Estimation of drug precipitation upon dilution of pH-controlled formulations

Molecular Pharmaceutics

Volumn 4, Issue 4, 2007, Pages 550-555

  Narazaki, Ryuichi ^a,b   Sanghvi, Ritesh ^a   Yalkowsky, Samuel H ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b Formulation Research Lab   (Japan)

Author keywords

Buffer; Estimation; pH; Phenytoin; Precipitation

Indexed keywords

PHENYTOIN;

ACIDITY; ARTICLE; DILUTION; DRUG FORMULATION; DRUG SOLUBILITY; PH; PRECIPITATION; PRIORITY JOURNAL;

ANTICONVULSANTS; BUFFERS; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; HYDROGEN-ION CONCENTRATION; PHARMACEUTICAL PREPARATIONS; PHENYTOIN; PRECIPITATION; SOLUBILITY;

EID: 34548190107     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp070007o     Document Type: Article

References (16)

1. Yalkowsky, S. H.; Valvani, S. C.; Johnson, B. W. In vitro method for detecting precipitation of parenteral formulations after injection. J. Pharm. Sci. 1983, 72 (9), 1014-1017.
2. Yalkowsky, S. H.; Krzyzaniak, J. F.; Ward, G. H. Formulation-related problems associated with intravenous drug delivery. J. Pharm. Sci. 1998, 87 (7), 787-796.
3. Stella, V. J.; Rajewski, R. A. Cyclodextrins: Their future in drug formulation and delivery. Pharm. Res. 1997, 14 (5), 556-567.
4. Jinno, J.; Oh, D.; Crison, J. R.; Amidon, G. L. Dissolution of ionizable water-insoluble drugs: The combined effect of pH and surfactant. J. Pharm. Sci. 2000, 89 (2), 268-274.
5. Strickley, R. G. Solubilizing excipients in oral and injectable formulations. Pharm. Res. 2004, 21 (2), 201-230.
6. Uekama, K. Design and evaluation of cyclodextrin-based drug formulation. Chem. Pharm. Bull. 2004, 52 (8), 900-915.
7. Johnson, J. L. H.; He, Y.; Yalkowsky, S. H. Prediction of precipitation-induced phlebitis: a statistical validation of an in vitro model. J. Pharm. Sci. 2003, 92 (8), 1574-1581.
8. Jain, N.; Yalkowsky, S. H. Estimation of the aqueous solubility I: application to organic nonelectrolytes. J. Pharm. Sci. 2001, 90 (2), 234-252.
9. Gao, H.; Shanmugasundaram, V.; Lee, P. Estimation of aqueous solubility of organic compounds with QSPR approach. Pharm. Res. 2002, 19 (4), 497-503.
10. Tetko, I. V.; Poda, G. I. Application of ALOGPS 2.1 to predict logD distribution coefficient for Pfizer proprietary compounds. J. Med. Chem. 2004, 47 (23), 4601-5604.
11. Schroeder, H. G.; DeLuca, P. P. A study on the in vitro precipitation of poorly soluble drugs from nonaqueous vehicles in human plasma. Bull. Parenter. Drug Assoc. 1974, 28 (1), 1-14.
12. Yalkowsky, S. H.; Valvani, S. C. Prediction of solubilized drugs due to injection or dilution. Drug Intell. Clin. Pharm. 1977, 11 (7), 417-419.
13. Powis, G.; Kovach, J. S. Disposition of bisantrene in humans and rabbits: evidence for intravascular deposition of drug as a cause of phlebitis. Cancer Res. 1983, 43 (2), 925-929.
14. Mydral, P. B.; Simamora, P.; Surakitbanharn, Y.; Yalkowsky, S. H. Studies in Phlebitis. VII: In vitro and in vivo evaluation of pH-solublized levemopamil. J. Pharm. Sci. 1995, 84 (7), 849-852.
15. Surakitbanharn, Y.; Simamora, P.; Ward, G. H.; Yalkowsky, S. H. Prediction of pH solubilized phenytoin. Int. J. Pharm. 1994, 109 (1), 27-33.
16. 4Cl. Fluid Phase Equilib. 2006, 241 (1-2), 59-69.