Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation

Immunity

Volumn 47, Issue 3, 2017, Pages 421-434.e3

  Purbey, Prabhat K ^a   Scumpia, Philip O ^a   Kim, Peter J ^a   Tong, Ann Jay ^a   Iwamoto, Keisuke S ^b   McBride, William H ^b   Smale, Stephen T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATM; Inflammation; Innate Immunity; Interferon Response; Ionizing Radiation; Macrophages; p53; Reactive Oxygen Species; Signal Transduction; Transcriptional Regulation

Indexed keywords

ATM PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 3; LIPID A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN P53; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR NRF2; ALPHA BETA INTERFERON RECEPTOR; DNA DEPENDENT PROTEIN KINASE; INTERFERON; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; TICAM1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR ERG; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; INFLAMMATION; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION RESPONSE; SIGNAL TRANSDUCTION; ANIMAL; CLUSTER ANALYSIS; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; HUMAN; MACROPHAGE; METABOLISM; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CLUSTER ANALYSIS; DNA-ACTIVATED PROTEIN KINASE; DOSE-RESPONSE RELATIONSHIP, RADIATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HUMANS; INFLAMMATION; INTERFERONS; MACROPHAGES; MEMBRANE PROTEINS; MICE; MYELOID DIFFERENTIATION FACTOR 88; NF-E2-RELATED FACTOR 2; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TRANSCRIPTIONAL REGULATOR ERG; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85031756266     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.08.017     Document Type: Article

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