메뉴 건너뛰기




Volumn 234, Issue 4, 2017, Pages 525-533

Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation

Author keywords

Brexpiprazole; Fluoxetine; Inflammation; Spine; SSRI

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BREXPIPRAZOLE; FLUOXETINE; ANTIDEPRESSANT AGENT; NEUROLEPTIC AGENT; QUINOLONE DERIVATIVE; THIOPHENE DERIVATIVE;

EID: 84995380118     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-016-4483-7     Document Type: Article
Times cited : (57)

References (51)
  • 1
    • 4444324234 scopus 로고    scopus 로고
    • The effectiveness of olanzapine, risperidone, quetiapine, and ziprasidone as augmentation agents in treatment-resistant major depressive disorder
    • COI: 1:CAS:528:DC%2BD2cXns1Ggt7Y%3D, PID: 15291687
    • Barbee JG, Conrad EJ, Jamhour NJ (2004) The effectiveness of olanzapine, risperidone, quetiapine, and ziprasidone as augmentation agents in treatment-resistant major depressive disorder. J Clin Psychiatry 65:975–981
    • (2004) J Clin Psychiatry , vol.65 , pp. 975-981
    • Barbee, J.G.1    Conrad, E.J.2    Jamhour, N.J.3
  • 2
    • 84901083930 scopus 로고    scopus 로고
    • Efficacy and safety of olanzapine/fluoxetine combination vs fluoxetine monotherapy following successful combination therapy of treatment-resistant major depressive disorder
    • COI: 1:CAS:528:DC%2BC2cXos1ehsb8%3D, PID: 24801768
    • Brunner E, Tohen M, Osuntokun O, Landry J, Thase ME (2014) Efficacy and safety of olanzapine/fluoxetine combination vs fluoxetine monotherapy following successful combination therapy of treatment-resistant major depressive disorder. Neuropsychopharmacology 39:2549–2559
    • (2014) Neuropsychopharmacology , vol.39 , pp. 2549-2559
    • Brunner, E.1    Tohen, M.2    Osuntokun, O.3    Landry, J.4    Thase, M.E.5
  • 3
    • 84943359035 scopus 로고    scopus 로고
    • Ketamine-like effects of a combination of olanzapine and fluoxetine on AMPA and NMDA receptor-mediated transmission in the medial prefrontal cortex of the rat
    • PID: 26233606
    • Björkholm C, Jardemark K, Schilstrom B, Svensson TH (2015) Ketamine-like effects of a combination of olanzapine and fluoxetine on AMPA and NMDA receptor-mediated transmission in the medial prefrontal cortex of the rat. Eur Neuropsychopharmacol 25:1842–1847
    • (2015) Eur Neuropsychopharmacol , vol.25 , pp. 1842-1847
    • Björkholm, C.1    Jardemark, K.2    Schilstrom, B.3    Svensson, T.H.4
  • 4
    • 84938677047 scopus 로고    scopus 로고
    • 2 receptor partial agonist for the treatment of schizophrenia and major depressive disorder
    • COI: 1:STN:280:DC%2BC287hvVOqsQ%3D%3D
    • 2 receptor partial agonist for the treatment of schizophrenia and major depressive disorder. Drugs Today (Barc) 51:397–414
    • (2015) Drugs Today (Barc) , vol.51 , pp. 397-414
    • Citrome, L.1
  • 5
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: when the immune system subjugates the brain
    • COI: 1:CAS:528:DC%2BD2sXhsVGjsbfJ, PID: 18073775
    • Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56
    • (2008) Nat Rev Neurosci , vol.9 , pp. 46-56
    • Dantzer, R.1    O’Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 6
    • 84959124220 scopus 로고    scopus 로고
    • Effects of escitalopram, R-citalopram, and reboxetine on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration
    • COI: 1:CAS:528:DC%2BC28XjtFOksbw%3D
    • Dong C, Zhang JC, Yao W, Ren Q, Yang C, Ma M, Han M, Saito R, Hashimoto K (2016) Effects of escitalopram, R-citalopram, and reboxetine on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration. See comment in PubMed Commons belowPharmacol Biochem Behav 144:7–12
    • (2016) See comment in PubMed Commons belowPharmacol Biochem Behav , vol.144 , pp. 7-12
    • Dong, C.1    Zhang, J.C.2    Yao, W.3    Ren, Q.4    Yang, C.5    Ma, M.6    Han, M.7    Saito, R.8    Hashimoto, K.9
  • 8
    • 84867227874 scopus 로고    scopus 로고
    • Synaptic dysfunction in depression: potential therapeutic targets
    • COI: 1:CAS:528:DC%2BC38XhsVejsLrE, PID: 23042884
    • Duman RS, Aghajanian GK (2012) Synaptic dysfunction in depression: potential therapeutic targets. Science 338:68–72
    • (2012) Science , vol.338 , pp. 68-72
    • Duman, R.S.1    Aghajanian, G.K.2
  • 9
    • 77955078119 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor as a biomarker for mood disorders: a historical overview and future directions
    • COI: 1:CAS:528:DC%2BC3cXhtFalt7vM, PID: 20653908
