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Volumn 12, Issue 1, 2016, Pages

BDNF DNA methylation changes as a biomarker of psychiatric disorders: Literature review and open access database analysis

Author keywords

BDNF; Biomarkers; DNA methylation; Psychiatric disorders

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BIOLOGICAL MARKER; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

EID: 84986905088     PISSN: None     EISSN: 17449081     Source Type: Journal    
DOI: 10.1186/s12993-016-0101-4     Document Type: Review
Times cited : (101)

References (71)
  • 1
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol. 2001;63(1):71-124.
    • (2001) Prog Neurobiol , vol.63 , Issue.1 , pp. 71-124
    • Murer, M.G.1    Yan, Q.2    Raisman-Vozari, R.3
  • 2
    • 34547499702 scopus 로고    scopus 로고
    • Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters
    • Pruunsild P, et al. Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics. 2007;90(3):397-406.
    • (2007) Genomics , vol.90 , Issue.3 , pp. 397-406
    • Pruunsild, P.1
  • 3
    • 84861454505 scopus 로고    scopus 로고
    • Epigenetic regulation of the BDNF gene: implications for psychiatric disorders
    • Boulle F, et al. Epigenetic regulation of the BDNF gene: implications for psychiatric disorders. Mol Psychiatry. 2012;17(6):584-96.
    • (2012) Mol Psychiatry , vol.17 , Issue.6 , pp. 584-596
    • Boulle, F.1
  • 4
    • 84907667345 scopus 로고    scopus 로고
    • Brain derived neurotrophic factor: epigenetic regulation in psychiatric disorders
    • Mitchelmore C, Gede L. Brain derived neurotrophic factor: epigenetic regulation in psychiatric disorders. Brain Res. 2014;1586:162-72.
    • (2014) Brain Res , vol.1586 , pp. 162-172
    • Mitchelmore, C.1    Gede, L.2
  • 5
    • 33645357786 scopus 로고    scopus 로고
    • Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    • Tsankova NM, et al. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9(4):519-25.
    • (2006) Nat Neurosci , vol.9 , Issue.4 , pp. 519-525
    • Tsankova, N.M.1
  • 6
    • 80052759046 scopus 로고    scopus 로고
    • Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV
    • Jha S, et al. Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV. Transl Psychiatry. 2011;1:e40. doi: 10.1038/tp.2011.33.
    • (2011) Transl Psychiatry , vol.1
    • Jha, S.1
  • 7
    • 84886498264 scopus 로고    scopus 로고
    • Association between the BDNF Val66Met polymorphism and chronicity of depression
    • Lee Y, et al. Association between the BDNF Val66Met polymorphism and chronicity of depression. Psychiatry Investig. 2013;10(1):56-61.
    • (2013) Psychiatry Investig , vol.10 , Issue.1 , pp. 56-61
    • Lee, Y.1
  • 8
    • 84897518914 scopus 로고    scopus 로고
    • BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population
    • Brooks SJ, et al. BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population. PLoS ONE. 2014;9(1):e82707. doi: 10.1371/journal.pone.0082707.
    • (2014) PLoS ONE , vol.9 , Issue.1
    • Brooks, S.J.1
  • 9
    • 84922240921 scopus 로고    scopus 로고
    • A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review
    • Notaras M, et al. A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review. Neurosci Biobehav Rev. 2015;51:15-30.
    • (2015) Neurosci Biobehav Rev , vol.51 , pp. 15-30
    • Notaras, M.1
  • 10
    • 47949100718 scopus 로고    scopus 로고
    • Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients
    • Sarchiapone M, et al. Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. Neuropsychobiology. 2008;57(3):139-45.
    • (2008) Neuropsychobiology , vol.57 , Issue.3 , pp. 139-145
    • Sarchiapone, M.1
  • 11
    • 0029347167 scopus 로고
    • Purification and identification of brain-derived neurotrophic factor from human serum
    • Rosenfeld RD, et al. Purification and identification of brain-derived neurotrophic factor from human serum. Protein Expr Purif. 1995;6(4):465-71.
    • (1995) Protein Expr Purif , vol.6 , Issue.4 , pp. 465-471
    • Rosenfeld, R.D.1
  • 12
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?
