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Volumn 22, Issue , 2016, Pages 1-39

Route-specific challenges in the delivery of poorly water-soluble drugs

Author keywords

Aqueous solubility; Biopharmaceutics Drug Disposition Classification System (BDDCS); Food effects; Metabolism; Oral; Parenteral; Pulmonary administration

Indexed keywords

ACETAZOLAMIDE; BUDESONIDE; CARBAMAZEPINE; CYCLODEXTRIN; CYCLOSPORIN A; DOCETAXEL; PACLITAXEL; PHENYTOIN; PILOCARPINE; TORCETRAPIB;

EID: 85030867203     PISSN: 22107371     EISSN: 2210738X     Source Type: Book Series    
DOI: 10.1007/978-3-319-42609-9_1     Document Type: Chapter
Times cited : (8)

References (179)
  • 1
    • 84944252286 scopus 로고    scopus 로고
    • Preparation, optimization, and in vitro simulated inhalation delivery of carvedilol nanoparticles loaded on a coarse carrier intended for pulmonary administration
    • Abdelbary AA, Al-mahallawi AM, Abdelrahim ME, Ali AM (2015) Preparation, optimization, and in vitro simulated inhalation delivery of carvedilol nanoparticles loaded on a coarse carrier intended for pulmonary administration. Int J Nanomedicine 10:6339-6353
    • (2015) Int J Nanomedicine , vol.10 , pp. 6339-6353
    • Abdelbary, A.A.1    Al-Mahallawi, A.M.2    Abdelrahim, M.E.3    Ali, A.M.4
  • 2
    • 0021842646 scopus 로고
    • Importance of the noncorneal absorption route in topical ophthalmic drug delivery
    • Ahmed I, Patton TF (1985) Importance of the noncorneal absorption route in topical ophthalmic drug delivery. IOVS 26(4):584-587
    • (1985) IOVS , vol.26 , Issue.4 , pp. 584-587
    • Ahmed, I.1    Patton, T.F.2
  • 4
    • 84864418999 scopus 로고    scopus 로고
    • Challenges in neuroprotective nanomedicine development: Progress towards noninvasive gene therapy of glaucoma
    • Alqawlaq S, Huzil JT, Ivanova MV, Foldvari M (2012) Challenges in neuroprotective nanomedicine development: progress towards noninvasive gene therapy of glaucoma. Nanomedicine 7(7):1067-1083
    • (2012) Nanomedicine , vol.7 , Issue.7 , pp. 1067-1083
    • Alqawlaq, S.1    Huzil, J.T.2    Ivanova, M.V.3    Foldvari, M.4
  • 5
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon GL, Lennernäs H, Shah VP, Crison JR (1995) A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12(3):413-420
    • (1995) Pharm Res , vol.12 , Issue.3 , pp. 413-420
    • Amidon, G.L.1    Lennernäs, H.2    Shah, V.P.3    Crison, J.R.4
  • 6
    • 33745044984 scopus 로고    scopus 로고
    • In vitro hemolysis: Guidance for the pharmaceutical scientist
    • Amin K, Dannenfelser RM (2006) In vitro hemolysis: guidance for the pharmaceutical scientist. J Pharm Sci 95(6):1173-1176
    • (2006) J Pharm Sci , vol.95 , Issue.6 , pp. 1173-1176
    • Amin, K.1    Dannenfelser, R.M.2
  • 7
    • 84902184383 scopus 로고    scopus 로고
    • Non-linear increases in danazol exposure with dose in older vs. Younger beagle dogs: The potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion
    • Anby MU, Williams HD, Feeney O, Edwards GA, Benameur H, Pouton CW et al (2014) Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion. Pharm Res 31(6):1536-1552
    • (2014) Pharm Res , vol.31 , Issue.6 , pp. 1536-1552
    • Anby, M.U.1    Williams, H.D.2    Feeney, O.3    Edwards, G.A.4    Benameur, H.5    Pouton, C.W.6
  • 8
    • 42149127078 scopus 로고    scopus 로고
    • Predicting drug absorption and the effects of food on oral bioavailability
    • Benet L et al (2006) Predicting drug absorption and the effects of food on oral bioavailability. Bullet Technique Gattefosse 99:9-16
    • (2006) Bullet Technique Gattefosse , vol.99 , pp. 9-16
    • Benet, L.1
  • 9
    • 77149165406 scopus 로고    scopus 로고
    • Predicting drug disposition via application of a biopharmaceutics drug disposition classification system
    • Benet LZ (2010) Predicting drug disposition via application of a biopharmaceutics drug disposition classification system. Basic Clin Pharmacol Toxicol 106(3):162-167
    • (2010) Basic Clin Pharmacol Toxicol , vol.106 , Issue.3 , pp. 162-167
    • Benet, L.Z.1
  • 11
    • 0036234785 scopus 로고    scopus 로고
    • Intravenous administration of poorly soluble new drug entities in early drug discovery: The potential impact of formulation on pharmacokinetic parameters
    • Bittner B, Mountfield RJ (2002) Intravenous administration of poorly soluble new drug entities in early drug discovery: the potential impact of formulation on pharmacokinetic parameters. Curr Opin Drug Discov Devel 5(1):59-71
    • (2002) Curr Opin Drug Discov Devel , vol.5 , Issue.1 , pp. 59-71
    • Bittner, B.1    Mountfield, R.J.2
  • 12
    • 0029620897 scopus 로고
    • Nebulized cyclosporine for prevention of acute pulmonary allograft rejection in the rat: Pharmacokinetic and histologic study
    • Blot F, Tavakoli R, Sellam S, Epardeau B, Faurisson F, Bernard N et al (1995) Nebulized cyclosporine for prevention of acute pulmonary allograft rejection in the rat: pharmacokinetic and histologic study. J Heart Lung Transplant 14(6 Pt 1):1162-1172
    • (1995) J Heart Lung Transplant , vol.14 , Issue.6 , pp. 1162-1172
    • Blot, F.1    Tavakoli, R.2    Sellam, S.3    Epardeau, B.4    Faurisson, F.5    Bernard, N.6
  • 13
    • 57349188986 scopus 로고    scopus 로고
    • Ethical observations on the choice of parenteral solvents
    • Bracq E, Lahiani-Skiba M, Guerbet M (2008) Ethical observations on the choice of parenteral solvents. Drug Dev Ind Pharm 34(12):1306-1310
    • (2008) Drug Dev Ind Pharm , vol.34 , Issue.12 , pp. 1306-1310
    • Bracq, E.1    Lahiani-Skiba, M.2    Guerbet, M.3
  • 14
    • 34548134519 scopus 로고    scopus 로고
    • Cyclodextrins as pharmaceutical solubilizers
    • Brewster ME, Loftsson T (2007) Cyclodextrins as pharmaceutical solubilizers. Adv Drug Deliv Rev 59(7):645-666
    • (2007) Adv Drug Deliv Rev , vol.59 , Issue.7 , pp. 645-666
    • Brewster, M.E.1    Loftsson, T.2
  • 15
    • 0030279709 scopus 로고    scopus 로고
    • Improved ocular bioavailability of indomethacin by novel ocular drug carriers
    • Calvo P, Alonso MJ, Vila-Jato JL, Robinson JR (1996) Improved ocular bioavailability of indomethacin by novel ocular drug carriers. J Pharmacy Pharmacol 48(11):1147-1152
    • (1996) J Pharmacy Pharmacol , vol.48 , Issue.11 , pp. 1147-1152
    • Calvo, P.1    Alonso, M.J.2    Vila-Jato, J.L.3    Robinson, J.R.4
  • 16
    • 79951577062 scopus 로고    scopus 로고
    • Influence of particle size on regional lung deposition— what evidence is there?
