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Volumn 8, Issue NOV, 2017, Pages

Lactoferrin in a context of inflammation-induced pathology

Author keywords

Immunopathology; Immunotherapy; Inflammation; Lactoferrin; Pathology

Indexed keywords

CATALASE; CD22 ANTIGEN; GLUTATHIONE PEROXIDASE; HEAT SHOCK PROTEIN; HYDROGEN PEROXIDE; INFLAMMASOME; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LACTOFERRIN; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

EID: 85034027512     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.01438     Document Type: Review
Times cited : (216)

References (156)
  • 1
    • 68449088241 scopus 로고    scopus 로고
    • Lactoferrin as a natural immune modulator
    • Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a natural immune modulator. Curr Pharm Des (2009) 15:1956-73. doi:10.2174/138161209788453202
    • (2009) Curr Pharm Des , vol.15 , pp. 1956-1973
    • Actor, J.K.1    Hwang, S.A.2    Kruzel, M.L.3
  • 4
    • 0036947672 scopus 로고    scopus 로고
    • Lactoferrin and immunologic dissonance: clinical implications
    • Kruzel ML, Zimecki M. Lactoferrin and immunologic dissonance: clinical implications. Arch Immunol Ther Exp (2002) 50:399-410
    • (2002) Arch Immunol Ther Exp , vol.50 , pp. 399-410
    • Kruzel, M.L.1    Zimecki, M.2
  • 5
    • 0041767528 scopus 로고    scopus 로고
    • Comparative analysis of the site-specific N-glycosylation of human lactoferrin produced in maize and tobacco plants
    • Samyn-Petit B, Wajda Dubos JP, Chirat F, Coddeville B, Demaizieres G, Farrer S, et al. Comparative analysis of the site-specific N-glycosylation of human lactoferrin produced in maize and tobacco plants. Eur J Biochem (2003) 270:3235-42. doi:10.1046/j.1432-1033.2003.03706.x
    • (2003) Eur J Biochem , vol.270 , pp. 3235-3242
    • Samyn-Petit, B.1    Wajda Dubos, J.P.2    Chirat, F.3    Coddeville, B.4    Demaizieres, G.5    Farrer, S.6
  • 7
    • 46649098416 scopus 로고    scopus 로고
    • Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response
    • Choi BK, Actor JK, Rios S, d'Anjou M, Stadheim TA, Warburton S, et al. Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response. Glycoconj J (2008) 25:581-93. doi:10.1007/s10719-008-9123-y
    • (2008) Glycoconj J , vol.25 , pp. 581-593
    • Choi, B.K.1    Actor, J.K.2    Rios, S.3    d'Anjou, M.4    Stadheim, T.A.5    Warburton, S.6
  • 8
    • 84903130718 scopus 로고    scopus 로고
    • The effect of carbohydrate moiety structure on the immunoregulatory activity of lactoferrin in vitro
    • Zimecki M, Artym J, Kocieba M, Duk M, Kruzel ML. The effect of carbohydrate moiety structure on the immunoregulatory activity of lactoferrin in vitro. Cell Mol Biol Lett (2014) 19:284-96. doi:10.2478/s11658-014-0196-2
    • (2014) Cell Mol Biol Lett , vol.19 , pp. 284-296
    • Zimecki, M.1    Artym, J.2    Kocieba, M.3    Duk, M.4    Kruzel, M.L.5
  • 9
    • 84889673143 scopus 로고    scopus 로고
    • Homologous lactoferrin triggers mobilization of the myelocytic lineage of bone marrow in experimental mice
    • Zimecki M, Artym J, Kocieba M, Kaleta-Kuratewicz K, Kuropka P, Kuryszko J, et al. Homologous lactoferrin triggers mobilization of the myelocytic lineage of bone marrow in experimental mice. Stem Cells Dev (2013) 22:3261-70. doi:10.1089/scd.2013.0242
    • (2013) Stem Cells Dev , vol.22 , pp. 3261-3270
    • Zimecki, M.1    Artym, J.2    Kocieba, M.3    Kaleta-Kuratewicz, K.4    Kuropka, P.5    Kuryszko, J.6
  • 10
    • 80051793186 scopus 로고    scopus 로고
    • Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events
    • Francis N, Wong SH, Hampson P, Wang K, Young SP, Deigner HP, et al. Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events. Biochim Biophys Acta (2011) 1813:1822-6. doi:10.1016/j.bbamcr.2011.07.004
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1822-1826
    • Francis, N.1    Wong, S.H.2    Hampson, P.3    Wang, K.4    Young, S.P.5    Deigner, H.P.6
  • 11
    • 85027932145 scopus 로고    scopus 로고
    • Lactoferrin suppresses neutrophil extracellular traps release in inflammation
    • Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, Mayadas T, et al. Lactoferrin suppresses neutrophil extracellular traps release in inflammation. EBioMedicine (2016) 10:204-15. doi:10.1016/j.ebiom.2016.07.012
    • (2016) EBioMedicine , vol.10 , pp. 204-215
    • Okubo, K.1    Kamiya, M.2    Urano, Y.3    Nishi, H.4    Herter, J.M.5    Mayadas, T.6
  • 12
    • 0029130333 scopus 로고
    • Lactoferrin: molecular structure and biological function
    • Lonnerdal B, Iyer S. Lactoferrin: molecular structure and biological function. Annu Rev Nutr (1995) 15:93-110. doi:10.1146/annurev.nu.15.070195.000521
    • (1995) Annu Rev Nutr , vol.15 , pp. 93-110
    • Lonnerdal, B.1    Iyer, S.2
  • 13
    • 0026582907 scopus 로고
    • Biological role of lactoferrin
    • Sanchez L, Calvo M, Brock JH. Biological role of lactoferrin. Arch Dis Child (1992) 67:657-61. doi:10.1136/adc.67.5.657
    • (1992) Arch Dis Child , vol.67 , pp. 657-661
    • Sanchez, L.1    Calvo, M.2    Brock, J.H.3
  • 14
    • 0032893748 scopus 로고    scopus 로고
    • Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process
    • Baveye S, Elass E, Mazurier J, Spik G, Legrand D. Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin Chem Lab Med (1999) 37:281-6. doi:10.1515/CCLM.1999.049
    • (1999) Clin Chem Lab Med , vol.37 , pp. 281-286
    • Baveye, S.1    Elass, E.2    Mazurier, J.3    Spik, G.4    Legrand, D.5
  • 15
    • 0028618679 scopus 로고
    • Lactoferrin and the inflammatory response
    • Baynes RD, Bezwoda WR. Lactoferrin and the inflammatory response. Adv Exp Med Biol (1994) 357:133-41. doi:10.1007/978-1-4615-2548-6_13
    • (1994) Adv Exp Med Biol , vol.357 , pp. 133-141
    • Baynes, R.D.1    Bezwoda, W.R.2
  • 16
    • 0036379733 scopus 로고    scopus 로고
    • Differential effects of prophylactic, concurrent and therapeutic lactoferrin treatment on LPS-induced inflammatory responses in mice
    • Kruzel ML, Harari Y, Mailman D, Actor JK, Zimecki M. Differential effects of prophylactic, concurrent and therapeutic lactoferrin treatment on LPS-induced inflammatory responses in mice. Clin Exp Immunol (2002) 130:25-31. doi:10.1046/j.1365-2249.2002.01956.x
    • (2002) Clin Exp Immunol , vol.130 , pp. 25-31
    • Kruzel, M.L.1    Harari, Y.2    Mailman, D.3    Actor, J.K.4    Zimecki, M.5
  • 17
    • 77957301153 scopus 로고    scopus 로고
    • Lactoferrin and prevention of late-onset sepsis in the pre-term neonates
    • Manzoni P, Decembrino L, Stolfi I, Pugni L, Rinaldi M, Cattani S, et al. Lactoferrin and prevention of late-onset sepsis in the pre-term neonates. Early Hum Dev (2010) 86(Suppl 1):59-61. doi:10.1016/j.earlhumdev.2010.01.009
    • (2010) Early Hum Dev , vol.86 , pp. 59-61
    • Manzoni, P.1    Decembrino, L.2    Stolfi, I.3    Pugni, L.4    Rinaldi, M.5    Cattani, S.6
  • 18
    • 70349914008 scopus 로고    scopus 로고
    • Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial
    • Manzoni P, Rinaldi M, Cattani S, Pugni L, Romeo MG, Messner H, et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial. JAMA (2009) 302:1421-8. doi:10.1001/jama.2009.1403
    • (2009) JAMA , vol.302 , pp. 1421-1428
    • Manzoni, P.1    Rinaldi, M.2    Cattani, S.3    Pugni, L.4    Romeo, M.G.5    Messner, H.6
  • 19
    • 84937712281 scopus 로고    scopus 로고
    • Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g
    • Ochoa TJ, Zegarra J, Cam L, Llanos R, Pezo A, Cruz K, et al. Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g. Pediatr Infect Dis J (2015) 34:571-6. doi:10.1097/INF.0000000000000593
    • (2015) Pediatr Infect Dis J , vol.34 , pp. 571-576
    • Ochoa, T.J.1    Zegarra, J.2    Cam, L.3    Llanos, R.4    Pezo, A.5    Cruz, K.6
