-
1
-
-
0020216124
-
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
-
Nusse, R. et al. (1982) Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell, 31, 99-109.
-
(1982)
Cell
, vol.31
, pp. 99-109
-
-
Nusse, R.1
-
2
-
-
0029920839
-
Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes
-
Papkoff, J. et al. (1996) Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. Mol. Cell. Biol., 16, 2128-2134.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2128-2134
-
-
Papkoff, J.1
-
3
-
-
67650594771
-
The opposing roles of Wnt-5a in cancer
-
McDonald, S.L. et al. (2009) The opposing roles of Wnt-5a in cancer. Br. J. Cancer, 101, 209-214.
-
(2009)
Br. J. Cancer
, vol.101
, pp. 209-214
-
-
McDonald, S.L.1
-
4
-
-
18244387242
-
Expression and signaling activity of Wnt-5a/discoidin domain receptor-1 and Syk plays distinct but decisive roles in breast cancer patient survival
-
Dejmek, J. et al. (2005) Expression and signaling activity of Wnt-5a/discoidin domain receptor-1 and Syk plays distinct but decisive roles in breast cancer patient survival. Clin. Cancer Res., 11(2 Pt 1), 520-528.
-
(2005)
Clin. Cancer Res.
, vol.11
, Issue.2 PART 1
, pp. 520-528
-
-
Dejmek, J.1
-
5
-
-
17444390878
-
WNT5A expression in human breast cancer
-
Leris, A.C. et al. (2005) WNT5A expression in human breast cancer. Anticancer Res., 25(2A), 731-734.
-
(2005)
Anticancer Res.
, vol.25
, Issue.2 A
, pp. 731-734
-
-
Leris, A.C.1
-
6
-
-
53249090604
-
WNT5A expression increases during melanoma progression and correlates with outcome
-
Da Forno, P.D. et al. (2008) WNT5A expression increases during melanoma progression and correlates with outcome. Clin. Cancer Res., 14, 5825-5832.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5825-5832
-
-
Da Forno, P.D.1
-
7
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan, D. et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
-
8
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden, M.G. et al. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 324, 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
-
9
-
-
12444279265
-
On the origin of cancer cells
-
Warburg, O. (1956) On the origin of cancer cells. Science, 123, 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
10
-
-
84865976786
-
Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review
-
Porporato, P.E. et al. (2011) Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front. Pharmacol., 2, 49.
-
(2011)
Front. Pharmacol.
, vol.2
, pp. 49
-
-
Porporato, P.E.1
-
11
-
-
77950877526
-
Wnt signalling and the control of cellular metabolism
-
Sethi, J.K. et al. (2010) Wnt signalling and the control of cellular metabolism. Biochem. J., 427, 1-17.
-
(2010)
Biochem. J.
, vol.427
, pp. 1-17
-
-
Sethi, J.K.1
-
12
-
-
0037191930
-
New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism
-
Cadoret, A. et al. (2002) New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene, 21, 8293-8301.
-
(2002)
Oncogene
, vol.21
, pp. 8293-8301
-
-
Cadoret, A.1
-
13
-
-
0037905677
-
Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas
-
Schwartz, D.R. et al. (2003) Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res., 63, 2913-2922.
-
(2003)
Cancer Res.
, vol.63
, pp. 2913-2922
-
-
Schwartz, D.R.1
-
14
-
-
84863545499
-
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition
-
Mori, H. et al. (2012) Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J. Clin. Invest., 122, 2405-2416.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2405-2416
-
-
Mori, H.1
-
15
-
-
77954851049
-
Wnt signaling regulates mitochondrial physiology and insulin sensitivity
-
Yoon, J.C. et al. (2010) Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev., 24, 1507-1518.
-
(2010)
Genes Dev.
, vol.24
, pp. 1507-1518
-
-
Yoon, J.C.1
-
16
-
-
1542611579
-
Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma
-
Lens, M.B. et al. (2004) Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma. Br. J. Dermatol., 150, 179-185.
-
(2004)
Br. J. Dermatol.