    • Hashimoto K (2010) Brain-derived neurotrophic factor as a biomarker for mood disorders: a historical overview and future directions. Psychiatry Clin Neurosci 64:341–357
    • (2010) Psychiatry Clin Neurosci , vol.64 , pp. 341-357
    • Hashimoto, K.1
  • 10
    • 84925513765 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) and its precursor proBDNF as diagnostic biomarkers for major depressive disorder and bipolar disorder
    • PID: 25362578
    • Hashimoto K (2015a) Brain-derived neurotrophic factor (BDNF) and its precursor proBDNF as diagnostic biomarkers for major depressive disorder and bipolar disorder. Eur Arch Psychiatry Clin Neurosci 265:83–84
    • (2015) Eur Arch Psychiatry Clin Neurosci , vol.265 , pp. 83-84
    • Hashimoto, K.1
  • 11
    • 84927667387 scopus 로고    scopus 로고
    • Inflammatory biomarkers as differential predictors of antidepressant response
    • COI: 1:CAS:528:DC%2BC2MXotFKjtL0%3D, PID: 25856677
    • Hashimoto K (2015b) Inflammatory biomarkers as differential predictors of antidepressant response. Int J Mol Sci 16:7796–7801
    • (2015) Int J Mol Sci , vol.16 , pp. 7796-7801
    • Hashimoto, K.1
  • 12
    • 15944381614 scopus 로고    scopus 로고
    • Relationship between brain serotonin transporter binding, plasma concentration and behavioral effect of selective serotonin reuptake inhibitors
    • COI: 1:CAS:528:DC%2BD2MXisVSiu7g%3D
    • Hirano K, Kimura R, Sugimoto Y, Yamada J, Uchida S, Kato Y, Hashimoto H, Yamada S (2005) Relationship between brain serotonin transporter binding, plasma concentration and behavioral effect of selective serotonin reuptake inhibitors. Bri J Pharmacol 144:695–702
    • (2005) Bri J Pharmacol , vol.144 , pp. 695-702
    • Hirano, K.1    Kimura, R.2    Sugimoto, Y.3    Yamada, J.4    Uchida, S.5    Kato, Y.6    Hashimoto, H.7    Yamada, S.8
  • 14
    • 54049133277 scopus 로고    scopus 로고
    • The molecular neurobiology of depression
    • COI: 1:CAS:528:DC%2BD1cXht1GgurrE, PID: 18923511
    • Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 455:894–902
    • (2008) Nature , vol.455 , pp. 894-902
    • Krishnan, V.1    Nestler, E.J.2
  • 15
    • 84899504520 scopus 로고    scopus 로고
    • Effects of brilliant blue G on serum tumor necrosis factor-α levels and depression-like behavior in mice after lipopolysaccharide administration
    • COI: 1:CAS:528:DC%2BC2cXhtVCqsbzF, PID: 24851118
    • Ma M, Ren Q, Zhang JC, Hashimoto K (2014) Effects of brilliant blue G on serum tumor necrosis factor-α levels and depression-like behavior in mice after lipopolysaccharide administration. Clin Psychopharmacol Neurosci 12:31–36
    • (2014) Clin Psychopharmacol Neurosci , vol.12 , pp. 31-36
    • Ma, M.1    Ren, Q.2    Zhang, J.C.3    Hashimoto, K.4
  • 18
    • 34447629382 scopus 로고    scopus 로고
    • Physiology and neurobiology of stress and adaptation: central role of the brain
    • PID: 17615391
    • McEwen BS (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87:873–904
    • (2007) Physiol Rev , vol.87 , pp. 873-904
    • McEwen, B.S.1
  • 19
    • 84959916961 scopus 로고    scopus 로고
    • Adjunctive brexpiprazole: a review in major depressive disorder
    • COI: 1:CAS:528:DC%2BC28Xis1CgtLs%3D, PID: 26849053
    • McKeage K (2016) Adjunctive brexpiprazole: a review in major depressive disorder. CNS Drugs 30:91–99
    • (2016) CNS Drugs , vol.30 , pp. 91-99
    • McKeage, K.1
  • 20
    • 84952342629 scopus 로고    scopus 로고
    • The role of inflammation in depression: from evolutionary imperative to modern treatment target
    • Miller AH, Raison CL (2015) The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 16:22–34
    • (2015) Nat Rev Immunol , vol.16 , pp. 22-34
    • Miller, A.H.1    Raison, C.L.2
  • 21
    • 84903584769 scopus 로고    scopus 로고
    • Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N = 9484)
    • COI: 1:CAS:528:DC%2BC2cXhtVKmurfL, PID: 23958957
    • Molendijk ML, Spinhoven P, Polak M, Bus BA, Penninx BW, Elzinga BM (2014) Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N = 9484). Mol Psychiatry 19:791–800
    • (2014) Mol Psychiatry , vol.19 , pp. 791-800
    • Molendijk, M.L.1    Spinhoven, P.2    Polak, M.3    Bus, B.A.4    Penninx, B.W.5    Elzinga, B.M.6
  • 22
    • 69949087539 scopus 로고    scopus 로고
    • PID: 19687129, Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials
    • Nelson JC, Papakostas GI (2009) Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials Am J Psychiatry 166:980–991.
