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Volumn 18, Issue 9, 1998, Pages 3261-3272

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins

Author keywords

Alzheimer's disease; Apolipoprotein E; Astrocyte; Low density lipoprotein receptor related protein; Receptor associated protein; Transgenic

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; GLIAL FIBRILLARY ACIDIC PROTEIN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

EID: 0032080231     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-09-03261.1998     Document Type: Article
Times cited : (205)

References (79)
  • 2
    • 0030957196 scopus 로고    scopus 로고
    • Isoform-specific modulation by apolipoprotein E of the activities of secreted β-amyloid precursor protein
    • Barger SW, Mattson MP (1997) Isoform-specific modulation by apolipoprotein E of the activities of secreted β-amyloid precursor protein. J Neurochem 69:60-67.
    • (1997) J Neurochem , vol.69 , pp. 60-67
    • Barger, S.W.1    Mattson, M.P.2
  • 5
    • 0028850374 scopus 로고
    • Stable expression and secretion of aplipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth
    • Bellosta S, Nathan BP, Orth M, Dong LM, Mahley RW, Pitas RE (1995) Stable expression and secretion of aplipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J Biol Chem 270:27063-27071.
    • (1995) J Biol Chem , vol.270 , pp. 27063-27071
    • Bellosta, S.1    Nathan, B.P.2    Orth, M.3    Dong, L.M.4    Mahley, R.W.5    Pitas, R.E.6
  • 7
    • 0028912790 scopus 로고
    • Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid
    • Borghini I, Barja F, Pometta D, James RW (1995) Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid. Biochim Biophys Acta 1255:192-200.
    • (1995) Biochim Biophys Acta , vol.1255 , pp. 192-200
    • Borghini, I.1    Barja, F.2    Pometta, D.3    James, R.W.4
  • 10
    • 0022350033 scopus 로고
    • Apolipoprotein E associated with astrocytic glia of the CNS and with nonmyelinating glia of the peripheral nervous system
    • Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM (1985) Apolipoprotein E associated with astrocytic glia of the CNS and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76:1501-1513.
    • (1985) J Clin Invest , vol.76 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 11
    • 0028256226 scopus 로고
    • GFAP promoter directs astrocyte-specific expression in transgenic mice
    • Brenner M, Kisseberth WC, Su Y, Besnard F, Messing A (1994) GFAP promoter directs astrocyte-specific expression in transgenic mice, J Neurosci 14:1030-1037.
    • (1994) J Neurosci , vol.14 , pp. 1030-1037
    • Brenner, M.1    Kisseberth, W.C.2    Su, Y.3    Besnard, F.4    Messing, A.5
  • 12
    • 0031053948 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture
    • Brown MD, Banker GA, Hussaini IM, Gonias SL, VandenBerg SR (1997) Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture. Brain Res 747:313-317.
    • (1997) Brain Res , vol.747 , pp. 313-317
    • Brown, M.D.1    Banker, G.A.2    Hussaini, I.M.3    Gonias, S.L.4    VandenBerg, S.R.5
  • 13
    • 0027278934 scopus 로고
    • Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human HepG2 cells
    • Bu G, Maksymovitch EA, Schwartz AL (1993) Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human HepG2 cells. J Biol Chem 268:13002-13009.
    • (1993) J Biol Chem , vol.268 , pp. 13002-13009
    • Bu, G.1    Maksymovitch, E.A.2    Schwartz, A.L.3
  • 14
    • 0028298886 scopus 로고
    • Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons
    • Bu G, Maksymovitch EA, Nerborrae JM, Schwartz AL (1994) Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. J Biol Chem 269:18521-18528.
    • (1994) J Biol Chem , vol.269 , pp. 18521-18528
    • Bu, G.1    Maksymovitch, E.A.2    Nerborrae, J.M.3    Schwartz, A.L.4
  • 15
    • 0030751161 scopus 로고    scopus 로고
    • Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury
    • Chen Y, Lomnitski L, Michaelson DM, Shohami E (1997) Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury. Neuroscience 80:1255-1262.