    • Carvalho TC, Peters JI, Williams RO (2011) Influence of particle size on regional lung deposition— what evidence is there? Int J Pharm 406(1-2):1-10
    • (2011) Int J Pharm , vol.406 , Issue.1-2 , pp. 1-10
    • Carvalho, T.C.1    Peters, J.I.2    Williams, R.O.3
  • 17
    • 0030614844 scopus 로고    scopus 로고
    • Physiochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH
    • Charman WN, Porter CJ, Mithani S, Dressman JB (1997) Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J Pharm Sci 86(3):269-282
    • (1997) J Pharm Sci , vol.86 , Issue.3 , pp. 269-282
    • Charman, W.N.1    Porter, C.J.2    Mithani, S.3    Dressman, J.B.4
  • 18
    • 84855216636 scopus 로고    scopus 로고
    • A review on mucoadhesive polymer used in nasal drug delivery system
    • Chaturvedi M, Kumar M, Pathak K (2011) A review on mucoadhesive polymer used in nasal drug delivery system. J Adv Pharm Technol Res 2(4):215-222
    • (2011) J Adv Pharm Technol Res , vol.2 , Issue.4 , pp. 215-222
    • Chaturvedi, M.1    Kumar, M.2    Pathak, K.3
  • 19
    • 0034885109 scopus 로고    scopus 로고
    • Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway
    • Cheng YS, Holmes TD, Gao J, Guilmette RA, Li S, Surakitbanharn Y et al (2001) Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway. J Aerosol Med 14(2):267-280
    • (2001) J Aerosol Med , vol.14 , Issue.2 , pp. 267-280
    • Cheng, Y.S.1    Holmes, T.D.2    Gao, J.3    Guilmette, R.A.4    Li, S.5    Surakitbanharn, Y.6
  • 20
    • 84898434126 scopus 로고    scopus 로고
    • Ophthalmic preparations
    • Allen LV Jr, Adejare A, Desselle SP, Felton LA, 22nd edn. Pharmaceutical Press, Philadelphia
    • Chowhan M, Lang J, Missel P (2012) Ophthalmic preparations. In: Allen LV Jr, Adejare A, Desselle SP, Felton LA (eds) The science and practice of pharmacy, 22nd edn. Pharmaceutical Press, Philadelphia
    • (2012) The Science and Practice of Pharmacy
    • Chowhan, M.1    Lang, J.2    Missel, P.3
  • 22
    • 0014790639 scopus 로고
    • Animal inhalation studies on ammonia, ethylene glycol, formaldehyde, dimethylamine, and ethanol
    • Coon RA, Jones RA, Jenkins LJ, Siegel J (1970) Animal inhalation studies on ammonia, ethylene glycol, formaldehyde, dimethylamine, and ethanol. Toxicol Appl Pharmacol 16(3):646-655
    • (1970) Toxicol Appl Pharmacol , vol.16 , Issue.3 , pp. 646-655
    • Coon, R.A.1    Jones, R.A.2    Jenkins, L.J.3    Siegel, J.4
  • 23
    • 33751251068 scopus 로고    scopus 로고
    • Inhaled delivery of aerosolized cyclosporine
    • Corcoran TE (2006) Inhaled delivery of aerosolized cyclosporine. Adv Drug Deliv Rev 58(9-10):1119-1127
    • (2006) Adv Drug Deliv Rev , vol.58 , Issue.9-10 , pp. 1119-1127
    • Corcoran, T.E.1
  • 24
    • 0036199308 scopus 로고    scopus 로고
    • Fundamental effects of particle morphology on lung delivery: Predictions of Stokes law and the particular relevance to dry powder inhaler formulation and development
    • Crowder TM, Rosati JA, Schroeter JD, Hickey AJ, Martonen TB (2002) Fundamental effects of particle morphology on lung delivery: predictions of Stokes law and the particular relevance to dry powder inhaler formulation and development. Pharm Res 19(3):239-245
    • (2002) Pharm Res , vol.19 , Issue.3 , pp. 239-245
    • Crowder, T.M.1    Rosati, J.A.2    Schroeter, J.D.3    Hickey, A.J.4    Martonen, T.B.5
  • 25
    • 39149115065 scopus 로고    scopus 로고
    • Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption
    • Custodio JM, Wu C-Y, Benet LZ (2008) Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv Drug Deliv Rev 60(6):717-733
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.6 , pp. 717-733
    • Custodio, J.M.1    Wu, C.-Y.2    Benet, L.Z.3
  • 26
    • 3042595327 scopus 로고    scopus 로고
    • Evaluation of different parameters that affect droplet-size distribution from nasal sprays using the Malvern Spraytec®
    • Dayal P, Shaik MS, Singh M (2004) Evaluation of different parameters that affect droplet-size distribution from nasal sprays using the Malvern Spraytec®. J Pharm Sci 93(7):1725-1742
    • (2004) J Pharm Sci , vol.93 , Issue.7 , pp. 1725-1742
    • Dayal, P.1    Shaik, M.S.2    Singh, M.3
  • 27
    • 77949833508 scopus 로고    scopus 로고
    • Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
    • Dhuria SV, Hanson LR, Frey WH (2010) Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99(4):1654-1673
    • (2010) J Pharm Sci , vol.99 , Issue.4 , pp. 1654-1673
    • Dhuria, S.V.1    Hanson, L.R.2    Frey, W.H.3
  • 29
    • 33644826138 scopus 로고    scopus 로고
    • Breath actuated device improves delivery to target sites beyond the nasal valve
    • A Djupesland PG, Skretting A, Winderen M, Holand T (2006) Breath actuated device improves delivery to target sites beyond the nasal valve. Laryngoscope 116(3):466-472
    • (2006) Laryngoscope , vol.116 , Issue.3 , pp. 466-472
    • A Djupesland, P.G.1    Skretting, A.2    Winderen, M.3    Holand, T.4
  • 30
    • 84875516600 scopus 로고    scopus 로고
    • Nasal drug delivery devices: Characteristics and performance in a clinical perspective—a review
    • Djupesland PG (2013) Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review. Drug Deliv Transl Res 3(1):42-62
    • (2013) Drug Deliv Transl Res , vol.3 , Issue.1 , pp. 42-62
    • Djupesland, P.G.1
  • 31
    • 0034745632 scopus 로고    scopus 로고
    • Ultrafine particles
    • Donaldson K (2001) Ultrafine particles. Occup Environ Med 58(3):211-216
    • (2001) Occup Environ Med , vol.58 , Issue.3 , pp. 211-216
    • Donaldson, K.1
  • 32
    • 0025118145 scopus 로고
    • Aerosolized cyclosporine as single-agent immunotherapy in canine lung allografts
    • Dowling RD, Zenati M, Burckart GJ, Yousem SA, Schaper M, Simmons RL et al (1990) Aerosolized cyclosporine as single-agent immunotherapy in canine lung allografts. Surgery 108(2):198-204
    • (1990) Surgery , vol.108 , Issue.2 , pp. 198-204
    • Dowling, R.D.1    Zenati, M.2    Burckart, G.J.3    Yousem, S.A.4    Schaper, M.5    Simmons, R.L.6
  • 34
    • 0031427707 scopus 로고    scopus 로고
    • Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells
    • Driscoll K (1997) Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis 18(2):423-443
    • (1997) Carcinogenesis , vol.18 , Issue.2 , pp. 423-443
    • Driscoll, K.1
  • 35
    • 84896692586 scopus 로고    scopus 로고
    • Study of aerodynamic and release properties of inhaled particles containing cyclodextrins
    • Drumond N, Couto AS, Costa A, Cabral-Marques H (2014) Study of aerodynamic and release properties of inhaled particles containing cyclodextrins. J Incl Phenom Macrocycl Chem 80(1-2):25-30
    • (2014) J Incl Phenom Macrocycl Chem , vol.80 , Issue.1-2 , pp. 25-30
    • Drumond, N.1    Couto, A.S.2    Costa, A.3    Cabral-Marques, H.4
  • 36
    • 84944413879 scopus 로고    scopus 로고
    • Interest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide
    • Dufour G, Bigazzi W, Wong N, Boschini F, de Tullio P, Piel G et al (2015) Interest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide. Int J Pharm 495(2):869-878
    • (2015) Int J Pharm , vol.495 , Issue.2 , pp. 869-878
    • Dufour, G.1    Bigazzi, W.2    Wong, N.3    Boschini, F.4    De Tullio, P.5    Piel, G.6
  • 37
    • 84870316205 scopus 로고    scopus 로고
    • New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis
    • Duret C, Wauthoz N, Sebti T, Vanderbist F, Amighi K (2012) New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis. Int J Nanomedicine 7:5475-5489
    • (2012) Int J Nanomedicine , vol.7 , pp. 5475-5489
    • Duret, C.1    Wauthoz, N.2    Sebti, T.3    Vanderbist, F.4    Amighi, K.5
  • 38
    • 0031696683 scopus 로고    scopus 로고
    • Fiber matrix model of sclera and corneal stroma for drug delivery to the eye