, vol.150
, pp. 179-185
-
-
Lens, M.B.1
-
17
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F.S. et al. (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med., 363, 711-723.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
18
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
BRIM-3 Study Group
-
Chapman, P.B. et al.; BRIM-3 Study Group. (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med., 364, 2507-2516.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
-
19
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert, C. et al. (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med., 364, 2517-2526.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
-
20
-
-
0036528247
-
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
-
Weeraratna, A.T. et al. (2002) Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell, 1, 279-288.
-
(2002)
Cancer Cell
, vol.1
, pp. 279-288
-
-
Weeraratna, A.T.1
-
21
-
-
73349119711
-
A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion
-
Jenei, V. et al. (2009) A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc. Natl Acad. Sci. USA, 106, 19473-19478.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 19473-19478
-
-
Jenei, V.1
-
22
-
-
84869416805
-
Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE
-
Lai, S.S. et al. (2012) Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE. Cancer Genet., 205, 552-562.
-
(2012)
Cancer Genet.
, vol.205
, pp. 552-562
-
-
Lai, S.S.1
-
23
-
-
73849123750
-
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
-
O'Connell, M.P. et al. (2010) The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene, 29, 34-44.
-
(2010)
Oncogene
, vol.29
, pp. 34-44
-
-
O'Connell, M.P.1
-
24
-
-
84875168586
-
The small GTPase ARF6 stimulates ß-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis
-
Grossmann, A.H. et al. (2013) The small GTPase ARF6 stimulates ß-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis. Sci. Signal., 6, ra14.
-
(2013)
Sci. Signal.
, vol.6
-
-
Grossmann, A.H.1
-
25
-
-
79954556422
-
Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion
-
Ekström, E.J. et al. (2011) Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion. PLoS ONE, 6, e18674.
-
(2011)
PLoS ONE
, vol.6
-
-
Ekström, E.J.1
-
26
-
-
0037081290
-
Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas
-
Jönsson, M. et al. (2002) Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res., 62, 409-416.
-
(2002)
Cancer Res.
, vol.62
, pp. 409-416
-
-
Jönsson, M.1
-
27
-
-
65249136504
-
Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma
-
Strömberg, S. et al. (2009) Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. J. Proteome Res., 8, 1639-1646.
-
(2009)
J. Proteome Res.
, vol.8
, pp. 1639-1646
-
-
Strömberg, S.1
-
28
-
-
67449128692
-
Wnt5A activates the calpain-mediated cleavage of filamin A
-
O'Connell, M.P. et al. (2009) Wnt5A activates the calpain-mediated cleavage of filamin A. J. Invest. Dermatol., 129, 1782-1789.
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 1782-1789
-
-
O'Connell, M.P.1
-
29
-
-
0036554644
-
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
-
Helmlinger, G. et al. (2002) Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin. Cancer Res., 8, 1284-1291.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1284-1291
-
-
Helmlinger, G.1
-
30
-
-
0016849248
-
Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation
-
Markert, C.L. et al. (1975) Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation. Science, 189, 102-114.
-
(1975)
Science
, vol.189
, pp. 102-114
-
-
Markert, C.L.1
-
31
-
-
80053109911
-
The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism
-
Quistorff, B. et al. (2011) The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism. Aging (Albany. NY)., 3, 457-460.
-
(2011)
Aging (Albany. NY).
, vol.3
, pp. 457-460
-
-
Quistorff, B.1
-
32
-
-
73949089935
-
Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
-
Zhuang, L. et al. (2010) Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. Mod. Pathol., 23, 45-53.
-
(2010)
Mod. Pathol.
, vol.23
, pp. 45-53
-
-
Zhuang, L.1
-
33
-
-
74949143594
-
Final version of 2009 AJCC melanoma staging and classification
-
Balch, C.M. et al. (2009) Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol., 27, 6199-6206.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 6199-6206
-
-
Balch, C.M.1
-
34
-
-
58149190789
-
The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility
-
Säfholm, A. et al. (2008) The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin. Cancer Res., 14, 6556-6563.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6556-6563
-
-
Säfholm, A.1
-
35
-
-
79953180902
-
Assessing mitochondrial dysfunction in cells
-
Brand, M.D. et al. (2011) Assessing mitochondrial dysfunction in cells. Biochem. J., 435, 297-312.