    • (1997) Neuroscience , vol.80 , pp. 1255-1262
    • Chen, Y.1    Lomnitski, L.2    Michaelson, D.M.3    Shohami, E.4
  • 16
    • 0029990315 scopus 로고    scopus 로고
    • Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the CNS and in Alzheimer's disease
    • Christie RH, Chung H, Rebeck GW, Strickland D, Hyman BT (1996) Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the CNS and in Alzheimer's disease. J Neuropathol Exp Neurol 55:491-498.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 491-498
    • Christie, R.H.1    Chung, H.2    Rebeck, G.W.3    Strickland, D.4    Hyman, B.T.5
  • 17
    • 0028872558 scopus 로고
    • Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer's disease
    • Evans KC, Berger EP, Cho C-G, Weisgraber KH, Lansbury PT (1994) Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer's disease. Proc Natl Acad Sci USA 92:763-767.
    • (1994) Proc Natl Acad Sci USA , vol.92 , pp. 763-767
    • Evans, K.C.1    Berger, E.P.2    Cho, C.-G.3    Weisgraber, K.H.4    Lansbury, P.T.5
  • 18
    • 0028203585 scopus 로고
    • Mechanisms of sprouting in the adult CNS: Cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus
    • Fagan AM, Gage FH (1994) Mechanisms of sprouting in the adult CNS: cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus. Neuroscience 58:705-725.
    • (1994) Neuroscience , vol.58 , pp. 705-725
    • Fagan, A.M.1    Gage, F.H.2
  • 19
    • 0029958248 scopus 로고    scopus 로고
    • Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein
    • Fagan AM, Bu G, Sun Y, Daugherty A, Holtzman DM (1996a) Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J Biol Chem 271:30121-30125.
    • (1996) J Biol Chem , vol.271 , pp. 30121-30125
    • Fagan, A.M.1    Bu, G.2    Sun, Y.3    Daugherty, A.4    Holtzman, D.M.5
  • 21
    • 0022973690 scopus 로고
    • Failed compensatory dendritic growth as a pathophysiological process in Alzheimer's disease
    • Flood DG, Coleman PD (1986) Failed compensatory dendritic growth as a pathophysiological process in Alzheimer's disease. Can J Neurol Sci 13:475-479.
    • (1986) Can J Neurol Sci , vol.13 , pp. 475-479
    • Flood, D.G.1    Coleman, P.D.2
  • 22
    • 0002329664 scopus 로고
    • Rat hippocampal neurons in low-density culture
    • (Banker G, Goslin K, eds), Cambridge, MA: MIT
    • Goslin K, Banker G (1991) Rat hippocampal neurons in low-density culture. In: Culturing nerve cells (Banker G, Goslin K, eds), pp 251-281. Cambridge, MA: MIT.
    • (1991) Culturing Nerve Cells , pp. 251-281
    • Goslin, K.1    Banker, G.2
  • 23
    • 0030792971 scopus 로고    scopus 로고
    • Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor
    • Gutman CR, Strittmatter WJ, Weisgraber KH, Matthew WD (1997) Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor. J Neurosci 17:6114-6124.
    • (1997) J Neurosci , vol.17 , pp. 6114-6124
    • Gutman, C.R.1    Strittmatter, W.J.2    Weisgraber, K.H.3    Matthew, W.D.4
  • 24
    • 0026443801 scopus 로고
    • Effects of apolipoprotein E, β-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro
    • Handelmann GE, Boyles JK, Weisgraber KH, Mahley RW, Pitas RE (1992) Effects of apolipoprotein E, β-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro. J Lipid Res 33:1677-1688.
    • (1992) J Lipid Res , vol.33 , pp. 1677-1688
    • Handelmann, G.E.1    Boyles, J.K.2    Weisgraber, K.H.3    Mahley, R.W.4    Pitas, R.E.5
  • 25
    • 0025786502 scopus 로고
    • 39 kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein /α2-macroglobulin receptor
    • Herz J, Goldstein JL, Strickland DK, Ho YK, Brown MS (1991) 39 kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein /α2-macroglobulin receptor. J Biol Chem 266:21232-21238.