  • 20
    • 0033976996 scopus 로고    scopus 로고
    • Lactoferrin protects gut mucosal integrity during endotoxemia induced by lipopolysaccharide in mice
    • Kruzel ML, Harari Y, Chen CY, Castro GA. Lactoferrin protects gut mucosal integrity during endotoxemia induced by lipopolysaccharide in mice. Inflammation (2000) 24:33-44. doi:10.1023/A:1006935908960
    • (2000) Inflammation , vol.24 , pp. 33-44
    • Kruzel, M.L.1    Harari, Y.2    Chen, C.Y.3    Castro, G.A.4
  • 21
    • 84872292894 scopus 로고    scopus 로고
    • Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children
    • Ochoa TJ, Chea-Woo E, Baiocchi N, Pecho I, Campos M, Prada A, et al. Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children. J Pediatr (2013) 162:349-56. doi:10.1016/j.jpeds.2012.07.043
    • (2013) J Pediatr , vol.162 , pp. 349-356
    • Ochoa, T.J.1    Chea-Woo, E.2    Baiocchi, N.3    Pecho, I.4    Campos, M.5    Prada, A.6
  • 23
    • 84877810753 scopus 로고    scopus 로고
    • A lactotransferrin single nucleotide polymorphism demonstrates biological activity that can reduce susceptibility to caries
    • Fine DH, Toruner GA, Velliyagounder K, Sampathkumar V, Godboley D, Furgang D. A lactotransferrin single nucleotide polymorphism demonstrates biological activity that can reduce susceptibility to caries. Infect Immun (2013) 81:1596-605. doi:10.1128/IAI.01063-12
    • (2013) Infect Immun , vol.81 , pp. 1596-1605
    • Fine, D.H.1    Toruner, G.A.2    Velliyagounder, K.3    Sampathkumar, V.4    Godboley, D.5    Furgang, D.6
  • 24
    • 33947380125 scopus 로고    scopus 로고
    • A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico
    • Mohamed JA, DuPont HL, Jiang ZD, Belkind-Gerson J, Figueroa JF, Armitige LY, et al. A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Clin Infect Dis (2007) 44:945-52. doi:10.1086/512199
    • (2007) Clin Infect Dis , vol.44 , pp. 945-952
    • Mohamed, J.A.1    DuPont, H.L.2    Jiang, Z.D.3    Belkind-Gerson, J.4    Figueroa, J.F.5    Armitige, L.Y.6
  • 25
    • 0031883875 scopus 로고    scopus 로고
    • Lactoferrin inhibits the endotoxin interaction with CD14 by competition with the lipopolysaccharide-binding protein
    • Elass-Rochard E, Legrand D, Salmon V, Roseanu A, Trif M, Tobias PS, et al. Lactoferrin inhibits the endotoxin interaction with CD14 by competition with the lipopolysaccharide-binding protein. Infect Immun (1998) 66:486-91
    • (1998) Infect Immun , vol.66 , pp. 486-491
    • Elass-Rochard, E.1    Legrand, D.2    Salmon, V.3    Roseanu, A.4    Trif, M.5    Tobias, P.S.6
  • 26
    • 84865982429 scopus 로고    scopus 로고
    • Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats
    • Okazaki Y, Kono I, Kuriki T, Funahashi S, Fushimi S, Iqbal M, et al. Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats. J Clin Biochem Nutr (2012) 51:84-90. doi:10.3164/jcbn.11-100
    • (2012) J Clin Biochem Nutr , vol.51 , pp. 84-90
    • Okazaki, Y.1    Kono, I.2    Kuriki, T.3    Funahashi, S.4    Fushimi, S.5    Iqbal, M.6
  • 27
    • 0022981174 scopus 로고
    • The non-immune inflammatory response: serial changes in plasma iron, iron-binding capacity, lactoferrin, ferritin and C-reactive protein
    • Baynes R, Bezwoda W, Bothwell T, Khan Q, Mansoor N. The non-immune inflammatory response: serial changes in plasma iron, iron-binding capacity, lactoferrin, ferritin and C-reactive protein. Scand J Clin Lab Invest (1986) 46:695-704. doi:10.3109/00365518609083733
    • (1986) Scand J Clin Lab Invest , vol.46 , pp. 695-704
    • Baynes, R.1    Bezwoda, W.2    Bothwell, T.3    Khan, Q.4    Mansoor, N.5
  • 28
    • 45549085804 scopus 로고    scopus 로고
    • Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses
    • de la Rosa G, Yang D, Tewary P, Varadhachary A, Oppenheim JJ. Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses. J Immunol (2008) 180:6868-76. doi:10.4049/jimmunol.180.10.6868
    • (2008) J Immunol , vol.180 , pp. 6868-6876
    • de la Rosa, G.1    Yang, D.2    Tewary, P.3    Varadhachary, A.4    Oppenheim, J.J.5
  • 30
  • 31
    • 34548130792 scopus 로고    scopus 로고
    • Lactoferrin modulation of IL-12 and IL-10 response from activated murine leukocytes
    • Hwang SA, Wilk KM, Bangale YA, Kruzel ML, Actor JK. Lactoferrin modulation of IL-12 and IL-10 response from activated murine leukocytes. Med Microbiol Immunol (2007) 196:171-80. doi:10.1007/s00430-007-0041-6
    • (2007) Med Microbiol Immunol , vol.196 , pp. 171-180
    • Hwang, S.A.1    Wilk, K.M.2    Bangale, Y.A.3    Kruzel, M.L.4    Actor, J.K.5
  • 33
    • 33947363724 scopus 로고    scopus 로고
    • Milk-derived proteins and peptides of potential therapeutic and nutritive value
    • Zimecki M, Kruzel ML. Milk-derived proteins and peptides of potential therapeutic and nutritive value. J Exp Ther Oncol (2007) 6:89-106
    • (2007) J Exp Ther Oncol , vol.6 , pp. 89-106
    • Zimecki, M.1    Kruzel, M.L.2
  • 34
    • 0029145713 scopus 로고
    • Human lactoferrin induces phenotypic and functional changes in murine splenic B cells
    • Zimecki M, Mazurier J, Spik G, Kapp JA. Human lactoferrin induces phenotypic and functional changes in murine splenic B cells. Immunology (1995) 86:122-7
    • (1995) Immunology , vol.86 , pp. 122-127
    • Zimecki, M.1    Mazurier, J.2    Spik, G.3    Kapp, J.A.4
  • 35
    • 0032603248 scopus 로고    scopus 로고
    • Regulatory effects of lactoferrin and lipopolysaccharide on LFA-1 expression on human peripheral blood mononuclear cells
    • Zimecki M, Miedzybrodzki R, Mazurier J, Spik G. Regulatory effects of lactoferrin and lipopolysaccharide on LFA-1 expression on human peripheral blood mononuclear cells. Arch Immunol Ther Exp (1999) 47:257-64
    • (1999) Arch Immunol Ther Exp , vol.47 , pp. 257-264
    • Zimecki, M.1    Miedzybrodzki, R.2    Mazurier, J.3    Spik, G.4
  • 36
    • 15944378224 scopus 로고    scopus 로고
    • Lactoferrin augments BCG vaccine efficacy to generate T helper response and subsequent protection against challenge with virulent Mycobacterium tuberculosis
    • Hwang SA, Kruzel ML, Actor JK. Lactoferrin augments BCG vaccine efficacy to generate T helper response and subsequent protection against challenge with virulent Mycobacterium tuberculosis. Int Immunopharmacol (2005) 5:591-9. doi:10.1016/j.intimp.2004.11.006
    • (2005) Int Immunopharmacol , vol.5 , pp. 591-599
    • Hwang, S.A.1    Kruzel, M.L.2    Actor, J.K.3
  • 37
    • 14944367060 scopus 로고    scopus 로고
    • Effect of lactoferrin on the methotrexate-induced suppression of the cellular and humoral immune response in mice
    • Artym J, Zimecki M, Kruzel ML. Effect of lactoferrin on the methotrexate-induced suppression of the cellular and humoral immune response in mice. Anticancer Res (2004) 24:3831-6
    • (2004) Anticancer Res , vol.24 , pp. 3831-3836
    • Artym, J.1    Zimecki, M.2    Kruzel, M.L.3
  • 38
    • 33748751668 scopus 로고    scopus 로고
    • Lactoferrin decreases pollen antigen-induced allergic airway inflammation in a murine model of asthma
    • Kruzel ML, Bacsi A, Choudhury B, Sur S, Boldogh I. Lactoferrin decreases pollen antigen-induced allergic airway inflammation in a murine model of asthma. Immunology (2006) 119:159-66. doi:10.1111/j.1365-2567.2006.02417.x
    • (2006) Immunology , vol.119 , pp. 159-166
    • Kruzel, M.L.1    Bacsi, A.2    Choudhury, B.3    Sur, S.4    Boldogh, I.5
  • 39
    • 84898903113 scopus 로고    scopus 로고
    • Bovine lactoferrin ingestion protects against inflammation via IL-11 induction in the small intestine of mice with hepatitis
    • Kuhara T, Tanaka A, Yamauchi K, Iwatsuki K. Bovine lactoferrin ingestion protects against inflammation via IL-11 induction in the small intestine of mice with hepatitis. Br J Nutr (2014) 111:1801-10. doi:10.1017/S0007114513004315
