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Volumn 24, Issue 2, 2018, Pages 168-179

Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

Author keywords

Brain; HIV 1; Mouse model; Tat; Transgenic

Indexed keywords

DOXYCYCLINE; GLIAL FIBRILLARY ACIDIC PROTEIN; MICRORNA 132; TRANSACTIVATOR PROTEIN; FUSION PROTEIN; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE;

EID: 85034037625     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-017-0598-9     Document Type: Review
Times cited : (29)

References (155)
  • 2
    • 0022455988 scopus 로고
    • Progressive multifocal leukoencephalopathy: JC virus detection by in situ hybridization compared with immunohistochemistry
    • Aksamit AJ, Sever JL, Major EO (1986) Progressive multifocal leukoencephalopathy: JC virus detection by in situ hybridization compared with immunohistochemistry. Neurology 36:499–504
    • (1986) Neurology , vol.36 , pp. 499-504
    • Aksamit, A.J.1    Sever, J.L.2    Major, E.O.3
  • 4
    • 0023452855 scopus 로고
    • Identification of Theiler’svirus infected cells in the central nervous system of the mouse during demyelinating disease
    • Aubert C, Chamorro M, Brahic M (1987) Identification of Theiler’svirus infected cells in the central nervous system of the mouse during demyelinating disease. Microb Pathog 3:319–326
    • (1987) Microb Pathog , vol.3 , pp. 319-326
    • Aubert, C.1    Chamorro, M.2    Brahic, M.3
  • 5
    • 0026335130 scopus 로고
    • New roles for glia
    • Barres BA (1991) New roles for glia. J Neurosci 11:3685–3694
    • (1991) J Neurosci , vol.11 , pp. 3685-3694
    • Barres, B.A.1
  • 6
    • 33745851534 scopus 로고    scopus 로고
    • Impact of HIVon regional & cellular organisation of the brain
    • Bell JE, Anthony IC, Simmonds P (2006a) Impact of HIVon regional & cellular organisation of the brain. Curr HIV Res 4:249–257
    • (2006) Curr HIV Res , vol.4 , pp. 249-257
    • Bell, J.E.1    Anthony, I.C.2    Simmonds, P.3
  • 7
    • 33747461037 scopus 로고    scopus 로고
    • Neurobiology of multiple insults: HIV-1-associated brain disorders in those who use illicit drugs
    • Bell JE, Arango JC, Anthony IC (2006b) Neurobiology of multiple insults: HIV-1-associated brain disorders in those who use illicit drugs. J NeuroImmune Pharmacol 1:182–191
    • (2006) J Neuroimmune Pharmacol , vol.1 , pp. 182-191
    • Bell, J.E.1    Arango, J.C.2    Anthony, I.C.3
  • 8
    • 17644365105 scopus 로고    scopus 로고
    • The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors
    • Belmadani A, Tran PB, Ren D, Assimacopoulos S, Grove EA, Miller RJ (2005) The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J Neurosci 25:3995–4003
    • (2005) J Neurosci , vol.25 , pp. 3995-4003
    • Belmadani, A.1    Tran, P.B.2    Ren, D.3    Assimacopoulos, S.4    Grove, E.A.5    Miller, R.J.6
  • 9
    • 33645231127 scopus 로고    scopus 로고
    • Chemokines regulate the migration of neural progenitors to sites of neuroinflammation
    • Belmadani A, Tran PB, Ren D, Miller RJ (2006) Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. J Neurosci 26:3182–3191
    • (2006) J Neurosci , vol.26 , pp. 3182-3191
    • Belmadani, A.1    Tran, P.B.2    Ren, D.3    Miller, R.J.4
  • 11
    • 0029145121 scopus 로고
    • Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding
    • Bonifaci N, Sitia R, Rubartelli A (1995) Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding. AIDS 9:995–1000
    • (1995) AIDS , vol.9 , pp. 995-1000
    • Bonifaci, N.1    Sitia, R.2    Rubartelli, A.3
  • 12
    • 0028256226 scopus 로고
    • GFAP promoter directs astrocyte-specific expression in transgenic mice
    • Brenner M, Kisseberth WC, Su Y, Besnard F, Messing A (1994) GFAP promoter directs astrocyte-specific expression in transgenic mice. J Neurosci 14:1030–1037
    • (1994) J Neurosci , vol.14 , pp. 1030-1037
    • Brenner, M.1    Kisseberth, W.C.2    Su, Y.3    Besnard, F.4    Messing, A.5
  • 13
    • 0032077767 scopus 로고    scopus 로고
    • Transgenic mice and cytokine actions in the brain: Bridging the gap between structural and functional neuropathology
    • Campbell IL (1998) Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology. Brain Res Brain Res Rev 26:327–336
    • (1998) Brain Res Brain Res Rev , vol.26 , pp. 327-336
    • Campbell, I.L.1
  • 17
    • 0025907420 scopus 로고
    • Borna disease virus replicates in astrocytes, Schwann cells and ependymal cells in persistently infected rats: Location of viral genomic and messenger RNAs by in situ hybridization
    • Carbone KM, Moench TR, Lipkin WI (1991) Borna disease virus replicates in astrocytes, Schwann cells and ependymal cells in persistently infected rats: location of viral genomic and messenger RNAs by in situ hybridization. J Neuropathol Exp Neurol 50:205–214
    • (1991) J Neuropathol Exp Neurol , vol.50 , pp. 205-214
    • Carbone, K.M.1    Moench, T.R.2    Lipkin, W.I.3
  • 18
    • 84855897049 scopus 로고    scopus 로고
    • Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse
    • Carey AN, Sypek EI, Singh HD, Kaufman MJ, McLaughlin JP (2012) Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse. Behav Brain Res 229:48–56
    • (2012) Behav Brain Res , vol.229 , pp. 48-56
    • Carey, A.N.1    Sypek, E.I.2    Singh, H.D.3    Kaufman, M.J.4    McLaughlin, J.P.5
  • 20
    • 84930972773 scopus 로고    scopus 로고
    • Conditional Tat protein brain expression in the GT-tg bigenic mouse induces cerebral fractional anisotropy abnormalities
    • Carey AN, Liu X, Mintzopoulos D, Paris JJ, McLaughlin JP, Kaufman MJ (2015) Conditional Tat protein brain expression in the GT-tg bigenic mouse induces cerebral fractional anisotropy abnormalities. Curr HIV Res 13:3–9
    • (2015) Curr HIV Res , vol.13 , pp. 3-9
    • Carey, A.N.1    Liu, X.2    Mintzopoulos, D.3    Paris, J.J.4    McLaughlin, J.P.5    Kaufman, M.J.6
  • 21
    • 0032212260 scopus 로고    scopus 로고
    • Astrocyte-targeted expression of IFN-alpha1 protects mice from acute ocular herpes simplex virus type 1 infection