    • Edwards A, Prausnitz MR (1998) Fiber matrix model of sclera and corneal stroma for drug delivery to the eye. AIChE J 44(1):214-225
    • (1998) Aiche J , vol.44 , Issue.1 , pp. 214-225
    • Edwards, A.1    Prausnitz, M.R.2
  • 40
    • 84864069253 scopus 로고    scopus 로고
    • Development of budesonide nanocluster dry powder aerosols: Processing
    • El-Gendy N, Selvam P, Soni P, Berkland C (2012a) Development of budesonide nanocluster dry powder aerosols: processing. J Pharm Sci 101(9):3425-3433
    • (2012) J Pharm Sci , vol.101 , Issue.9 , pp. 3425-3433
    • El-Gendy, N.1    Selvam, P.2    Soni, P.3    Berkland, C.4
  • 41
    • 84864071117 scopus 로고    scopus 로고
    • Development of budesonide nanocluster dry powder aerosols: Formulation and stability
    • El-Gendy N, Huang S, Selvam P, Soni P, Berkland C (2012b) Development of budesonide nanocluster dry powder aerosols: formulation and stability. J Pharm Sci 101(9):3445-3455
    • (2012) J Pharm Sci , vol.101 , Issue.9 , pp. 3445-3455
    • El-Gendy, N.1    Huang, S.2    Selvam, P.3    Soni, P.4    Berkland, C.5
  • 42
    • 0029960921 scopus 로고    scopus 로고
    • Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80
    • Ellis AG, Crinis NA, Webster LK (1996) Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80. Cancer Chemother Pharmacol 38(1):81-87
    • (1996) Cancer Chemother Pharmacol , vol.38 , Issue.1 , pp. 81-87
    • Ellis, A.G.1    Crinis, N.A.2    Webster, L.K.3
  • 43
    • 33845714689 scopus 로고    scopus 로고
    • Alternative drug formulations of docetaxel: A review
    • Engels FK, Mathot RA, Verweij J (2007) Alternative drug formulations of docetaxel: a review. Anticancer Drugs 18(2):95-103
    • (2007) Anticancer Drugs , vol.18 , Issue.2 , pp. 95-103
    • Engels, F.K.1    Mathot, R.A.2    Verweij, J.3
  • 47
    • 0032927254 scopus 로고    scopus 로고
    • Drug, meal and formulation interactions influencing drug absorption after oral administration clinical implications
    • Fleisher D, Li C, Zhou Y, Pao LH, Karim A (1999) Drug, meal and formulation interactions influencing drug absorption after oral administration clinical implications. Clin Pharmacokinet 36(3):233-254
    • (1999) Clin Pharmacokinet , vol.36 , Issue.3 , pp. 233-254
    • Fleisher, D.1    Li, C.2    Zhou, Y.3    Pao, L.H.4    Karim, A.5
  • 48
    • 37548998558 scopus 로고    scopus 로고
    • The influence of spray properties on intranasal deposition
    • Foo MY, Cheng Y-S, Su W-C, Donovan MD (2007) The influence of spray properties on intranasal deposition. J Aerosol Med 20(4):495-508
    • (2007) J Aerosol Med , vol.20 , Issue.4 , pp. 495-508
    • Foo, M.Y.1    Cheng, Y.-S.2    Su, W.-C.3    Donovan, M.D.4
  • 50
    • 85081149121 scopus 로고    scopus 로고
    • Ocular anatomy, physiology, and embryology
    • Elsevier, Philadelphia
    • Friedman NJ, Kaiser, Peter K (2007) Ocular anatomy, physiology, and embryology. In: Essentials of ophthalmology. Elsevier, Philadelphia, pp 1-17
    • (2007) Essentials of Ophthalmology , pp. 1-17
    • Friedman, N.J.1    Kaiser, P.K.2
  • 52
    • 28844501442 scopus 로고    scopus 로고
    • Nasal administration of Carbamazepine using chitosan microspheres: In vitro/in vivo studies
    • Gavini E, Hegge AB, Rassu G, Sanna V, Testa C, Pirisino G et al (2006) Nasal administration of Carbamazepine using chitosan microspheres: in vitro/in vivo studies. Int J Pharm 307(1):9-15
    • (2006) Int J Pharm , vol.307 , Issue.1 , pp. 9-15
    • Gavini, E.1    Hegge, A.B.2    Rassu, G.3    Sanna, V.4    Testa, C.5    Pirisino, G.6
  • 54
    • 34249037098 scopus 로고    scopus 로고
    • Predicting effect of food on extent of drug absorption based on physicochemical properties
    • Gu C-H, Li H, Levons J, Lentz K, Gandhi RB, Raghavan K et al (2007) Predicting effect of food on extent of drug absorption based on physicochemical properties. Pharm Res 24(6):1118-1130
    • (2007) Pharm Res , vol.24 , Issue.6 , pp. 1118-1130
    • Gu, C.-H.1    Li, H.2    Levons, J.3    Lentz, K.4    Gandhi, R.B.5    Raghavan, K.6
  • 55
    • 0038471153 scopus 로고    scopus 로고
    • Balancing ethanol cosolvent concentration with product performance in 134a-based pressurized metered dose inhalers
    • Gupta A, Stein SW, Myrdal PB (2003) Balancing ethanol cosolvent concentration with product performance in 134a-based pressurized metered dose inhalers. J Aerosol Med 16(2):167-174
    • (2003) J Aerosol Med , vol.16 , Issue.2 , pp. 167-174
    • Gupta, A.1    Stein, S.W.2    Myrdal, P.B.3
  • 56
    • 0021959078 scopus 로고
    • Intranasal drug delivery by spray and drops
    • Hardy JG, Lee SW, Wilson CG (1985) Intranasal drug delivery by spray and drops. J Pharmacy Pharmacol 37(5):294-297
    • (1985) J Pharmacy Pharmacol , vol.37 , Issue.5 , pp. 294-297
    • Hardy, J.G.1    Lee, S.W.2    Wilson, C.G.3
  • 57
    • 0022889862 scopus 로고
    • Deposition of particles in the human respiratory tract in the size range 0.005-15 μm
    • Heyder J, Gebhart J, Rudolf G, Schiller C, Stahlhofen W (1986) Deposition of particles in the human respiratory tract in the size range 0.005-15 μm. J Aerosol Sci 17(5):811-825
    • (1986) J Aerosol Sci , vol.17 , Issue.5 , pp. 811-825
    • Heyder, J.1    Gebhart, J.2    Rudolf, G.3    Schiller, C.4    Stahlhofen, W.5
  • 58
    • 0033957756 scopus 로고    scopus 로고
    • Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A 4
    • Hochman JH, Chiba M, Nishime J, Yamazaki M, Lin JH (2000) Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A 4. J Pharmacol Exp Ther 292(1):310-318
    • (2000) J Pharmacol Exp Ther , vol.292 , Issue.1 , pp. 310-318
    • Hochman, J.H.1    Chiba, M.2    Nishime, J.3    Yamazaki, M.4    Lin, J.H.5
  • 59
    • 0023307976 scopus 로고
    • Bile salts as biological surfactants
    • Hofmann AF, Mysels KJ (1987) Bile salts as biological surfactants. Colloid Surf 30(1):145-173
    • (1987) Colloid Surf , vol.30 , Issue.1 , pp. 145-173
    • Hofmann, A.F.1    Mysels, K.J.2
  • 60
    • 0037459005 scopus 로고    scopus 로고
    • Nasal drug delivery—possibilities, problems and solutions
    • Illum L (2003) Nasal drug delivery—possibilities, problems and solutions. J Control Release 87(1-3):187-198
    • (2003) J Control Release , vol.87 , Issue.1-3 , pp. 187-198
    • Illum, L.1
  • 61
    • 0036176196 scopus 로고    scopus 로고
    • Production and characterization of a budesonide nanosuspension for pulmonary administration
    • Jacobs C, Müller RH (2002) Production and characterization of a budesonide nanosuspension for pulmonary administration. Pharm Res 19(2):189-194
    • (2002) Pharm Res , vol.19 , Issue.2 , pp. 189-194
    • Jacobs, C.1    Müller, R.H.2
  • 62
    • 79953742744 scopus 로고    scopus 로고
    • Drug delivery systems—an overview
    • Jain KK, Humana Press, Totowa
    • Jain KK (2008) Drug delivery systems—an overview. In: Jain KK (ed) Drug delivery systems. Humana Press, Totowa
    • (2008) Drug Delivery Systems
    • Jain, K.K.1
  • 64
    • 33344478634 scopus 로고    scopus 로고
    • Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs
    • Jinno J-I, Kamada N, Miyake M, Yamada K, Mukai T, Odomi M et al (2006) Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs. J Control Release 111(1-2):56-64
    • (2006) J Control Release , vol.111 , Issue.1-2 , pp. 56-64
    • Jinno, J.-I.1    Kamada, N.2    Miyake, M.3    Yamada, K.4    Mukai, T.5    Odomi, M.6
  • 65
    • 0043212022 scopus 로고    scopus 로고
    • Prediction of precipitation-induced phlebitis: A statistical validation of an in vitro model
    • Johnson JLH, He Y, Yalkowsky SH (2003) Prediction of precipitation-induced phlebitis: a statistical validation of an in vitro model. J Pharm Sci 92(8):1574-1581
    • (2003) J Pharm Sci , vol.92 , Issue.8 , pp. 1574-1581