    • (2014) Br J Nutr , vol.111 , pp. 1801-1810
    • Kuhara, T.1    Tanaka, A.2    Yamauchi, K.3    Iwatsuki, K.4
  • 40
    • 0036435816 scopus 로고    scopus 로고
    • Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance
    • Togawa J, Nagase H, Tanaka K, Inamori M, Nakajima A, Ueno N, et al. Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. J Gastroenterol Hepatol (2002) 17:1291-8. doi:10.1046/j.1440-1746.2002.02868.x
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 1291-1298
    • Togawa, J.1    Nagase, H.2    Tanaka, K.3    Inamori, M.4    Nakajima, A.5    Ueno, N.6
  • 41
    • 84655164969 scopus 로고    scopus 로고
    • Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology
    • Welsh KJ, Hwang SA, Boyd S, Kruzel ML, Hunter RL, Actor JK. Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology. Tuberculosis (2011) 91(Suppl 1):S105-13. doi:10.1016/j.tube.2011.10.019
    • (2011) Tuberculosis , vol.91 , pp. S105-S113
    • Welsh, K.J.1    Hwang, S.A.2    Boyd, S.3    Kruzel, M.L.4    Hunter, R.L.5    Actor, J.K.6
  • 42
    • 77957303723 scopus 로고    scopus 로고
    • Lactoferrin modulation of mycobacterial cord factor trehalose 6-6'-dimycolate induced granulomatous response
    • Welsh KJ, Hwang SA, Hunter RL, Kruzel ML, Actor JK. Lactoferrin modulation of mycobacterial cord factor trehalose 6-6'-dimycolate induced granulomatous response. Transl Res (2010) 156:207-15. doi:10.1016/j.trsl.2010.06.001
    • (2010) Transl Res , vol.156 , pp. 207-215
    • Welsh, K.J.1    Hwang, S.A.2    Hunter, R.L.3    Kruzel, M.L.4    Actor, J.K.5
  • 43
    • 84861361791 scopus 로고    scopus 로고
    • Lactoferrin, a bird's eye view
    • Vogel HJ. Lactoferrin, a bird's eye view. Biochem Cell Biol (2012) 90:233-44. doi:10.1139/o2012-016
    • (2012) Biochem Cell Biol , vol.90 , pp. 233-244
    • Vogel, H.J.1
  • 44
    • 84970004115 scopus 로고    scopus 로고
    • Overview of lactoferrin as a natural immune modulator
    • Legrand D. Overview of lactoferrin as a natural immune modulator. J Pediatr (2016) 173(Suppl):S10-5. doi:10.1016/j.jpeds.2016.02.071
    • (2016) J Pediatr , vol.173 , pp. S10-S15
    • Legrand, D.1
  • 45
    • 58149125767 scopus 로고    scopus 로고
    • A structural framework for understanding the multifunctional character of lactoferrin
    • Baker EN, Baker HM. A structural framework for understanding the multifunctional character of lactoferrin. Biochimie (2009) 91:3-10. doi:10.1016/j.biochi.2008.05.006
    • (2009) Biochimie , vol.91 , pp. 3-10
    • Baker, E.N.1    Baker, H.M.2
  • 47
    • 58149140244 scopus 로고    scopus 로고
    • Immunomodulatory effects of lactoferrin on antigen presenting cells
    • Puddu P, Valenti P, Gessani S. Immunomodulatory effects of lactoferrin on antigen presenting cells. Biochimie (2009) 91:11-8. doi:10.1016/j.biochi.2008.05.005
    • (2009) Biochimie , vol.91 , pp. 11-18
    • Puddu, P.1    Valenti, P.2    Gessani, S.3
  • 48
    • 33748416650 scopus 로고    scopus 로고
    • Interactions of lactoferrin with cells involved in immune function
    • Legrand D, Elass E, Carpentier M, Mazurier J. Interactions of lactoferrin with cells involved in immune function. Biochem Cell Biol (2006) 84:282-90. doi:10.1139/o06-045
    • (2006) Biochem Cell Biol , vol.84 , pp. 282-290
    • Legrand, D.1    Elass, E.2    Carpentier, M.3    Mazurier, J.4
  • 49
    • 84969776833 scopus 로고    scopus 로고
    • Lactoferrin, a pleiotropic protein in health and disease
    • Mayeur S, Spahis S, Pouliot Y, Levy E. Lactoferrin, a pleiotropic protein in health and disease. Antioxid Redox Signal (2016) 24:813-36. doi:10.1089/ars.2015.6458
    • (2016) Antioxid Redox Signal , vol.24 , pp. 813-836
    • Mayeur, S.1    Spahis, S.2    Pouliot, Y.3    Levy, E.4
  • 50
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: sensing and reacting to damage
    • Chen GY, Nunez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol (2010) 10:826-37. doi:10.1038/nri2873
    • (2010) Nat Rev Immunol , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nunez, G.2
  • 51
    • 34548849117 scopus 로고    scopus 로고
    • The role of complement in inflammatory diseases from behind the scenes into the spotlight
    • Markiewski MM, Lambris JD. The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol (2007) 171:715-27. doi:10.2353/ajpath.2007.070166
    • (2007) Am J Pathol , vol.171 , pp. 715-727
    • Markiewski, M.M.1    Lambris, J.D.2
  • 52
    • 84979743338 scopus 로고    scopus 로고
    • Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection
    • Calame DG, Mueller-Ortiz SL, Wetsel RA. Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection. Immunobiology (2016) 221:1407-17. doi:10.1016/j.imbio.2016.07.004
    • (2016) Immunobiology , vol.221 , pp. 1407-1417
    • Calame, D.G.1    Mueller-Ortiz, S.L.2    Wetsel, R.A.3
  • 53
    • 77957943307 scopus 로고    scopus 로고
    • Intravascular danger signals guide neutrophils to sites of sterile inflammation
    • McDonald B, Pittman K, Menezes GB, Hirota SA, Slaba I, Waterhouse CC, et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science (2010) 330:362-6. doi:10.1126/science.1195491
    • (2010) Science , vol.330 , pp. 362-366
    • McDonald, B.1    Pittman, K.2    Menezes, G.B.3    Hirota, S.A.4    Slaba, I.5    Waterhouse, C.C.6
  • 54
    • 84923049818 scopus 로고    scopus 로고
    • Cell death-associated molecular-pattern molecules: inflammatory signaling and control
    • Sangiuliano B, Perez NM, Moreira DF, Belizario JE. Cell death-associated molecular-pattern molecules: inflammatory signaling and control. Mediators Inflamm (2014) 2014:821043. doi:10.1155/2014/821043
    • (2014) Mediators Inflamm , vol.2014
    • Sangiuliano, B.1    Perez, N.M.2    Moreira, D.F.3    Belizario, J.E.4
  • 55
    • 85000443028 scopus 로고    scopus 로고
    • Human milk components modulate toll-like receptor-mediated inflammation
    • He Y, Lawlor NT, Newburg DS. Human milk components modulate toll-like receptor-mediated inflammation. Adv Nutr (2016) 7:102-11. doi:10.3945/an.115.010090
    • (2016) Adv Nutr , vol.7 , pp. 102-111
    • He, Y.1    Lawlor, N.T.2    Newburg, D.S.3
  • 56
    • 77953286718 scopus 로고    scopus 로고
    • A critical review of the roles of host lactoferrin in immunity
    • Legrand D, Mazurier J. A critical review of the roles of host lactoferrin in immunity. Biometals (2010) 23:365-76. doi:10.1007/s10534-010-9297-1
    • (2010) Biometals , vol.23 , pp. 365-376
    • Legrand, D.1    Mazurier, J.2
  • 57
    • 33845464963 scopus 로고    scopus 로고
    • Lactoferrin activates macrophages via TLR4-dependent and-independent signaling pathways
    • Curran CS, Demick KP, Mansfield JM. Lactoferrin activates macrophages via TLR4-dependent and-independent signaling pathways. Cell Immunol (2006) 242:23-30. doi:10.1016/j.cellimm.2006.08.006
    • (2006) Cell Immunol , vol.242 , pp. 23-30
    • Curran, C.S.1    Demick, K.P.2    Mansfield, J.M.3
  • 58
    • 84856081379 scopus 로고    scopus 로고
    • Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects
    • Drago-Serrano ME, de la Garza-Amaya M, Luna JS, Campos-Rodriguez R. Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects. Int Immunopharmacol (2012) 12:1-9. doi:10.1016/j.intimp.2011.11.002
    • (2012) Int Immunopharmacol , vol.12 , pp. 1-9
    • Drago-Serrano, M.E.1    de la Garza-Amaya, M.2    Luna, J.S.3    Campos-Rodriguez, R.4
  • 59
    • 84908478396 scopus 로고    scopus 로고
    • Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9
    • Zheng Y, Qin Z, Ye Q, Chen P, Wang Z, Yan Q, et al. Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9. Lab Invest (2014) 94:1188-99. doi:10.1038/labinvest.2014.105
    • (2014) Lab Invest , vol.94 , pp. 1188-1199
