Oral recombinant human or mouse lactoferrin reduces Mycobacterium tuberculosis TDM induced granulomatous lung pathology1

Biochemistry and Cell Biology

Volumn 95, Issue 1, 2017, Pages 148-154

  Hwang, Shen An ^a   Kruzel, Marian L ^a   Actor, Jeffrey K ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Human lactoferrin; Mouse lactoferrin; Trehalose dimycolate

Indexed keywords

BIOLOGICAL ORGANS; PATHOLOGY;

CYTOKINE PRODUCTION; HUMAN LACTOFERRIN; LACTOFERRIN; LUNG PATHOLOGY; MOUSE MODELS; MYCOBACTERIUM TUBERCULOSIS; REDUCED PRODUCTION; TREHALOSE DIMYCOLATE;

MAMMALS;

CORD FACTOR; CXCL1 CHEMOKINE; INTERLEUKIN 12P40; INTERLEUKIN 6; LACTOFERRIN; RECOMBINANT PROTEIN; CYTOKINE; LTF PROTEIN, HUMAN; LTF PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; LEUKOCYTE MIGRATION; LUNG GRANULOMATOSIS; LUNG PARENCHYMA; LUNG TUBERCULOSIS; LUNG WEIGHT; MACROPHAGE; MOUSE; NONHUMAN; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; GRANULOMA; HUMAN; LUNG DISEASES; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; ORAL DRUG ADMINISTRATION; PATHOLOGY; TUBERCULOSIS;

ADMINISTRATION, ORAL; ANIMALS; CORD FACTORS; CYTOKINES; FEMALE; GRANULOMA; HUMANS; LACTOFERRIN; LUNG DISEASES; MACROPHAGES; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; RECOMBINANT PROTEINS; TUBERCULOSIS;

EID: 85012092891     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/bcb-2016-0061     Document Type: Article

References (42)

