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Volumn 66, Issue 2, 1998, Pages 486-491

Lactoferrin inhibits the endotoxin interaction with CD14 by competition with the lipopolysaccharide-binding protein

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CD14 ANTIGEN; ESCHERICHIA COLI ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLYCOPROTEIN; LACTOFERRIN;

EID: 0031883875     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.2.486-491.1998     Document Type: Article
Times cited : (169)

References (53)
  • 2
    • 0024389662 scopus 로고
    • Structure of human lactoferrin: Crystallographic structure analysis and refinement at 2.8 Å resolution
    • Andersen, B. F., H. M. Baker, G. E. Norris, D. W. Rice, and E. N. Baker. 1989. Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 Å resolution. J. Mol. Biol. 209:711-734.
    • (1989) J. Mol. Biol. , vol.209 , pp. 711-734
    • Andersen, B.F.1    Baker, H.M.2    Norris, G.E.3    Rice, D.W.4    Baker, E.N.5
  • 5
    • 0002120690 scopus 로고
    • Iron and cells of the immune system
    • M. de Souza and J. Brock (ed.). John Wiley and Sons, Chichester, England
    • Brock, J. 1986. Iron and cells of the immune system, p. 81-98. In M. de Souza and J. Brock (ed.), Iron in immunity, cancer and inflammation. John Wiley and Sons, Chichester, England.
    • (1986) Iron in Immunity, Cancer and Inflammation , pp. 81-98
    • Brock, J.1
  • 6
    • 0026463507 scopus 로고
    • Interaction of lactoferrin and lipopolysaccharide: Effects on the antioxidant property of lactoferrin and the ability of lipopolysaccharide to prime human neutrophils for enhanced Superoxide anion
    • Cohen, M. S., J. Mao, G. T. Rasmusen, J. S. Serody, and B. E. Britigan. 1992. Interaction of lactoferrin and lipopolysaccharide: effects on the antioxidant property of lactoferrin and the ability of lipopolysaccharide to prime human neutrophils for enhanced Superoxide anion. J. Infect. Dis. 166:1375-1378.
    • (1992) J. Infect. Dis. , vol.166 , pp. 1375-1378
    • Cohen, M.S.1    Mao, J.2    Rasmusen, G.T.3    Serody, J.S.4    Britigan, B.E.5
  • 7
    • 0026716209 scopus 로고
    • Regulation of cytokine release from mononuclear cells by the iron-binding protein lactoferrin
    • Crouch, S. M., K. J. Slater, and J. Fletcher. 1992. Regulation of cytokine release from mononuclear cells by the iron-binding protein lactoferrin. Blood 80:235-240.
    • (1992) Blood , vol.80 , pp. 235-240
    • Crouch, S.M.1    Slater, K.J.2    Fletcher, J.3
  • 8
    • 0027495168 scopus 로고
    • Antagonistic effects of lipopolysaccharide binding protein and bactericidal/increasing permeability protein on LPS induced cytokine release by mononuclear phagocytes
    • Dentener, M. A., E. J. U. von Asmuth, G. J. M. Fraucot, M. N. Marra, and W. A. Buurman. 1993. Antagonistic effects of lipopolysaccharide binding protein and bactericidal/increasing permeability protein on LPS induced cytokine release by mononuclear phagocytes. J. Immunol. 151:4258-4265.
    • (1993) J. Immunol. , vol.151 , pp. 4258-4265
    • Dentener, M.A.1    Von Asmuth, E.J.U.2    Fraucot, G.J.M.3    Marra, M.N.4    Buurman, W.A.5
  • 9
    • 0029892231 scopus 로고    scopus 로고
    • Processes underlying interactions of human lactoferrin with the Jurkat human lymphoblastic T-cell line receptor. I. Quantitative structure affinity relationships studies
    • Elass, A., G. Vergoten, D. Legrand, J. Mazurier, E. Elass-Rochard, and G. Spik. 1996. Processes underlying interactions of human lactoferrin with the Jurkat human lymphoblastic T-cell line receptor. I. Quantitative structure affinity relationships studies. Quant. Struct. Act. Relat. 15:95-101.