    • Kerschensteiner M, et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med. 1999;189(5):865-70.
    • (1999) J Exp Med , vol.189 , Issue.5 , pp. 865-870
    • Kerschensteiner, M.1
  • 13
    • 0032404127 scopus 로고    scopus 로고
    • Transport of brain-derived neurotrophic factor across the blood-brain barrier
    • Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 1998;37(12):1553-61.
    • (1998) Neuropharmacology , vol.37 , Issue.12 , pp. 1553-1561
    • Pan, W.1    Banks, W.A.2    Fasold, M.B.3    Bluth, J.4    Kastin, A.J.5
  • 14
    • 80054848287 scopus 로고    scopus 로고
    • Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment
    • Molendijk ML, et al. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Mol Psychiatry. 2011;16(11):1088-95.
    • (2011) Mol Psychiatry. , vol.16 , Issue.11 , pp. 1088-1095
    • Molendijk, M.L.1
  • 15
    • 84865804807 scopus 로고    scopus 로고
    • A review of brain-derived neurotrophic factor as a candidate biomarker in Schizophrenia
    • Nurjono M, et al. A review of brain-derived neurotrophic factor as a candidate biomarker in Schizophrenia. Clin Psychopharmacol Neurosci. 2012;10(2):61-70.
    • (2012) Clin Psychopharmacol Neurosci , vol.10 , Issue.2 , pp. 61-70
    • Nurjono, M.1
  • 16
    • 85172042297 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis
    • Suliman S, et al. Brain-derived neurotrophic factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Front Integr Neurosci. 2013;7:55.
    • (2013) Front Integr Neurosci , vol.7 , pp. 55
    • Suliman, S.1
  • 17
    • 84869198825 scopus 로고    scopus 로고
    • Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients
    • Koenigsberg HW, et al. Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients. Psychiatry Res. 2012;199(2):92-7.
    • (2012) Psychiatry Res , vol.199 , Issue.2 , pp. 92-97
    • Koenigsberg, H.W.1
  • 18
    • 79961126702 scopus 로고    scopus 로고
    • Serum BDNF levels before treatment predict SSRI response in depression
    • Wolkowitz OM, et al. Serum BDNF levels before treatment predict SSRI response in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(7):1623-30.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , Issue.7 , pp. 1623-1630
    • Wolkowitz, O.M.1
  • 19
    • 84958127169 scopus 로고    scopus 로고
    • Role of epigenetic factors in the development of mental illness throughout life
    • Guintivano J, Kaminsky ZA. Role of epigenetic factors in the development of mental illness throughout life. Neurosci Res. 2016;102:56-66.
    • (2016) Neurosci Res , vol.102 , pp. 56-66
    • Guintivano, J.1    Kaminsky, Z.A.2
  • 20
    • 84896696669 scopus 로고    scopus 로고
    • The epigenome and postnatal environmental influences in psychotic disorders
    • Pishva E, et al. The epigenome and postnatal environmental influences in psychotic disorders. Soc Psychiatry Psychiatr Epidemiol. 2014;49(3):337-48.
    • (2014) Soc Psychiatry Psychiatr Epidemiol , vol.49 , Issue.3 , pp. 337-348
    • Pishva, E.1
  • 21
    • 84925283589 scopus 로고    scopus 로고
    • miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF
    • Varendi K, et al. miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF. Cell Mol Life Sci CMLS. 2014;71(22):4443-56.
    • (2014) Cell Mol Life Sci CMLS , vol.71 , Issue.22 , pp. 4443-4456
    • Varendi, K.1
  • 22
    • 84880867623 scopus 로고    scopus 로고
    • DNA methylation of the BDNF gene and its relevance to psychiatric disorders
    • Ikegame T, et al. DNA methylation of the BDNF gene and its relevance to psychiatric disorders. J Hum Genet. 2013;58(7):434-8.
    • (2013) J Hum Genet , vol.58 , Issue.7 , pp. 434-438
    • Ikegame, T.1
  • 23
    • 0242300612 scopus 로고    scopus 로고
    • DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    • Martinowich K, et al. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003;302(5646):890-3.