1. Abbott A.N. Guidry T.V. Welsh K.J. Thomas A.M. Kling M.A. Hunter R.L. Actor J.K. 2009. 11β-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6′-dimycolate. NeuroImmunoModulation, 16 (3): 147-154. 10.1159/000204227. 19246936
2. Abdi K. Singh N.J. 2015. Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines. Cytokine, 76 (1): 53-57. 10.1016/j.cyto.2015.07.026. 26242928
3. Actor J.K. 2015. Lactoferrin: a modulator for immunity against tuberculosis related granulomatous pathology. Mediators Inflammation, 2015: 409596. 10.1155/2015/409596. 26788020
4. Actor J.K. Indrigo J. Beachdel C.M. Olsen M. Wells A. Hunter R.L. Jr. Dasgupta A. 2002. Mycobacterial glycolipid cord factor trehalose 6,6′-dimycolate causes a decrease in serum cortisol during the granulomatous response. NeuroImmunoModulation, 10 (5): 270-282. 10.1159/000069971. 12759564
5. Ahsan M.J. 2015. Recent advances in the development of vaccines for tuberculosis. Ther. Adv. Vaccines, 3 (3): 66-75. 10.1177/2051013615593891. 26288734
6. Blazek K. Eames H.L. Weiss M. Byrne A.J. Perocheau D. Pease J.E. et al 2015. IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production. J. Exp. Med. 212 (6): 845-853. 10.1084/jem.20140995. 25941255
7. Donnachie E. Fedotova E.P. Hwang S.-A. 2016. Trehalose 6,6-dimycolate from Mycobacterium tuberculosis induces hypercoagulation. Am. J. Pathol. 186 (5): 1221-1233. 10.1016/j.ajpath.2015.12.019. 26968340
8. Doursout M.-F. Horton H. Hoang L. Liang Y. Hwang S.-A. Boyd S. et al 2013. Lactoferrin moderates LPS-induced hypotensive response and gut injury in rats. Int. Immunopharmacol. 15 (2): 227-231. 10.1016/j.intimp.2012.12.009. 23267765
9. Guidry T.V. Hunter R.L. Jr. Actor J.K. 2006. CD3+ cells transfer the hypersensitive granulomatous response to mycobacterial glycolipid trehalose 6,6′-dimycolate in mice. Microbiology, 152 (. Pt 12): 3765-3775. 10.1099/mic.0.29290-0. 17159227
10. Guidry T.V. Hunter R.L. Jr. Actor J.K. 2007. Mycobacterial glycolipid trehalose 6,6′-dimycolate-induced hypersensitive granulomas: contribution of CD4+ lymphocytes. Microbiology, 153 (. Pt 10): 3360-3369. 10.1099/mic.0.2007/010850-0. 17906135
11. Guidry T.V. Olsen M. Kil K.-S. Hunter R.L. Jr. Geng Y.-J. Actor J.K. 2004. Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6′-dimycolate. J. Interferon Cytokine Res. 24 (6): 362-371. 10.1089/107999004323142222. 15212710
12. Hunter R.L. Armitige L. Jagannath C. Actor J.K. 2009. TB research at UT-Houston-a review of cord factor: new approaches to drugs, vaccines and the pathogenesis of tuberculosis. Tuberculosis (Edinb), 89 (Suppl. 1): S18-S25. 10.1016/S1472-9792(09)70007-1. 20006299
13. Hwang S.-A. Actor J.K. 2009. Lactoferrin modulation of BCG-infected dendritic cell functions. Int. Immunol. 21 (10): 1185-1197. 10.1093/intimm/dxp084. 19692539
14. Hwang S.-A. Kruzel M.L. Actor J.K. 2005. Lactoferrin augments BCG vaccine efficacy to generate T helper response and subsequent protection against challenge with virulent Mycobacterium tuberculosis. Int. Immunopharmacol. 5 (3): 591-599. 10.1016/j.intimp.2004.11.006. 15683854
15. Hwang S.-A. Wilk K.M. Bangale Y.A. Kruzel M.L. Actor J.K. 2007 a. Lactoferrin modulation of IL-12 and IL-10 response from activated murine leukocytes. Med. Microbiol. Immunol. 196 (3): 171-180. 10.1007/s00430-007-0041-6. 17377816
16. Hwang S.-A. Wilk K.M. Budnicka M. Olsen M. Bangale Y.A. Hunter R.L. et al 2007 b. Lactoferrin enhanced efficacy of the BCG vaccine to generate host protective responses against challenge with virulent Mycobacterium tuberculosis. Vaccine, 25 (37-38): 6730-6743. 10.1016/j.vaccine.2007.07.005. 17698261
17. Hwang S.-A. Arora R. Kruzel M.L. Actor J.K. 2009 a. Lactoferrin enhances efficacy of the BCG vaccine: comparison between two inbred mice strains (C57BL/6 and BALB/c). Tuberculosis (Edinb), 89 (Suppl. 1): S49-S54. 10.1016/S1472-9792(09)70012-5. 20006305
18. Hwang S.-A. Kruzel M.L. Actor J.K. 2009 b. Influence of bovine lactoferrin on expression of presentation molecules on BCG-infected bone marrow derived macrophages. Biochimie, 91 (1): 76-85. 10.1016/j.biochi.2008.04.008. 18486627
19. Hwang S.-A. Wilk K. Kruzel M.L. Actor J.K. 2009 c. A novel recombinant human lactoferrin augments the BCG vaccine and protects alveolar integrity upon infection with Mycobacterium tuberculosis in mice. Vaccine, 27 (23): 3026-3034. 10.1016/j.vaccine.2009.03.036. 19428915
20. Hwang S.-A. Welsh K.J. Boyd S. Kruzel M.L. Actor J.K. 2011 a. Comparing efficacy of BCG/lactoferrin primary vaccination versus booster regimen. Tuberculosis (Edinb), 91 (Suppl. 1): S90-S95. 10.1016/j.tube.2011.10.017. 22088320
21. Hwang S.-A. Welsh K.J. Kruzel M.L. Actor J.K. 2011 b. Lactoferrin augmentation of the BCG vaccine leads to increased pulmonary integrity. Tuberc. Res. Treat. 2011: 835410. 10.1155/2011/835410. 22567270
