitumor activity of 3-indolylmethanamines 31B and PS121912
-
Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA et al. (2015). Antitumor activity of 3-indolylmethanamines 31B and PS121912. Anticancer Res 35: 6001–6007.
-
(2015)
Anticancer Res
, vol.35
, pp. 6001-6007
-
-
Guthrie, M.L.1
Sidhu, P.S.2
Hill, E.K.3
Horan, T.C.4
Nandhikonda, P.5
Teske, K.A.6
-
32
-
-
85022220538
-
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity
-
He X, Zhang W, Yan C, Nie F, Li C, Liu X et al. (2017). Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discov 3: 17003.
-
(2017)
Cell Discov
, vol.3
, pp. 17003
-
-
He, X.1
Zhang, W.2
Yan, C.3
Nie, F.4
Li, C.5
Liu, X.6
-
33
-
-
0034678610
-
The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
-
Hecht A, Vleminckx K, Stemmler MP, van Roy F, Kemler R (2000). The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates. EMBO J 19: 1839–1850.
-
(2000)
EMBO J
, vol.19
, pp. 1839-1850
-
-
Hecht, A.1
Vleminckx, K.2
Stemmler, M.P.3
van Roy, F.4
Kemler, R.5
-
34
-
-
84942869666
-
Rational design of selective small-molecule inhibitors for β-catenin/B-cell lymphoma 9 protein-protein interactions
-
Hoggard LR, Zhang Y, Zhang M, Panic V, Wisniewski JA, Ji H (2015). Rational design of selective small-molecule inhibitors for β-catenin/B-cell lymphoma 9 protein-protein interactions. J Am Chem Soc 137: 12249–12260.
-
(2015)
J Am Chem Soc
, vol.137
, pp. 12249-12260
-
-
Hoggard, L.R.1
Zhang, Y.2
Zhang, M.3
Panic, V.4
Wisniewski, J.A.5
Ji, H.6
-
35
-
-
84994151988
-
Ribociclib as first-line therapy for HR-positive, advanced breast cancer
-
Hortobagyi GN, Stemmer SM, Burris HA, Yap Y-S, Sonke GS, Paluch-Shimon S et al. (2016). Ribociclib as first-line therapy for HR-positive, advanced breast cancer. N Engl J Med 375: 1738–1748.
-
(2016)
N Engl J Med
, vol.375
, pp. 1738-1748
-
-
Hortobagyi, G.N.1
Stemmer, S.M.2
Burris, H.A.3
Yap, Y.-S.4
Sonke, G.S.5
Paluch-Shimon, S.6
-
36
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W et al. (2004). Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350: 2335–2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
-
37
-
-
84991063920
-
Direct targeting of β-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/β-catenin signaling
-
Hwang S-Y, Deng X, Byun S, Lee C, Lee S-J, Suh H et al. (2016). Direct targeting of β-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/β-catenin signaling. Cell Rep 16: 28–36.
-
(2016)
Cell Rep
, vol.16
, pp. 28-36
-
-
Hwang, S.-Y.1
Deng, X.2
Byun, S.3
Lee, C.4
Lee, S.-J.5
Suh, H.6
-
38
-
-
84912096468
-
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
-
Jain RK (2014). Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell 26: 605–622.
-
(2014)
Cancer Cell
, vol.26
, pp. 605-622
-
-
Jain, R.K.1
-
39
-
-
58549110011
-
Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival
-
Jin G, Lu D, Yao S, Wu CC, Liu JX, Carson DA et al. (2009). Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. Bioorg Med Chem Lett 19: 606–609.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 606-609
-
-
Jin, G.1
Lu, D.2
Yao, S.3
Wu, C.C.4
Liu, J.X.5
Carson, D.A.6
-
40
-
-
84903767326
-
Can we safely target the WNT pathway?