    • (1996) Quant. Struct. Act. Relat. , vol.15 , pp. 95-101
    • Elass, A.1    Vergoten, G.2    Legrand, D.3    Mazurier, J.4    Elass-Rochard, E.5    Spik, G.6
  • 10
    • 0029924561 scopus 로고    scopus 로고
    • Processes underlying interactions of human lactoferrin with the Jurkat human lymphoblastic T-cell line receptor. II. Comparative molecular field analysis
    • Elass, A., G. Vergoten, D. Legrand, J. Mazurier, E. Elass-Rochard, and G. Spik. 1996. Processes underlying interactions of human lactoferrin with the Jurkat human lymphoblastic T-cell line receptor. II. Comparative molecular field analysis. Quant. Struct. Act. Relat. 15:102-107.
    • (1996) Quant. Struct. Act. Relat. , vol.15 , pp. 102-107
    • Elass, A.1    Vergoten, G.2    Legrand, D.3    Mazurier, J.4    Elass-Rochard, E.5    Spik, G.6
  • 11
    • 0029620277 scopus 로고
    • Lactoferrin-LPS interactions: Involvement of the 28-34 loop region of human lactoferrin in the high-affinity binding to Escherichia coli 055:B5 lipopolysaccharides
    • Elass-Rochard, E., A. Roseanu, D. Legrand, M. Trif, V. Salmon, C. Motas, J. Montreuil, and G. Spik. 1995. Lactoferrin-LPS interactions: involvement of the 28-34 loop region of human lactoferrin in the high-affinity binding to Escherichia coli 055:B5 lipopolysaccharides. Biochem. J. 312:839-845.
    • (1995) Biochem. J. , vol.312 , pp. 839-845
    • Elass-Rochard, E.1    Roseanu, A.2    Legrand, D.3    Trif, M.4    Salmon, V.5    Motas, C.6    Montreuil, J.7    Spik, G.8
  • 12
    • 0029005366 scopus 로고
    • Characterization of the structural elements in lipid A required for binding of a recombinant fragment of bactericidal/permeability-increasing protein
    • Gazzano-Santoro, H., J. B. Parent, P. J. Conlon, H. G. Kasler, C. M. Tsai, D. A. Lill-Elghanian, and R. I. Hollingsworth. 1995. Characterization of the structural elements in lipid A required for binding of a recombinant fragment of bactericidal/permeability-increasing protein. Infect. Immun. 63:2201-2205.
    • (1995) Infect. Immun. , vol.63 , pp. 2201-2205
    • Gazzano-Santoro, H.1    Parent, J.B.2    Conlon, P.J.3    Kasler, H.G.4    Tsai, C.M.5    Lill-Elghanian, D.A.6    Hollingsworth, R.I.7
  • 13
    • 0024327707 scopus 로고
    • Cloning of the cDNA of a human neutrophil bactericidal protein-structure and functional correlations
    • Gray, P. W., G. Flaggs, S. R. Leong, R. J. Gumina, J. Weiss, C. E. Ooi, and P. Elsbach. 1989. Cloning of the cDNA of a human neutrophil bactericidal protein-structure and functional correlations. J. Biol. Chem. 264:9505-9509.
    • (1989) J. Biol. Chem. , vol.264 , pp. 9505-9509
    • Gray, P.W.1    Flaggs, G.2    Leong, S.R.3    Gumina, R.J.4    Weiss, J.5    Ooi, C.E.6    Elsbach, P.7
  • 14
    • 0028286765 scopus 로고
    • Lipopolysaccharide binding protein truncated at Ile-197 binds LPS but does not transfer LPS to CD14
    • Han, J., J. Mathison, R. Ulevitch, and P. S. Tobias. 1994. Lipopolysaccharide binding protein truncated at Ile-197 binds LPS but does not transfer LPS to CD14. J. Biol. Chem. 269:8172-8177.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8172-8177
    • Han, J.1    Mathison, J.2    Ulevitch, R.3    Tobias, P.S.4
  • 15
    • 0027171383 scopus 로고
    • Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5Å resolution
    • Hoess, A., S. Watson, G. R. Siber, and R. Liddington. 1993. Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5Å resolution. EMBO J. 12:3351-3356.