-
(2011)
Biochem. J.
, vol.435
, pp. 297-312
-
-
Brand, M.D.1
-
36
-
-
78651431471
-
Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility
-
Camilli, T.C. et al. (2011) Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility. Pigment Cell Melanoma Res., 24, 175-186.
-
(2011)
Pigment Cell Melanoma Res.
, vol.24
, pp. 175-186
-
-
Camilli, T.C.1
-
37
-
-
42349093195
-
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors
-
Witze, E.S. et al. (2008) Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science, 320, 365-369.
-
(2008)
Science
, vol.320
, pp. 365-369
-
-
Witze, E.S.1
-
38
-
-
58749096052
-
Assaying Wnt5A-mediated invasion in melanoma cells
-
O'Connell, M.P. et al. (2008) Assaying Wnt5A-mediated invasion in melanoma cells. Methods Mol. Biol., 468, 243-253.
-
(2008)
Methods Mol. Biol.
, vol.468
, pp. 243-253
-
-
O'Connell, M.P.1
-
39
-
-
0025701432
-
Glycolysis as primary energy source in tumor cell chemotaxis
-
Beckner, M.E. et al. (1990) Glycolysis as primary energy source in tumor cell chemotaxis. J. Natl Cancer Inst., 82, 1836-1840.
-
(1990)
J. Natl Cancer Inst.
, vol.82
, pp. 1836-1840
-
-
Beckner, M.E.1
-
40
-
-
0034669656
-
Prognostic factors in metastatic melanoma: a pooled analysis of Eastern Cooperative Oncology Group trials
-
Manola, J. et al. (2000) Prognostic factors in metastatic melanoma: a pooled analysis of Eastern Cooperative Oncology Group trials. J. Clin. Oncol., 18, 3782-3793.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 3782-3793
-
-
Manola, J.1
-
41
-
-
0020655520
-
LDH and melanoma
-
Finck, S.J. et al. (1983) LDH and melanoma. Cancer, 51, 840-843.
-
(1983)
Cancer
, vol.51
, pp. 840-843
-
-
Finck, S.J.1
-
42
-
-
84867128553
-
Importance of glycolysis and oxidative phosphorylation in advanced melanoma
-
Ho, J. et al. (2012) Importance of glycolysis and oxidative phosphorylation in advanced melanoma. Mol. Cancer, 11, 76.
-
(2012)
Mol. Cancer
, vol.11
, pp. 76
-
-
Ho, J.1
-
43
-
-
34547580590
-
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation
-
Gordan, J.D. et al. (2007) HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell, 12, 108-113.
-
(2007)
Cancer Cell
, vol.12
, pp. 108-113
-
-
Gordan, J.D.1
-
44
-
-
60549111398
-
Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis
-
Robey, R.B. et al. (2009) Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. Semin. Cancer Biol., 19, 25-31.
-
(2009)
Semin. Cancer Biol.
, vol.19
, pp. 25-31
-
-
Robey, R.B.1
-
45
-
-
34948906833
-
Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal
-
Kawasaki, A. et al. (2007) Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal. Cell. Signal., 19, 2498-2506.
-
(2007)
Cell. Signal.
, vol.19
, pp. 2498-2506
-
-
Kawasaki, A.1
-
46
-
-
84855659496
-
Wnt5a potentiates U46619-induced platelet aggregation via the PI3K/Akt pathway
-
Kim, S.Y. et al. (2011) Wnt5a potentiates U46619-induced platelet aggregation via the PI3K/Akt pathway. Mol. Cells, 32, 333-336.
-
(2011)
Mol. Cells
, vol.32
, pp. 333-336
-
-
Kim, S.Y.1
-
47
-
-
4143080443
-
The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver
-
Reiter, A.K. et al. (2004) The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. Int. J. Biochem. Cell Biol., 36, 2169-2179.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2169-2179
-
-
Reiter, A.K.1
-
48
-
-
84860527756
-
A unifying model for mTORC1-mediated regulation of mRNA translation
-
Thoreen, C.C. et al. (2012) A unifying model for mTORC1-mediated regulation of mRNA translation. Nature, 485, 109-113.