-
Kahn M (2014). Can we safely target the WNT pathway? Nat Rev Drug Discov 13: 513–532.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 513-532
-
-
Kahn, M.1
-
41
-
-
85037973416
-
Molecular regulation and pharmacological targeting of the β-catenin destruction complex
-
van Kappel EC, Maurice MM (2017). Molecular regulation and pharmacological targeting of the β-catenin destruction complex. Br J Pharmacol.
-
(2017)
Br J Pharmacol
-
-
van Kappel, E.C.1
Maurice, M.M.2
-
42
-
-
84968343089
-
Targeting MYC in cancer therapy: RNA processing offers new opportunities
-
Koh CM, Sabò A, Guccione E (2016). Targeting MYC in cancer therapy: RNA processing offers new opportunities. Bioessays 38: 266–275.
-
(2016)
Bioessays
, vol.38
, pp. 266-275
-
-
Koh, C.M.1
Sabò, A.2
Guccione, E.3
-
43
-
-
0030975671
-
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC−/− colon carcinoma
-
Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW et al. (1997). Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC−/− colon carcinoma. Science 275: 1784–1787.
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
van Wichen, D.4
de Weger, R.5
Kinzler, K.W.6
-
44
-
-
0037023584
-
Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
-
Kramps T, Peter O, Brunner E, Nellen D, Froesch B, Chatterjee S et al. (2002). Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 109: 47–60.
-
(2002)
Cell
, vol.109
, pp. 47-60
-
-
Kramps, T.1
Peter, O.2
Brunner, E.3
Nellen, D.4
Froesch, B.5
Chatterjee, S.6
-
45
-
-
84919456263
-
Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28
-
Le PN, McDermott JD, Jimeno A (2015). Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28. Pharmacol Ther 146: 1–11.
-
(2015)
Pharmacol Ther
, vol.146
, pp. 1-11
-
-
Le, P.N.1
McDermott, J.D.2
Jimeno, A.3
-
46
-
-
85013872279
-
Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer
-
Lee M, Chen GT, Edwards RA, Wang K, Waterman ML, Lowengrub J (2017). Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Rev 13: 912.
-
(2017)
Rev
, vol.13
, pp. 912
-
-
Lee, M.1
Chen, G.T.2
Edwards, R.A.3
Wang, K.4
Waterman, M.L.5
Lowengrub, J.6
-
47
-
-
84863917176
-
Wnt/snail signaling regulates cytochrome c oxidase and glucose metabolism
-
Lee SY, Jeon HM, Ju MK, Kim CH, Yoon G, Han SI et al. (2012). Wnt/snail signaling regulates cytochrome c oxidase and glucose metabolism. Cancer Res 72: 3607–3617.
-
(2012)
Cancer Res
, vol.72
, pp. 3607-3617
-
-
Lee, S.Y.1
Jeon, H.M.2
Ju, M.K.3
Kim, C.H.4
Yoon, G.5
Han, S.I.6
-
48
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
-
Lepourcelet M, Chen Y-NP, France DS, Wang H, Crews P, Petersen F et al. (2004). Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell 5: 91–102.
-
(2004)
Cancer Cell
, vol.5
, pp. 91-102
-
-
Lepourcelet, M.1
Chen, Y.-N.P.2
France, D.S.3
Wang, H.4
Crews, P.5
Petersen, F.6
-
49
-
-
0032578394
-
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
-
Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S et al. (1998). Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci U S A 95: 11590–11595.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 11590-11595
-
-
Levanon, D.1
Goldstein, R.E.2
Bernstein, Y.3
Tang, H.4
Goldenberg, D.5
Stifani, S.6
-
50
-
-
77954069621
-
Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/β-catenin pathway
-
Lu D, Liu JX, Endo T, Zhou H, Yao S, Willert K et al. (2009). Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/β-catenin pathway. PLoS One 4: e8294.
-
(2009)
PLoS One
, vol.4
-
-
Lu, D.1
Liu, J.X.2
Endo, T.3
Zhou, H.4
Yao, S.5
Willert, K.6
-
51
-
-
24044500959
-
Wnt/β-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells
-
Masckauchán TNH, Shawber CJ, Funahashi Y, Li C-M, Kitajewski J (2005). Wnt/β-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis 8: 43–51.
