Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

Nature Structural and Molecular Biology

Volumn 23, Issue 5, 2016, Pages 416-425

  Lu, Alvin ^a,b   Li, Yang ^a,b   Schmidt, Florian I ^c   Yin, Qian ^a,b,g   Chen, Shuobing ^d,e   Fu, Tian Min ^a,b   Tong, Alexander B ^a,b   Ploegh, Hidde L ^c,f   Mao, Youdong ^a,d,e   Wu, Hao ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d PEKING UNIVERSITY   (China)

^e INTEL CORPORATION   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g FLORIDA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; CRYOPYRIN; NLRP3 PROTEIN, HUMAN;

ARTICLE; CAPPING PHENOMENON; CELL ACTIVATION; COMPLEX FORMATION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; IN VITRO STUDY; POLYMERIZATION; PRIORITY JOURNAL; ALPHA HELIX; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; CONSERVED SEQUENCE; ENZYME ACTIVE SITE; HYDROGEN BOND; METABOLISM; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE;

AMINO ACID SEQUENCE; CASPASE 1; CATALYTIC DOMAIN; CELL LINE; CONSERVED SEQUENCE; CRYOELECTRON MICROSCOPY; HUMANS; HYDROGEN BONDING; INFLAMMASOMES; MODELS, MOLECULAR; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; POLYMERIZATION; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY;

EID: 84962120866     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3199     Document Type: Article

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