    • Carr DJ, Veress LA, Noisakran S, Campbell IL (1998) Astrocyte-targeted expression of IFN-alpha1 protects mice from acute ocular herpes simplex virus type 1 infection. J Immunol 161:4859–4865
    • (1998) J Immunol , vol.161 , pp. 4859-4865
    • Carr, D.J.1    Veress, L.A.2    Noisakran, S.3    Campbell, I.L.4
  • 22
    • 0030862924 scopus 로고    scopus 로고
    • HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region
    • Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B (1997) HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. AIDS 11:1421–1431
    • (1997) AIDS , vol.11 , pp. 1421-1431
    • Chang, H.C.1    Samaniego, F.2    Nair, B.C.3    Buonaguro, L.4    Ensoli, B.5
  • 23
    • 0030884230 scopus 로고    scopus 로고
    • The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases
    • Chen P, Mayne M, Power C, Nath A (1997) The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. J Biol Chem 272: 22385–22388
    • (1997) J Biol Chem , vol.272 , pp. 22385-22388
    • Chen, P.1    Mayne, M.2    Power, C.3    Nath, A.4
  • 26
    • 0034603123 scopus 로고    scopus 로고
    • Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice
    • Choi J, Liu RM, Kundu RK, Sangiorgi F, Wu W, Maxson R, Forman HJ (2000) Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. J Biol Chem 275:3693–3698
    • (2000) J Biol Chem , vol.275 , pp. 3693-3698
    • Choi, J.1    Liu, R.M.2    Kundu, R.K.3    Sangiorgi, F.4    Wu, W.5    Maxson, R.6    Forman, H.J.7
  • 29
    • 84905979212 scopus 로고    scopus 로고
    • Reduction of pyramidal and immature hippocampal neurons in pediatric simian immunodeficiency virus infection
    • Curtis K, Rollins M, Carryl H, Bradshaw K, Van Rompay KK, Abel K, Burke MW (2014) Reduction of pyramidal and immature hippocampal neurons in pediatric simian immunodeficiency virus infection. Neuroreport 25:973–978
    • (2014) Neuroreport , vol.25 , pp. 973-978
    • Curtis, K.1    Rollins, M.2    Carryl, H.3    Bradshaw, K.4    van Rompay, K.K.5    Abel, K.6    Burke, M.W.7
  • 31
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes— implications for their role in neurologic disease
    • Eddleston M, Mucke L (1993) Molecular profile of reactive astrocytes— implications for their role in neurologic disease. Neuroscience 54: 15–36
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston, M.1    Mucke, L.2
  • 32
    • 33845775666 scopus 로고    scopus 로고
    • HIV and antiretroviral therapy in the brain: Neuronal injury and repair
    • Ellis R, Langford D, Masliah E (2007) HIV and antiretroviral therapy in the brain: neuronal injury and repair. Nat Rev Neurosci 8:33–44
    • (2007) Nat Rev Neurosci , vol.8 , pp. 33-44
    • Ellis, R.1    Langford, D.2    Masliah, E.3
  • 33
    • 0025344596 scopus 로고
    • Tat protein of HIV-1 stimulates growth of cells derived from Kaposi’s sarcoma lesions of AIDS patients
    • Ensoli B, Barillari G, Salahuddin SZ, Gallo RC, Wong-Staal F (1990) Tat protein of HIV-1 stimulates growth of cells derived from Kaposi’s sarcoma lesions of AIDS patients. Nature 345:84–86
    • (1990) Nature , vol.345 , pp. 84-86
    • Ensoli, B.1    Barillari, G.2    Salahuddin, S.Z.3    Gallo, R.C.4    Wong-Staal, F.5
  • 35
    • 84992371884 scopus 로고    scopus 로고
    • HIV-1 Tat induces unfolded protein response and endoplasmic reticulum stress in astrocytes and causes neurotoxicity through glial Fibrillary acidic protein (GFAP) activation and aggregation
    • Fan Y, He JJ (2016a) HIV-1 Tat induces unfolded protein response and endoplasmic reticulum stress in astrocytes and causes neurotoxicity through glial Fibrillary acidic protein (GFAP) activation and aggregation. J Biol Chem 291:22819–22829
    • (2016) J Biol Chem , vol.291 , pp. 22819-22829
    • Fan, Y.1    He, J.J.2
  • 36
    • 84992390018 scopus 로고    scopus 로고
    • HIV-1 Tat promotes Lysosomal exocytosis in astrocytes and contributes to astrocyte-mediated Tat neurotoxicity
    • Fan Y, He JJ (2016b) HIV-1 Tat promotes Lysosomal exocytosis in astrocytes and contributes to astrocyte-mediated Tat neurotoxicity. J Biol Chem 291:22830–22840
    • (2016) J Biol Chem , vol.291 , pp. 22830-22840
    • Fan, Y.1    He, J.J.2
  • 37
    • 79251630527 scopus 로고    scopus 로고
    • Activation of Egr-1 expression in astrocytes by HIV-1 Tat: New insights into astrocyte-mediated Tat neurotoxicity
    • Fan Y, Zou W, Green LA, Kim BO, He JJ (2011) Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity. J NeuroImmune Pharmacol 6:121–129
    • (2011) J Neuroimmune Pharmacol , vol.6 , pp. 121-129
    • Fan, Y.1    Zou, W.2    Green, L.A.3    Kim, B.O.4    He, J.J.5
  • 38
    • 84930972869 scopus 로고    scopus 로고
    • STAT3 and its phosphorylation are involved in HIV-1 Tat-induced transactivation of glial fibrillary acidic protein
    • Fan Y, Timani KA, He JJ (2015) STAT3 and its phosphorylation are involved in HIV-1 Tat-induced transactivation of glial fibrillary acidic protein. Curr HIV Res 13:55–63
    • (2015) Curr HIV Res , vol.13 , pp. 55-63
    • Fan, Y.1    Timani, K.A.2    He, J.J.3
  • 39
    • 84994403261 scopus 로고    scopus 로고
    • HIV Tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway
    • Fan Y, Gao X, Chen J, Liu Y, He JJ (2016) HIV Tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway. J Neurosci 36:11362–11373
    • (2016) J Neurosci , vol.36 , pp. 11362-11373
    • Fan, Y.1    Gao, X.2    Chen, J.3    Liu, Y.4    He, J.J.5
  • 42
    • 84930979148 scopus 로고    scopus 로고
    • Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: Role in HIV-associated neurocognitive disorders
    • Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E (2015b) Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res 13:43–54
    • (2015) Curr HIV Res , vol.13 , pp. 43-54
    • Fields, J.A.1    Dumaop, W.2    Crews, L.3    Adame, A.4    Spencer, B.5    Metcalf, J.6    He, J.7    Rockenstein, E.8    Masliah, E.9
  • 43
    • 77956544206 scopus 로고    scopus 로고
    • Interactive comorbidity between opioid drug abuse and HIV-1 Tat: Chronic exposure augments spine loss and sublethal dendritic pathology in striatal neurons