-
(2005)
Angiogenesis
, vol.8
, pp. 43-51
-
-
Masckauchán, T.N.H.1
Shawber, C.J.2
Funahashi, Y.3
Li, C.-M.4
Kitajewski, J.5
-
52
-
-
85014541439
-
JB special review – Wnt signaling: biological functions and its implications in diseases: context-dependent regulation of the β-catenin transcriptional complex supports diverse functions of Wnt/β-catenin signaling
-
Masuda T, Ishitani T (2017). JB special review – Wnt signaling: biological functions and its implications in diseases: context-dependent regulation of the β-catenin transcriptional complex supports diverse functions of Wnt/β-catenin signaling. J Biochem 161: 9–17.
-
(2017)
J Biochem
, vol.161
, pp. 9-17
-
-
Masuda, T.1
Ishitani, T.2
-
53
-
-
84907969130
-
AXIN1 and AXIN2 variants in gastrointestinal cancers
-
Mazzoni SM, Fearon ER (2014). AXIN1 and AXIN2 variants in gastrointestinal cancers. Cancer Lett 355: 1–8.
-
(2014)
Cancer Lett
, vol.355
, pp. 1-8
-
-
Mazzoni, S.M.1
Fearon, E.R.2
-
54
-
-
0024435879
-
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis
-
McMahon AP, Moon RT (1989). Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell 58: 1075–1084.
-
(1989)
Cell
, vol.58
, pp. 1075-1084
-
-
McMahon, A.P.1
Moon, R.T.2
-
55
-
-
85015292732
-
A phase Ib dose-escalation study of PRI-724, a CBP/beta-catenin modulator, plus gemcitabine (GEM) in patients with advanced pancreatic adenocarcinoma (APC) as second-line therapy after FOLFIRINOX or FOLFOX
-
McWilliams RR, Ko AH, Chiorean EG, Kwak EL, Lenz H-J, Nadler PI et al. (2015). A phase Ib dose-escalation study of PRI-724, a CBP/beta-catenin modulator, plus gemcitabine (GEM) in patients with advanced pancreatic adenocarcinoma (APC) as second-line therapy after FOLFIRINOX or FOLFOX. J Clin Oncol 33: (suppl); abstr e15270.
-
(2015)
J Clin Oncol
, vol.33
-
-
McWilliams, R.R.1
Ko, A.H.2
Chiorean, E.G.3
Kwak, E.L.4
Lenz, H.-J.5
Nadler, P.I.6
-
56
-
-
85029866445
-
Phase 1b study of WNT inhibitor vantictumab (VAN, human monoclonal antibody) with paclitaxel (P) in patients (pts) with 1st- to 3rd-line metastatic HER2-negative breast cancer (BC)
-
Mita MM, Becerra C, Richards DA, Mita AC, Shagisultanova E, Osborne CRC et al. (2016). Phase 1b study of WNT inhibitor vantictumab (VAN, human monoclonal antibody) with paclitaxel (P) in patients (pts) with 1st- to 3rd-line metastatic HER2-negative breast cancer (BC). J Clin Oncol 34: 2516.
-
(2016)
J Clin Oncol
, vol.34
, pp. 2516
-
-
Mita, M.M.1
Becerra, C.2
Richards, D.A.3
Mita, A.C.4
Shagisultanova, E.5
Osborne, C.R.C.6
-
57
-
-
77949409084
-
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
-
Mohan M, Herz H-M, Takahashi Y-H, Lin C, Lai KC, Zhang Y et al. (2010). Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev 24: 574–589.
-
(2010)
Genes Dev
, vol.24
, pp. 574-589
-
-
Mohan, M.1
Herz, H.-M.2
Takahashi, Y.-H.3
Lin, C.4
Lai, K.C.5
Zhang, Y.6
-
58
-
-
84994336739
-
Cancer metabolism pipeline breaks new ground
-
Mullard A (2016). Cancer metabolism pipeline breaks new ground. Nat Rev Drug Discov 15: 735–737.