    • Johnson, J.1    He, Y.2    Yalkowsky, S.H.3
  • 66
    • 54049091605 scopus 로고    scopus 로고
    • Iluvien TM: A new sustained delivery technology for posterior eye disease
    • Kane FE, Burdan J, Cutino A, Green KE (2008) Iluvien TM: a new sustained delivery technology for posterior eye disease. Expert Opin Drug Deliv 5(9):1039-1046
    • (2008) Expert Opin Drug Deliv , vol.5 , Issue.9 , pp. 1039-1046
    • Kane, F.E.1    Burdan, J.2    Cutino, A.3    Green, K.E.4
  • 67
    • 3242885512 scopus 로고    scopus 로고
    • Controlled drug release from an ocular implant: An evaluation using dynamic three-dimensional magnetic resonance imaging
    • Kim H, Robinson MR, Lizak MJ, Tansey G, Lutz RJ, Yuan P et al (2004) Controlled drug release from an ocular implant: an evaluation using dynamic three-dimensional magnetic resonance imaging. Invest Ophthalmol Vis Sci 45(8):2722-2731
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , Issue.8 , pp. 2722-2731
    • Kim, H.1    Robinson, M.R.2    Lizak, M.J.3    Tansey, G.4    Lutz, R.J.5    Yuan, P.6
  • 68
    • 84908269334 scopus 로고    scopus 로고
    • Nanotherapy for posterior eye diseases
    • Kaur IP, Kakkar S (2014) Nanotherapy for posterior eye diseases. J Control Release 193:100-112
    • (2014) J Control Release , vol.193 , pp. 100-112
    • Kaur, I.P.1    Kakkar, S.2
  • 69
    • 84900847597 scopus 로고    scopus 로고
    • Budesonide/cyclodextrin complex-loaded lyophilized microparticles for intranasal application
    • Kim J-E, Cho H-J, Kim D-D (2014) Budesonide/cyclodextrin complex-loaded lyophilized microparticles for intranasal application. Drug Dev Ind Pharm 40(6):743-748
    • (2014) Drug Dev Ind Pharm , vol.40 , Issue.6 , pp. 743-748
    • Kim, J.-E.1    Cho, H.-J.2    Kim, D.-D.3
  • 70
    • 80051936901 scopus 로고    scopus 로고
    • Development of a novel ophthalmic cyclosporin A-loaded nanosuspension using top-down media milling methods
    • Kim JH, Jang SW, Han SD, Hwang HD, Choi H-G (2011) Development of a novel ophthalmic cyclosporin A-loaded nanosuspension using top-down media milling methods. Pharmazie 66(7):491-495
    • (2011) Pharmazie , vol.66 , Issue.7 , pp. 491-495
    • Kim, J.H.1    Jang, S.W.2    Han, S.D.3    Hwang, H.D.4    Choi, H.-G.5
  • 72
    • 34147176581 scopus 로고    scopus 로고
    • The tablet formulation of lopinavir/ritonavir provides similar bioavailability to the soft-gelatin capsule formulation with less pharmacokinetic variability and diminished food effect
    • Klein CE, Chiu Y-L, Awni W, Zhu T, Heuser RS, Doan T et al (2007) The tablet formulation of lopinavir/ritonavir provides similar bioavailability to the soft-gelatin capsule formulation with less pharmacokinetic variability and diminished food effect. J Acquir Immune Defic Syndr 44(4):401-410
    • (2007) J Acquir Immune Defic Syndr , vol.44 , Issue.4 , pp. 401-410
    • Klein, C.E.1    Chiu, Y.-L.2    Awni, W.3    Zhu, T.4    Heuser, R.S.5    Doan, T.6
  • 73
    • 33748417554 scopus 로고    scopus 로고
    • Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: A major challenge
    • Knight B, Troutman M, Thakker DR (2006) Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge. Curr Opin Pharmacol 6(5):528-532
    • (2006) Curr Opin Pharmacol , vol.6 , Issue.5 , pp. 528-532
    • Knight, B.1    Troutman, M.2    Thakker, D.R.3
  • 74
    • 84945308590 scopus 로고    scopus 로고
    • Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studies
    • Koziolek M, Schneider F, Grimm M, Modeβ C, Seekamp A, Roustom T et al (2015) Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studies. J Controll Release 220(Part A):71-78
    • (2015) J Controll Release , vol.220 , pp. 71-78
    • Koziolek, M.1    Schneider, F.2    Grimm, M.3    Modeβ, C.4    Seekamp, A.5    Roustom, T.6
  • 76
    • 15644383223 scopus 로고    scopus 로고
    • Lysis of human red blood cells. 4. Comparison of in vitro and in vivo hemolysis data
    • Krzyzaniak JF, Fa AN, Raymond DM, Yalkowsky SH (1997) Lysis of human red blood cells. 4. Comparison of in vitro and in vivo hemolysis data. J Pharm Sci 86(11):1215-1217
    • (1997) J Pharm Sci , vol.86 , Issue.11 , pp. 1215-1217
    • Krzyzaniak, J.F.1    Fa, A.N.2    Raymond, D.M.3    Yalkowsky, S.H.4
  • 77
    • 0032484588 scopus 로고    scopus 로고
    • Nasal delivery systems and their effect on deposition and absorption
    • Kublik H, Vidgren MT (1998) Nasal delivery systems and their effect on deposition and absorption. Adv Drug Deliv Rev 29(1-2):157-177
    • (1998) Adv Drug Deliv Rev , vol.29 , Issue.1-2 , pp. 157-177
    • Kublik, H.1    Vidgren, M.T.2
  • 78
    • 56349091496 scopus 로고    scopus 로고
    • Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting
    • Kumar M, Misra A, Mishra AK, Mishra P, Pathak K (2008) Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting. J Drug Target 16(10):806-814
    • (2008) J Drug Target , vol.16 , Issue.10 , pp. 806-814
    • Kumar, M.1    Misra, A.2    Mishra, A.K.3    Mishra, P.4    Pathak, K.5
  • 79
    • 0344943933 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part II: The role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications
    • Labiris NR, Dolovich MB (2003) Pulmonary drug delivery. Part II: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol 56(6):600-612
    • (2003) Br J Clin Pharmacol , vol.56 , Issue.6 , pp. 600-612
    • Labiris, N.R.1    Dolovich, M.B.2
  • 81
    • 0037422391 scopus 로고    scopus 로고
    • An intravenous formulation decision tree for discovery compound formulation development
    • Lee Y-C, Zocharski PD, Samas B (2003) An intravenous formulation decision tree for discovery compound formulation development. Int J Pharm 253(1-2):111-119
    • (2003) Int J Pharm , vol.253 , Issue.1-2 , pp. 111-119
    • Lee, Y.-C.1    Zocharski, P.D.2    Samas, B.3
  • 82
    • 0014738424 scopus 로고
    • Factors affecting gastrointestinal absorption of drugs
    • Levine RR (1970) Factors affecting gastrointestinal absorption of drugs. Am J Dig Dis 15(2):171-188
    • (1970) Am J Dig Dis , vol.15 , Issue.2 , pp. 171-188
    • Levine, R.R.1
  • 83
    • 84883870236 scopus 로고    scopus 로고
    • A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate
    • Li J, Wu L, Wu W, Wang B, Wang Z, Xin H et al (2013) A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate. Int J Pharm 455(1-2):75-84
    • (2013) Int J Pharm , vol.455 , Issue.1 , pp. 75-84
    • Li, J.1    Wu, L.2    Wu, W.3    Wang, B.4    Wang, Z.5    Xin, H.6
  • 84
    • 34447646495 scopus 로고    scopus 로고
    • Developing early formulations: Practice and perspective
    • Li P, Zhao L (2007) Developing early formulations: practice and perspective. Int J Pharm 341(1-2):1-19
    • (2007) Int J Pharm , vol.341 , Issue.1-2 , pp. 1-19
    • Li, P.1    Zhao, L.2
  • 85
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski CA (2000) Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods 44(1):235-249
    • (2000) J Pharmacol Toxicol Methods , vol.44 , Issue.1 , pp. 235-249
    • Lipinski, C.A.1
  • 86
    • 85081145451 scopus 로고    scopus 로고
    • Use of solubilizers in preclinical formulations: Effect of Cremophor EL on the pharmacokinetic properties on early discovery compounds
    • Liu B, Gordon WP, Richmond W, Groessl T, Tuntland T (2016) Use of solubilizers in preclinical formulations: effect of Cremophor EL on the pharmacokinetic properties on early discovery compounds. Eur J Pharmaceut Sci 59(10):6385-6394
    • (2016) Eur J Pharmaceut Sci , vol.59 , Issue.10 , pp. 6385-6394
    • Liu, B.1    Gordon, W.P.2    Richmond, W.3    Groessl, T.4    Tuntland, T.5
  • 87
    • 84860193946 scopus 로고    scopus 로고
    • Intranasal delivery of biologics to the central nervous system
    • Lochhead JJ, Thorne RG (2012) Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev 64(7):614-628