    • Fitting S, Xu R, Bull C, Buch SK, El-Hage N, Nath A, Knapp PE, Hauser KF (2010) Interactive comorbidity between opioid drug abuse and HIV-1 Tat: chronic exposure augments spine loss and sublethal dendritic pathology in striatal neurons. Am J Pathol 177:1397–1410
    • (2010) Am J Pathol , vol.177 , pp. 1397-1410
    • Fitting, S.1    Xu, R.2    Bull, C.3    Buch, S.K.4    El-Hage, N.5    Nath, A.6    Knapp, P.E.7    Hauser, K.F.8
  • 46
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • Frankel AD, Pabo CO (1988) Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55:1189–1193
    • (1988) Cell , vol.55 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 47
    • 0033927294 scopus 로고    scopus 로고
    • Mini-review: In vivo neurogenesis in the adult brain: Regulation and functional implications
    • Fuchs E, Gould E (2000) Mini-review: in vivo neurogenesis in the adult brain: regulation and functional implications. Eur J Neurosci 12: 2211–2214
    • (2000) Eur J Neurosci , vol.12 , pp. 2211-2214
    • Fuchs, E.1    Gould, E.2
  • 49
    • 0029922931 scopus 로고    scopus 로고
    • Aberrant regulation of cytokines in HIV-1 TAT72-transgenic mice
    • Garza HH Jr, Prakash O, Carr DJ (1996) Aberrant regulation of cytokines in HIV-1 TAT72-transgenic mice. J Immunol 156:3631–3637
    • (1996) J Immunol , vol.156 , pp. 3631-3637
    • Garza, H.H.1    Prakash, O.2    Carr, D.J.3
  • 50
    • 84937758281 scopus 로고    scopus 로고
    • Neuropathology of HAND with suppressive antiretroviral therapy: Encephalitis and neurodegeneration reconsidered
    • Gelman BB (2015) Neuropathology of HAND with suppressive antiretroviral therapy: encephalitis and neurodegeneration reconsidered. Curr HIV/AIDS Rep 12:272–279
    • (2015) Curr HIV/AIDS Rep , vol.12 , pp. 272-279
    • Gelman, B.B.1
  • 53
    • 0026440742 scopus 로고
    • Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: Implications for the neuropathogenesis of HIV disease
    • Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ et al (1992) Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 176: 1703–1718
    • (1992) J Exp Med , vol.176 , pp. 1703-1718
    • Genis, P.1    Jett, M.2    Bernton, E.W.3    Boyle, T.4    Gelbard, H.A.5    Dzenko, K.6    Keane, R.W.7    Resnick, L.8    Mizrachi, Y.9    Volsky, D.J.10
  • 55
    • 0028967032 scopus 로고
    • Tat-expressing Jurkat cells show an increased resistance to different apoptotic stimuli, including acute human immunodeficiency virus-type 1 (HIV-1) infection
    • Gibellini D, Caputo A, Celeghini C, Bassini A, La Placa M, Capitani S, Zauli G (1995) Tat-expressing Jurkat cells show an increased resistance to different apoptotic stimuli, including acute human immunodeficiency virus-type 1 (HIV-1) infection. Br J Haematol 89:24–33
    • (1995) Br J Haematol , vol.89 , pp. 24-33
    • Gibellini, D.1    Caputo, A.2    Celeghini, C.3    Bassini, A.4    la Placa, M.5    Capitani, S.6    Zauli, G.7
  • 56
    • 0028878797 scopus 로고
    • Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions
    • Gomi H, Yokoyama T, Fujimoto K, Ikeda T, Katoh A, Itoh T, Itohara S (1995) Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions. Neuron 14:29–41
    • (1995) Neuron , vol.14 , pp. 29-41
    • Gomi, H.1    Yokoyama, T.2    Fujimoto, K.3    Ikeda, T.4    Katoh, A.5    Itoh, T.6    Itohara, S.7
  • 57
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547–5551
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 58
    • 0024392386 scopus 로고
    • Mutational analysis of HIV-1 Tat minimal domain peptides: Identification of trans-dominant mutants that suppress HIV-LTR-driven gene expression
    • Green M, Ishino M, Loewenstein PM (1989) Mutational analysis of HIV-1 Tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR-driven gene expression. Cell 58: 215–223
    • (1989) Cell , vol.58 , pp. 215-223
    • Green, M.1    Ishino, M.2    Loewenstein, P.M.3
  • 59
    • 84930972208 scopus 로고    scopus 로고
    • Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: Evidence for sex-related effects
    • Hahn YK, Masvekar RR, Xu R, Hauser KF, Knapp PE (2015a) Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects. Curr HIV Res 13:10–20
    • (2015) Curr HIV Res , vol.13 , pp. 10-20
    • Hahn, Y.K.1    Masvekar, R.R.2    Xu, R.3    Hauser, K.F.4    Knapp, P.E.5
  • 60
    • 84891821284 scopus 로고    scopus 로고
    • Effects of chronic HIV-1 Tat exposure in the CNS: Heightened vulnerability of males versus females to changes in cell numbers, synaptic integrity, and behavior
    • Hahn YK, Podhaizer EM, Farris SP, Miles MF, Hauser KF, Knapp PE (2015b) Effects of chronic HIV-1 Tat exposure in the CNS: heightened vulnerability of males versus females to changes in cell numbers, synaptic integrity, and behavior. Brain Struct Funct 220:605–623
    • (2015) Brain Struct Funct , vol.220 , pp. 605-623
    • Hahn, Y.K.1    Podhaizer, E.M.2    Farris, S.P.3    Miles, M.F.4    Hauser, K.F.5    Knapp, P.E.6
  • 61
    • 84960970169 scopus 로고    scopus 로고
    • Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered muopioid receptor-mediated G-protein activation and beta-arrestin 2 activity in the forebrain
    • Hahn YK, Paris JJ, Lichtman AH, Hauser KF, Sim-Selley LJ, Selley DE, Knapp PE (2016) Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered muopioid receptor-mediated G-protein activation and beta-arrestin 2 activity in the forebrain. Neurobiol Dis 92:124–136
    • (2016) Neurobiol Dis , vol.92 , pp. 124-136
    • Hahn, Y.K.1    Paris, J.J.2    Lichtman, A.H.3    Hauser, K.F.4    Sim-Selley, L.J.5    Selley, D.E.6    Knapp, P.E.7
  • 63
    • 0028853961 scopus 로고
    • Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity
    • He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR (1995) Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J Virol 69:6705–6711
    • (1995) J Virol , vol.69 , pp. 6705-6711
    • He, J.1    Choe, S.2    Walker, R.3    Di Marzio, P.4    Morgan, D.O.5    Landau, N.R.6