    • Zheng, Y.1    Qin, Z.2    Ye, Q.3    Chen, P.4    Wang, Z.5    Yan, Q.6
  • 60
    • 0035955425 scopus 로고    scopus 로고
    • The plasticity of dendritic cell responses to pathogens and their components
    • Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, et al. The plasticity of dendritic cell responses to pathogens and their components. Science (2001) 294:870-5. doi:10.1126/science.294.5543.870
    • (2001) Science , vol.294 , pp. 870-875
    • Huang, Q.1    Liu, D.2    Majewski, P.3    Schulte, L.C.4    Korn, J.M.5    Young, R.A.6
  • 61
    • 84994834809 scopus 로고    scopus 로고
    • Bovine lactoferrin free of lipopolysaccharide can induce a proinflammatory response of macrophages
    • Zemankova N, Chlebova K, Matiasovic J, Prodelalova J, Gebauer J, Faldyna M. Bovine lactoferrin free of lipopolysaccharide can induce a proinflammatory response of macrophages. BMC Vet Res (2016) 12:251. doi:10.1186/s12917-016-0878-2
    • (2016) BMC Vet Res , vol.12 , pp. 251
    • Zemankova, N.1    Chlebova, K.2    Matiasovic, J.3    Prodelalova, J.4    Gebauer, J.5    Faldyna, M.6
  • 62
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol (2009) 27:693-733. doi:10.1146/annurev.immunol.021908.132641
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 63
    • 0027170227 scopus 로고
    • Activation of the classical pathway of complement by binding of bovine lactoferrin to unencapsulated Streptococcus agalactiae
    • Rainard P. Activation of the classical pathway of complement by binding of bovine lactoferrin to unencapsulated Streptococcus agalactiae. Immunology (1993) 79:648-52
    • (1993) Immunology , vol.79 , pp. 648-652
    • Rainard, P.1
  • 64
    • 0021954044 scopus 로고
    • Inhibition of C3 deposition on solid-phase bound immune complexes by lactoferrin
    • Kievits F, Kijlstra A. Inhibition of C3 deposition on solid-phase bound immune complexes by lactoferrin. Immunology (1985) 54:449-56
    • (1985) Immunology , vol.54 , pp. 449-456
    • Kievits, F.1    Kijlstra, A.2
  • 66
    • 0346734183 scopus 로고    scopus 로고
    • Neutrophil serine proteinases cleave bacterial flagellin, abrogating its host response-inducing activity
    • Lopez-Boado YS, Espinola M, Bahr S, Belaaouaj A. Neutrophil serine proteinases cleave bacterial flagellin, abrogating its host response-inducing activity. J Immunol (2004) 172:509-15. doi:10.4049/jimmunol.172.1.509
    • (2004) J Immunol , vol.172 , pp. 509-515
    • Lopez-Boado, Y.S.1    Espinola, M.2    Bahr, S.3    Belaaouaj, A.4
  • 67
    • 84978054079 scopus 로고    scopus 로고
    • Lactoferrin is an allosteric enhancer of the proteolytic activity of cathepsin G
    • Eipper S, Steiner R, Lesner A, Sienczyk M, Palesch D, Halatsch ME, et al. Lactoferrin is an allosteric enhancer of the proteolytic activity of cathepsin G. PLoS One (2016) 11:e0151509. doi:10.1371/journal.pone.0151509
    • (2016) PLoS One , vol.11
    • Eipper, S.1    Steiner, R.2    Lesner, A.3    Sienczyk, M.4    Palesch, D.5    Halatsch, M.E.6
  • 68
    • 85021222063 scopus 로고    scopus 로고
    • Lactoferrin efficiently counteracts the inflammation-induced changes of the iron homeostasis system in macrophages
    • Cutone A, Rosa L, Lepanto MS, Scotti MJ, Berlutti F, Bonaccorsi di Patti MC, et al. Lactoferrin efficiently counteracts the inflammation-induced changes of the iron homeostasis system in macrophages. Front Immunol (2017) 8:705. doi:10.3389/fimmu.2017.00705
    • (2017) Front Immunol , vol.8 , pp. 705
    • Cutone, A.1    Rosa, L.2    Lepanto, M.S.3    Scotti, M.J.4    Berlutti, F.5    Bonaccorsi di Patti, M.C.6
  • 69
    • 0036203775 scopus 로고    scopus 로고
    • Immunoregulatory activities of lactoferrin in the delayed type hypersensitivity in mice are mediated by a receptor with affinity to mannose
    • Zimecki M, Kocieba M, Kruzel M. Immunoregulatory activities of lactoferrin in the delayed type hypersensitivity in mice are mediated by a receptor with affinity to mannose. Immunobiology (2002) 205:120-31. doi:10.1078/0171-2985-00115
    • (2002) Immunobiology , vol.205 , pp. 120-131
    • Zimecki, M.1    Kocieba, M.2    Kruzel, M.3
  • 70
    • 84888847586 scopus 로고    scopus 로고
    • Novel recombinant human lactoferrin: differential activation of oxidative stress related gene expression
    • Kruzel ML, Actor JK, Zimecki M, Wise J, Ploszaj P, Mirza S, et al. Novel recombinant human lactoferrin: differential activation of oxidative stress related gene expression. J Biotechnol (2013) 168:666-75. doi:10.1016/j.jbiotec.2013.09.011
    • (2013) J Biotechnol , vol.168 , pp. 666-675
    • Kruzel, M.L.1    Actor, J.K.2    Zimecki, M.3    Wise, J.4    Ploszaj, P.5    Mirza, S.6
  • 71
    • 0034011261 scopus 로고    scopus 로고
    • Oxyradicals and DNA damage
    • Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis (2000) 21:361-70. doi:10.1093/carcin/21.3.361
    • (2000) Carcinogenesis , vol.21 , pp. 361-370
    • Marnett, L.J.1
  • 72
    • 0034643895 scopus 로고    scopus 로고
    • Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells
    • Misonou H, Morishima-Kawashima M, Ihara Y. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry (2000) 39:6951-9. doi:10.1021/bi000169p
    • (2000) Biochemistry , vol.39 , pp. 6951-6959
    • Misonou, H.1    Morishima-Kawashima, M.2    Ihara, Y.3
  • 73
    • 0033389110 scopus 로고    scopus 로고
    • Oxidative stress and atherosclerosis: its relationship to growth factors, thrombus formation and therapeutic approaches
    • Ruef J, Peter K, Nordt TK, Runge MS, Kubler W, Bode C. Oxidative stress and atherosclerosis: its relationship to growth factors, thrombus formation and therapeutic approaches. Thromb Haemost (1999) 82(Suppl 1):32-7
    • (1999) Thromb Haemost , vol.82 , pp. 32-37
    • Ruef, J.1    Peter, K.2    Nordt, T.K.3    Runge, M.S.4    Kubler, W.5    Bode, C.6
  • 74
    • 0034456018 scopus 로고    scopus 로고
    • 4-Hydroxynonenal in the pathomechanisms of oxidative stress
    • Poli G, Schaur RJ. 4-Hydroxynonenal in the pathomechanisms of oxidative stress. IUBMB Life (2000) 50:315-21. doi:10.1080/713803726
    • (2000) IUBMB Life , vol.50 , pp. 315-321
    • Poli, G.1    Schaur, R.J.2
  • 75
    • 77952395053 scopus 로고    scopus 로고
    • Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model
    • Kruzel ML, Actor JK, Radak Z, Bacsi A, Saavedra-Molina A, Boldogh I. Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model. Innate Immun (2010) 16:67-79. doi:10.1177/1753425909105317
    • (2010) Innate Immun , vol.16 , pp. 67-79
    • Kruzel, M.L.1    Actor, J.K.2    Radak, Z.3    Bacsi, A.4    Saavedra-Molina, A.5    Boldogh, I.6
  • 76
    • 59449109182 scopus 로고    scopus 로고
    • Iron homeostasis: recently identified proteins provide insight into novel control mechanisms
    • Zhang AS, Enns CA. Iron homeostasis: recently identified proteins provide insight into novel control mechanisms. J Biol Chem (2009) 284:711-5. doi:10.1074/jbc.R800017200
    • (2009) J Biol Chem , vol.284 , pp. 711-715
    • Zhang, A.S.1    Enns, C.A.2
  • 77
    • 0024917926 scopus 로고
    • Structures on T cells and macrophages involved in interleukin 1 (Il-1) secretion by macrophages upon contact with syngeneic thymocytes
    • Zimecki M, Wieczorek Z, Kapp JA, Pierce CW. Structures on T cells and macrophages involved in interleukin 1 (Il-1) secretion by macrophages upon contact with syngeneic thymocytes. Arch Immunol Ther Exp (1989) 37:587-92
    • (1989) Arch Immunol Ther Exp , vol.37 , pp. 587-592
    • Zimecki, M.1    Wieczorek, Z.2    Kapp, J.A.3    Pierce, C.W.4
  • 78
    • 84978112663 scopus 로고    scopus 로고
    • Lactoferrin gene polymorphisms in Italian patients with recurrent tonsillitis