    • (1993) EMBO J. , vol.12 , pp. 3351-3356
    • Hoess, A.1    Watson, S.2    Siber, G.R.3    Liddington, R.4
  • 17
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of hacteriophagc T4
    • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of hacteriophagc T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 18
    • 0026803187 scopus 로고
    • Molecular interactions between human lactoferrin and the PHA-activated human lymphocyte lactoferrin receptor lie in the two loop containing regions of the N-terminal domain I of human lactoferrin
    • Legrand, D., J. Mazurier, A. Elass, E. Rochard, G. Vergoten, P. Maes, J. Montreuil, and G. Spik, 1992. Molecular interactions between human lactoferrin and the PHA-activated human lymphocyte lactoferrin receptor lie in the two loop containing regions of the N-terminal domain I of human lactoferrin. Biochemistry 31:9243-9251.
    • (1992) Biochemistry , vol.31 , pp. 9243-9251
    • Legrand, D.1    Mazurier, J.2    Elass, A.3    Rochard, E.4    Vergoten, G.5    Maes, P.6    Montreuil, J.7    Spik, G.8
  • 19
    • 0029043238 scopus 로고
    • Structural determination of two N-linked glycans isolated from recombinant human lactoferrin expressed in BHK cells
    • Legrand, D., V. Salmon, B. Coddeville, M. Benaissa, Y., Plancke, and G. Spik. 1995. Structural determination of two N-linked glycans isolated from recombinant human lactoferrin expressed in BHK cells. FEES Lett. 365:57-60.
    • (1995) FEES Lett. , vol.365 , pp. 57-60
    • Legrand, D.1    Salmon, V.2    Coddeville, B.3    Benaissa, M.4    Plancke, Y.5    Spik, G.6
  • 20
    • 0030663974 scopus 로고    scopus 로고
    • The N-terminal Arg2, Arg3 and Arg4 of human lactoferrin interact with sulfated molecules but not with the receptor expressed in the Jurkat human lymphoblastic T-cells
    • Legrand, D. L., P. H. C. van Berkel, V. Salmon, H. A. van Veen, M. C. Slomianny, J. H. Nuijens, and G. Spik. 1997. The N-terminal Arg2, Arg3 and Arg4 of human lactoferrin interact with sulfated molecules but not with the receptor expressed in the Jurkat human lymphoblastic T-cells. Biochem. J. 327:841-546.
    • (1997) Biochem. J. , vol.327 , pp. 841-1546
    • Legrand, D.L.1    Van Berkel, P.H.C.2    Salmon, V.3    Van Veen, H.A.4    Slomianny, M.C.5    Nuijens, J.H.6    Spik, G.7
  • 21
    • 0028154017 scopus 로고
    • Functional domains of recombinant bactericidal/increasing permeability protein (rBPI23)
    • Little, R. G., D. N. Kelner, E. Lim, D. J. Burke, and P. J. Colon. 1994. Functional domains of recombinant bactericidal/increasing permeability protein (rBPI23). J. Biol. Chem. 269:1865-1872.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1865-1872
    • Little, R.G.1    Kelner, D.N.2    Lim, E.3    Burke, D.J.4    Colon, P.J.5
  • 22
    • 0027515007 scopus 로고
    • Lactoferrin regulates the release of tumor necrosis factor α, Il-6 in vivo
    • Machnicki, M., M. Zimecki, and T. Zagulski. 1993. Lactoferrin regulates the release of tumor necrosis factor α, Il-6 in vivo. J. Exp. Pathol. 74:433-439.