    • (1991) J Biol Chem , vol.266 , pp. 21232-21238
    • Herz, J.1    Goldstein, J.L.2    Strickland, D.K.3    Ho, Y.K.4    Brown, M.S.5
  • 30
    • 0029922119 scopus 로고    scopus 로고
    • Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain
    • Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T (1996) Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J Biol Chem 271:8373-8380.
    • (1996) J Biol Chem , vol.271 , pp. 8373-8380
    • Kim, D.H.1    Iijima, H.2    Goto, K.3    Sakai, J.4    Ishii, H.5    Kim, H.J.6    Suzuki, H.7    Kondo, H.8    Saeki, S.9    Yamamoto, T.10
  • 31
    • 0030601055 scopus 로고    scopus 로고
    • Biochemical characterization of Alzheimer's soluble beta protein in human cerebrospinal fluid-association with high density lipoprotein
    • Koudinov AR, Koudinova NV, Kumar A, Beavis RC, Ghiso J (1996) Biochemical characterization of Alzheimer's soluble beta protein in human cerebrospinal fluid-association with high density lipoprotein. Biochem Biophys Res Commun 223:592-597.
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 592-597
    • Koudinov, A.R.1    Koudinova, N.V.2    Kumar, A.3    Beavis, R.C.4    Ghiso, J.5
  • 32
    • 0025302165 scopus 로고
    • Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein
    • Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL (1990) Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem 265:10771-10779.
    • (1990) J Biol Chem , vol.265 , pp. 10771-10779
    • Kowal, R.C.1    Herz, J.2    Weisgraber, K.H.3    Mahley, R.W.4    Brown, M.S.5    Goldstein, J.L.6
  • 33
    • 0028173897 scopus 로고
    • Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP)
    • Krieger M, Herz J (1994) Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 63:601-637.
    • (1994) Annu Rev Biochem , vol.63 , pp. 601-637
    • Krieger, M.1    Herz, J.2
  • 39
    • 0028173205 scopus 로고
    • Amyloid-associated proteins alpha-1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
    • Ma J, Yee A, Brewer HB, Das S, Potter H (1994) Amyloid-associated proteins alpha-1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 372:92-94.
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer, H.B.3    Das, S.4    Potter, H.5
  • 40
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley RW (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240:622-630.
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 42
    • 0028175579 scopus 로고
    • Secreted forms of β-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons
    • MattsonMP (1994) Secreted forms of β-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons. J Neurobiol 25:439-450.
    • (1994) J Neurobiol , vol.25 , pp. 439-450
    • Mattson, M.P.1
  • 43
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein E allele-spedfic antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides
    • Miyata M, Smith JD (1996) Apolipoprotein E allele-spedfic antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat Genet 14:55-61.
    • (1996) Nat Genet , vol.14 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 44
    • 0001585073 scopus 로고
    • Nerve growth factor increases mRNA levels for the prion protein and the betaamyloid protein precursor in developing hamster brain
    • Mobley WC, Neve RL, Prusiner SB, McKinley MP (1988) Nerve growth factor increases mRNA levels for the prion protein and the betaamyloid protein precursor in developing hamster brain. Proc Natl Acad Sci USA 85:9811-9815.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9811-9815
    • Mobley, W.C.1    Neve, R.L.2    Prusiner, S.B.3    McKinley, M.P.4
  • 45
    • 0026731852 scopus 로고
    • Distribution of the α2macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues
    • Moestrup SK, Gliemann J, Pallesen G (1992) Distribution of the α2macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res 269:375-382.
    • (1992) Cell Tissue Res , vol.269 , pp. 375-382
    • Moestrup, S.K.1    Gliemann, J.2    Pallesen, G.3
  • 46
    • 0029554320 scopus 로고
    • Apolipoprotein E expression in astrocytes: Developmental pattern and regulation
    • Mouchel Y, Lefrancois T, Pages C, Tardy M (1995) Apolipoprotein E expression in astrocytes: developmental pattern and regulation. NeuroReport 7:205-208.
