Design of experiments to optimize an in vitro cast to predict human nasal drug deposition

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 27, Issue 1, 2014, Pages 21-29

  Shah, Samir A ^a   Dickens, Colin J ^b   Ward, David J ^b   Banaszek, Anna A ^b   George, Chris ^a   Horodnik, Walter ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Bespak Europe Ltd   (United Kingdom)

Author keywords

design of experiments; in vitro; nasal cast; nasal deposition; nasal drug delivery

Indexed keywords

GLYCEROL; NYLON; POLIDOCANOL;

ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; EQUIPMENT; FILTER; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MUCUS; NASOPHARYNX; NOSE AIRFLOW; NOSE CAVITY; NYLON NASAL CAST; OPERATOR; PREDICTIVE VALUE; REPRODUCIBILITY; SUSPENSION; THROAT; TURBINATE;

ADMINISTRATION, INTRANASAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLYCEROL; HUMANS; MODELS, ANATOMIC; MUCUS; NASAL SPRAYS; NOSE; PHARMACEUTICAL PREPARATIONS; POLYETHYLENE GLYCOLS; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; TECHNOLOGY, PHARMACEUTICAL;

EID: 84893105547     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2012.1011     Document Type: Article

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