    • Zupin L, Angelelli F, Grasso DL, Crovella S. Lactoferrin gene polymorphisms in Italian patients with recurrent tonsillitis. Int J Pediatr Otorhinolaryngol (2016) 88:153-6. doi:10.1016/j.ijporl.2016.07.002
    • (2016) Int J Pediatr Otorhinolaryngol , vol.88 , pp. 153-156
    • Zupin, L.1    Angelelli, F.2    Grasso, D.L.3    Crovella, S.4
  • 79
    • 84930463280 scopus 로고    scopus 로고
    • Lactoferrin: a roadmap to the borderland between caries and periodontal disease
    • Fine DH. Lactoferrin: a roadmap to the borderland between caries and periodontal disease. J Dent Res (2015) 94:768-76. doi:10.1177/0022034515577413
    • (2015) J Dent Res , vol.94 , pp. 768-776
    • Fine, D.H.1
  • 80
    • 84974628250 scopus 로고    scopus 로고
    • Antimicrobial functions of lactoferrin promote genetic conflicts in ancient primates and modern humans
    • Barber MF, Kronenberg Z, Yandell M, Elde NC. Antimicrobial functions of lactoferrin promote genetic conflicts in ancient primates and modern humans. PLoS Genet (2016) 12:e1006063. doi:10.1371/journal.pgen.1006063
    • (2016) PLoS Genet , vol.12
    • Barber, M.F.1    Kronenberg, Z.2    Yandell, M.3    Elde, N.C.4
  • 81
    • 0031959269 scopus 로고    scopus 로고
    • Lactoferrin lowers serum interleukin 6 and tumor necrosis factor alpha levels in mice subjected to surgery
    • Zimecki M, Wlaszczyk A, Zagulski T, Kubler A. Lactoferrin lowers serum interleukin 6 and tumor necrosis factor alpha levels in mice subjected to surgery. Arch Immunol Ther Exp (1998) 46:97-104
    • (1998) Arch Immunol Ther Exp , vol.46 , pp. 97-104
    • Zimecki, M.1    Wlaszczyk, A.2    Zagulski, T.3    Kubler, A.4
  • 83
    • 79960724573 scopus 로고    scopus 로고
    • Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells
    • Puddu P, Latorre D, Carollo M, Catizone A, Ricci G, Valenti P, et al. Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells. PLoS One (2011) 6:e22504. doi:10.1371/journal.pone.0022504
    • (2011) PLoS One , vol.6
    • Puddu, P.1    Latorre, D.2    Carollo, M.3    Catizone, A.4    Ricci, G.5    Valenti, P.6
  • 84
    • 77953987745 scopus 로고    scopus 로고
    • Human lactoferrin stimulates skin keratinocyte function and wound re-epithelialization
    • Tang L, Wu JJ, Ma Q, Cui T, Andreopoulos FM, Gil J, et al. Human lactoferrin stimulates skin keratinocyte function and wound re-epithelialization. Br J Dermatol (2010) 163:38-47. doi:10.1111/j.1365-2133.2010.09748.x
    • (2010) Br J Dermatol , vol.163 , pp. 38-47
    • Tang, L.1    Wu, J.J.2    Ma, Q.3    Cui, T.4    Andreopoulos, F.M.5    Gil, J.6
  • 85
    • 20244387428 scopus 로고    scopus 로고
    • Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells
    • Uehara A, Sugawara Y, Kurata S, Fujimoto Y, Fukase K, Kusumoto S, et al. Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells. Cell Microbiol (2005) 7:675-86. doi:10.1111/j.1462-5822.2004.00500.x
    • (2005) Cell Microbiol , vol.7 , pp. 675-686
    • Uehara, A.1    Sugawara, Y.2    Kurata, S.3    Fujimoto, Y.4    Fukase, K.5    Kusumoto, S.6
  • 86
    • 84894555299 scopus 로고    scopus 로고
    • Recombinant human lactoferrin induces human and mouse dendritic cell maturation via Toll-like receptors 2 and 4
    • Spadaro M, Montone M, Arigoni M, Cantarella D, Forni G, Pericle F, et al. Recombinant human lactoferrin induces human and mouse dendritic cell maturation via Toll-like receptors 2 and 4. FASEB J (2014) 28:416-29. doi:10.1096/fj.13-229591
    • (2014) FASEB J , vol.28 , pp. 416-429
    • Spadaro, M.1    Montone, M.2    Arigoni, M.3    Cantarella, D.4    Forni, G.5    Pericle, F.6
  • 87
    • 79958835936 scopus 로고    scopus 로고
    • Mucosal dendritic cells in allergy and immunotherapy
    • Novak N, Allam JP. Mucosal dendritic cells in allergy and immunotherapy. Allergy (2011) 66(Suppl 95):22-4. doi:10.1111/j.1398-9995.2011.02626.x
    • (2011) Allergy , vol.66 , pp. 22-24
    • Novak, N.1    Allam, J.P.2
  • 88
    • 0034650930 scopus 로고    scopus 로고
    • Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors
    • Cario E, Rosenberg IM, Brandwein SL, Beck PL, Reinecker HC, Podolsky DK. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors. J Immunol (2000) 164:966-72. doi:10.4049/jimmunol.164.2.966
    • (2000) J Immunol , vol.164 , pp. 966-972
    • Cario, E.1    Rosenberg, I.M.2    Brandwein, S.L.3    Beck, P.L.4    Reinecker, H.C.5    Podolsky, D.K.6
  • 89
    • 85021092896 scopus 로고    scopus 로고
    • Salivary lactoferrin is transferred into the brain via the sublingual route
    • Hayashi T, To M, Saruta J, Sato C, Yamamoto Y, Kondo Y, et al. Salivary lactoferrin is transferred into the brain via the sublingual route. Biosci Biotechnol Biochem (2017) 81:1300-4. doi:10.1080/09168451.2017.1308241
    • (2017) Biosci Biotechnol Biochem , vol.81 , pp. 1300-1304
    • Hayashi, T.1    To, M.2    Saruta, J.3    Sato, C.4    Yamamoto, Y.5    Kondo, Y.6
  • 90
    • 84979249496 scopus 로고    scopus 로고
    • Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury
    • Ginet V, van de Looij Y, Petrenko V, Toulotte A, Kiss J, Huppi PS, et al. Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury. Biofactors (2016) 42:323-36. doi:10.1002/biof.1278
    • (2016) Biofactors , vol.42 , pp. 323-336
    • Ginet, V.1    van de Looij, Y.2    Petrenko, V.3    Toulotte, A.4    Kiss, J.5    Huppi, P.S.6
  • 91
    • 84896324507 scopus 로고    scopus 로고
    • Immunomodulatory properties of human recombinant lactoferrin in mice and their implications for therapeutic use in humans
    • Artym J, Kocieba M, Zaczynska E, Adamik B, Kubler A, Zimecki M, et al. Immunomodulatory properties of human recombinant lactoferrin in mice and their implications for therapeutic use in humans. Int Immunopharmacol (2014) 20(1):157-63. doi:10.1016/j.intimp.2014.02.029
    • (2014) Int Immunopharmacol , vol.20 , Issue.1 , pp. 157-163
    • Artym, J.1    Kocieba, M.2    Zaczynska, E.3    Adamik, B.4    Kubler, A.5    Zimecki, M.6
  • 92
    • 46149105672 scopus 로고    scopus 로고
    • The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome
    • Wang H, Ma S. The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome. Am J Emerg Med (2008) 26:711-5. doi:10.1016/j.ajem.2007.10.031
    • (2008) Am J Emerg Med , vol.26 , pp. 711-715
    • Wang, H.1    Ma, S.2
  • 93
    • 84918814358 scopus 로고    scopus 로고
    • Collaborative action of Toll-like and NOD-like receptors as modulators of the inflammatory response to pathogenic bacteria
    • Oviedo-Boyso J, Bravo-Patino A, Baizabal-Aguirre VM. Collaborative action of Toll-like and NOD-like receptors as modulators of the inflammatory response to pathogenic bacteria. Mediators Inflamm (2014) 2014:432785. doi:10.1155/2014/432785
    • (2014) Mediators Inflamm , vol.2014
    • Oviedo-Boyso, J.1    Bravo-Patino, A.2    Baizabal-Aguirre, V.M.3
  • 94
    • 42649100331 scopus 로고    scopus 로고
    • Mitochondrial mechanisms of sepsis-induced organ failure
    • Exline MC, Crouser ED. Mitochondrial mechanisms of sepsis-induced organ failure. Front Biosci (2008) 13:5030-41
    • (2008) Front Biosci , vol.13 , pp. 5030-5041
    • Exline, M.C.1    Crouser, E.D.2
  • 95
    • 0027549862 scopus 로고
    • Cytokines and sepsis: pathophysiology and therapy
    • Shapiro L, Gelfand JA. Cytokines and sepsis: pathophysiology and therapy. New Horiz (1993) 1:13-22
    • (1993) New Horiz , vol.1 , pp. 13-22
    • Shapiro, L.1    Gelfand, J.A.2
  • 96
    • 0038447123 scopus 로고    scopus 로고
    • Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock
    • Van Amersfoort ES, Van Berkel TJ, Kuiper J. Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev (2003) 16:379-414. doi:10.1128/CMR.16.3.379-414.2003
    • (2003) Clin Microbiol Rev , vol.16 , pp. 379-414
