TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 43, 2017, Pages 11524-11529

  Leyns, Cheryl E G ^a   Ulrich, Jason D ^a   Finn, Mary B ^a   Stewart, Floy R ^a   Koscal, Lauren J ^a   Serrano, Javier Remolina ^a   Robinson, Grace O ^a   Anderson, Elise ^a   Colonna, Marco ^a   Holtzman, David M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Neurodegeneration; Neuroinflammation; Tau; TREM2

Indexed keywords

CYTOKINE; TAU PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN ATROPHY; BRAIN SIZE; CONTROLLED STUDY; ENTORHINAL CORTEX; GENE EXPRESSION; GLIOSIS; HIPPOCAMPUS; HUMAN; IMMUNOHISTOCHEMISTRY; LOSS OF FUNCTION MUTATION; MALE; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PYRIFORM CORTEX; TAUOPATHY; ANIMAL; DEGENERATIVE DISEASE; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; GENE EXPRESSION REGULATION; INFLAMMATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; RECEPTORS, IMMUNOLOGIC; TAUOPATHIES;

EID: 85032175930     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1710311114     Document Type: Article

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