    • (1993) J. Exp. Pathol. , vol.74 , pp. 433-439
    • Machnicki, M.1    Zimecki, M.2    Zagulski, T.3
  • 23
    • 0027978954 scopus 로고
    • Delineation of the glycosaminoglycan-binding site in the human inflammatory response protein lactoferrin
    • Mann, D. M., E. Romm, and M. Migliorini. 1994. Delineation of the glycosaminoglycan-binding site in the human inflammatory response protein lactoferrin. J. Biol. Chem. 269:23661-23667.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23661-23667
    • Mann, D.M.1    Romm, E.2    Migliorini, M.3
  • 24
    • 0027051652 scopus 로고
    • Lipopolysaccharide-binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide: Implications for cytokine production in normal and injured lungs
    • Martin, T. R., J. C. Mathison, P. S. Tobias, D. J. Letureq, A. M. Moriarty, R. J. Maunder, and R. J. Ulevitch. 1992. Lipopolysaccharide-binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide: implications for cytokine production in normal and injured lungs, J. Clin. Invest. 90:2209-2219.
    • (1992) J. Clin. Invest. , vol.90 , pp. 2209-2219
    • Martin, T.R.1    Mathison, J.C.2    Tobias, P.S.3    Letureq, D.J.4    Moriarty, A.M.5    Maunder, R.J.6    Ulevitch, R.J.7
  • 25
    • 0014574791 scopus 로고
    • Lactoferrin an iron binding protein in neutrophilic leukocytes
    • Masson, P. L., J. F. Heremans, and E. Schönne. 1969. Lactoferrin an iron binding protein in neutrophilic leukocytes. J. Exp. Med. 130:643-656.
    • (1969) J. Exp. Med. , vol.130 , pp. 643-656
    • Masson, P.L.1    Heremans, J.F.2    Schönne, E.3
  • 26
    • 0026740630 scopus 로고
    • Plasma LPS binding protein, a key component in macrophage recognition of gram (-) LPS
    • Mathison, J. C., P. S. Tobias, E. Wolfson, and R. J. Ulevitch. 1992. Plasma LPS binding protein, a key component in macrophage recognition of gram (-) LPS. J. Immunol. 194:200-206.
    • (1992) J. Immunol. , vol.194 , pp. 200-206
    • Mathison, J.C.1    Tobias, P.S.2    Wolfson, E.3    Ulevitch, R.J.4
  • 27
    • 0029888252 scopus 로고    scopus 로고
    • Lactoferrin or a fragment thereof inhibits the endotoxin-induced interleukin 6 response in human monocytic cells
    • Mattsby-Baltzer, I., A. Roseanu, C. Motas, J. Elverfors, I. Engberg, and L. A. Hanson. 1996. Lactoferrin or a fragment thereof inhibits the endotoxin-induced interleukin 6 response in human monocytic cells. Pediatr. Res. 40:257-261.
    • (1996) Pediatr. Res. , vol.40 , pp. 257-261
    • Mattsby-Baltzer, I.1    Roseanu, A.2    Motas, C.3    Elverfors, J.4    Engberg, I.5    Hanson, L.A.6
  • 28
    • 0024586305 scopus 로고
    • Expression of human lactoferrin receptors in PHA-stimulated human peripheral blood lymphocytes: Isolation of the receptors by anti-ligand affinity chromatography
    • Mazurier, J., D. Legrand, W. L. Hu, J. Montreuil, and G. Spik. 1989. Expression of human lactoferrin receptors in PHA-stimulated human peripheral blood lymphocytes: isolation of the receptors by anti-ligand affinity chromatography. Eur. J. Biochem. 179:481-487.
    • (1989) Eur. J. Biochem. , vol.179 , pp. 481-487
    • Mazurier, J.1    Legrand, D.2    Hu, W.L.3    Montreuil, J.4    Spik, G.5
  • 29
    • 0019153180 scopus 로고
    • Comparative study of the iron-binding properties of human transferrins. Complete and sequential iron saturation and desaturation of the lactotransferrin
    • Mazurier, J., and G. Spik. 1980. Comparative study of the iron-binding properties of human transferrins. Complete and sequential iron saturation and desaturation of the lactotransferrin. Biochim. Biophys. Acta 629:399- 408.
