TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Journal of Neuroscience

Volumn 37, Issue 7, 2017, Pages 1772-1784

  Zheng, Honghua ^a   Jia, Lin ^a,b   Liu, Chia Chen ^a,b   Rong, Zhouyi ^a   Zhong, Li ^a   Yang, Longyu ^a   Chen, Xiao Fen ^a   Fryer, John D ^b,c   Wang, Xin ^a   Zhang, Yun Wu ^a,d   Xu, Huaxi ^a,d   Bu, Guojun ^a,b,c  

^a XIAMEN UNIVERSITY   (China)

^b MAYO GRADUATE SCHOOL   (United States)

^c MAYO CLINIC   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Akt GSK3 signaling pathway; Alzheimer s disease; Cell survival; Microglia; TREM2; Wnt catenin signaling pathway

Indexed keywords

ALPHA TUBULIN; BETA ACTIN; BETA CATENIN; CASPASE 3; CYCLIN D1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN SYNTHASE KINASE 3; KAINIC ACID; LITHIUM CHLORIDE; MYC PROTEIN; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE; AMINO ACID RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; IMMUNOGLOBULIN RECEPTOR; IMMUNOLOGICAL ADJUVANT; MEMBRANE PROTEIN; THIADIAZOLE DERIVATIVE; TREM2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRDU ASSAY; CELL CYCLE ASSAY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CORONAL CORTEX; DOWN REGULATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; GLIOSIS; HIPPOCAMPUS; IMMUNOFLUORESCENCE; MALE; MICROGLIA; MOUSE; MTT ASSAY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECTROPHOTOMETRY; TUNEL ASSAY; WESTERN BLOTTING; WNT SIGNALING PATHWAY; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; CELL CYCLE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN DEGRADATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANIMALS, NEWBORN; BETA CATENIN; BRAIN; CASPASE 3; CELL CYCLE; CELL SURVIVAL; CELLS, CULTURED; CYCLIN D1; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GENE EXPRESSION REGULATION; KAINIC ACID; LITHIUM CHLORIDE; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROGLIA; PROTEOLYSIS; RECEPTORS, IMMUNOLOGIC; THIADIAZOLES; WNT SIGNALING PATHWAY;

EID: 85013127196     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2459-16.2017     Document Type: Article

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