    • (2012) Adv Drug Deliv Rev , vol.64 , Issue.7 , pp. 614-628
    • Lochhead, J.J.1    Thorne, R.G.2
  • 88
    • 34447334610 scopus 로고    scopus 로고
    • Cyclodextrin microparticles for drug delivery to the posterior segment of the eye: Aqueous dexamethasone eye drops
    • Loftsson T, Hreinsdóttir D, Stefánsson E (2007) Cyclodextrin microparticles for drug delivery to the posterior segment of the eye: aqueous dexamethasone eye drops. J Pharmacy Pharmacol 59(5):629-635
    • (2007) J Pharmacy Pharmacol , vol.59 , Issue.5 , pp. 629-635
    • Loftsson, T.1    Hreinsdóttir, D.2    Stefánsson, E.3
  • 90
    • 84868200133 scopus 로고    scopus 로고
    • Topical drug delivery to the eye: Dorzolamide
    • Loftsson T, Jansook P, Stefánsson E (2012) Topical drug delivery to the eye: dorzolamide. Acta Ophthalmol 90(7):603-608
    • (2012) Acta Ophthalmol , vol.90 , Issue.7 , pp. 603-608
    • Loftsson, T.1    Jansook, P.2    Stefánsson, E.3
  • 91
    • 84889566066 scopus 로고    scopus 로고
    • Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy
    • Martens TF, Vercauteren D, Forier K, Deschout H, Remaut K, Paesen R et al (2013) Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy. Nanomedicine 8(12):1955-1968
    • (2013) Nanomedicine , vol.8 , Issue.12 , pp. 1955-1968
    • Martens, T.F.1    Vercauteren, D.2    Forier, K.3    Deschout, H.4    Remaut, K.5    Paesen, R.6
  • 92
    • 0036000312 scopus 로고    scopus 로고
    • A mechanistic approach to understanding the factors affecting drug absorption: A review of fundamentals
    • Martinez MN, Amidon GL (2002) A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. J Clin Pharmacol 42(6):620-643
    • (2002) J Clin Pharmacol , vol.42 , Issue.6 , pp. 620-643
    • Martinez, M.N.1    Amidon, G.L.2
  • 94
    • 84931573683 scopus 로고    scopus 로고
    • Food effect in humans: Predicting the risk through in vitro dissolution and in vivo pharmacokinetic models
    • Mathias N, Xu Y, Vig B, Kestur U, Saari A, Crison J et al (2015) Food effect in humans: predicting the risk through in vitro dissolution and in vivo pharmacokinetic models. AAPS J 17(4):988-998
    • (2015) AAPS J , vol.17 , Issue.4 , pp. 988-998
    • Mathias, N.1    Xu, Y.2    Vig, B.3    Kestur, U.4    Saari, A.5    Crison, J.6
  • 95
    • 0031771926 scopus 로고    scopus 로고
    • Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs
    • Marttin E, Verhoef JC, Merkus FW (1998) Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs. J Drug Target 6(1):17-36
    • (1998) J Drug Target , vol.6 , Issue.1 , pp. 17-36
    • Marttin, E.1    Verhoef, J.C.2    Merkus, F.W.3
  • 96
    • 0029586446 scopus 로고
    • Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers
    • McCallion ON, Taylor KM, Thomas M, Taylor AJ (1995) Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers. Pharm Res 12(11):1682-1688
    • (1995) Pharm Res , vol.12 , Issue.11 , pp. 1682-1688
    • McCallion, O.N.1    Taylor, K.M.2    Thomas, M.3    Taylor, A.J.4
  • 97
    • 0031786221 scopus 로고    scopus 로고
    • Prevention of precipitation of phenytoin in an infusion fluid by hydroxypropyl beta-cyclodextrin
    • McDonald C, Muzumdar PP (1998) Prevention of precipitation of phenytoin in an infusion fluid by hydroxypropyl beta-cyclodextrin. J Clin Pharm Ther 23(3):235-239
    • (1998) J Clin Pharm Ther , vol.23 , Issue.3 , pp. 235-239
    • McDonald, C.1    Muzumdar, P.P.2
  • 98
    • 79551510841 scopus 로고    scopus 로고
    • Incidence of rhegmatogenous retinal detachments after intravitreal antivascular endothelial factor injections
    • Meyer CH, Michels S, Rodrigues EB, Hager A, Mennel S, Schmidt JC et al (2011) Incidence of rhegmatogenous retinal detachments after intravitreal antivascular endothelial factor injections. Acta Ophthalmol 89(1):70-75
    • (2011) Acta Ophthalmol , vol.89 , Issue.1 , pp. 70-75
    • Meyer, C.H.1    Michels, S.2    Rodrigues, E.B.3    Hager, A.4    Mennel, S.5    Schmidt, J.C.6
  • 99
    • 0031890274 scopus 로고    scopus 로고
    • Aerosol cyclosporine prevents acute allograft rejection in experimental lung transplantation
    • Mitruka SN, Pham SM, Zeevi A, Li S, Cai J, Burckart GJ et al (1998) Aerosol cyclosporine prevents acute allograft rejection in experimental lung transplantation. J Thorac Cardiovasc Surg 115(1):28-37
    • (1998) J Thorac Cardiovasc Surg , vol.115 , Issue.1 , pp. 28-37
    • Mitruka, S.N.1    Pham, S.M.2    Zeevi, A.3    Li, S.4    Cai, J.5    Burckart, G.J.6
  • 100
    • 0035965508 scopus 로고    scopus 로고
    • In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride
    • Miyazaki S, Suzuki S, Kawasaki N, Endo K, Takahashi A, Attwood D (2001) In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. Int J Pharm 229(1-2):29-36
    • (2001) Int J Pharm , vol.229 , Issue.1-2 , pp. 29-36
    • Miyazaki, S.1    Suzuki, S.2    Kawasaki, N.3    Endo, K.4    Takahashi, A.5    Attwood, D.6
  • 104
    • 0035140752 scopus 로고    scopus 로고
    • Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection
    • Mottu F, Stelling M-J, Rüfenacht DA, Doelker E (2001) Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection. PDA J Pharm Sci Technol 55(1):16
    • (2001) PDA J Pharm Sci Technol , vol.55 , Issue.1 , pp. 16
    • Mottu, F.1    Stelling, M.-J.2    Rüfenacht, D.A.3    Doelker, E.4
  • 105
    • 80053471751 scopus 로고    scopus 로고
    • In silico, in vitro and in situ models to assess interplay between CYP3A and P-gp
    • Mudra DR, Desino KE, Desai PV (2011) In silico, in vitro and in situ models to assess interplay between CYP3A and P-gp. Curr Drug Metab 12(8):750-773
    • (2011) Curr Drug Metab , vol.12 , Issue.8 , pp. 750-773
    • Mudra, D.R.1    Desino, K.E.2    Desai, P.V.3
  • 106
    • 84922612491 scopus 로고    scopus 로고
    • A nanoparticle formulation of disulfiram prolongs corneal residence time of the drug and reduces intraocular pressure
    • Nagai N, Yoshioka C, Mano Y, Tnabe W, Ito Y, Okamoto N et al (2015) A nanoparticle formulation of disulfiram prolongs corneal residence time of the drug and reduces intraocular pressure. Exp Eye Res 132:115-123
    • (2015) Exp Eye Res , vol.132 , pp. 115-123
    • Nagai, N.1    Yoshioka, C.2    Mano, Y.3    Tnabe, W.4    Ito, Y.5    Okamoto, N.6
  • 107
    • 34548190107 scopus 로고    scopus 로고
    • Estimation of drug precipitation upon dilution of pH-controlled formulations
    • Narazaki R, Sanghvi R, Yalkowsky SH (2007) Estimation of drug precipitation upon dilution of pH-controlled formulations. Mol Pharm 4(4):550-555
    • (2007) Mol Pharm , vol.4 , Issue.4 , pp. 550-555
    • Narazaki, R.1    Sanghvi, R.2    Yalkowsky, S.H.3
  • 108
    • 0028110468 scopus 로고
    • Pilocarpine incorporated into a submicron emulsion vehicle causes an unexpectedly prolonged ocular hypotensive effect in rabbits
    • Naveh N, Muchtar S, Benita S (1994) Pilocarpine incorporated into a submicron emulsion vehicle causes an unexpectedly prolonged ocular hypotensive effect in rabbits. J Ocul Pharmacol Ther 10(3):509-520
    • (1994) J Ocul Pharmacol Ther , vol.10 , Issue.3 , pp. 509-520
    • Naveh, N.1    Muchtar, S.2    Benita, S.3
  • 109
    • 0002642747 scopus 로고
    • Theorie der Reaktionsgeschwindigkeit in heterogenen Systemen
    • Nernst W (1904) Theorie der Reaktionsgeschwindigkeit in heterogenen Systemen. Zeitschrift f Physikalische Chemie 47:52-55
    • (1904) Zeitschrift F Physikalische Chemie , vol.47 , pp. 52-55
    • Nernst, W.1
  • 110
    • 0036882590 scopus 로고    scopus 로고
    • Medical aerosol propellants
    • Noakes T (2002) Medical aerosol propellants. J Fluor Chem 118(1-2):35-45
    • (2002) J Fluor Chem , vol.118 , Issue.1-2 , pp. 35-45
    • Noakes, T.1
  • 111
    • 33947487639 scopus 로고