  • 66
    • 0025815391 scopus 로고
    • Transcellular transactivation by the human immunodeficiency virus type 1 tat protein
    • Helland DE, Welles JL, Caputo A, Haseltine WA (1991) Transcellular transactivation by the human immunodeficiency virus type 1 tat protein. J Virol 65:4547–4549
    • (1991) J Virol , vol.65 , pp. 4547-4549
    • Helland, D.E.1    Welles, J.L.2    Caputo, A.3    Haseltine, W.A.4
  • 67
    • 0033081556 scopus 로고    scopus 로고
    • HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells
    • Hofman FM, Chen P, Incardona F, Zidovetzki R, Hinton DR (1999) HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells. J Neuroimmunol 94:28–39
    • (1999) J Neuroimmunol , vol.94 , pp. 28-39
    • Hofman, F.M.1    Chen, P.2    Incardona, F.3    Zidovetzki, R.4    Hinton, D.R.5
  • 70
    • 0026065348 scopus 로고
    • Early loss of astrocytes in herpes simplex virus-induced central nervous system demyelination
    • Itoyama Y, Sekizawa T, Openshaw H, Kogure K, Goto I (1991) Early loss of astrocytes in herpes simplex virus-induced central nervous system demyelination. Ann Neurol 29:285–292
    • (1991) Ann Neurol , vol.29 , pp. 285-292
    • Itoyama, Y.1    Sekizawa, T.2    Openshaw, H.3    Kogure, K.4    Goto, I.5
  • 71
    • 84860777870 scopus 로고    scopus 로고
    • Modeling HIV-associated neurocognitive disorders in mice: New approaches in the changing face of HIV neuropathogenesis
    • Jaeger LB, Nath A (2012) Modeling HIV-associated neurocognitive disorders in mice: new approaches in the changing face of HIV neuropathogenesis. Dis Model Mech 5:313–322
    • (2012) Dis Model Mech , vol.5 , pp. 313-322
    • Jaeger, L.B.1    Nath, A.2
  • 74
    • 0031747096 scopus 로고    scopus 로고
    • Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement
    • Jones M, Olafson K, Del Bigio MR, Peeling J, Nath A (1998) Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement. J Neuropathol Exp Neurol 57:563–570
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 563-570
    • Jones, M.1    Olafson, K.2    Del Bigio, M.R.3    Peeling, J.4    Nath, A.5
  • 76
    • 77955651632 scopus 로고    scopus 로고
    • Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production
    • Kiebala M, Polesskaya O, Yao Z, Perry SW, Maggirwar SB (2010) Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production. PLoS One 5:e11875
    • (2010) Plos One , vol.5
    • Kiebala, M.1    Polesskaya, O.2    Yao, Z.3    Perry, S.W.4    Maggirwar, S.B.5
  • 77
    • 0037406230 scopus 로고    scopus 로고
    • Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline
    • Kim BO, Liu Y, Ruan Y, ZC X, Schantz L, He JJ (2003) Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline. Am J Pathol 162:1693–1707
    • (2003) Am J Pathol , vol.162 , pp. 1693-1707
    • Kim, B.O.1    Liu, Y.2    Ruan, Y.3    Zc, X.4    Schantz, L.5    He, J.J.6
  • 78
    • 1642443931 scopus 로고    scopus 로고
    • Induction of C chemokine XCL1 (Lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein
    • Kim BO, Liu Y, Zhou BY, He JJ (2004) Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein. J Immunol 172:1888–1895
    • (2004) J Immunol , vol.172 , pp. 1888-1895
    • Kim, B.O.1    Liu, Y.2    Zhou, B.Y.3    He, J.J.4
  • 79
    • 21344455519 scopus 로고    scopus 로고
    • Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus
    • Kramer-Hammerle S, Rothenaigner I, Wolff H, Bell JE, Brack-Werner R (2005) Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus. Virus Res 111:194–213
    • (2005) Virus Res , vol.111 , pp. 194-213
    • Kramer-Hammerle, S.1    Rothenaigner, I.2    Wolff, H.3    Bell, J.E.4    Brack-Werner, R.5
  • 80
    • 0348141712 scopus 로고    scopus 로고
    • Chemokines promote quiescence and survival of human neural progenitor cells
    • Krathwohl MD, Kaiser JL (2004a) Chemokines promote quiescence and survival of human neural progenitor cells. Stem Cells 22:109–118
    • (2004) Stem Cells , vol.22 , pp. 109-118
    • Krathwohl, M.D.1    Kaiser, J.L.2
  • 81
    • 3242721108 scopus 로고    scopus 로고
    • HIV-1 promotes quiescence in human neural progenitor cells
    • Krathwohl MD, Kaiser JL (2004b) HIV-1 promotes quiescence in human neural progenitor cells. J Infect Dis 190:216–226
    • (2004) J Infect Dis , vol.190 , pp. 216-226
    • Krathwohl, M.D.1    Kaiser, J.L.2
  • 82
    • 0032412520 scopus 로고    scopus 로고
    • HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress
    • Kruman II, Nath A, Mattson MP (1998) HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol 154: 276–288
    • (1998) Exp Neurol , vol.154 , pp. 276-288
    • Kruman, I.I.1    Nath, A.2    Mattson, M.P.3
  • 83
    • 0032478643 scopus 로고    scopus 로고
    • HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin
    • Kundu M, Sharma S, De Luca A, Giordano A, Rappaport J, Khalili K, Amini S (1998) HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin. J Biol Chem 273:8130–8136
    • (1998) J Biol Chem , vol.273 , pp. 8130-8136
    • Kundu, M.1    Sharma, S.2    de Luca, A.3    Giordano, A.4    Rappaport, J.5    Khalili, K.6    Amini, S.7
  • 84
    • 0033168754 scopus 로고    scopus 로고
    • Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma
    • Kundu RK, Sangiorgi F, LY W, Pattengale PK, Hinton DR, Gill PS, Maxson R (1999) Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma. Blood 94:275–282
    • (1999) Blood , vol.94 , pp. 275-282
    • Kundu, R.K.1    Sangiorgi, F.2    Ly, W.3    Pattengale, P.K.4    Hinton, D.R.5    Gill, P.S.6    Maxson, R.7
  • 85
    • 3142758747 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells
    • Lawrence DM, Durham LC, Schwartz L, Seth P, Maric D, Major EO (2004) Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells. J Virol 78:7319–7328
    • (2004) J Virol , vol.78 , pp. 7319-7328
    • Lawrence, D.M.1    Durham, L.C.2    Schwartz, L.3    Seth, P.4    Maric, D.5    Major, E.O.6
  • 86
    • 33645098296 scopus 로고    scopus 로고
    • Is there a link between adult neurogenesis and learning?