    • (1995) NeuroReport , vol.7 , pp. 205-208
    • Mouchel, Y.1    Lefrancois, T.2    Pages, C.3    Tardy, M.4
  • 48
    • 0031030661 scopus 로고    scopus 로고
    • The low density lipoprotein receptor-related protein (LRP), a multifunctional apoE receptor, modulates hippocampal neurite development
    • Narita M, Bu G, Holtzman DM, Schwartz AL (1997) The low density lipoprotein receptor-related protein (LRP), a multifunctional apoE receptor, modulates hippocampal neurite development. J Neurochem 68:587-595.
    • (1997) J Neurochem , vol.68 , pp. 587-595
    • Narita, M.1    Bu, G.2    Holtzman, D.M.3    Schwartz, A.L.4
  • 51
    • 0029157112 scopus 로고
    • The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
    • Nathan BP, Chang KC, Bellosta S, Brisch E, Ge N, Mahley RW. Pitas RE (1995) The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J Biol Chem 270:19791-19799.
    • (1995) J Biol Chem , vol.270 , pp. 19791-19799
    • Nathan, B.P.1    Chang, K.C.2    Bellosta, S.3    Brisch, E.4    Ge, N.5    Mahley, R.W.6    Pitas, R.E.7
  • 52
    • 0028986690 scopus 로고
    • ApoE E4 allele is associated with deposition of amyloid beta-protein following head injury
    • Nicoll JAR, Roberts GW, Graham DI (1995) ApoE E4 allele is associated with deposition of amyloid beta-protein following head injury. Nat Med 1:135-137.
    • (1995) Nat Med , vol.1 , pp. 135-137
    • Nicoll, J.A.R.1    Roberts, G.W.2    Graham, D.I.3
  • 53
    • 0026536066 scopus 로고
    • Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
    • Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells, Proc Natl Acad Sci USA 89:4471-4475.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4471-4475
    • Piedrahita, J.A.1    Zhang, S.H.2    Hagaman, J.R.3    Oliver, P.M.4    Maeda, N.5
  • 54
    • 0023080585 scopus 로고
    • Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoprotcins
    • Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW (1987a) Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoprotcins. Biochim Biophys Acta 917:148-161.
    • (1987) Biochim Biophys Acta , vol.917 , pp. 148-161
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3    Foss, D.4    Mahley, R.W.5
  • 55
  • 56
    • 0025826774 scopus 로고
    • Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning
    • Poirier J, Hess M, May PC, Finch CE (1991) Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Mol Brain Res 11:97-106.
    • (1991) Mol Brain Res , vol.11 , pp. 97-106
    • Poirier, J.1    Hess, M.2    May, P.C.3    Finch, C.E.4
  • 57
    • 0027298061 scopus 로고
    • Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats
    • Poirier J, Baccichet A, Dea D, Gauthier S (1993) Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats. Neuroscience 55:81-90.
    • (1993) Neuroscience , vol.55 , pp. 81-90
    • Poirier, J.1    Baccichet, A.2    Dea, D.3    Gauthier, S.4
  • 58
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
    • Rebeck GW, Reiter JS, Strickland DK, Hyman BT (1993) Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 11:575-580.
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 60
    • 0001884447 scopus 로고
    • Cytotoxicity in murine neocortical cell culture. in vitro biological methods
    • Tyson CA, Frazier JM, eds, San Diego: Academic
    • Rose K, Goldberg MP, Choi DW (1993) Cytotoxicity in murine neocortical cell culture. In vitro biological methods. In: Methods in toxicology (Tyson CA, Frazier JM, eds), pp 46-60. San Diego: Academic.
    • (1993) Methods in Toxicology , pp. 46-60
    • Rose, K.1    Goldberg, M.P.2    Choi, D.W.3
  • 61
    • 0030696944 scopus 로고    scopus 로고
    • Apolipoprotein E, a gene with complex biological interactions in the aging brain
    • Roses AD (1997) Apolipoprotein E, a gene with complex biological interactions in the aging brain. Neurobiol Dis 4:170-186.