    • (2003) Science , vol.302 , Issue.5646 , pp. 890-893
    • Martinowich, K.1
  • 24
    • 84872241553 scopus 로고    scopus 로고
    • Epigenetic mechanisms of depression and antidepressant action
    • Vialou V, et al. Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol. 2013;53:59-87.
    • (2013) Annu Rev Pharmacol Toxicol , vol.53 , pp. 59-87
    • Vialou, V.1
  • 25
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, et al. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004;429(6990):457-63.
    • (2004) Nature , vol.429 , Issue.6990 , pp. 457-463
    • Egger, G.1
  • 27
    • 67349255210 scopus 로고    scopus 로고
    • CpG islands-'a rough guide'
    • Illingworth RS, Bird AP. CpG islands-'a rough guide'. FEBS Lett. 2009;583(11):1713-20.
    • (2009) FEBS Lett , vol.583 , Issue.11 , pp. 1713-1720
    • Illingworth, R.S.1    Bird, A.P.2
  • 28
    • 34047116826 scopus 로고    scopus 로고
    • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    • Weber M, et al. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet. 2007;39(4):457-66.
    • (2007) Nat Genet , vol.39 , Issue.4 , pp. 457-466
    • Weber, M.1
  • 29
    • 63449103531 scopus 로고    scopus 로고
    • DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution
    • Zhang Y, et al. DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet. 2009;5(3):e1000438. doi: 10.1371/journal.pgen.1000438.
    • (2009) PLoS Genet , vol.5 , Issue.3
    • Zhang, Y.1
  • 30
    • 84908876468 scopus 로고    scopus 로고
    • DNA methylation: old dog, new tricks?
    • Spruijt CG, Vermeulen M. DNA methylation: old dog, new tricks? Nat Struct Mol Biol. 2014;21(11):949-54.
    • (2014) Nat Struct Mol Biol , vol.21 , Issue.11 , pp. 949-954
    • Spruijt, C.G.1    Vermeulen, M.2
  • 31
    • 64349091471 scopus 로고    scopus 로고
    • Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
    • Ball MP, et al. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol. 2009;27(4):361-8.
    • (2009) Nat Biotechnol , vol.27 , Issue.4 , pp. 361-368
    • Ball, M.P.1
  • 32
    • 84887214395 scopus 로고    scopus 로고
    • Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition
    • Maunakea AK, et al. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res. 2013;23(11):1256-69.
    • (2013) Cell Res , vol.23 , Issue.11 , pp. 1256-1269
    • Maunakea, A.K.1
  • 33
    • 76249090741 scopus 로고    scopus 로고
    • Nucleosome deposition and DNA methylation at coding region boundaries
    • Choi JK, et al. Nucleosome deposition and DNA methylation at coding region boundaries. Genome Biol. 2009;10(9):R89. doi: 10.1186/gb-2009-10-9-r89.
    • (2009) Genome Biol , vol.10 , Issue.9 , pp. R89
    • Choi, J.K.1
  • 34
    • 84868538457 scopus 로고    scopus 로고
    • Epigenetic Islands in a genetic ocean
    • Schübeler D. Epigenetic Islands in a genetic ocean. Science. 2012;338(6108):756-7.
    • (2012) Science , vol.338 , Issue.6108 , pp. 756-757
    • Schübeler, D.1
  • 35
    • 0038581890 scopus 로고    scopus 로고
    • Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease
    • Tufarelli C, et al. Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease. Nat Genet. 2003;34(2):157-65.
    • (2003) Nat Genet , vol.34 , Issue.2 , pp. 157-165
    • Tufarelli, C.1
  • 36
    • 10744230544 scopus 로고    scopus 로고
    • Suv39 h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
    • Lehnertz B, et al. Suv39 h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol CB. 2003;13(14):1192-200.
    • (2003) Curr Biol CB , vol.13 , Issue.14 , pp. 1192-1200
    • Lehnertz, B.1
  • 37
    • 84862210732 scopus 로고    scopus 로고
    • Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    • Davies MN, et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol. 2012;13(6):R43. doi: 10.1186/gb-2012-13-6-r43.