    • Leuner B, Gould E, Shors TJ (2006) Is there a link between adult neurogenesis and learning? Hippocampus 16:216–224
    • (2006) Hippocampus , vol.16 , pp. 216-224
    • Leuner, B.1    Gould, E.2    Shors, T.J.3
  • 87
    • 0027409048 scopus 로고
    • Human immunodeficiency virus coat protein gp120 inhibits the beta-adrenergic regulation of astroglial and microglial functions
    • Levi G, Patrizio M, Bernardo A, Petrucci TC, Agresti C (1993) Human immunodeficiency virus coat protein gp120 inhibits the beta-adrenergic regulation of astroglial and microglial functions. Proc Natl Acad Sci USA 90:1541–1545
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1541-1545
    • Levi, G.1    Patrizio, M.2    Bernardo, A.3    Petrucci, T.C.4    Agresti, C.5
  • 88
    • 0030273614 scopus 로고    scopus 로고
    • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination
    • Liedtke W, Edelmann W, Bieri PL, Chiu FC, Cowan NJ, Kucherlapati R, Raine CS (1996) GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron 17:607–615
    • (1996) Neuron , vol.17 , pp. 607-615
    • Liedtke, W.1    Edelmann, W.2    Bieri, P.L.3    Chiu, F.C.4    Cowan, N.J.5    Kucherlapati, R.6    Raine, C.S.7
  • 89
    • 0034529953 scopus 로고    scopus 로고
    • Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands
    • Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ (2000) Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med 6:1380–1387
    • (2000) Nat Med , vol.6 , pp. 1380-1387
    • Liu, Y.1    Jones, M.2    Hingtgen, C.M.3    Bu, G.4    Laribee, N.5    Tanzi, R.E.6    Moir, R.D.7    Nath, A.8    He, J.J.9
  • 90
    • 0025797055 scopus 로고
    • Endocytosis and targeting of exogenous HIV-1 Tat protein
    • Mann DA, Frankel AD (1991) Endocytosis and targeting of exogenous HIV-1 Tat protein. EMBO J 10:1733–1739
    • (1991) EMBO J , vol.10 , pp. 1733-1739
    • Mann, D.A.1    Frankel, A.D.2
  • 92
    • 0026780318 scopus 로고
    • Transcellular activation of the human immunodeficiency virus type 1 long terminal repeat in T lymphocytes requires CD4-gp120 binding
    • Marcuzzi A, Lowy I, Weinberger OK (1992) Transcellular activation of the human immunodeficiency virus type 1 long terminal repeat in T lymphocytes requires CD4-gp120 binding. J Virol 66:4536–4539
    • (1992) J Virol , vol.66 , pp. 4536-4539
    • Marcuzzi, A.1    Lowy, I.2    Weinberger, O.K.3
  • 95
    • 84928723998 scopus 로고    scopus 로고
    • Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice
    • Mediouni S, Jablonski J, Paris JJ, Clementz MA, Thenin-Houssier S, McLaughlin JP, Valente ST (2015) Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice. Curr HIV Res 13:64–79
    • (2015) Curr HIV Res , vol.13 , pp. 64-79
    • Mediouni, S.1    Jablonski, J.2    Paris, J.J.3    Clementz, M.A.4    Thenin-Houssier, S.5    McLaughlin, J.P.6    Valente, S.T.7
  • 97
    • 0027738065 scopus 로고
    • Influence of the human immunodeficiency virus type 1 Tat protein on the proliferation and differentiation of PC12 rat pheochromocytoma cells
    • Pt 12
    • Milani D, Zauli G, Neri LM, Marchisio M, Previati M, Capitani S (1993) Influence of the human immunodeficiency virus type 1 Tat protein on the proliferation and differentiation of PC12 rat pheochromocytoma cells. J Gen Virol 74(Pt 12):2587–2594
    • (1993) J Gen Virol , vol.74 , pp. 2587-2594
    • Milani, D.1    Zauli, G.2    Neri, L.M.3    Marchisio, M.4    Previati, M.5    Capitani, S.6
  • 98
    • 23244458855 scopus 로고    scopus 로고
    • Adult neurogenesis in the mammalian central nervous system
    • Ming GL, Song H (2005) Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci 28:223–250
    • (2005) Annu Rev Neurosci , vol.28 , pp. 223-250
    • Ming, G.L.1    Song, H.2
  • 99
    • 77957241751 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Tat modulates proliferation and differentiation of human neural precursor cells: Implication in NeuroAIDS
    • Mishra M, Taneja M, Malik S, Khalique H, Seth P (2010) Human immunodeficiency virus type 1 Tat modulates proliferation and differentiation of human neural precursor cells: implication in NeuroAIDS. J Neuro-Oncol 16:355–367
    • (2010) J Neuro-Oncol , vol.16 , pp. 355-367
    • Mishra, M.1    Taneja, M.2    Malik, S.3    Khalique, H.4    Seth, P.5
  • 101
    • 0030891387 scopus 로고    scopus 로고
    • The association of HIV-1 Tat with nuclei is regulated by Ca2+ ions and cytosolic factors
    • Morgavi P, Bonifaci N, Pagani M, Costigliolo S, Sitia R, Rubartelli A (1997) The association of HIV-1 Tat with nuclei is regulated by Ca2+ ions and cytosolic factors. J Biol Chem 272:11256–11260
    • (1997) J Biol Chem , vol.272 , pp. 11256-11260
    • Morgavi, P.1    Bonifaci, N.2    Pagani, M.3    Costigliolo, S.4    Sitia, R.5    Rubartelli, A.6
  • 103
    • 0036891081 scopus 로고    scopus 로고
    • Human immunodeficiency virus (HIV) proteins in neuropathogenesis of HIV dementia
    • Nath A (2002) Human immunodeficiency virus (HIV) proteins in neuropathogenesis of HIV dementia. J Infect Dis 186(Suppl 2): S193–S198
    • (2002) J Infect Dis , vol.186 , pp. S193-S198
    • Nath, A.1
  • 104
    • 0023189928 scopus 로고
    • The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice
    • Nerenberg M, Hinrichs SH, Reynolds RK, Khoury G, Jay G (1987) The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237:1324–1329
    • (1987) Science , vol.237 , pp. 1324-1329
    • Nerenberg, M.1    Hinrichs, S.H.2    Reynolds, R.K.3    Khoury, G.4    Jay, G.5
  • 105