    • Van Amersfoort, E.S.1    Van Berkel, T.J.2    Kuiper, J.3
  • 97
    • 0026744448 scopus 로고
    • Multiple organ failure. Pathophysiology and potential future therapy
    • Deitch EA. Multiple organ failure. Pathophysiology and potential future therapy. Ann Surg (1992) 216:117-34. doi:10.1097/00000658-199208000-00002
    • (1992) Ann Surg , vol.216 , pp. 117-134
    • Deitch, E.A.1
  • 98
    • 0028320473 scopus 로고
    • Role of bacterial translocation in necrotizing enterocolitis
    • Deitch EA. Role of bacterial translocation in necrotizing enterocolitis. Acta Paediatr (1994) 396:33-6. doi:10.1111/j.1651-2227.1994.tb13239.x
    • (1994) Acta Paediatr , vol.396 , pp. 33-36
    • Deitch, E.A.1
  • 100
    • 0002355592 scopus 로고    scopus 로고
    • Bacterial translocation and the release of endotoxin and cytokines following trauma
    • Sugerman HJ, DeMaria EJ, editors. Portland, OR: Chapman & Hall
    • DeMaria EJ, Dalton J. Bacterial translocation and the release of endotoxin and cytokines following trauma. In: Sugerman HJ, DeMaria EJ, editors. Cytokines in Trauma and Hemorrhage. Portland, OR: Chapman & Hall (1997). p. 43-61
    • (1997) Cytokines in Trauma and Hemorrhage , pp. 43-61
    • DeMaria, E.J.1    Dalton, J.2
  • 101
    • 0024842051 scopus 로고
    • Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo
    • Zagulski T, Lipinski P, Zagulska A, Broniek S, Jarzabek Z. Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo. Br J Exp Pathol (1989) 70:697-704
    • (1989) Br J Exp Pathol , vol.70 , pp. 697-704
    • Zagulski, T.1    Lipinski, P.2    Zagulska, A.3    Broniek, S.4    Jarzabek, Z.5
  • 103
    • 84872767740 scopus 로고    scopus 로고
    • Lactoferrin moderates LPS-induced hypotensive response and gut injury in rats
    • Doursout MF, Horton H, Hoang L, Liang Y, Hwang SA, Boyd S, et al. Lactoferrin moderates LPS-induced hypotensive response and gut injury in rats. Int Immunopharmacol (2013) 15:227-31. doi:10.1016/j.intimp.2012.12.009
    • (2013) Int Immunopharmacol , vol.15 , pp. 227-231
    • Doursout, M.F.1    Horton, H.2    Hoang, L.3    Liang, Y.4    Hwang, S.A.5    Boyd, S.6
  • 104
    • 3142608843 scopus 로고    scopus 로고
    • Enhanced clearance of Escherichia coli and Staphylococcus aureus in mice treated with cyclophosphamide and lactoferrin
    • Artym J, Zimecki M, Kruzel ML. Enhanced clearance of Escherichia coli and Staphylococcus aureus in mice treated with cyclophosphamide and lactoferrin. Int Immunopharmacol (2004) 4:1149-57. doi:10.1016/j.intimp.2004.05.002
    • (2004) Int Immunopharmacol , vol.4 , pp. 1149-1157
    • Artym, J.1    Zimecki, M.2    Kruzel, M.L.3
  • 105
    • 3242762938 scopus 로고    scopus 로고
    • Protective effects of lactoferrin in Escherichia coli-induced bacteremia in mice: relationship to reduced serum TNF alpha level and increased turnover of neutrophils
    • Zimecki M, Artym J, Chodaczek G, Kocieba M, Kruzel ML. Protective effects of lactoferrin in Escherichia coli-induced bacteremia in mice: relationship to reduced serum TNF alpha level and increased turnover of neutrophils. Inflamm Res (2004) 53:292-6. doi:10.1007/s00011-004-1257-1
    • (2004) Inflamm Res , vol.53 , pp. 292-296
    • Zimecki, M.1    Artym, J.2    Chodaczek, G.3    Kocieba, M.4    Kruzel, M.L.5
  • 106
    • 4444300562 scopus 로고    scopus 로고
    • Lethality in LPS-induced endotoxemia in C3H/HeCr mice is associated with prevalence of proinflammatory cytokines: lack of protective action of lactoferrin
    • Zimecki M, Chodaczek G, Kocieba M, Kruzel ML. Lethality in LPS-induced endotoxemia in C3H/HeCr mice is associated with prevalence of proinflammatory cytokines: lack of protective action of lactoferrin. FEMS Immunol Med Microbiol (2004) 42:167-72. doi:10.1016/j.femsim.2004.04.003
    • (2004) FEMS Immunol Med Microbiol , vol.42 , pp. 167-172
    • Zimecki, M.1    Chodaczek, G.2    Kocieba, M.3    Kruzel, M.L.4
  • 107
    • 0027978770 scopus 로고
    • The pathophysiology of biliary obstruction and its effect on phagocytic and immune function
    • Scott-Conner CE, Grogan JB. The pathophysiology of biliary obstruction and its effect on phagocytic and immune function. J Surg Res (1994) 57:316-36. doi:10.1006/jsre.1994.1151
    • (1994) J Surg Res , vol.57 , pp. 316-336
    • Scott-Conner, C.E.1    Grogan, J.B.2
  • 108
    • 0038574574 scopus 로고    scopus 로고
    • Bovine lactoferrin decreases histopathological changes in the liver and regulates cytokine production by splenocytes of obstructive jaundiced rats
    • Zimecki M, Dawiskiba J, Zawirska B, Krawczyk Z, Kruzel M. Bovine lactoferrin decreases histopathological changes in the liver and regulates cytokine production by splenocytes of obstructive jaundiced rats. Inflamm Res (2003) 52:305-10. doi:10.1007/s00011-003-1178-4
    • (2003) Inflamm Res , vol.52 , pp. 305-310
    • Zimecki, M.1    Dawiskiba, J.2    Zawirska, B.3    Krawczyk, Z.4    Kruzel, M.5
  • 110
    • 0036089589 scopus 로고    scopus 로고
    • Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance
    • Togawa J, Nagase H, Tanaka K, Inamori M, Umezawa T, Nakajima A, et al. Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. Am J Physiol Gastrointest Liver Physiol (2002) 283:G187-95. doi:10.1152/ajpgi.00331.2001
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283 , pp. G187-G195
    • Togawa, J.1    Nagase, H.2    Tanaka, K.3    Inamori, M.4    Umezawa, T.5    Nakajima, A.6
  • 111
    • 84883386698 scopus 로고    scopus 로고
    • Determination of the effects of lactoferrin in a preclinical mouse model of experimental colitis
    • Li L, Ren F, Yun Z, An Y, Wang C, Yan X. Determination of the effects of lactoferrin in a preclinical mouse model of experimental colitis. Mol Med Rep (2013) 8:1125-9. doi:10.3892/mmr.2013.1632
    • (2013) Mol Med Rep , vol.8 , pp. 1125-1129
    • Li, L.1    Ren, F.2    Yun, Z.3    An, Y.4    Wang, C.5    Yan, X.6
  • 112
    • 85031325878 scopus 로고    scopus 로고
    • VEN-120, a recombinant human lactoferrin, promotes a regulatory T cell (Treg) phenotype and drives resolution of inflammation in distinct murine models of inflammatory bowel disease
    • MacManus CF, Collins CB, Nguyen TT, Alfano RW, Jedlicka P, de Zoeten EF. VEN-120, a recombinant human lactoferrin, promotes a regulatory T cell (Treg) phenotype and drives resolution of inflammation in distinct murine models of inflammatory bowel disease. J Crohns Colitis (2017) 11(9):1101-12. doi:10.1093/ecco-jcc/jjx056
    • (2017) J Crohns Colitis , vol.11 , Issue.9 , pp. 1101-1112
    • MacManus, C.F.1    Collins, C.B.2    Nguyen, T.T.3    Alfano, R.W.4    Jedlicka, P.5    de Zoeten, E.F.6
  • 113
    • 84867220710 scopus 로고    scopus 로고
    • Oral administration of lactoferrin attenuates intestinal ischemia-reperfusion injury in rats
    • Zhang T, Wang Y, Ban R, Tong L, Qiao H, Lao H, et al. Oral administration of lactoferrin attenuates intestinal ischemia-reperfusion injury in rats. Eur Surg Res (2012) 49:99-106. doi:10.1159/000342633
    • (2012) Eur Surg Res , vol.49 , pp. 99-106
    • Zhang, T.1    Wang, Y.2    Ban, R.3    Tong, L.4    Qiao, H.5    Lao, H.6
  • 114
    • 84920287470 scopus 로고    scopus 로고
    • Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine
    • Iigo M, Alexander DB, Xu J, Futakuchi M, Suzui M, Kozu T, et al. Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine. Biometals (2014) 27:1017-29. doi:10.1007/s10534-014-9747-2
    • (2014) Biometals , vol.27 , pp. 1017-1029
    • Iigo, M.1    Alexander, D.B.2    Xu, J.3    Futakuchi, M.4    Suzui, M.5    Kozu, T.6
  • 116
    • 0033604596 scopus 로고    scopus 로고
    • The epidemic of allergy and asthma
    • Holgate ST. The epidemic of allergy and asthma. Nature (1999) 402:B2-4. doi:10.1038/35037000