    • (1997) Neurobiol Dis , vol.4 , pp. 170-186
    • Roses, A.D.1
  • 64
    • 0028898620 scopus 로고
    • Effects of apoprotein E on intracellular metabolism of model triglyceride-rich particles are distinct from effects on cell particle uptake
    • Schwiegelshohn B, Presley JF, Gorecki M, Vogel T, Carpentier YA, Maxfield FR, Deckelbaum RJ (1995) Effects of apoprotein E on intracellular metabolism of model triglyceride-rich particles are distinct from effects on cell particle uptake. J Biol Chem 270:1761-1769.
    • (1995) J Biol Chem , vol.270 , pp. 1761-1769
    • Schwiegelshohn, B.1    Presley, J.F.2    Gorecki, M.3    Vogel, T.4    Carpentier, Y.A.5    Maxfield, F.R.6    Deckelbaum, R.J.7
  • 65
    • 0028123071 scopus 로고
    • Alzheimer's disease: A central role for amyloid
    • SelkoeDJ (1994) Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol 53:438-447.
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 438-447
    • Selkoe, D.J.1
  • 66
    • 0030614814 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon-4 and the risk of dementia with stroke-a population based investigation
    • Slooter AJC, Tang MX, Vanduijn CM (1997) Apolipoprotein E epsilon-4 and the risk of dementia with stroke-a population based investigation. JAMA 277:818-821.
    • (1997) JAMA , vol.277 , pp. 818-821
    • Slooter, A.J.C.1    Tang, M.X.2    Vanduijn, C.M.3
  • 67
    • 0031079601 scopus 로고    scopus 로고
    • Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro
    • Stone DJ, Rozovsky I, Morgan TE, Anderson CP, Hajian H, Finch CE (1997) Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Exp Neurol 143:313-318.
    • (1997) Exp Neurol , vol.143 , pp. 313-318
    • Stone, D.J.1    Rozovsky, I.2    Morgan, T.E.3    Anderson, C.P.4    Hajian, H.5    Finch, C.E.6
  • 72
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein E gene with the common human apoE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • Sullivan PM, Mezdour H, Aratani Y. Knouff C, Najib J, Reddick RL, Quarfordt SH, Maeda N (1997) Targeted replacement of the mouse apolipoprotein E gene with the common human apoE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 272:17972-17980.
    • (1997) J Biol Chem , vol.272 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3    Knouff, C.4    Najib, J.5    Reddick, R.L.6    Quarfordt, S.H.7    Maeda, N.8
  • 74
    • 0030770308 scopus 로고    scopus 로고
    • Association of apolipoprotein E polymorphism with outcome after head injury
    • Teasdale GM, Nicoll JAR. Murray G, Fiddes M (1997) Association of apolipoprotein E polymorphism with outcome after head injury. Lancet 350:1069-1071.
    • (1997) Lancet , vol.350 , pp. 1069-1071
    • Teasdale, G.M.1    Nicoll, J.A.R.2    Murray, G.3    Fiddes, M.4
  • 75
    • 0029844205 scopus 로고    scopus 로고
    • Human apolipoprotein E: The Alzheimer's disease connection
    • Weisgraber KH, Mahley RW (1996) Human apolipoprotein E: the Alzheimer's disease connection. FASEB J 10:1485-1494.
    • (1996) FASEB J , vol.10 , pp. 1485-1494
    • Weisgraber, K.H.1    Mahley, R.W.2
  • 76
    • 0026542786 scopus 로고
    • Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid
    • Wisniewski T, Frangione B (1992) Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 135:235-238.
    • (1992) Neurosci Lett , vol.135 , pp. 235-238
    • Wisniewski, T.1    Frangione, B.2
  • 77
    • 0026693345 scopus 로고
    • Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein) in human brain
    • Wolf BB, Loppes MBS, VandenBerg SR, Gonias S (1992) Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein) in human brain. Am J Pathol 141:37-42.
    • (1992) Am J Pathol , vol.141 , pp. 37-42
    • Wolf, B.B.1    Loppes, M.B.S.2    VandenBerg, S.R.3    Gonias, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.