-
(2016)
Nat Rev Drug Discov
, vol.15
, pp. 735-737
-
-
Mullard, A.1
-
59
-
-
79960836823
-
Cyclin D as a therapeutic target in cancer
-
Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL (2011). Cyclin D as a therapeutic target in cancer. Nat Rev Cancer 11: 558–572.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 558-572
-
-
Musgrove, E.A.1
Caldon, C.E.2
Barraclough, J.3
Stone, A.4
Sutherland, R.L.5
-
60
-
-
70349554461
-
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
-
Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM et al. (2009). Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet 41: 1068–1075.
-
(2009)
Nat Genet
, vol.41
, pp. 1068-1075
-
-
Nguyen, H.1
Merrill, B.J.2
Polak, L.3
Nikolova, M.4
Rendl, M.5
Shaver, T.M.6
-
61
-
-
84862207091
-
Mitotic and mitogenic Wnt signalling
-
Niehrs C, Acebron SP (2012). Mitotic and mitogenic Wnt signalling. EMBO J 31: 2705–2713.
-
(2012)
EMBO J
, vol.31
, pp. 2705-2713
-
-
Niehrs, C.1
Acebron, S.P.2
-
62
-
-
85020025659
-
Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
-
Nusse R, Clevers H (2017). Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell 169: 985–999.
-
(2017)
Cell
, vol.169
, pp. 985-999
-
-
Nusse, R.1
Clevers, H.2
-
63
-
-
0020216124
-
Many Tumors Induced by the Mouse Mammary Tumor Virus Contain a Provirus Integrated in the Same Region of the Host Genome
-
Nusse R, Varmus HE (1982). Many Tumors Induced by the Mouse Mammary Tumor Virus Contain a Provirus Integrated in the Same Region of the Host Genome. Cell 31: 99–109.
-
(1982)
Cell
, vol.31
, pp. 99-109
-
-
Nusse, R.1
Varmus, H.E.2
-
64
-
-
84903702539
-
Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer
-
Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP et al. (2014). Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J 33: 1454–1473.
-
(2014)
EMBO J
, vol.33
, pp. 1454-1473
-
-
Pate, K.T.1
Stringari, C.2
Sprowl-Tanio, S.3
Wang, K.4
TeSlaa, T.5
Hoverter, N.P.6
-
67
-
-
84961257208
-
Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer
-
Rennoll S, Yochum G (2015). Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer. World J Biol Chem 6: 290–300.
-
(2015)
World J Biol Chem
, vol.6
, pp. 290-300
-
-
Rennoll, S.1
Yochum, G.2
-
68
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
Reya T, Clevers H (2005). Wnt signalling in stem cells and cancer. Nature 434: 843–850.
-
(2005)
Nature
, vol.434
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
69
-
-
0030829387
-
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
-
Rocheleau CE, Downs WD, Lin R, Wittmann C, Bei Y, Cha YH et al. (1997). Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell 90: 707–716.
-
(1997)
Cell
, vol.90
, pp. 707-716
-
-
Rocheleau, C.E.1
Downs, W.D.2
Lin, R.3
Wittmann, C.4
Bei, Y.5
Cha, Y.H.6
-
70
-
-
33749685412
-
Crystal structure of a β-catenin/BCL9/Tcf4 complex
-
Sampietro J, Dahlberg CL, Cho U, Hinds TR, Kimelman D, Xu W (2006). Crystal structure of a β-catenin/BCL9/Tcf4 complex. Mol Cell 24: 293–300.
-
(2006)
Mol Cell
, vol.24
, pp. 293-300
-
-
Sampietro, J.1
Dahlberg, C.L.2
Cho, U.3
Hinds, T.R.4
Kimelman, D.5
Xu, W.6
-
71
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A et al. (2006). Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355: 2542–2550.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
-
72
-
-
58849095379
-
Targeting Wnt pathway in lymphoma and myeloma cells
-
Schmidt M, Sievers E, Endo T, Lu D, Carson D, Schmidt-Wolf IGH et al. (2009). Targeting Wnt pathway in lymphoma and myeloma cells. Br J Haematol 144: 796–798.