    • 0032504151 scopus 로고    scopus 로고
    • HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism
    • New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA (1998) HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. J Biol Chem 273:17852–17858
    • (1998) J Biol Chem , vol.273 , pp. 17852-17858
    • New, D.R.1    Maggirwar, S.B.2    Epstein, L.G.3    Dewhurst, S.4    Gelbard, H.A.5
  • 108
    • 84890559561 scopus 로고    scopus 로고
    • Effects of conditional central expression of HIV-1 tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice
    • Paris JJ, Carey AN, Shay CF, Gomes SM, He JJ, McLaughlin JP (2014a) Effects of conditional central expression of HIV-1 tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice. Neuropsychopharmacology 39:380–388
    • (2014) Neuropsychopharmacology , vol.39 , pp. 380-388
    • Paris, J.J.1    Carey, A.N.2    Shay, C.F.3    Gomes, S.M.4    He, J.J.5    McLaughlin, J.P.6
  • 109
    • 84899655556 scopus 로고    scopus 로고
    • Progesterone protects normative anxiety-like responding among ovariectomized female mice that conditionally express the HIV-1 regulatory protein, Tat, in the CNS
    • Paris JJ, Fenwick J, McLaughlin JP (2014b) Progesterone protects normative anxiety-like responding among ovariectomized female mice that conditionally express the HIV-1 regulatory protein, Tat, in the CNS. Horm Behav 65:445–453
    • (2014) Horm Behav , vol.65 , pp. 445-453
    • Paris, J.J.1    Fenwick, J.2    McLaughlin, J.P.3
  • 110
    • 84900866610 scopus 로고    scopus 로고
    • Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat
    • Paris JJ, Singh HD, Ganno ML, Jackson P, McLaughlin JP (2014c) Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat. Psychopharmacology 231:2349–2360
    • (2014) Psychopharmacology , vol.231 , pp. 2349-2360
    • Paris, J.J.1    Singh, H.D.2    Ganno, M.L.3    Jackson, P.4    McLaughlin, J.P.5
  • 111
    • 84934943131 scopus 로고    scopus 로고
    • Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice
    • Paris JJ, Singh HD, Carey AN, McLaughlin JP (2015) Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice. Behav Brain Res 291:209–218
    • (2015) Behav Brain Res , vol.291 , pp. 209-218
    • Paris, J.J.1    Singh, H.D.2    Carey, A.N.3    McLaughlin, J.P.4
  • 112
    • 0028143517 scopus 로고
    • Regulated expression of foreign genes in vivo after germline transfer
    • Passman RS, Fishman GI (1994) Regulated expression of foreign genes in vivo after germline transfer. J Clin Invest 94:2421–2425
    • (1994) J Clin Invest , vol.94 , pp. 2421-2425
    • Passman, R.S.1    Fishman, G.I.2
  • 113
    • 0031814670 scopus 로고    scopus 로고
    • GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation density
    • Pekny M, Eliasson C, Chien CL, Kindblom LG, Liem R, Hamberger A, Betsholtz C (1998) GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation density. Exp Cell Res 239:332–343
    • (1998) Exp Cell Res , vol.239 , pp. 332-343
    • Pekny, M.1    Eliasson, C.2    Chien, C.L.3    Kindblom, L.G.4    Liem, R.5    Hamberger, A.6    Betsholtz, C.7
  • 114
    • 77958566966 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax
    • Perry SW, Barbieri J, Tong N, Polesskaya O, Pudasaini S, Stout A, Lu R, Kiebala M, Maggirwar SB, Gelbard HA (2010) Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. J Neurosci 30:14153–14164
    • (2010) J Neurosci , vol.30 , pp. 14153-14164
    • Perry, S.W.1    Barbieri, J.2    Tong, N.3    Polesskaya, O.4    Pudasaini, S.5    Stout, A.6    Lu, R.7    Kiebala, M.8    Maggirwar, S.B.9    Gelbard, H.A.10
  • 115
    • 30444434294 scopus 로고    scopus 로고
    • Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis
    • Poluektova L, Meyer V, Walters L, Paez X, Gendelman HE (2005) Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis. Glia 52:344–353
    • (2005) Glia , vol.52 , pp. 344-353
    • Poluektova, L.1    Meyer, V.2    Walters, L.3    Paez, X.4    Gendelman, H.E.5
  • 116
    • 0030591671 scopus 로고    scopus 로고
    • Neurological complications of HIV infection
    • Price RW (1996) Neurological complications of HIV infection. Lancet 348:445–452
    • (1996) Lancet , vol.348 , pp. 445-452
    • Price, R.W.1
  • 117
    • 0031439207 scopus 로고    scopus 로고
    • Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice
    • Raber J, O'Shea RD, Bloom FE, Campbell IL (1997) Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice. J Neurosci 17:9473–9480
    • (1997) J Neurosci , vol.17 , pp. 9473-9480
    • Raber, J.1    O'shea, R.D.2    Bloom, F.E.3    Campbell, I.L.4
  • 118
    • 84966709677 scopus 로고    scopus 로고
    • Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein
    • Rahimian P, He JJ (2016a) Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein. J Neuro-Oncol 22:774–788
    • (2016) J Neuro-Oncol , vol.22 , pp. 774-788
    • Rahimian, P.1    He, J.J.2
  • 119
    • 84987918380 scopus 로고    scopus 로고
    • HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression
    • Rahimian P, He JJ (2016b) HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression. J Neuroinflammation 13:247
    • (2016) J Neuroinflammation , vol.13 , pp. 247
    • Rahimian, P.1    He, J.J.2
  • 123
    • 0027476736 scopus 로고
    • Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages to central neuronal infection with pseudorabies virus
    • Rinaman L, Card JP, Enquist LW (1993) Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages to central neuronal infection with pseudorabies virus. J Neurosci 13:685–702