    • (1980) Biochim. Biophys. Acta , vol.629 , pp. 399-408
    • Mazurier, J.1    Spik, G.2
  • 30
    • 0001213833 scopus 로고
    • Préparation et propriétés de la lactotransferrine du lait de femme
    • Montreuil, J., J. Tonnelat, and S. Mullet. 1960. Préparation et propriétés de la lactotransferrine du lait de femme. Biochim. Biophys. Acta 45:413-421.
    • (1960) Biochim. Biophys. Acta , vol.45 , pp. 413-421
    • Montreuil, J.1    Tonnelat, J.2    Mullet, S.3
  • 31
    • 0017119987 scopus 로고
    • Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharide
    • Morrison, D. C., and D. M. Jacobs. 1976. Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharide. Immunochemistry 13:813-818.
    • (1976) Immunochemistry , vol.13 , pp. 813-818
    • Morrison, D.C.1    Jacobs, D.M.2
  • 32
    • 0023352436 scopus 로고
    • Primary structure of anti-LPS factor from American horseshoe crab, Limu- Lus polyphenus
    • Muta, T., T. Miyata, F. Tokunaga, T. Nakamura, and S. Iwanaga. 1987. Primary structure of anti-LPS factor from American horseshoe crab, Limu- lus polyphenus. J. Biochem. 101:1321-1330.
    • (1987) J. Biochem. , vol.101 , pp. 1321-1330
    • Muta, T.1    Miyata, T.2    Tokunaga, F.3    Nakamura, T.4    Iwanaga, S.5
  • 33
    • 0024519425 scopus 로고
    • Lipopolysaccharide interaction with lysozyme
    • Ohno, N., and D. C. Morrison. 1989. Lipopolysaccharide interaction with lysozyme. J. Biol. Chem. 264:4434-4441.
    • (1989) J. Biol. Chem. , vol.264 , pp. 4434-4441
    • Ohno, N.1    Morrison, D.C.2
  • 34
    • 0027920980 scopus 로고
    • Pathogenetic mechanisms of septic shock
    • Parillo, J. E. 1993. Pathogenetic mechanisms of septic shock. N. Engl. J. Med. 328:1471-1477.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 1471-1477
    • Parillo, J.E.1
  • 39
    • 0029028016 scopus 로고
    • Lipopolysaccharide neutralizing peptides reveal a lipid A binding site of LPS binding protein
    • Taylor, A. H., G. Heauner, M. Nedelman, D. Sherris, E. Brunt, D. Knight, and J. Ghrayeb, 1995. Lipopolysaccharide neutralizing peptides reveal a lipid A binding site of LPS binding protein. J. Biol. Chem. 270:17934-17938.
    • (1995) J. Biol. Chem. , vol.270 , pp. 17934-17938
    • Taylor, A.H.1    Heauner, G.2    Nedelman, M.3    Sherris, D.4    Brunt, E.5    Knight, D.6    Ghrayeb, J.7
  • 41
    • 0023761244 scopus 로고
    • A family of LPS-binding proteins involved in responses to gram (-) sepsis
    • Tobias, P. S., J. C. Mathison, and R. J. Ulevitch. 1988. A family of LPS-binding proteins involved in responses to gram (-) sepsis. J. Biol. Chem. 263:13479-13481.
    • (1988) J. Biol. Chem. , vol.263 , pp. 13479-13481
    • Tobias, P.S.1    Mathison, J.C.2    Ulevitch, R.J.3
  • 42
    • 0022462376 scopus 로고
    • Isolation of a LPS binding acute phase reactant from rabbit serum
    • Tobias, P. S., K. Soldau, and R. J. Ulevitch. 1986. Isolation of a LPS binding acute phase reactant from rabbit serum. J. Exp. Med. 164:777-793.
    • (1986) J. Exp. Med. , vol.164 , pp. 777-793
    • Tobias, P.S.1    Soldau, K.2    Ulevitch, R.J.3
  • 43
    • 0024316023 scopus 로고
    • Identification of a lipid A binding site in the acute phase reactant LPS binding protein
    • Tobias, P. S., K. Soldau, and R. J. Ulevitch. 1989. Identification of a lipid A binding site in the acute phase reactant LPS binding protein. J. Biol. Chem. 264:10867-10871.