-
(2009)
Br J Haematol
, vol.144
, pp. 796-798
-
-
Schmidt, M.1
Sievers, E.2
Endo, T.3
Lu, D.4
Carson, D.5
Schmidt-Wolf, I.G.H.6
-
73
-
-
84898645562
-
WNT5A-mediated ß-catenin-independent signalling is a novel regulator of cancer cell metabolism
-
Sherwood V, Chaurasiya SK, Ekström EJ, Guilmain W, Liu Q, Koeck T et al. (2014). WNT5A-mediated ß-catenin-independent signalling is a novel regulator of cancer cell metabolism. Carcinogenesis 35: 784–794.
-
(2014)
Carcinogenesis
, vol.35
, pp. 784-794
-
-
Sherwood, V.1
Chaurasiya, S.K.2
Ekström, E.J.3
Guilmain, W.4
Liu, Q.5
Koeck, T.6
-
74
-
-
84976865494
-
The IUPHAR/BPS guide to PHARMACOLOGY in 2016: Towards curated quantitative interactions between 1300 protein targets and 6000 ligands
-
Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH et al. (2016). The IUPHAR/BPS guide to PHARMACOLOGY in 2016: Towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl Acids Res 44: D1054–D1068.
-
(2016)
Nucl Acids Res
, vol.44
, pp. D1054-D1068
-
-
Southan, C.1
Sharman, J.L.2
Benson, H.E.3
Faccenda, E.4
Pawson, A.J.5
Alexander, S.P.H.6
-
75
-
-
85013963052
-
Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer
-
Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA et al. (2016). Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer Metab 4: 20.
-
(2016)
Cancer Metab
, vol.4
, pp. 20
-
-
Sprowl-Tanio, S.1
Habowski, A.N.2
Pate, K.T.3
McQuade, M.M.4
Wang, K.5
Edwards, R.A.6
-
76
-
-
0033741508
-
Regulation of beta -catenin transformation by the p300 transcriptional coactivator
-
Sun Y, Kolligs FT, Hottiger MO, Mosavin R, Fearon ER, Nabel GJ (2000). Regulation of beta -catenin transformation by the p300 transcriptional coactivator. Proc Natl Acad Sci 97: 12613–12618.
-
(2000)
Proc Natl Acad Sci
, vol.97
, pp. 12613-12618
-
-
Sun, Y.1
Kolligs, F.T.2
Hottiger, M.O.3
Mosavin, R.4
Fearon, E.R.5
Nabel, G.J.6
-
77
-
-
84865315399
-
Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling
-
Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao J-J, Mani M et al. (2012). Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med 4: 148ra117–148ra117.
-
(2012)
Sci Transl Med
, vol.4
, pp. 148ra117
-
-
Takada, K.1
Zhu, D.2
Bird, G.H.3
Sukhdeo, K.4
Zhao, J.-J.5
Mani, M.6
-
78
-
-
0034678357
-
The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression
-
Takemaru KI, Moon RT (2000). The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. J Cell Biol 149: 249–254.
-
(2000)
J Cell Biol
, vol.149
, pp. 249-254
-
-
Takemaru, K.I.1
Moon, R.T.2
-
79
-
-
0036097733
-
A new nuclear component of the Wnt signalling pathway
-
Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M (2002). A new nuclear component of the Wnt signalling pathway. Nat Cell Biol 4: 367–373.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 367-373
-
-
Thompson, B.1
Townsley, F.2
Rosin-Arbesfeld, R.3
Musisi, H.4
Bienz, M.5
-
80
-
-
84862916465
-
Structure-based discovery of a novel inhibitor targeting the beta-catenin/Tcf4 interaction
-
Tian W, Han X, Yan M, Xu Y, Duggineni S, Lin N et al. (2012). Structure-based discovery of a novel inhibitor targeting the beta-catenin/Tcf4 interaction. Biochemistry 51: 724–731.
