Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 1 46-1, 2002, Pages

  Togawa, Jun Ichi ^a   Nagase, Hajime ^a   Tanaka, Katsuaki ^a   Inamori, Masahiko ^a   Umezawa, Tadashi ^a   Nakajima, Atsushi ^a   Naito, Makoto ^a   Sato, Shinobu ^a   Saito, Toshifumi ^a   Sekihara, Hisahiko ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Inflammatory bowel disease; Interleukin; Nuclear factor B; Trinitrobenzenesulfonic acid; Tumor necrosis factor

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LACTOFERRIN; MYELOPEROXIDASE; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DESCENDING COLON; DOSE RESPONSE; DRUG EFFECT; HISTOPATHOLOGY; IMMUNOMODULATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0036089589     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00331.2001     Document Type: Article

References (42)

1. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumor necrosis factor a production in trinitrobenzene sulphonic acid induced colitis
2. Balance between pro- and anti-inflammatory cytokines in the colonic mucosa in inflammatory bowel disease (IBD)
3. Function and activation of NFκB in the immune system
4. Strain differences in susceptibility to TNBS-induced colitis
5. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
6. Regulation of cytokine release from mononuclear cells by the iron-binding protein lactoferrin
7. Regulation of epidermal Langerhans cell migration by lactoferrin
8. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12
9. Hapten-induced model of murine inflammatory bowel disease: Mucosa immune responses and protections by tolerance
10. Experimental models of IBD
11. Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis
12. Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
13. Spatial and temporal control of gene therapy using ionizing radiation
14. Characteristic transport of lactoferrin from the intestinal lumen into the bile via the blood in piglets
15. Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA
16. Influence of infant diets on the ecology of the intestinal tract of human flora-associated mice
17. Origin of intact lactoferrin and its DNA-binding fragments found in the urine of human milk-fed preterm infants. Evaluation by stable isotopic enrichment
18. Cytokine mRNA profiles in inflammatory bowel disease mucosa detected by PCR amplification
19. Interleukin-10-deficient mice develop chronic enterocolitis
20. Role of interleukin-1 in inflammatory bowel disease-enhanced production during active disease
21. Lactoferrin: Molecular structure and biological function
22. Tyrosine kinase inhibition ameliorates the hyperdynamic state and decreases nitric oxidase production in cirrhotic rats with portal hypertension and ascites
23. Immune activation genes in inflammatory bowel disease
24. Lactoferrin or a fragment thereof inhibits the endotoxin-induced IL-6 release response in human monocytic cells
25. Hapten-induced model of chronic inflammation and ulceration in the rat colon
26. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice
27. Local administration of antisense phosphorothioate oligonucleotides to the p-65 subunit of NF-kappa B abrogates established experimental colitis in mice
28. Altered Thl/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
29. Non-lymphoid and lymphoid cells in acute, chronic and relapsing experimental colitis
30. Inflammatory bowel disease
31. Enhanced secretion of tumor necrosis factor-α, IL-6, and IL-1β by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
32. Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis
33. Comparison of parenteral nutrition and enteral feeding with pectin in experimental colitis in the rat
34. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids
35. Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease
36. Interleukin-4 inhibits secretion of I.L.-1β, tumor necrosis factor α, and I.L.-6 by human monocytes
37. Lactoferrin: A multifunctional glycoprotein
38. Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease
39. 13-Week oral repeated administration toxicity study of bovine lactoferrin in rats
40. Human lactoferrin induces phenotypic and functional changes in murine splenic B cells
41. Oral treatment of rats with bovine lactoferrin inhibits carrageenan-induced inflammation; correlation with decreased cytokine production