-
(2012)
Nature
, vol.485
, pp. 109-113
-
-
Thoreen, C.C.1
-
49
-
-
84870351089
-
PI3K/Akt-dependent phosphorylation of GSK3ß and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration
-
Liu, J. et al. (2013) PI3K/Akt-dependent phosphorylation of GSK3ß and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration. Cell. Signal., 25, 447-456.
-
(2013)
Cell. Signal.
, vol.25
, pp. 447-456
-
-
Liu, J.1
-
50
-
-
0033179481
-
Top-down control analysis of ATP turnover, glycolysis and oxidative phosphorylation in rat hepatocytes
-
Ainscow, E.K. et al. (1999) Top-down control analysis of ATP turnover, glycolysis and oxidative phosphorylation in rat hepatocytes. Eur. J. Biochem., 263, 671-685.
-
(1999)
Eur. J. Biochem.
, vol.263
, pp. 671-685
-
-
Ainscow, E.K.1
-
51
-
-
59049101982
-
Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
-
Chien, A.J. et al. (2009) Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc. Natl Acad. Sci. USA, 106, 1193-1198.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 1193-1198
-
-
Chien, A.J.1
-
52
-
-
84871846692
-
WNT signalling pathways as therapeutic targets in cancer
-
Anastas, J.N. et al. (2013) WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer, 13, 11-26.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 11-26
-
-
Anastas, J.N.1
-
53
-
-
77949395248
-
Neurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinoma
-
Kim, M.S. et al. (2010) Neurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinoma. PLoS ONE, 5, e9003.
-
(2010)
PLoS ONE
, vol.5
-
-
Kim, M.S.1
-
54
-
-
84863917176
-
Wnt/Snail signaling regulates cytochrome C oxidase and glucose metabolism
-
Lee, S.Y. et al. (2012) Wnt/Snail signaling regulates cytochrome C oxidase and glucose metabolism. Cancer Res., 72, 3607-3617.
-
(2012)
Cancer Res.
, vol.72
, pp. 3607-3617
-
-
Lee, S.Y.1
-
55
-
-
77954365864
-
Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization
-
Nishita, M. et al. (2010) Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization. Mol. Cell. Biol., 30, 3610-3619.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 3610-3619
-
-
Nishita, M.1
-
56
-
-
75649084593
-
Wnt5a regulates distinct signalling pathways by binding to Frizzled2
-
Sato, A. et al. (2010) Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J., 29, 41-54.
-
(2010)
EMBO J.
, vol.29
, pp. 41-54
-
-
Sato, A.1
-
57
-
-
24344462625
-
Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation
-
Takada, R. et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells, 10, 919-928.
-
(2005)
Genes Cells
, vol.10
, pp. 919-928
-
-
Takada, R.1
-
58
-
-
42949121156
-
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
-
Fukuda, T. et al. (2008) Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc. Natl Acad. Sci. USA, 105, 3047-3052.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 3047-3052
-
-
Fukuda, T.1
-
59
-
-
65949084004
-
Wnt5a induces simultaneous cortical axon outgrowth and repulsive axon guidance through distinct signaling mechanisms
-
Li, L. et al. (2009) Wnt5a induces simultaneous cortical axon outgrowth and repulsive axon guidance through distinct signaling mechanisms. J. Neurosci., 29, 5873-5883.
-
(2009)
J. Neurosci.
, vol.29
, pp. 5873-5883
-
-
Li, L.1
-
60
-
-
84876115558
-
Metabolic symbiosis in cancer: refocusing the Warburg lens
-
Nakajima, E.C. et al. (2013) Metabolic symbiosis in cancer: refocusing the Warburg lens. Mol. Carcinog., 52, 329-337.
-
(2013)
Mol. Carcinog.
, vol.52
, pp. 329-337
-
-
Nakajima, E.C.1
|