    • (1999) Nature , vol.402 , pp. B2-B4
    • Holgate, S.T.1
  • 117
    • 25844507043 scopus 로고    scopus 로고
    • Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis
    • Bacsi A, Dharajiya N, Choudhury BK, Sur S, Boldogh I. Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis. J Allergy Clin Immunol (2005) 116:836-43. doi:10.1016/j.jaci.2005.06.002
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 836-843
    • Bacsi, A.1    Dharajiya, N.2    Choudhury, B.K.3    Sur, S.4    Boldogh, I.5
  • 118
    • 23644456321 scopus 로고    scopus 로고
    • ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation
    • Boldogh I, Bacsi A, Choudhury BK, Dharajiya N, Alam R, Hazra TK, et al. ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest (2005) 115:2169-79. doi:10.1172/JCI24422
    • (2005) J Clin Invest , vol.115 , pp. 2169-2179
    • Boldogh, I.1    Bacsi, A.2    Choudhury, B.K.3    Dharajiya, N.4    Alam, R.5    Hazra, T.K.6
  • 119
    • 4043147798 scopus 로고    scopus 로고
    • Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins
    • Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, et al. Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med (2004) 37:755-67. doi:10.1016/j.freeradbiomed.2004.05.034
    • (2004) Free Radic Biol Med , vol.37 , pp. 755-767
    • Brand, M.D.1    Affourtit, C.2    Esteves, T.C.3    Green, K.4    Lambert, A.J.5    Miwa, S.6
  • 120
    • 0029893572 scopus 로고    scopus 로고
    • Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung
    • Gutteridge JM, Mumby S, Quinlan GJ, Chung KF, Evans TW. Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung. Biochem Biophys Res Commun (1996) 220:1024-7. doi:10.1006/bbrc.1996.0518
    • (1996) Biochem Biophys Res Commun , vol.220 , pp. 1024-1027
    • Gutteridge, J.M.1    Mumby, S.2    Quinlan, G.J.3    Chung, K.F.4    Evans, T.W.5
  • 121
    • 0031866706 scopus 로고    scopus 로고
    • Iron metabolism in the lower respiratory tract
    • Mateos F, Brock JH, Perez-Arellano JL. Iron metabolism in the lower respiratory tract. Thorax (1998) 53:594-600. doi:10.1136/thx.53.7.594
    • (1998) Thorax , vol.53 , pp. 594-600
    • Mateos, F.1    Brock, J.H.2    Perez-Arellano, J.L.3
  • 122
    • 0042885835 scopus 로고    scopus 로고
    • Serum ferritin increases in hemorrhaged rats that develop acute lung injury: effect of an iron-deficient diet
    • Park YY, Hybertson BM, Wright RM, Repine JE. Serum ferritin increases in hemorrhaged rats that develop acute lung injury: effect of an iron-deficient diet. Inflammation (2003) 27:257-63. doi:10.1023/A:1025044732423
    • (2003) Inflammation , vol.27 , pp. 257-263
    • Park, Y.Y.1    Hybertson, B.M.2    Wright, R.M.3    Repine, J.E.4
  • 123
    • 0031093227 scopus 로고    scopus 로고
    • Role of iron in ischemia-reperfusion oxidative injury of rat lungs
    • Zhao G I, Ayene S, Fisher AB. Role of iron in ischemia-reperfusion oxidative injury of rat lungs. Am J Respir Cell Mol Biol (1997) 16:293-9. doi:10.1165/ajrcmb.16.3.9070614
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 293-299
    • Zhao, G.I.1    Ayene, S.2    Fisher, A.B.3
  • 125
    • 84888405764 scopus 로고    scopus 로고
    • Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms
    • Wang SB, Deng YQ, Ren J, Xiao BK, Chen Z, Tao ZZ. Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms. Scand J Immunol (2013) 78:507-15. doi:10.1111/sji.12118
    • (2013) Scand J Immunol , vol.78 , pp. 507-515
    • Wang, S.B.1    Deng, Y.Q.2    Ren, J.3    Xiao, B.K.4    Chen, Z.5    Tao, Z.Z.6
  • 127
    • 84953897324 scopus 로고    scopus 로고
    • Lactoferrin: a modulator for immunity against tuberculosis related granulomatous pathology
    • Actor JK. Lactoferrin: a modulator for immunity against tuberculosis related granulomatous pathology. Mediators Inflamm (2015) 2015:409596. doi:10.1155/2015/409596
    • (2015) Mediators Inflamm , vol.2015
    • Actor, J.K.1
  • 128
    • 0025914111 scopus 로고
    • Immunostimulatory activity of lactotransferrin and maturation of CD4-CD8-murine thymocytes
    • Zimecki M, Mazurier J, Machnicki M, Wieczorek Z, Montreuil J, Spik G. Immunostimulatory activity of lactotransferrin and maturation of CD4-CD8-murine thymocytes. Immunol Lett (1991) 30:119-23. doi:10.1016/0165-2478(91)90099-V
    • (1991) Immunol Lett , vol.30 , pp. 119-123
    • Zimecki, M.1    Mazurier, J.2    Machnicki, M.3    Wieczorek, Z.4    Montreuil, J.5    Spik, G.6
  • 129
    • 33750183408 scopus 로고    scopus 로고
    • A complex of lactoferrin with monophosphoryl lipid A is an efficient adjuvant of the humoral and cellular immune response in mice
    • Chodaczek G, Zimecki M, Lukasiewicz J, Lugowski C. A complex of lactoferrin with monophosphoryl lipid A is an efficient adjuvant of the humoral and cellular immune response in mice. Med Microbiol Immunol (2006) 195:207-16. doi:10.1007/s00430-006-0020-3
    • (2006) Med Microbiol Immunol , vol.195 , pp. 207-216
    • Chodaczek, G.1    Zimecki, M.2    Lukasiewicz, J.3    Lugowski, C.4
  • 130
    • 84655163938 scopus 로고    scopus 로고
    • Comparing efficacy of BCG/lactoferrin primary vaccination versus booster regimen
    • Hwang SA, Welsh KJ, Boyd S, Kruzel ML, Actor JK. Comparing efficacy of BCG/lactoferrin primary vaccination versus booster regimen. Tuberculosis (2011) 91(Suppl 1):S90-5. doi:10.1016/j.tube.2011.10.017
    • (2011) Tuberculosis , vol.91 , pp. S90-S95
    • Hwang, S.A.1    Welsh, K.J.2    Boyd, S.3    Kruzel, M.L.4    Actor, J.K.5
  • 131
    • 84895927078 scopus 로고    scopus 로고
    • Lactoferrin augmentation of the BCG vaccine leads to increased pulmonary integrity
    • Hwang SA, Welsh KJ, Kruzel ML, Actor JK. Lactoferrin augmentation of the BCG vaccine leads to increased pulmonary integrity. Tuberc Res Treat (2011) 2011:835410. doi:10.1155/2011/835410
    • (2011) Tuberc Res Treat , vol.2011
    • Hwang, S.A.1    Welsh, K.J.2    Kruzel, M.L.3    Actor, J.K.4
  • 132
    • 67349256155 scopus 로고    scopus 로고
    • A novel recombinant human lactoferrin augments the BCG vaccine and protects alveolar integrity upon infection with Mycobacterium tuberculosis in mice
    • Hwang SA, Wilk K, Kruzel ML, Actor JK. A novel recombinant human lactoferrin augments the BCG vaccine and protects alveolar integrity upon infection with Mycobacterium tuberculosis in mice. Vaccine (2009) 27:3026-34. doi:10.1016/j.vaccine.2009.03.036
    • (2009) Vaccine , vol.27 , pp. 3026-3034
    • Hwang, S.A.1    Wilk, K.2    Kruzel, M.L.3    Actor, J.K.4
  • 133
    • 72049096356 scopus 로고    scopus 로고
    • Lactoferrin enhances efficacy of the BCG vaccine: comparison between two inbred mice strains (C57BL/6 and BALB/c)
    • Hwang SA, Arora R, Kruzel ML, Actor JK. Lactoferrin enhances efficacy of the BCG vaccine: comparison between two inbred mice strains (C57BL/6 and BALB/c). Tuberculosis (2009) 89(Suppl 1):S49-54. doi:10.1016/S1472-9792(09)70012-5
    • (2009) Tuberculosis , vol.89 , pp. S49-S54
    • Hwang, S.A.1    Arora, R.2    Kruzel, M.L.3    Actor, J.K.4
  • 134
    • 0029582878 scopus 로고
    • Lactoferrin lowers the incidence of positive Coombs' test in New Zealand black mice
    • Zimecki M, Wieczorek Z, Mazurier J, Spik G. Lactoferrin lowers the incidence of positive Coombs' test in New Zealand black mice. Arch Immunol Ther Exp (1995) 43:207-9
    • (1995) Arch Immunol Ther Exp , vol.43 , pp. 207-209
    • Zimecki, M.1    Wieczorek, Z.2    Mazurier, J.3    Spik, G.4
  • 135
    • 0017708214 scopus 로고
    • The role of prostaglandins in the control of the immune response to an autologous red blood cell antigen (Hb)
    • Zimecki M, Webb DR Jr. The role of prostaglandins in the control of the immune response to an autologous red blood cell antigen (Hb). Clin Immunol Immunopathol (1977) 8:420-9. doi:10.1016/0090-1229(77)90006-X