    • The rate of solution of solid substances in their own solutions
    • Noyes A, Whitney W (1897) The rate of solution of solid substances in their own solutions. J Am Chem Soc 19:930-934
    • (1897) J am Chem Soc , vol.19 , pp. 930-934
    • Noyes, A.1    Whitney, W.2
  • 112
    • 0031218394 scopus 로고    scopus 로고
    • Pulmonary carcinogenicity of inhaled particles and the maximum tolerated dose
    • Oberdörster G (1997) Pulmonary carcinogenicity of inhaled particles and the maximum tolerated dose. Environ Health Perspect 105(Suppl):1347-1355
    • (1997) Environ Health Perspect , vol.105 , pp. 1347-1355
    • Oberdörster, G.1
  • 113
    • 84945477033 scopus 로고    scopus 로고
    • Topical dexamethasone γ-cyclodextrin nanoparticle eye drops increase visual acuity and decrease macular thickness in diabetic macular oedema
    • Ohira A, Hara K, Jóhannesson G, Tanito M, Ásgrímsdóttir GM, Lund SH et al (2015) Topical dexamethasone γ-cyclodextrin nanoparticle eye drops increase visual acuity and decrease macular thickness in diabetic macular oedema. Acta Ophthalmol 93(7):610-615
    • (2015) Acta Ophthalmol , vol.93 , Issue.7 , pp. 610-615
    • Ohira, A.1    Hara, K.2    Jóhannesson, G.3    Tanito, M.4    Ásgrímsdóttir, G.M.5    Lund, S.H.6
  • 114
    • 0027624518 scopus 로고
    • The effect of nonionic surfactant structure on hemolysis
    • Ohnishi M, Sagitani H (1993) The effect of nonionic surfactant structure on hemolysis. J Am Oil Chem Soc 70(7):679-684
    • (1993) J am Oil Chem Soc , vol.70 , Issue.7 , pp. 679-684
    • Ohnishi, M.1    Sagitani, H.2
  • 116
    • 26944439522 scopus 로고    scopus 로고
    • The lungs as a portal of entry for systemic drug delivery
    • Patton JS, Fishburn CS, Weers JG (2004) The lungs as a portal of entry for systemic drug delivery. Proc Am Thorac Soc 1(4):338-344
    • (2004) Proc am Thorac Soc , vol.1 , Issue.4 , pp. 338-344
    • Patton, J.S.1    Fishburn, C.S.2    Weers, J.G.3
  • 117
    • 33845906339 scopus 로고    scopus 로고
    • Inhaling medicines: Delivering drugs to the body through the lungs
    • Patton JS, Byron PR (2007) Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6(1):67-74
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.1 , pp. 67-74
    • Patton, J.S.1    Byron, P.R.2
  • 119
    • 0021262876 scopus 로고
    • Treatment of glaucoma using minidrops of clonidine
    • Petursson G, Cole R, Hanna C (1984) Treatment of glaucoma using minidrops of clonidine. Arch Ophthalmol 102(8):1180-1181
    • (1984) Arch Ophthalmol , vol.102 , Issue.8 , pp. 1180-1181
    • Petursson, G.1    Cole, R.2    Hanna, C.3
  • 120
    • 77952744763 scopus 로고    scopus 로고
    • Formulation strategy and use of excipients in pulmonary drug delivery
    • Pilcer G, Amighi K (2010) Formulation strategy and use of excipients in pulmonary drug delivery. Int J Pharm 392(1-2):1-19
    • (2010) Int J Pharm , vol.392 , Issue.1-2 , pp. 1-19
    • Pilcer, G.1    Amighi, K.2
  • 121
    • 0028938542 scopus 로고
    • Effects of formulation variables on nasal epithelial cell integrity: Biochemical evaluations
    • Pujara CP, Shao Z, Duncan MR, Mitra AK (1995) Effects of formulation variables on nasal epithelial cell integrity: biochemical evaluations. Int J Pharm 114(2):197-203
    • (1995) Int J Pharm , vol.114 , Issue.2 , pp. 197-203
    • Pujara, C.P.1    Shao, Z.2    Duncan, M.R.3    Mitra, A.K.4
  • 122
    • 84876736176 scopus 로고    scopus 로고
    • Electrochemistry of cyclodextrin inclusion complexes of pharmaceutical compounds
    • Radi AE, Eissa S (2010) Electrochemistry of cyclodextrin inclusion complexes of pharmaceutical compounds. Open Chem Biomed Meth J 3:74-85
    • (2010) Open Chem Biomed Meth J , vol.3 , pp. 74-85
    • Radi, A.E.1    Eissa, S.2
  • 123
    • 0023108799 scopus 로고
    • Lysis of human red blood cells in the presence of various cosolvents III. The relationship between hemolytic potential and structure
    • Reed KW, Yalkowsky SH (1987) Lysis of human red blood cells in the presence of various cosolvents III. The relationship between hemolytic potential and structure. J Parenter Science Technol 41(1):37-39
    • (1987) J Parenter Science Technol , vol.41 , Issue.1 , pp. 37-39
    • Reed, K.W.1    Yalkowsky, S.H.2
  • 124
    • 0035871227 scopus 로고    scopus 로고
    • Impairment of alveolar macrophage phagocytosis by ultrafine particles
    • Renwick LC, Donaldson K, Clouter A (2001) Impairment of alveolar macrophage phagocytosis by ultrafine particles. Toxicol Appl Pharmacol 172(2):119-127
    • (2001) Toxicol Appl Pharmacol , vol.172 , Issue.2 , pp. 119-127
    • Renwick, L.C.1    Donaldson, K.2    Clouter, A.3
  • 125
    • 2442498325 scopus 로고    scopus 로고
    • Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types
    • Renwick LC, Brown D, Clouter A, Donaldson K (2004) Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup Environ Med 61(5):442-447
    • (2004) Occup Environ Med , vol.61 , Issue.5 , pp. 442-447
    • Renwick, L.C.1    Brown, D.2    Clouter, A.3    Donaldson, K.4
  • 126
    • 34249655139 scopus 로고    scopus 로고
    • Particle size and charge distribution analysis of pharmaceutical aerosols generated by inhalers
    • Saini D, Biris AS, Srirama PK, Mazumder MK (2007) Particle size and charge distribution analysis of pharmaceutical aerosols generated by inhalers. Pharm Dev Technol 12(1):35-41
    • (2007) Pharm Dev Technol , vol.12 , Issue.1 , pp. 35-41
    • Saini, D.1    Biris, A.S.2    Srirama, P.K.3    Mazumder, M.K.4
  • 127
    • 67349272759 scopus 로고    scopus 로고
    • Sparing methylation of beta-cyclodextrin mitigates cytotoxicity and permeability induction in respiratory epithelial cell layers in vitro
    • Salem LB, Bosquillon C, Dailey LA, Delattre L, Martin GP, Evrard B et al (2009) Sparing methylation of beta-cyclodextrin mitigates cytotoxicity and permeability induction in respiratory epithelial cell layers in vitro. J Control Release 136(2):110-116
    • (2009) J Control Release , vol.136 , Issue.2 , pp. 110-116
    • Salem, L.B.1    Bosquillon, C.2    Dailey, L.A.3    Delattre, L.4    Martin, G.P.5    Evrard, B.6
  • 128
    • 0035211330 scopus 로고    scopus 로고
    • Effect of particle size of polymeric nanospheres on intravitreal kinetics
    • Sakurai E, Ozeki H, Kunou N, Ogura Y (2001) Effect of particle size of polymeric nanospheres on intravitreal kinetics. Ophthalmic Res 33(1):31-36
    • (2001) Ophthalmic Res , vol.33 , Issue.1 , pp. 31-36
    • Sakurai, E.1    Ozeki, H.2    Kunou, N.3    Ogura, Y.4
  • 129
    • 0034176470 scopus 로고    scopus 로고
    • Recent technological advances in oral drug delivery—a review
    • Sastry S, Nyshadham J, Fix J (2000) Recent technological advances in oral drug delivery—a review. Pharmaceut Sci Tech Today 3(4):138-145
    • (2000) Pharmaceut Sci Tech Today , vol.3 , Issue.4 , pp. 138-145
    • Sastry, S.1    Nyshadham, J.2    Fix, J.3
  • 131
    • 85081146789 scopus 로고    scopus 로고
    • Vitreous anatomy and pathology
    • YanoffM, Duker JS, 4th edn. Saunders, Philadelphia
    • Sebag J (2013) Vitreous anatomy and pathology. In: YanoffM, Duker JS (eds) Ophthalmology: expert consult: online and print, 4th edn. Saunders, Philadelphia, pp 687-689
    • (2013) Ophthalmology: Expert Consult: Online and Print , pp. 687-689
    • Sebag, J.1
  • 133
    • 0036389405 scopus 로고    scopus 로고
    • The mechanism of hemolysis by surfactants: Effect of solution composition
    • Shalel S, Streichman S, Marmur A (2002) The mechanism of hemolysis by surfactants: effect of solution composition. J Colloid Interface Sci 252(1):66-76
    • (2002) J Colloid Interface Sci , vol.252 , Issue.1 , pp. 66-76
    • Shalel, S.1    Streichman, S.2    Marmur, A.3
  • 135
    • 71249130735 scopus 로고    scopus 로고
    • Recent advances in intravenous delivery of poorly water-soluble compounds