    • (1993) J Neurosci , vol.13 , pp. 685-702
    • Rinaman, L.1    Card, J.P.2    Enquist, L.W.3
  • 127
    • 33745812840 scopus 로고    scopus 로고
    • Neural progenitors and HIV-1-associated central nervous system disease in adults and children
    • Schwartz L, Major EO (2006) Neural progenitors and HIV-1-associated central nervous system disease in adults and children. Curr HIV Res 4:319–327
    • (2006) Curr HIV Res , vol.4 , pp. 319-327
    • Schwartz, L.1    Major, E.O.2
  • 128
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285:1569–1572
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 129
    • 0031863689 scopus 로고    scopus 로고
    • Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: Potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia
    • Shi B, Raina J, Lorenzo A, Busciglio J, Gabuzda D (1998) Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia. J Neuro-Oncol 4:281–290
    • (1998) J Neuro-Oncol , vol.4 , pp. 281-290
    • Shi, B.1    Raina, J.2    Lorenzo, A.3    Busciglio, J.4    Gabuzda, D.5
  • 130
    • 84908154265 scopus 로고    scopus 로고
    • Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity
    • Silva JN, Polesskaya O, Wei HS, Rasheed IY, Chamberlain JM, Nishimura C, Feng C, Dewhurst S (2014) Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity. Microcirculation 21:664–676
    • (2014) Microcirculation , vol.21 , pp. 664-676
    • Silva, J.N.1    Polesskaya, O.2    Wei, H.S.3    Rasheed, I.Y.4    Chamberlain, J.M.5    Nishimura, C.6    Feng, C.7    Dewhurst, S.8
  • 131
    • 0032424913 scopus 로고    scopus 로고
    • Human apolipoprotein E allele-specific brain expressing transgenic mice
    • Smith JD, Sikes J, Levin JA (1998) Human apolipoprotein E allele-specific brain expressing transgenic mice. Neurobiol Aging 19: 407–413
    • (1998) Neurobiol Aging , vol.19 , pp. 407-413
    • Smith, J.D.1    Sikes, J.2    Levin, J.A.3
  • 133
    • 0032080231 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein-apolipoprotein E (ApoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipo-proteins
    • Sun Y, Wu S, Bu G, Onifade MK, Patel SN, LaDu MJ, Fagan AM, Holtzman DM (1998) Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipo-proteins. J Neurosci 18:3261–3272
    • (1998) J Neurosci , vol.18 , pp. 3261-3272
    • Sun, Y.1    Wu, S.2    Bu, G.3    Onifade, M.K.4    Patel, S.N.5    Ladu, M.J.6    Fagan, A.M.7    Holtzman, D.M.8
  • 134
    • 0028009187 scopus 로고
    • Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice
    • Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367:188–193
    • (1994) Nature , vol.367 , pp. 188-193
    • Toggas, S.M.1    Masliah, E.2    Rockenstein, E.M.3    Rall, G.F.4    Abraham, C.R.5    Mucke, L.6
  • 135
    • 0026041114 scopus 로고
    • Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(S) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta
    • Tornatore C, Nath A, Amemiya K, Major EO (1991) Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta. J Virol 65:6094–6100
    • (1991) J Virol , vol.65 , pp. 6094-6100
    • Tornatore, C.1    Nath, A.2    Amemiya, K.3    Major, E.O.4
  • 136
    • 13844253237 scopus 로고    scopus 로고
    • The HIV-1 coat protein gp120 regulates CXCR4-mediated signaling in neural progenitor cells
    • Tran PB, Ren D, Miller RJ (2005) The HIV-1 coat protein gp120 regulates CXCR4-mediated signaling in neural progenitor cells. J Neuroimmunol 160:68–76
    • (2005) J Neuroimmunol , vol.160 , pp. 68-76
    • Tran, P.B.1    Ren, D.2    Miller, R.J.3
  • 137
    • 1642345976 scopus 로고    scopus 로고
    • Cognitive impairment in older HIV-1-seropositive individuals: Prevalence and potential mechanisms
    • Valcour VG, Shikuma CM, Watters MR, Sacktor NC (2004) Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanisms. AIDS 18(Suppl 1):S79–S86
    • (2004) AIDS , vol.18 , pp. S79-S86
    • Valcour, V.G.1    Shikuma, C.M.2    Watters, M.R.3    Sacktor, N.C.4
  • 139
    • 0024810651 scopus 로고
    • Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1
    • Viscidi RP, Mayur K, Lederman HM, Frankel AD (1989) Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1. Science 246:1606–1608
    • (1989) Science , vol.246 , pp. 1606-1608
    • Viscidi, R.P.1    Mayur, K.2    Lederman, H.M.3    Frankel, A.D.4
  • 140
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • Vives E, Brodin P, Lebleu B (1997) A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 272:16010–16017
    • (1997) J Biol Chem , vol.272 , pp. 16010-16017
    • Vives, E.1    Brodin, P.2    Lebleu, B.3
  • 141
    • 0023681089 scopus 로고
    • The HIV tat gene induces dermal lesions resembling Kaposi’s sarcoma in transgenic mice
    • Vogel J, Hinrichs SH, Reynolds RK, Luciw PA, Jay G (1988) The HIV tat gene induces dermal lesions resembling Kaposi’s sarcoma in transgenic mice. Nature 335:606–611
    • (1988) Nature , vol.335 , pp. 606-611
    • Vogel, J.1    Hinrichs, S.H.2    Reynolds, R.K.3    Luciw, P.A.4    Jay, G.5
  • 143
    • 55749104704 scopus 로고    scopus 로고
    • A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis
    • Wheeler D, Bandaru VV, Calabresi PA, Nath A, Haughey NJ (2008) A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis. Brain 131:3092–3102
    • (2008) Brain , vol.131 , pp. 3092-3102
    • Wheeler, D.1    Bandaru, V.V.2    Calabresi, P.A.3    Nath, A.4    Haughey, N.J.5
  • 144
    • 61349197560 scopus 로고    scopus 로고