22. Hwang S.-A. Kruzel M.L. Actor J.K. 2015. Effects of CHO-expressed recombinant lactoferrins on mouse dendritic cell presentation and function. Innate Immun. 21 (5): 553-561. 10.1177/1753425914564609. 25537452
23. Indrigo J. Hunter R.L. Jr. Actor J.K. 2002. Influence of trehalose 6,6′-dimycolate (TDM) during mycobacterial infection of bone marrow macrophages. Microbiology, 148 (. Pt 7): 1991-1998. 10.1099/00221287-148-7-1991. 12101287
24. Indrigo J. Hunter R.L. Jr. Actor J.K. 2003. Cord factor trehalose 6,6′-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages. Microbiology, 149 (. Pt 8): 2049-2059. 10.1099/mic.0.26226-0. 12904545
25. Karmakar M. Katsnelson M. Malak H.A. Greene N.G. Howell S.J. Hise A.G. et al 2015. Neutrophil IL-1beta processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J. Immunol. 194 (4): 1763-1775. 10.4049/jimmunol.1401624. 25609842
26. Kim S.J. Yu D.Y. Pak K.W. Jeong S. Kim S.W. Lee K.K. 1998. Structure of the human lactoferrin gene and its chromosomal localization. Mol. Cells, 8 (6): 663-668. 9895117
27. Korb V.C. Chuturgoon A.A. Moodley D. 2016. Mycobacterium tuberculosis: manipulator of protective immunity. Int. J. Mol. Sci. 17 (3): 131. 10.3390/ijms17030131. 26927066
28. Kruzel M.L. Actor J.K. Zimecki M. Wise J. Płoszaj P. Mirza S. et al 2013. Novel recombinant human lactoferrin: differential activation of oxidative stress related gene expression. J. Biotechnol. 168 (4): 666-675. 10.1016/j.jbiotec.2013.09.011. 24070904
29. Lee W.-B. Kang J.-S. Yan J.-J. Lee M.S. Jeon B.-Y. Cho S.-N. Kim Y.-J. 2012. Neutrophils promote mycobacterial trehalose dimycolate-induced lung inflammation via the Mincle pathway. PLoS Pathog. 8 (4): e1002614. 10.1371/journal.ppat.1002614. 22496642
30. McMullen A.M. Hwang S.-A. O'Shea K. Aliru M.L. Actor J.K. 2013. Evidence for a unique species-specific hypersensitive epitope in Mycobacterium tuberculosis derived cord factor. Tuberculosis (Edinb), 93 (Suppl.): S88-S93. 10.1016/S1472-9792(13)70017-9
31. Netea M.G. Simon A. van de Veerdonk F. Kullberg B.-J. Van der Meer J.W.M. Joosten L.A.B. 2010. IL-1β processing in host defense: beyond the inflammasomes. PLoS Pathog. 6 (2): e1000661. 10.1371/journal.ppat.1000661. 20195505
32. O'Garra A. Redford P.S. McNab F.W. Bloom C.I. Wilkinson R.J. Berry M.P.R. 2013. The immune response in tuberculosis. Annu. Rev. Immunol. 31: 475-527. 10.1146/annurev-immunol-032712-095939. 23516984
33. O'Shea K.M. Hwang S.-A. Actor J.K. 2015. Immune activity of BCG infected mouse macrophages treated with a novel recombinant mouse lactoferrin. Ann. Clin. Lab. Sci. 45 (5): 487-494. 26586698
34. Perez R.L. Roman J. Roser S. Little C. Olsen M. Indrigo J. et al 2000. Cytokine message and protein expression during lung granuloma formation and resolution induced by the mycobacterial cord factor trehalose-6,6′-dimycolate. J. Interferon Cytokine Res. 20 (9): 795-804. 10.1089/10799900050151067. 11032399
35. Rossol M. Heine H. Meusch U. Quandt D. Klein C. Sweet M.J. Hauschildt S. 2011. LPS-induced cytokine production in human monocytes and macrophages. Crit. Rev. Immunol. 31 (5): 379-446. 10.1615/CritRevImmunol.v31.i5.20. 22142165
36. Welsh K.J. Abbott A.N. Hwang S.-A. Indrigo J. Armitige L.Y. Blackburn M.R. et al 2008. A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6′-dimycolate induced granulomatous response. Microbiology, 154 (. Pt 6): 1813-1824. 10.1099/mic.0.2008/016923-0. 18524936
37. Welsh K.J. Hwang S.-A. Hunter R.L. Kruzel M.L. Actor J.K. 2010. Lactoferrin modulation of mycobacterial cord factor trehalose 6-6′-dimycolate induced granulomatous response. Transl. Res. 156 (4): 207-215. 10.1016/j.trsl.2010.06.001. 20875896
38. Welsh K.J. Hwang S.-A. Boyd S. Kruzel M.L. Hunter R.L. Actor J.K. 2011. Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology. Tuberculosis (Edinb), 91 (Suppl. 1): S105-S113. 10.1016/j.tube.2011.10.019. 22138562
39. Welsh K.J. Hunter R.L. Actor J.K. 2013. Trehalose 6,6′-dimycolate-a coat to regulate tuberculosis immunopathogenesis. Tuberculosis (Edinb), 93 (Suppl.): S3-S9. 10.1016/S1472-9792(13)70003-9
40. WHO. 2015. Global tuberculosis report 2015 [online]. Available from http://apps.who.int/iris/bitstream/10665/191102/1/9789241565059-eng.pdf?ua=1 [accessed 16 June 2016]
41. Wilk K.M. Hwang S.-A. Actor J.K. 2007. Lactoferrin modulation of antigen-presenting-cell response to BCG infection. Postepy Hig. Med. Dosw. (Online), 61: 277-282. 17507876
42. Zimecki M. Artym J. Kociba M. Kaleta-Kuratewicz K. Kuropka P. Kuryszko J. Kruzel M. 2013. Homologous lactoferrin triggers mobilization of the myelocytic lineage of bone marrow in experimental mice. Stem Cells Dev. 22 (24): 3261-3270. 10.1089/scd.2013.0242. 23879888