    • Shi Y, Porter W, Merdan T, Li LC (2009) Recent advances in intravenous delivery of poorly water-soluble compounds. Expert Opin Drug Deliv 6(12):1261-1282
    • (2009) Expert Opin Drug Deliv , vol.6 , Issue.12 , pp. 1261-1282
    • Shi, Y.1    Porter, W.2    Merdan, T.3    Li, L.C.4
  • 137
    • 0037139411 scopus 로고    scopus 로고
    • Paclitaxel and its formulations
    • Singla AK, Garg A, Aggarwal D (2002) Paclitaxel and its formulations. Int J Pharm 235(1-2):179-192
    • (2002) Int J Pharm , vol.235 , Issue.1-2 , pp. 179-192
    • Singla, A.K.1    Garg, A.2    Aggarwal, D.3
  • 138
    • 0029865450 scopus 로고    scopus 로고
    • Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
    • Smith DA, Jones BC, Walker DK (1996) Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics. Med Res Rev 16(3):243-266
    • (1996) Med Res Rev , vol.16 , Issue.3 , pp. 243-266
    • Smith, D.A.1    Jones, B.C.2    Walker, D.K.3
  • 139
    • 0038433196 scopus 로고    scopus 로고
    • The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers
    • Smyth HDC (2003) The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers. Adv Drug Deliv Rev 55(7):807-828
    • (2003) Adv Drug Deliv Rev , vol.55 , Issue.7 , pp. 807-828
    • Smyth, H.1
  • 141
    • 0029921281 scopus 로고    scopus 로고
    • Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle cremophor EL
    • Sparreboom A, van Tellingen O, Nooijen WJ, Beijnen JH (1996) Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle cremophor EL. Cancer Res 56(9):2112-2115
    • (1996) Cancer Res , vol.56 , Issue.9 , pp. 2112-2115
    • Sparreboom, A.1    Van Tellingen, O.2    Nooijen, W.J.3    Beijnen, J.H.4
  • 142
    • 0033118955 scopus 로고    scopus 로고
    • Cremophor EL-mediated alteration of paclitaxel distribution in human blood: Clinical pharmacokinetic implications
    • Sparreboom A, van Zuylen L, Brouwer E, Loos WJ, de Bruijn P, Gelderblom H et al (1999) Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications. Cancer Res 59(7):1454-1457
    • (1999) Cancer Res , vol.59 , Issue.7 , pp. 1454-1457
    • Sparreboom, A.1    Van Zuylen, L.2    Brouwer, E.3    Loos, W.J.4    De Bruijn, P.5    Gelderblom, H.6
  • 144
    • 0033106029 scopus 로고    scopus 로고
    • Mechanisms of drug release from cyclodextrin complexes
    • Stella V, Rao V, Zannou E, Zia V (1999) Mechanisms of drug release from cyclodextrin complexes. Adv Drug Deliv Rev 36(1):3-16
    • (1999) Adv Drug Deliv Rev , vol.36 , Issue.1 , pp. 3-16
    • Stella, V.1    Rao, V.2    Zannou, E.3    Zia, V.4
  • 145
    • 1242337285 scopus 로고    scopus 로고
    • Solubilizing excipients in oral and injectable formulations
    • Strickley RG (2004) Solubilizing excipients in oral and injectable formulations. Pharm Res 21(2):201-230
    • (2004) Pharm Res , vol.21 , Issue.2 , pp. 201-230
    • Strickley, R.G.1
  • 147
    • 0032754596 scopus 로고    scopus 로고
    • Comparison of nasal deposition and clearance of aerosol generated by a nebulizer and an aqueous spray pump
    • Suman JD, Laube BL, Dalby R (1999) Comparison of nasal deposition and clearance of aerosol generated by a nebulizer and an aqueous spray pump. Pharm Res 16(10):1648-1652
    • (1999) Pharm Res , vol.16 , Issue.10 , pp. 1648-1652
    • Suman, J.D.1    Laube, B.L.2    Dalby, R.3
  • 148
    • 14144252561 scopus 로고    scopus 로고
    • Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug
    • Sunesen VH, Vedelsdal R, Kristensen HG, Christrup L, Müllertz A (2005) Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug. Eur J Pharm Sci 24(4):297-303
    • (2005) Eur J Pharm Sci , vol.24 , Issue.4 , pp. 297-303
    • Sunesen, V.H.1    Vedelsdal, R.2    Kristensen, H.G.3    Christrup, L.4    Müllertz, A.5
  • 149
    • 0032542499 scopus 로고    scopus 로고
    • Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: An in vitro study
    • Szebeni J, Muggia FM, Alving CR (1998) Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study. J Natl Cancer Inst 90(4): 300-306
    • (1998) J Natl Cancer Inst , vol.90 , Issue.4 , pp. 300-306
    • Szebeni, J.1    Muggia, F.M.2    Alving, C.R.3
  • 150
    • 47949090122 scopus 로고    scopus 로고
    • Amorphous cyclosporin nanodispersions for enhanced pulmonary deposition and dissolution
    • Tam JM, McConville JT, Williams RO, Johnston KP (2008) Amorphous cyclosporin nanodispersions for enhanced pulmonary deposition and dissolution. J Pharm Sci 97(11):4915-4933
    • (2008) J Pharm Sci , vol.97 , Issue.11 , pp. 4915-4933
    • Tam, J.M.1    McConville, J.T.2    Williams, R.O.3    Johnston, K.P.4
  • 151
    • 3843096094 scopus 로고    scopus 로고
    • The potential of lipid emulsion for ocular delivery of lipophilic drugs
    • Tamilvanan S, Benita S (2004) The potential of lipid emulsion for ocular delivery of lipophilic drugs. Eur J Pharm Biopharm 58(2):357-368
    • (2004) Eur J Pharm Biopharm , vol.58 , Issue.2 , pp. 357-368
    • Tamilvanan, S.1    Benita, S.2
  • 152
    • 79961158933 scopus 로고    scopus 로고
    • Influence of acetazolamide loading on the (In vitro) performances of non-phospholipid-based cationic nanosized emulsion in comparison with phospholipid-based anionic and neutral-charged nanosized emulsions
    • Tamilvanan S, Kumar BA (2011) Influence of acetazolamide loading on the (in vitro) performances of non-phospholipid-based cationic nanosized emulsion in comparison with phospholipid-based anionic and neutral-charged nanosized emulsions. Drug Dev Ind Pharm 37(9):1003-1015
    • (2011) Drug Dev Ind Pharm , vol.37 , Issue.9 , pp. 1003-1015
    • Tamilvanan, S.1    Kumar, B.A.2
  • 153
    • 84939198268 scopus 로고    scopus 로고
    • Impact of luminal fluid volume on the drug absorption after oral administration: Analysis based on in vivo drug concentration— time profile in the gastrointestinal tract
    • Tanaka Y, Goto T, Kataoka M, Sakuma S, Yamashita S (2015) Impact of luminal fluid volume on the drug absorption after oral administration: analysis based on in vivo drug concentration— time profile in the gastrointestinal tract. J Pharm Sci 104(9):3120-3127
    • (2015) J Pharm Sci , vol.104 , Issue.9 , pp. 3120-3127
    • Tanaka, Y.1    Goto, T.2    Kataoka, M.3    Sakuma, S.4    Yamashita, S.5
  • 154
    • 0041703019 scopus 로고    scopus 로고
    • Pharmacological effects of formulation vehicles: Implications for cancer chemotherapy
    • Ten Tije AJ, Verweij J, Loos WJ, Sparreboom A (2003) Pharmacological effects of formulation vehicles: implications for cancer chemotherapy. Clin Pharmacokinet 42(7):665-685
    • (2003) Clin Pharmacokinet , vol.42 , Issue.7 , pp. 665-685
    • Ten Tije, A.J.1    Verweij, J.2    Loos, W.J.3    Sparreboom, A.4
  • 155
    • 45049083552 scopus 로고    scopus 로고
    • Formulation of rifampicin-cyclodextrin complexes for lung nebulization
    • Tewes F, Brillault J, Couet W, Olivier J-C (2008) Formulation of rifampicin-cyclodextrin complexes for lung nebulization. J Control Release 129(2):93-99
    • (2008) J Control Release , vol.129 , Issue.2 , pp. 93-99
    • Tewes, F.1    Brillault, J.2    Couet, W.3    Olivier, J.-C.4
  • 156
    • 62949122349 scopus 로고    scopus 로고
    • Characterization and in vitro evaluation of the formoterol/ cyclodextrin complex for pulmonary administration by nebulization
    • Thi THH, Azaroual N, Flament M-P (2009) Characterization and in vitro evaluation of the formoterol/ cyclodextrin complex for pulmonary administration by nebulization. Eur J Pharm Biopharm 72(1):214-218
    • (2009) Eur J Pharm Biopharm , vol.72 , Issue.1 , pp. 214-218
    • Thi, T.1    Azaroual, N.2    Flament, M.-P.3
  • 158
    • 74949083533 scopus 로고    scopus 로고
    • Advances in the pulmonary delivery of poorly water-soluble drugs: Influence of solubilization on pharmacokinetic properties