    • Inflammation mediates varying effects in neurogenesis: Relevance to the pathogenesis of brain injury and neurodegenerative disorders
    • Whitney NP, Eidem TM, Peng H, Huang Y, Zheng JC (2009) Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. J Neurochem 108:1343–1359
    • (2009) J Neurochem , vol.108 , pp. 1343-1359
    • Whitney, N.P.1    Eidem, T.M.2    Peng, H.3    Huang, Y.4    Zheng, J.C.5
  • 145
    • 0037083174 scopus 로고    scopus 로고
    • Antiretroviral therapy reduces markers of endothelial and coagulation activation in patients infected with human immunodeficiency virus type 1
    • Wolf K, Tsakiris DA, Weber R, Erb P, Battegay M, Swiss HIVCS (2002) Antiretroviral therapy reduces markers of endothelial and coagulation activation in patients infected with human immunodeficiency virus type 1. J Infect Dis 185:456–462
    • (2002) J Infect Dis , vol.185 , pp. 456-462
    • Wolf, K.1    Tsakiris, D.A.2    Weber, R.3    Erb, P.4    Battegay, M.5    Swiss, H.I.V.C.S.6
  • 147
    • 84863884677 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB restores human immunodeficiency virus Tat-cocaine-mediated impairment of neurogenesis: Role of TRPC1 channels
    • Yao H, Duan M, Yang L, Buch S (2012) Platelet-derived growth factor-BB restores human immunodeficiency virus Tat-cocaine-mediated impairment of neurogenesis: role of TRPC1 channels. J Neurosci 32:9835–9847
    • (2012) J Neurosci , vol.32 , pp. 9835-9847
    • Yao, H.1    Duan, M.2    Yang, L.3    Buch, S.4
  • 148
    • 0027424166 scopus 로고
    • Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis
    • Zauli G, Gibellini D, Milani D, Mazzoni M, Borgatti P, La Placa M, Capitani S (1993) Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis. Cancer Res 53:4481–4485
    • (1993) Cancer Res , vol.53 , pp. 4481-4485
    • Zauli, G.1    Gibellini, D.2    Milani, D.3    Mazzoni, M.4    Borgatti, P.5    la Placa, M.6    Capitani, S.7
  • 149
    • 0028843803 scopus 로고
    • An autocrine loop of HIV type-1 Tat protein responsible for the improved survival/ proliferation capacity of permanently Tat-transfected cells and required for optimal HIV-1 LTR transactivating activity
    • Zauli G, La Placa M, Vignoli M, Re MC, Gibellini D, Furlini G, Milani D, Marchisio M, Mazzoni M, Capitani S (1995) An autocrine loop of HIV type-1 Tat protein responsible for the improved survival/ proliferation capacity of permanently Tat-transfected cells and required for optimal HIV-1 LTR transactivating activity. J Acquir Immune Defic Syndr Hum Retrovirol 10:306–316
    • (1995) J Acquir Immune Defic Syndr Hum Retrovirol , vol.10 , pp. 306-316
    • Zauli, G.1    la Placa, M.2    Vignoli, M.3    Re, M.C.4    Gibellini, D.5    Furlini, G.6    Milani, D.7    Marchisio, M.8    Mazzoni, M.9    Capitani, S.10
  • 150
    • 1842556605 scopus 로고    scopus 로고
    • Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein
    • Zhou BY, He JJ (2004) Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein. Neurosci Lett 359:155–158
    • (2004) Neurosci Lett , vol.359 , pp. 155-158
    • Zhou, B.Y.1    He, J.J.2
  • 151
    • 7444220727 scopus 로고    scopus 로고
    • Astrocyte activation and dysfunction and neuron death by HIV-1 Tat expression in astrocytes
    • Zhou BY, Liu Y, Kim B, Xiao Y, He JJ (2004) Astrocyte activation and dysfunction and neuron death by HIV-1 Tat expression in astrocytes. MolCellNeurosci27:296–305
    • (2004) Molcellneurosci , vol.27 , pp. 296-305
    • Zhou, B.Y.1    Liu, Y.2    Kim, B.3    Xiao, Y.4    He, J.J.5
  • 152
    • 0032504015 scopus 로고    scopus 로고
    • Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C-and cAMP-dependent protein kinase pathways
    • Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (1998) Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C-and cAMP-dependent protein kinase pathways. AIDS Res Hum Retrovir 14:825–833
    • (1998) AIDS Res Hum Retrovir , vol.14 , pp. 825-833
    • Zidovetzki, R.1    Wang, J.L.2    Chen, P.3    Jeyaseelan, R.4    Hofman, F.5
  • 153
    • 38349057863 scopus 로고    scopus 로고
    • Protection against human immunodeficiency virus type 1 Tat neurotoxicity by Ginkgo biloba extract EGb 761 involving glial fibrillary acidic protein
    • Zou W, Kim BO, Zhou BY, Liu Y, Messing A, He JJ (2007) Protection against human immunodeficiency virus type 1 Tat neurotoxicity by Ginkgo biloba extract EGb 761 involving glial fibrillary acidic protein. Am J Pathol 171:1923–1935
    • (2007) Am J Pathol , vol.171 , pp. 1923-1935
    • Zou, W.1    Kim, B.O.2    Zhou, B.Y.3    Liu, Y.4    Messing, A.5    He, J.J.6
  • 154
    • 77957373530 scopus 로고    scopus 로고
    • Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes
    • Zou W, Wang Z, Liu Y, Fan Y, Zhou BY, Yang XF, He JJ (2010) Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes. Glia 58:1640–1648
    • (2010) Glia , vol.58 , pp. 1640-1648
    • Zou, W.1    Wang, Z.2    Liu, Y.3    Fan, Y.4    Zhou, B.Y.5    Yang, X.F.6    He, J.J.7
  • 155
    • 83755224872 scopus 로고    scopus 로고
    • Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at mu-opioid receptor-expressing glia
    • Zou S, Fitting S, Hahn YK, Welch SP, El-Hage N, Hauser KF, Knapp PE (2011) Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at mu-opioid receptor-expressing glia. Brain 134: 3616–3631
    • (2011) Brain , vol.134 , pp. 3616-3631
    • Zou, S.1    Fitting, S.2    Hahn, Y.K.3    Welch, S.P.4    El-Hage, N.5    Hauser, K.F.6    Knapp, P.E.7


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