The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 81, Issue , 2018, Pages 468-476

  Zager, Adriano ^a   Brandão, Wesley Nogueira ^a   Margatho, Rafael Oliveira ^a   Peron, Jean Pierre ^a   Tufik, Sergio ^b   Andersen, Monica Levy ^b   Kornum, Birgitte Rahbek ^c   Palermo Neto, João ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c University of Copenhagen   (Denmark)

Author keywords

Dopaminergic D1 receptor; Lipopolysaccharide; Modafinil; Neuroinflammation; Sickness behavior

Indexed keywords

CD11B ANTIGEN; CD45 ANTIGEN; DOPAMINE 1 RECEPTOR; INTERLEUKIN 1BETA; MESSENGER RNA; MODAFINIL; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BENZAZEPINE DERIVATIVE; BENZHYDRYL DERIVATIVE; DOPAMINE RECEPTOR STIMULATING AGENT; DRD1A PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; WAKEFULNESS PROMOTING AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DAYTIME SOMNOLENCE; DEPRESSION; DRUG EFFICACY; ELEVATED PLUS MAZE TEST; FLOW CYTOMETRY; GENE; GENE EXPRESSION; IL 1BETA GENE; ILLNESS BEHAVIOR; INTRACELLULAR SIGNALING; MALE; MOTOR DYSFUNCTION; MOUSE; NARCOLEPSY; NONHUMAN; OPEN FIELD TEST; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; TAIL SUSPENSION TEST; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ANXIETY; BRAIN; C57BL MOUSE; CELL MOTION; DISEASE MODEL; DRUG EFFECT; ESCHERICHIA COLI; IMMUNOMODULATION; MACROPHAGE; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANXIETY; BENZAZEPINES; BENZHYDRYL COMPOUNDS; BRAIN; CELL MOVEMENT; DEPRESSION; DISEASE MODELS, ANIMAL; DOPAMINE AGENTS; ESCHERICHIA COLI; ILLNESS BEHAVIOR; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE, INBRED C57BL; MOTOR ACTIVITY; MOVEMENT DISORDERS; NEUROIMMUNOMODULATION; RECEPTORS, DOPAMINE D1; WAKEFULNESS-PROMOTING AGENTS;

EID: 85019703106     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2017.05.003     Document Type: Article

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