Characterization and in vitro evaluation of the formoterol/cyclodextrin complex for pulmonary administration by nebulization

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 1, 2009, Pages 214-218

  Thi, Thanh Huong Hoang ^a   Azaroual, Nathalie ^b   Flament, Marie Pierre ^a  

^a Laboratoire de Pharmacotechnie Industrielle   (France)

^b UNITÉ DE CATALYSE ET DE CHIMIE DU SOLIDE   (France)

Author keywords

Cyclodextrins; Formoterol; Nebulization efficiency; NMR

Indexed keywords

CRYSMEB; CYCLODEXTRIN DERIVATIVE; FORMOTEROL; KLEPTOSE; MW 1190; MW 1481; UNCLASSIFIED DRUG;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; DRUG SOLUTION; DRUG STRUCTURE; IN VITRO STUDY; NEBULIZATION; NEBULIZER; NUCLEAR MAGNETIC RESONANCE;

ADMINISTRATION, INHALATION; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLODEXTRINS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ETHANOLAMINES; HUMANS; LUNG; MAGNETIC RESONANCE SPECTROSCOPY; NEBULIZERS AND VAPORIZERS; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY;

EID: 62949122349     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.10.012     Document Type: Article

References (23)

1. Agu R.U., Ugwoke M.I., Armand M., Kinget R., and Verbeke N. The lungs as a route for systemic delivery of therapeutic proteins and peptides. Respiratory research 2 (2001) 198-209
2. Williams III R.O., Mahaguna V., and Sriwongjanya M. Characterization of an inclusion complex of cholesterol and hydroxypropyl-b-cyclodextrin. European Journal of Pharmaceutics and Biopharmaceutics 46 (1998) 355-360
3. Duchêne D., and Wouessidjewe D. Pharmaceutical uses of cyclodextrins and derivatives. Drug Development and Industrial Pharmacy 16 (1990) 2487-2499
4. Loftsson T., and Brewster M.E. Pharmaceutical applications of cyclodextrins. I. Drug solubilization and stabilization. Journal of Pharmaceutical Sciences 85 (1996) 1017-1025
5. Cabral Margues H.M., Hadgratt J., Kellaway I.W., and Taylor G. Studies of cyclodextrin inclusion complexes Part 3: Pulmonary absorption of beta, DM-beta and HP-beta-cyclodextrins in rabbits. International Journal of Pharmaceutics 77 (1991) 297-302
6. H.U. Bryant, G.J. Cullinan, P.C. Francis, D.E. Magee, S.A. Sweetana, A.I. Thakkar, Aqueous solution inclusion complexes of benzothiophene compounds with water soluble cyclodextrins and pharmaceutical formulations and methods thereof U.S. patent 5 624 940, 1997.
7. Moren F. Dosage forms and formulation for drug administration to the respiratory tract. Drug Development and Industrial Pharmacy 13 (1987) 655-728
8. Newman S.P., Pellow P.G.D., and Clarke S.W. Drop sizes from medical atomisers (nebulisers) for drug solutions with different viscosities and surface tensions. Atomization Spray Technology 3 (1987) 1-11
9. McCollion O.N.M., Taylor K.M.G., Thomas M., and Taylor A.J. The influence of surface tension on aerosols produced by medical nebulisers. International Journal of Pharmaceutics 129 (1996) 123-136
10. McCallion O.N.M., and Patel M.J. Viscosity effects on nebulisation of aqueous solutions. International Journal of Pharmaceutics 130 (1996) 245-249
11. Flament M.P., Leterme P., and Gayot A. Factors influencing nebulizing efficiency. Drug Development and Industrial Pharmacy 21 20 (1995) 2263-2285
12. 1 protease inhibitor. International Journal of Pharmaceutics 148 (1997) 93-101
13. Le V.N.P., Leterme P., Gayot A., and Flament M.P. Aerosolization potential of cyclodextrins - Influence of the operating conditions. PDA Journal of Pharmaceutical Science and Technology 60 (2006) 314-322
14. Akapo S.O., and Asif M. Validation of a RP-HPLC method for the assay of formoterol and its related substances in formoterol fumarate dihydrate drug substance. Journal of Pharmaceutical and Biomedical Analysis 33 (2003) 935-945
15. European Pharmacopoeia. 2.2.9, Viscosité - Méthode au tube capillaire, 2005, p. 30.
16. de Boer A.H., Gjaltema D., Hagedoorn P., and Frijlink H.W. Characterization of inhalation aerosols: a critical evaluation of cascade impactor analysis and laser diffraction technique. International Journal of Pharmaceutics 249 (2002) 219-231
17. Bridges P.A., and Taylor K.M.G. Nebulizers for the generation of liposomal aerosols. International Journal of Pharmaceutics 173 (1998) 117-125
18. Hurley P.K., Smye S.W., and Cunliffe H. Assessment of antibiotic aerosol generation using commercial jet nebulizers. Journal of Aerosol Medicine 7 (1994) 217-228
19. Clark A.R. The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers. International Journal of Pharmaceutics 115 (1995) 69-78
20. Flament M.P., Leterme P., Burnouf T., and Gayot A.T. Jet nebulisation: influence of dynamic conditions and nebuliser on nebulisation quality - Application to the alpha 1 protease inhibitor. International Journal of Pharmaceutics 148 (1997) 93-101
21. Davis S.S. Physicochemical studies on aerosol solutions for drug delivery. I. Water-propylene glycol systems. International Journal of Pharmaceutics 1 (1978) 71-83
22. United States Pharmacopoeia 28, 601: Aerosols, nasal sprays, metered dose inhalers and dry powder inhalers - Particle size, 2005, p. 2364.
23. Flament M.P., Leterme P., and Gayot A.T. Factors influencing nebulizing efficiency. Drug Development and Industrial Pharmacy 21 20 (1995) 2263-2285