    • (1977) Clin Immunol Immunopathol , vol.8 , pp. 420-429
    • Zimecki, M.1    Webb, D.R.2
  • 136
    • 33845881154 scopus 로고    scopus 로고
    • Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats
    • Zimecki M, Kocieba M, Chodaczek G, Houszka M, Kruzel ML. Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats. J Neuroimmunol (2007) 182:160-6. doi:10.1016/j.jneuroim.2006.10.008
    • (2007) J Neuroimmunol , vol.182 , pp. 160-166
    • Zimecki, M.1    Kocieba, M.2    Chodaczek, G.3    Houszka, M.4    Kruzel, M.L.5
  • 138
    • 37849030667 scopus 로고    scopus 로고
    • Bovine lactoferrin protects RSC96 Schwann cells from tumor necrosis factor-alpha-induced growth arrest via extracellular-signal-regulated kinase 1/2
    • Lin TY, Kuo CD. Bovine lactoferrin protects RSC96 Schwann cells from tumor necrosis factor-alpha-induced growth arrest via extracellular-signal-regulated kinase 1/2. Neuroscience (2008) 151:396-402. doi:10.1016/j.neuroscience.2007.10.018
    • (2008) Neuroscience , vol.151 , pp. 396-402
    • Lin, T.Y.1    Kuo, C.D.2
  • 139
    • 0030010950 scopus 로고    scopus 로고
    • Lactoferrin inhibits proliferative response and cytokine production of TH1 but not TH2 cell lines
    • Zimecki M, Mazurier J, Spik G, Kapp JA. Lactoferrin inhibits proliferative response and cytokine production of TH1 but not TH2 cell lines. Arch Immunol Ther Exp (1996) 44:51-6
    • (1996) Arch Immunol Ther Exp , vol.44 , pp. 51-56
    • Zimecki, M.1    Mazurier, J.2    Spik, G.3    Kapp, J.A.4
  • 140
    • 84867942037 scopus 로고    scopus 로고
    • Effects of lactoferrin on elicitation of the antigen-specific cellular and humoral cutaneous response in mice
    • Zimecki M, Artym J, Kocieba M, Kruzel M. Effects of lactoferrin on elicitation of the antigen-specific cellular and humoral cutaneous response in mice. Postepy Hig Med Dosw (2012) 66:16-22. doi:10.5604/17322693.975145
    • (2012) Postepy Hig Med Dosw , vol.66 , pp. 16-22
    • Zimecki, M.1    Artym, J.2    Kocieba, M.3    Kruzel, M.4
  • 141
    • 77950625993 scopus 로고    scopus 로고
    • Lactoferrin protects against concanavalin A-induced liver injury in mice
    • Yin H, Cheng L, Agarwal C, Agarwal R, Ju C. Lactoferrin protects against concanavalin A-induced liver injury in mice. Liver Int (2010) 30:623-32. doi:10.1111/j.1478-3231.2009.02199.x
    • (2010) Liver Int , vol.30 , pp. 623-632
    • Yin, H.1    Cheng, L.2    Agarwal, C.3    Agarwal, R.4    Ju, C.5
  • 142
    • 0027276711 scopus 로고
    • Protective effect of lactoferrin on caerulein-induced acute pancreatitis in rats
    • Koike D, Makino I. Protective effect of lactoferrin on caerulein-induced acute pancreatitis in rats. Digestion (1993) 54:84-90. doi:10.1159/000201018
    • (1993) Digestion , vol.54 , pp. 84-90
    • Koike, D.1    Makino, I.2
  • 143
    • 4344694236 scopus 로고    scopus 로고
    • Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo
    • Cornish J, Callon KE, Naot D, Palmano KP, Banovic T, Bava U, et al. Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology (2004) 145:4366-74. doi:10.1210/en.2003-1307
    • (2004) Endocrinology , vol.145 , pp. 4366-4374
    • Cornish, J.1    Callon, K.E.2    Naot, D.3    Palmano, K.P.4    Banovic, T.5    Bava, U.6
  • 144
    • 84867203022 scopus 로고    scopus 로고
    • Bovine lactoferrin improves bone mass and microstructure in ovariectomized rats via OPG/RANKL/RANK pathway
    • Hou JM, Xue Y, Lin QM. Bovine lactoferrin improves bone mass and microstructure in ovariectomized rats via OPG/RANKL/RANK pathway. Acta Pharmacol Sin (2012) 33:1277-84. doi:10.1038/aps.2012.83
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1277-1284
    • Hou, J.M.1    Xue, Y.2    Lin, Q.M.3
  • 145
  • 146
    • 0027515007 scopus 로고
    • Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo
    • Machnicki M, Zimecki M, Zagulski T. Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo. Int J Exp Pathol (1993) 74:433-9
    • (1993) Int J Exp Pathol , vol.74 , pp. 433-439
    • Machnicki, M.1    Zimecki, M.2    Zagulski, T.3
  • 147
    • 34548248672 scopus 로고    scopus 로고
    • Lactoferrin enhanced efficacy of the BCG vaccine to generate host protective responses against challenge with virulent Mycobacterium tuberculosis
    • Hwang SA, Wilk KM, Budnicka M, Olsen M, Bangale YA, Hunter RL, et al. Lactoferrin enhanced efficacy of the BCG vaccine to generate host protective responses against challenge with virulent Mycobacterium tuberculosis. Vaccine (2007) 25:6730-43. doi:10.1016/j.vaccine.2007.07.005
    • (2007) Vaccine , vol.25 , pp. 6730-6743
    • Hwang, S.A.1    Wilk, K.M.2    Budnicka, M.3    Olsen, M.4    Bangale, Y.A.5    Hunter, R.L.6
  • 148
    • 85012092891 scopus 로고    scopus 로고
    • Oral recombinant human or mouse lactoferrin reduces Mycobacterium tuberculosis TDM induced granulomatous lung pathology
    • Hwang S-A, Kruzel ML, Actor JK. Oral recombinant human or mouse lactoferrin reduces Mycobacterium tuberculosis TDM induced granulomatous lung pathology. Biochem Cell Biol (2017) 95(1):148-54. doi:10.1139/bcb-2016-0061
    • (2017) Biochem Cell Biol , vol.95 , Issue.1 , pp. 148-154
    • Hwang, S.-A.1    Kruzel, M.L.2    Actor, J.K.3
  • 149
    • 0028034634 scopus 로고
    • Lactoferrin interaction with salmonellae potentiates antibiotic susceptibility in vitro
    • Naidu AS, Arnold RR. Lactoferrin interaction with salmonellae potentiates antibiotic susceptibility in vitro. Diagn Microbiol Infect Dis (1994) 20:69-75. doi:10.1016/0732-8893(94)90094-9
    • (1994) Diagn Microbiol Infect Dis , vol.20 , pp. 69-75
    • Naidu, A.S.1    Arnold, R.R.2
  • 150
    • 0031464369 scopus 로고    scopus 로고
    • MICs of rifampicin and chloramphenicol for mucoid Pseudomonas aeruginosa strains are lower when human lactoferrin is present
    • Fowler CE, Soothill JS, Oakes L. MICs of rifampicin and chloramphenicol for mucoid Pseudomonas aeruginosa strains are lower when human lactoferrin is present. J Antimicrob Chemother (1997) 40:877-9. doi:10.1093/jac/40.6.877
    • (1997) J Antimicrob Chemother , vol.40 , pp. 877-879
    • Fowler, C.E.1    Soothill, J.S.2    Oakes, L.3
  • 151
    • 0033087374 scopus 로고    scopus 로고
    • Enhancement of the activity of novobiocin against Escherichia coli by lactoferrin
    • Sanchez MS, Watts JL. Enhancement of the activity of novobiocin against Escherichia coli by lactoferrin. J Dairy Sci (1999) 82:494-9. doi:10.3168/jds.S0022-0302(99)75259-8
    • (1999) J Dairy Sci , vol.82 , pp. 494-499
    • Sanchez, M.S.1    Watts, J.L.2
  • 153
    • 58149121478 scopus 로고    scopus 로고
    • Effect of lactoferrin on enteric pathogens
    • Ochoa TJ, Cleary TG. Effect of lactoferrin on enteric pathogens. Biochimie (2009) 91:30-4. doi:10.1016/j.biochi.2008.04.006
    • (2009) Biochimie , vol.91 , pp. 30-34
    • Ochoa, T.J.1    Cleary, T.G.2
  • 154
  • 155
    • 28344457682 scopus 로고    scopus 로고
    • Lactoferrin: an important host defence against microbial and viral attack
    • Valenti P, Antonini G. Lactoferrin: an important host defence against microbial and viral attack. Cell Mol Life Sci (2005) 62:2576-87. doi:10.1007/s00018-005-5372-0
    • (2005) Cell Mol Life Sci , vol.62 , pp. 2576-2587
    • Valenti, P.1    Antonini, G.2
  • 156
    • 84896324507 scopus 로고    scopus 로고
    • Immunomodulatory effects of recombinant lactoferrin during MRSA infection
    • Hwang SA, Kruzel ML, Actor JK. Immunomodulatory effects of recombinant lactoferrin during MRSA infection. Int Immunopharmacol (2014) 20:157-63. doi:10.1016/j.intimp.2014.02.029
    • (2014) Int Immunopharmacol , vol.20 , pp. 157-163
    • Hwang, S.A.1    Kruzel, M.L.2    Actor, J.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.