Adaptations of energy metabolism associated with increased levels of mitochondrial cholesterol in Niemann-Pick type C1-deficient cells

Journal of Biological Chemistry

Volumn 289, Issue 23, 2014, Pages 16278-16289

  Kennedy, Barry E ^a   Madreiter, Corina T ^b   Vishnu, Neelanjan ^b   Malli, Roland ^b   Graier, Wolfgang F ^b   Karten, Barbara ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIOXIDANTS; CELL MEMBRANES; CHOLESTEROL; CYTOLOGY; METABOLISM;

ANTI-OXIDANT RESPONSE; CHINESE HAMSTER OVARY CELLS; CHOLESTEROL ACCUMULATION; CHOLESTEROL TRANSPORT; ENDOPLASMIC RETICULUM; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL RESPIRATION;

MITOCHONDRIA;

ADENOSINE TRIPHOSPHATE; CHOLESTEROL; GLUTAMINE; LACTIC ACID; MEMBRANE PROTEIN; MESSENGER RNA; MITOCHONDRIAL CHOLESTEROL; NIEMANN PICK TYPE C1; NIEMANN PICK TYPE C2; PROTEIN MLN64; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ADAPTATION; ARTICLE; BIOACCUMULATION; CELL MEMBRANE TRANSPORT; CHO CELL LINE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DISEASE ASSOCIATION; ENERGY METABOLISM; ENZYME INACTIVATION; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORT; GLYCOLYSIS; HOMEOSTASIS; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; RNA INTERFERENCE;

CHOLESTEROL METABOLISM; GLUCOSE METABOLISM; GLUTAMINE; MITOCHONDRIAL CHOLESTEROL; NIEMANN-PICK TYPE C; OXIDATIVE STRESS; RESPIRATION;

ANIMALS; CARRIER PROTEINS; CELL LINE; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; ENERGY METABOLISM; GLUCOSE; GLUTAMINE; HUMANS; LACTIC ACID; MEMBRANE GLYCOPROTEINS; MITOCHONDRIA; RNA INTERFERENCE;

EID: 84902186984     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.559914     Document Type: Article

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