    • (2009) Am J Psychiatry , vol.166 , pp. 980-991
    • Nelson, J.C.1    Papakostas, G.I.2
  • 23
    • 33746900423 scopus 로고    scopus 로고
    • The mesolimbic dopamine reward circuit in depression
    • COI: 1:CAS:528:DC%2BD28XmtVOitrk%3D, PID: 16566899
    • Nestler EJ, Carlezon WA Jr (2006) The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 59:1151–1159
    • (2006) Biol Psychiatry , vol.59 , pp. 1151-1159
    • Nestler, E.J.1    Carlezon, W.A.2
  • 25
    • 84929619652 scopus 로고    scopus 로고
    • Glutamate signaling in synaptogenesis and NMDA receptors as potential therapeutic targets for psychiatric disorders
    • COI: 1:CAS:528:DC%2BC2MXosVGgurk%3D, PID: 25817855
    • Ohgi Y, Futamura T, Hashimoto K (2015) Glutamate signaling in synaptogenesis and NMDA receptors as potential therapeutic targets for psychiatric disorders. Curr Mol Med 15:206–221
    • (2015) Curr Mol Med , vol.15 , pp. 206-221
    • Ohgi, Y.1    Futamura, T.2    Hashimoto, K.3
  • 26
    • 84872534794 scopus 로고    scopus 로고
    • Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration
    • COI: 1:CAS:528:DC%2BC3sXitVGgu7c%3D, PID: 23262300
    • Ohgi Y, Futamura T, Kikuchi T, Hashimoto K (2013) Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration. Pharmacol Biochem Behav 103:853–859
    • (2013) Pharmacol Biochem Behav , vol.103 , pp. 853-859
    • Ohgi, Y.1    Futamura, T.2    Kikuchi, T.3    Hashimoto, K.4
  • 27
    • 85006483249 scopus 로고    scopus 로고
    • Efficacy of aripiprazole augmentation in Japanese patients with major depressive disorder: a subgroup analysis and Montgomery-Åsberg depression rating scale and Hamilton rating scale for depression item analyses of the aripiprazole depression multicenter efficacy study
    • COI: 1:CAS:528:DC%2BC2MXhvFGnsw%3D%3D, PID: 24965202
    • Ozaki N, Otsubo T, Kato M, Higuchi T, Ono H, Kamijima K, ADMIRE Study Group (2015) Efficacy of aripiprazole augmentation in Japanese patients with major depressive disorder: a subgroup analysis and Montgomery-Åsberg depression rating scale and Hamilton rating scale for depression item analyses of the aripiprazole depression multicenter efficacy study. Psychiatry Clin Neurosci 69:34–42
    • (2015) Psychiatry Clin Neurosci , vol.69 , pp. 34-42
    • Ozaki, N.1    Otsubo, T.2    Kato, M.3    Higuchi, T.4    Ono, H.5    Kamijima, K.6
  • 28
    • 84949200946 scopus 로고    scopus 로고
    • Ziprasidone augmentation of escitalopram for major depressive disorder: efficacy results from a randomized, double-blind, placebo-controlled study
    • PID: 26085041
    • Papakostas GI, Fava M, Baer L, Swee MB, Jaeger A, Bobo WV, Shelton RC (2015) Ziprasidone augmentation of escitalopram for major depressive disorder: efficacy results from a randomized, double-blind, placebo-controlled study. Am J Psychiatry 172:1251–1258
    • (2015) Am J Psychiatry , vol.172 , pp. 1251-1258
    • Papakostas, G.I.1    Fava, M.2    Baer, L.3    Swee, M.B.4    Jaeger, A.5    Bobo, W.V.6    Shelton, R.C.7
  • 30
    • 34347345918 scopus 로고    scopus 로고
    • Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis
    • COI: 1:CAS:528:DC%2BD2sXot1eitrg%3D, PID: 17592905
    • Papakostas GI, Shelton RC, Smith J, Fava M (2007) Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis. J Clin Psychiatry 68:826–831
    • (2007) J Clin Psychiatry , vol.68 , pp. 826-831
    • Papakostas, G.I.1    Shelton, R.C.2    Smith, J.3    Fava, M.4
  • 31
    • 84894205935 scopus 로고    scopus 로고
    • Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: preclinical and clinical efficacy
