Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

Journal of Neuroinflammation

Volumn 14, Issue 1, 2017, Pages

  Li, Mengmeng ^a   Li, Chenli ^a   Yu, Hanjie ^a   Cai, Xiongxiong ^a   Shen, Xinbei ^a   Sun, Xin ^a   Wang, Jinting ^a   Zhang, Yanhua ^a   Wang, Chuang ^a  

^a NINGBO UNIVERSITY   (China)

Author keywords

Anxiety; Depression; Interleukin 1 (IL 1 ); Lipopolysaccharides (LPS); Memory deficits

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; HEME OXYGENASE 1; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MALONALDEHYDE; NEUROPEPTIDE; SHORT HAIRPIN RNA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; VASCULOTROPIN RECEPTOR;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; DOWN REGULATION; ELEVATED ZERO MAZE TEST; ENZYME LINKED IMMUNOSORBENT ASSAY; FORCED SWIM TEST; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LENTIVIRINAE; MALE; MENTAL DISEASE; MICROINJECTION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OPEN FIELD TEST; OXIDATIVE STRESS; SUCROSE PREFERENCE TEST; ANIMAL; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECT; GENE KNOCKDOWN; IMMUNOLOGY; INFLAMMATION; LENTIVIRUS; MEMORY DISORDER; METABOLISM; PHYSIOLOGY;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; DEPRESSION; GENE KNOCKDOWN TECHNIQUES; HIPPOCAMPUS; INFLAMMATION; INTERLEUKIN-1BETA; LENTIVIRUS; LIPOPOLYSACCHARIDES; MALE; MEMORY DISORDERS; MICE;

EID: 85029757499     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-017-0964-9     Document Type: Article

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