    • Tolman JA, Williams RO (2009) Advances in the pulmonary delivery of poorly water-soluble drugs: influence of solubilization on pharmacokinetic properties. Drug Dev Ind Pharm 36(1):1-30
    • (2009) Drug Dev Ind Pharm , vol.36 , Issue.1 , pp. 1-30
    • Tolman, J.A.1    Williams, R.O.2
  • 160
    • 0023835180 scopus 로고
    • Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits
    • Tsuji A, Tamai I, Sasaki K (1988) Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits. Ophthalmic Res 20(1):31-43
    • (1988) Ophthalmic Res , vol.20 , Issue.1 , pp. 31-43
    • Tsuji, A.1    Tamai, I.2    Sasaki, K.3
  • 161
    • 33751187547 scopus 로고    scopus 로고
    • Challenges and obstacles of ocular pharmacokinetics and drug delivery
    • Urtti A (2006) Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliv Rev 58(11):1131-1135
    • (2006) Adv Drug Deliv Rev , vol.58 , Issue.11 , pp. 1131-1135
    • Urtti, A.1
  • 162
    • 1542301742 scopus 로고    scopus 로고
    • Determinants of eye drop size
    • Van Santvliet L, Ludwig A (2004) Determinants of eye drop size. Surv Ophthalmol 49(2):197-213
    • (2004) Surv Ophthalmol , vol.49 , Issue.2 , pp. 197-213
    • Van Santvliet, L.1    Ludwig, A.2
  • 164
    • 34249787025 scopus 로고    scopus 로고
    • Ocular drug delivery: Nanomedicine applications
    • Vandervoort J, Ludwig A (2007) Ocular drug delivery: nanomedicine applications. Nanomedicine 2(1):11-21
    • (2007) Nanomedicine , vol.2 , Issue.1 , pp. 11-21
    • Vandervoort, J.1    Ludwig, A.2
  • 165
    • 84884582583 scopus 로고    scopus 로고
    • Development, in vitro and in vivo characterization of Eudragit RL 100 nanoparticles for improved ocular bioavailability of acetazolamide
    • Verma P, Gupta RN, Jha AK, Pandey R (2013) Development, in vitro and in vivo characterization of Eudragit RL 100 nanoparticles for improved ocular bioavailability of acetazolamide. Drug Deliv 20(7):269-276
    • (2013) Drug Deliv , vol.20 , Issue.7 , pp. 269-276
    • Verma, P.1    Gupta, R.N.2    Jha, A.K.3    Pandey, R.4
  • 166
    • 84868349955 scopus 로고    scopus 로고
    • Formulation and evaluation of microemulsion-based in situ ion-sensitive gelling systems for intranasal administration of curcumin
    • Wang S, Chen P, Zhang L, Yang C, Zhai G (2012) Formulation and evaluation of microemulsion-based in situ ion-sensitive gelling systems for intranasal administration of curcumin. J Drug Target 20(10):831-840
    • (2012) J Drug Target , vol.20 , Issue.10 , pp. 831-840
    • Wang, S.1    Chen, P.2    Zhang, L.3    Yang, C.4    Zhai, G.5
  • 168
    • 0030041325 scopus 로고    scopus 로고
    • Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice
    • Webster LK, Cosson EJ, Stokes KH, Millward MJ (1996) Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice. Br J Cancer 73(4):522-524
    • (1996) Br J Cancer , vol.73 , Issue.4 , pp. 522-524
    • Webster, L.K.1    Cosson, E.J.2    Stokes, K.H.3    Millward, M.J.4
  • 169
    • 2442643730 scopus 로고    scopus 로고
    • Primary open-angle glaucoma
    • Weinreb RN, Khaw PT (2004) Primary open-angle glaucoma. Lancet 363(9422):1711-1720
    • (2004) Lancet , vol.363 , Issue.9422 , pp. 1711-1720
    • Weinreb, R.N.1    Khaw, P.T.2
  • 170
    • 0029825085 scopus 로고    scopus 로고
    • Effects of food on drug absorption
    • Welling PG (1996) Effects of food on drug absorption. Annu Rev Nutr 16:383-415
    • (1996) Annu Rev Nutr , vol.16 , pp. 383-415
    • Welling, P.G.1
  • 171
    • 42649115104 scopus 로고    scopus 로고
    • Suspensions for intravenous (IV) injection: A review of development, preclinical and clinical aspects
    • Wong J, Brugger A, Khare A, Chaubal M, Papadopoulos P, Rabinow B et al (2008) Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects. Adv Drug Deliv Rev 60(8):939-954
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.8 , pp. 939-954
    • Wong, J.1    Brugger, A.2    Khare, A.3    Chaubal, M.4    Papadopoulos, P.5    Rabinow, B.6
  • 172
    • 38749146264 scopus 로고    scopus 로고
    • Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers
    • Woo JS, Song Y-K, Hong J-Y, Lim S-J, Kim C-K (2008) Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Eur J Pharm Sci 33(2):159-165
    • (2008) Eur J Pharm Sci , vol.33 , Issue.2 , pp. 159-165
    • Woo, J.S.1    Song, Y.-K.2    Hong, J.-Y.3    Lim, S.-J.4    Kim, C.-K.5
  • 173
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu C-Y, Benet LZ (2005) Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 22(1):11-23
    • (2005) Pharm Res , vol.22 , Issue.1 , pp. 11-23
    • Wu, C.-Y.1    Benet, L.Z.2
  • 174
    • 0031854230 scopus 로고    scopus 로고
    • Formulation-related problems associated with intravenous drug delivery
    • Yalkowsky SH, Krzyzaniak JF, Ward GH (1998) Formulation-related problems associated with intravenous drug delivery. J Pharm Sci 87(7):787-796
    • (1998) J Pharm Sci , vol.87 , Issue.7 , pp. 787-796
    • Yalkowsky, S.H.1    Krzyzaniak, J.F.2    Ward, G.H.3
  • 175
    • 47949098294 scopus 로고    scopus 로고
    • High bioavailability from nebulized itraconazole nanoparticle dispersions with biocompatible stabilizers
    • Yang W, Tam J, Miller DA, Zhou J, McConville JT, Johnston KP et al (2008) High bioavailability from nebulized itraconazole nanoparticle dispersions with biocompatible stabilizers. Int J Pharm 361(1-2):177-188
    • (2008) Int J Pharm , vol.361 , Issue.1-2 , pp. 177-188
    • Yang, W.1    Tam, J.2    Miller, D.A.3    Zhou, J.4    McConville, J.T.5    Johnston, K.P.6
  • 176
    • 77549085772 scopus 로고    scopus 로고
    • In vitro characterization and pharmacokinetics in mice following pulmonary delivery of itraconazole as cyclodextrin solubilized solution
    • Yang W, Chow KT, Lang B, Wiederhold NP, Johnston KP, Williams RO (2010) In vitro characterization and pharmacokinetics in mice following pulmonary delivery of itraconazole as cyclodextrin solubilized solution. Eur J Pharm Sci 39(5):336-347
    • (2010) Eur J Pharm Sci , vol.39 , Issue.5 , pp. 336-347
    • Yang, W.1    Chow, K.T.2    Lang, B.3    Wiederhold, N.P.4    Johnston, K.P.5    Williams, R.O.6
  • 177
    • 84884161844 scopus 로고    scopus 로고
    • Drug delivery to the ocular posterior segment using lipid emulsion via eye drop administration: Effect of emulsion formulations and surface modification
    • Ying L, Tahara K, Takeuchi H (2013) Drug delivery to the ocular posterior segment using lipid emulsion via eye drop administration: effect of emulsion formulations and surface modification. Int J Pharm 453(2):329-335
    • (2013) Int J Pharm , vol.453 , Issue.2 , pp. 329-335
    • Ying, L.1    Tahara, K.2    Takeuchi, H.3
  • 178
    • 84055176267 scopus 로고    scopus 로고
    • The effect of food on the oral bioavailability of drugs: A review of current developments and pharmaceutical technologies for pharmacokinetic control
    • Yasuji T, Kondo H, Sako K (2011) The effect of food on the oral bioavailability of drugs: a review of current developments and pharmaceutical technologies for pharmacokinetic control. Ther Deliv 3(1):81-90
    • (2011) Ther Deliv , vol.3 , Issue.1 , pp. 81-90
    • Yasuji, T.1    Kondo, H.2    Sako, K.3
  • 179
    • 0018144615 scopus 로고
    • Action of surface-active substances of biological membranes III. Comparison of hemolytic activity of ionic and nonionic surfactants
    • Zaslavsky BY, Ossipov NN, Rogozhin SV (1978) Action of surface-active substances of biological membranes III. Comparison of hemolytic activity of ionic and nonionic surfactants. Biochim Biophys Acta 510(1):151-159
    • (1978) Biochim Biophys Acta , vol.510 , Issue.1 , pp. 151-159
    • Zaslavsky, B.Y.1    Ossipov, N.N.2    Rogozhin, S.V.3


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