HIV-1 tat induces unfolded protein response and endoplasmic reticulum stress in astrocytes and causes neurotoxicity through glial fibrillary acidic protein (GFAP) activation and aggregation

Journal of Biological Chemistry

Volumn 291, Issue 43, 2016, Pages 22819-22829

  Fan, Yan ^a   He, Johnny J ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CHEMICAL ACTIVATION;

CHEMICAL CHAPERONE; ENDOPLASMIC RETICULUM STRESS; GLIAL FIBRILLARY ACIDIC PROTEINS; INTERMEDIATE FILAMENTS; MOLECULAR MECHANISM; STRESS INDUCTION; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

PROTEINS;

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 6; COMPLEMENTARY DNA; COMPLEMENTARY DNA 3; GLIAL FIBRILLARY ACIDIC PROTEIN; INITIATION FACTOR 2ALPHA; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; 4-PHENYLBUTYRIC ACID; ARYLBUTYRIC ACID DERIVATIVE; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL LOSS; CONTROLLED STUDY; DEMENTIA; DENDRITE; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM STRESS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; BRAIN; GENETICS; METABOLISM; NEUROTOXICITY SYNDROMES; PATHOLOGY; PROTEIN AGGREGATION, PATHOLOGICAL; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; ASTROCYTES; BRAIN; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; GLIAL FIBRILLARY ACIDIC PROTEIN; HIV-1; HUMANS; MICE; MICE, TRANSGENIC; NEUROTOXICITY SYNDROMES; PHENYLBUTYRATES; PROTEIN AGGREGATION, PATHOLOGICAL; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; UNFOLDED PROTEIN RESPONSE;

EID: 84992371884     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.731828     Document Type: Article

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