-
(2012)
Biochemistry
, vol.51
, pp. 724-731
-
-
Tian, W.1
Han, X.2
Yan, M.3
Xu, Y.4
Duggineni, S.5
Lin, N.6
-
81
-
-
85015682207
-
Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9
-
van Tienen LM, Mieszczanek J, Fiedler M, Rutherford TJ, Bienz M (2017). Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. Elife 6: 1–23.
-
(2017)
Elife
, vol.6
, pp. 1-23
-
-
van Tienen, L.M.1
Mieszczanek, J.2
Fiedler, M.3
Rutherford, T.J.4
Bienz, M.5
-
82
-
-
1242317058
-
Pygopus residues required for its binding to Legless are critical for transcription and development
-
Townsley FM, Thompson B, Bienz M (2004). Pygopus residues required for its binding to Legless are critical for transcription and development. J Biol Chem 279: 5177–5183.
-
(2004)
J Biol Chem
, vol.279
, pp. 5177-5183
-
-
Townsley, F.M.1
Thompson, B.2
Bienz, M.3
-
83
-
-
84937042338
-
Palbociclib in hormone-receptor–Positive advanced breast cancer
-
Turner NC, Ro J, André F, Loi S, Verma S, Iwata H et al. (2015). Palbociclib in hormone-receptor–Positive advanced breast cancer. N Engl J Med 373: 209–219.
-
(2015)
N Engl J Med
, vol.373
, pp. 209-219
-
-
Turner, N.C.1
Ro, J.2
André, F.3
Loi, S.4
Verma, S.5
Iwata, H.6
-
84
-
-
36049037819
-
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
-
Vredenburgh JJ, Desjardins A, Herndon JE, Marcello J, Reardon DA, Quinn JA et al. (2007). Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 25: 4722–4729.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4722-4729
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon, J.E.3
Marcello, J.4
Reardon, D.A.5
Quinn, J.A.6
-
85
-
-
0032189630
-
Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
-
Waltzer L, Bienz M (1998). Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature 395: 521–525.
-
(1998)
Nature
, vol.395
, pp. 521-525
-
-
Waltzer, L.1
Bienz, M.2
-
86
-
-
79955613593
-
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis
-
Wang W, Liu H, Wang S, Hao X, Li L (2011). A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res 21: 730–740.
-
(2011)
Cell Res
, vol.21
, pp. 730-740
-
-
Wang, W.1
Liu, H.2
Wang, S.3
Hao, X.4
Li, L.5
-
87
-
-
0032520975
-
Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21
-
Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM et al. (1998). Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21. Blood 91: 1873–1881.
-
(1998)
Blood
, vol.91
, pp. 1873-1881
-
-
Willis, T.G.1
Zalcberg, I.R.2
Coignet, L.J.3
Wlodarska, I.4
Stul, M.5
Jadayel, D.M.6
-
88
-
-
35648965654
-
Mechanistic insights from structural studies of beta-catenin and its binding partners
-
Xu W, Kimelman D (2007). Mechanistic insights from structural studies of beta-catenin and its binding partners. J Cell Sci 120: 3337–3344.
-
(2007)
J Cell Sci
, vol.120
, pp. 3337-3344
-
-
Xu, W.1
Kimelman, D.2
-
90
-
-
0035882030
-
Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
-
Zhang X, Gaspard JP, Chung DC (2001). Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 61: 6050–6054.
-
(2001)
Cancer Res
, vol.61
, pp. 6050-6054
-
-
Zhang, X.1
Gaspard, J.P.2
Chung, D.C.3
-
91
-
-
85020943692
-
Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors
-
Zimmerli D, Hausmann G, Cantù C, Basler K (2017). Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors. Br J Pharmacol 1–11.
-
(2017)
Br J Pharmacol
, pp. 1-11
-
-
Zimmerli, D.1
Hausmann, G.2
Cantù, C.3
Basler, K.4
|