    • (1989) J. Biol. Chem. , vol.264 , pp. 10867-10871
    • Tobias, P.S.1    Soldau, K.2    Ulevitch, R.J.3
  • 46
    • 0027291534 scopus 로고
    • Recognition of bacterial endotoxins by receptor-dependent mechanisms
    • Ulevitch, R. J. 1993. Recognition of bacterial endotoxins by receptor-dependent mechanisms. Adv. Immunol. 53:267-289.
    • (1993) Adv. Immunol. , vol.53 , pp. 267-289
    • Ulevitch, R.J.1
  • 47
    • 0027976138 scopus 로고
    • Recognition of endotoxin by cells leading to transmembrane signalling
    • Ulevitch, R. J., and P. S. Tobias. 1994. Recognition of endotoxin by cells leading to transmembrane signalling. Curr. Opin. Immunol. 6:125-130.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 125-130
    • Ulevitch, R.J.1    Tobias, P.S.2
  • 48
    • 0028965644 scopus 로고
    • Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
    • Ulevitch, R. J., and P. S. Tobias. 1995. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13:437-457.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 437-457
    • Ulevitch, R.J.1    Tobias, P.S.2
  • 49
    • 0026737397 scopus 로고
    • 2VitD3 induce on THP-1 cells distinct patterns of cell surface antigen expression. Cytokine production and responsiveness to contact with activated T cells
    • 2VitD3 induce on THP-1 cells distinct patterns of cell surface antigen expression. Cytokine production and responsiveness to contact with activated T cells. J. Immunol. 149:2040-2046.
    • (1992) J. Immunol. , vol.149 , pp. 2040-2046
    • Vey, E.1    Zhang, D.E.2    Dayer, J.M.3
  • 50
    • 0029009708 scopus 로고
    • Lipopolysaccharide-inactivating activity of neutrophils is due to lactoferrin
    • Wang, D., K. M. Pabst, Y. Aida, and M. J. Pabst. 1995. Lipopolysaccharide-inactivating activity of neutrophils is due to lactoferrin. J. Leukocyte Biol. 57:865-874.
    • (1995) J. Leukocyte Biol. , vol.57 , pp. 865-874
    • Wang, D.1    Pabst, K.M.2    Aida, Y.3    Pabst, M.J.4
  • 51
    • 0025166114 scopus 로고
    • CD14 serves as the cellular receptor for complexes of LPS with LPS binding protein
    • Wright, S. D., R. A. Ramos, P. S. Tobias, R. J., Ulevitch, and J. C., Mathison. 1990. CD14 serves as the cellular receptor for complexes of LPS with LPS binding protein. Science 249:1431-1433.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 52
    • 0024842051 scopus 로고
    • Lactoferrin can protect mice against a lethal dose of Eschenchia coli in experimental infection in vivo
    • Zagulski, T., P. Lipinski, A. Zagulska, S. Broniek, Z. Jarzabek. 1989. Lactoferrin can protect mice against a lethal dose of Eschenchia coli in experimental infection in vivo. Br. J. Exp. Pathol. 70:697-704.
    • (1989) Br. J. Exp. Pathol. , vol.70 , pp. 697-704
    • Zagulski, T.1    Lipinski, P.2    Zagulska, A.3    Broniek, S.4    Jarzabek, Z.5
  • 53
    • 0025914111 scopus 로고
    • Immunostimulatory activity of lactoferrin and maturation of CD4(-)-CD8(-) murine thymocytes
    • Zimecki, M., J. Mazurier, M. Machnicki, Z. Wieczorek, J. Montreuil, and G. Spik. 1991. Immunostimulatory activity of lactoferrin and maturation of CD4(-)-CD8(-) murine thymocytes. Immunol. Lett. 30:377-382.
    • (1991) Immunol. Lett. , vol.30 , pp. 377-382
    • Zimecki, M.1    Mazurier, J.2    Machnicki, M.3    Wieczorek, Z.4    Montreuil, J.5    Spik, G.6


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