    • Rogóz Z (2013) Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: preclinical and clinical efficacy. Pharmacol Rep 65:1536–1544
    • (2013) Pharmacol Rep , vol.65 , pp. 1536-1544
    • Rogóz, Z.1
  • 32
    • 84992220435 scopus 로고    scopus 로고
    • Inflammation models of depression in rodents: relevance to psychotropic drug discovery
    • PID: 27026361
    • Remus JL, Dantzer R (2016) Inflammation models of depression in rodents: relevance to psychotropic drug discovery. Int J Neuropsychopharmacol 19:pyw028
    • (2016) Int J Neuropsychopharmacol , vol.19 , pp. pyw028
    • Remus, J.L.1    Dantzer, R.2
  • 34
    • 84989352639 scopus 로고    scopus 로고
    • BDNF-TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms
    • COI: 1:CAS:528:DC%2BC2MXhslakt7bI, PID: 26506052
    • Ren Q, Ma M, Yang C, Zhang JC, Yao W, Hashimoto K (2015) BDNF-TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms. Transl Psychiatry 5:e666
    • (2015) Transl Psychiatry , vol.5
    • Ren, Q.1    Ma, M.2    Yang, C.3    Zhang, J.C.4    Yao, W.5    Hashimoto, K.6
  • 35
    • 40449093482 scopus 로고    scopus 로고
    • Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder
    • COI: 1:CAS:528:DC%2BD1cXkslyqur8%3D, PID: 18190674
    • Shelton RC, Papakostas GI (2008) Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder. Acta Psychiatr Scand 117:253–259
    • (2008) Acta Psychiatr Scand , vol.117 , pp. 253-259
    • Shelton, R.C.1    Papakostas, G.I.2
  • 37
    • 84945448917 scopus 로고    scopus 로고
    • Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist
    • COI: 1:CAS:528:DC%2BC2MXhsFWls7rE, PID: 26419294
    • Shirayama Y, Yang C, Zhang JC, Ren Q, Yao W, Hashimoto K (2015) Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist. Eur Neuropsychopharmacol 25:2449–2458
    • (2015) Eur Neuropsychopharmacol , vol.25 , pp. 2449-2458
    • Shirayama, Y.1    Yang, C.2    Zhang, J.C.3    Ren, Q.4    Yao, W.5    Hashimoto, K.6
  • 38
    • 84959338879 scopus 로고    scopus 로고
    • Mechanism of action of brexpiprazole: comparison with aripiprazole
    • PID: 26899451
    • Stahl SM (2016) Mechanism of action of brexpiprazole: comparison with aripiprazole. CNS Spectr 21:1–6
    • (2016) CNS Spectr , vol.21 , pp. 1-6
    • Stahl, S.M.1
  • 40
    • 85052350866 scopus 로고    scopus 로고
    • The novel atypical antipsychotic brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism. Abstract at the Monitoring Molecules in Neuroscience 2016
    • Gothenburg, Sweden
    • Svensson TH, Björkholm C, Konradsson-Geuken A, Jardemark K, Marcus MM (2016) The novel atypical antipsychotic brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism. Abstract at the Monitoring Molecules in Neuroscience 2016. May 29 – June 2, Gothenburg, Sweden
    • (2016) May 29 – June 2
    • Svensson, T.H.1    Björkholm, C.2    Konradsson-Geuken, A.3    Jardemark, K.4    Marcus, M.M.5
  • 41
    • 84942502416 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants
    • PID: 26301701
    • Thase ME, Youakim JM, Skuban A, Hobart M, Augustine C, Zhang P, McQuade RD, Carson WH, Nyilas M, Sanchez R, Eriksson H (2015a) Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants. J Clin Psychiatry 76:1224–1231
    • (2015) J Clin Psychiatry , vol.76 , pp. 1224-1231
    • Thase, M.E.1    Youakim, J.M.2    Skuban, A.3    Hobart, M.4    Augustine, C.5    Zhang, P.6    McQuade, R.D.7    Carson, W.H.8    Nyilas, M.9    Sanchez, R.10    Eriksson, H.11
  • 42
    • 84942502416 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants
    • PID: 26301771
    • Thase ME, Youakim JM, Skuban A, Hobart M, Zhang P, McQuade RD, Nyilas M, Carson WH, Sanchez R, Eriksson H (2015b) Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants. J Clin Psychiatry 76:1232–1240
    • (2015) J Clin Psychiatry , vol.76 , pp. 1232-1240
    • Thase, M.E.1    Youakim, J.M.2    Skuban, A.3    Hobart, M.4    Zhang, P.5    McQuade, R.D.6    Nyilas, M.7    Carson, W.H.8    Sanchez, R.9    Eriksson, H.10
  • 43
    • 84929647417 scopus 로고    scopus 로고
    • Regional differences in brain-derived neurotrophic factor levels and dendritic spine density confer resilience to inescapable stress
    • PID: 25568287
    • Yang C, Shirayama Y, Zhang JC, Ren Q, Hashimoto K (2015a) Regional differences in brain-derived neurotrophic factor levels and dendritic spine density confer resilience to inescapable stress. Int J Neuropsychopharmacol 18:pyu121
    • (2015) Int J Neuropsychopharmacol , vol.18 , pp. pyu121
    • Yang, C.1    Shirayama, Y.2    Zhang, J.C.3    Ren, Q.4    Hashimoto, K.5
  • 44
    • 84940855007 scopus 로고    scopus 로고
    • R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
    • COI: 1:CAS:528:DC%2BC2MXhsV2jsLjE, PID: 26327690
    • Yang C, Shirayama Y, Zhang JC, Ren Q, Yao W, Ma M, Dong C, Hashimoto K (2015b) R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects. Transl Psychiatry 5:e632
    • (2015) Transl Psychiatry , vol.5
    • Yang, C.1    Shirayama, Y.2    Zhang, J.C.3    Ren, Q.4    Yao, W.5    Ma, M.6    Dong, C.7    Hashimoto, K.8
  • 45
    • 84934755205 scopus 로고    scopus 로고
    • Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration
    • COI: 1:CAS:528:DC%2BC2MXhtlWhurzE, PID: 26150007
    • Yao W, Zhang JC, Dong C, Zhuang C, Hirota S, Inanaga K, Hashimoto K (2015) Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration. Pharmacol Biochem Behav 136:7–12
    • (2015) Pharmacol Biochem Behav , vol.136 , pp. 7-12
    • Yao, W.1    Zhang, J.C.2    Dong, C.3    Zhuang, C.4    Hirota, S.5    Inanaga, K.6    Hashimoto, K.7
  • 48
    • 84925944263 scopus 로고    scopus 로고
    • Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator
    • COI: 1:CAS:528:DC%2BC2MXmslGjtA%3D%3D, PID: 25600995
    • Yoshimi N, Futamura T, Hashimoto K (2015) Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. Eur Neuropsychopharmacol 25:356–364
    • (2015) Eur Neuropsychopharmacol , vol.25 , pp. 356-364
    • Yoshimi, N.1    Futamura, T.2    Hashimoto, K.3
  • 50
    • 84945469252 scopus 로고    scopus 로고
    • Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression
    • COI: 1:CAS:528:DC%2BC2MXhsVGnsbbO, PID: 26337614
    • Zhang JC, Yao W, Dong C, Yang C, Ren Q, Ma M, Han M, Hashimoto K (2015b) Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology 232:4325–4335
    • (2015) Psychopharmacology , vol.232 , pp. 4325-4335
    • Zhang, J.C.1    Yao, W.2    Dong, C.3    Yang, C.4    Ren, Q.5    Ma, M.6    Han, M.7    Hashimoto, K.8
  • 51
    • 84986877596 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF)–TrkB signaling in inflammation-related depression and potential therapeutic targets
    • COI: 1:CAS:528:DC%2BC28XhsVOiu7fI, PID: 26786147
    • Zhang JC, Yao W, Hashimoto K (2016) Brain-derived neurotrophic factor (BDNF)–TrkB signaling in inflammation-related depression and potential therapeutic targets. Curr Neuropharmacol 14:721–731
    • (2016) Curr Neuropharmacol , vol.14 , pp. 721-731
    • Zhang, J.C.1    Yao, W.2    Hashimoto, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.