Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Cell

Volumn 171, Issue 5, 2017, Pages 1057-1071.e11

  Dang, Eric V ^a   McDonald, Jeffrey G ^b   Russell, David W ^b   Cyster, Jason G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

25 hydroxycholesterol; AIM2; Ch25h; cholesterol; IL 1 ; inflammasome; macrophage; mitochondria; oxysterol; SREBP

Indexed keywords

25 HYDROXYCHOLESTEROL; ABSENT IN MELANOMA 2 PROTEIN; BINDING PROTEIN; CHOLESTEROL; CRYOPYRIN; CYTOCHROME C; FILIPIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MITOCHONDRIAL DNA; PROTEIN S6; REACTIVE OXYGEN METABOLITE; S6 KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; 25-HYDROXYCHOLESTEROL; AIM2 PROTEIN, HUMAN; CHOLESTEROL DERIVATIVE; DNA BINDING PROTEIN; MEMBRANE PROTEIN; OXYSTEROL; SIGNAL PEPTIDE; SREBP CLEAVAGE-ACTIVATING PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BONE MARROW DERIVED MACROPHAGE; CHOLESTEROL SYNTHESIS; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; LIMIT OF DETECTION; LIPID HOMEOSTASIS; LISTERIOSIS; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; MUTANT; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONEUM MACROPHAGE; PERITONITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; UPREGULATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; CYTOLOGY; HUMAN; IMMUNOLOGY; INFLAMMATION; LISTERIA MONOCYTOGENES; MACROPHAGE; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CHOLESTEROL; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; HUMANS; HYDROXYCHOLESTEROLS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGES; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; OXYSTEROLS;

EID: 85031296044     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.09.029     Document Type: Article

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