    • (2012) Genome Biol , vol.13 , Issue.6 , pp. R43
    • Davies, M.N.1
  • 38
    • 84923928121 scopus 로고    scopus 로고
    • Methylomic trajectories across human fetal brain development
    • Spiers H, et al. Methylomic trajectories across human fetal brain development. Genome Res. 2015;25:338. doi: 10.1101/gr.180273.114.
    • (2015) Genome Res , vol.25 , pp. 338
    • Spiers, H.1
  • 39
    • 84884920554 scopus 로고    scopus 로고
    • Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes
    • Masliah E, et al. Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics. 2013;8(10):1030-8.
    • (2013) Epigenetics , vol.8 , Issue.10 , pp. 1030-1038
    • Masliah, E.1
  • 40
    • 84899091504 scopus 로고    scopus 로고
    • Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
    • Wen L, et al. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biol. 2014;15(3):R49. doi: 10.1186/gb-2014-15-3-r49.
    • (2014) Genome Biol , vol.15 , Issue.3 , pp. R49
    • Wen, L.1
  • 41
    • 79952255488 scopus 로고    scopus 로고
    • Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene
    • Pruunsild P, et al. Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene. J Neurosci. 2011;31(9):3295-308.
    • (2011) J Neurosci , vol.31 , Issue.9 , pp. 3295-3308
    • Pruunsild, P.1
  • 42
    • 63449085750 scopus 로고    scopus 로고
    • Lasting epigenetic influence of early-life adversity on the BDNF gene
    • Roth TL, et al. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry. 2009;65(9):760-9.
    • (2009) Biol Psychiatry , vol.65 , Issue.9 , pp. 760-769
    • Roth, T.L.1
  • 43
    • 79952700004 scopus 로고    scopus 로고
    • Epigenetic marking of the BDNF gene by early-life adverse experiences
    • Roth TL, Sweatt JD. Epigenetic marking of the BDNF gene by early-life adverse experiences. Horm Behav. 2011;59(3):315-20.
    • (2011) Horm Behav , vol.59 , Issue.3 , pp. 315-320
    • Roth, T.L.1    Sweatt, J.D.2
  • 44
    • 41149140859 scopus 로고    scopus 로고
    • Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    • Mill J, et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet. 2008;82(3):696-711.
    • (2008) Am J Hum Genet , vol.82 , Issue.3 , pp. 696-711
    • Mill, J.1
  • 45
    • 84940101430 scopus 로고    scopus 로고
    • DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women
    • Chagnon YC, et al. DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. Genet Aging. 2015;6:230.
    • (2015) Genet Aging , vol.6 , pp. 230
    • Chagnon, Y.C.1
  • 46
    • 77649194621 scopus 로고    scopus 로고
    • Increased BDNF promoter methylation in the Wernicke area of suicide subjects
    • Keller S, et al. Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry. 2010;67(3):258-67.
    • (2010) Arch Gen Psychiatry , vol.67 , Issue.3 , pp. 258-267
    • Keller, S.1
  • 47
    • 80052287594 scopus 로고    scopus 로고
    • DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression
    • Fuchikami M, et al. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS ONE. 2011;6(8):e23881. doi: 10.1371/journal.pone.0023881.
    • (2011) PLoS ONE , vol.6 , Issue.8
    • Fuchikami, M.1
  • 48
    • 84885476091 scopus 로고    scopus 로고
    • BDNF promoter methylation and suicidal behavior in depressive patients
    • Kang H-J, et al. BDNF promoter methylation and suicidal behavior in depressive patients. J Affect Disord. 2013;151(2):679-85.
    • (2013) J Affect Disord , vol.151 , Issue.2 , pp. 679-685
    • Kang, H.-J.1
  • 49
    • 84925297855 scopus 로고    scopus 로고
    • Longitudinal associations between BDNF promoter methylation and late-life depression
    • Kang HJ, et al. Longitudinal associations between BDNF promoter methylation and late-life depression. Neurobiol Aging. 2015;36(4):1764. doi: 10.1016/j.neurobiolaging.2014.12.035.
    • (2015) Neurobiol Aging , vol.36 , Issue.4 , pp. 1764
    • Kang, H.J.1
  • 50
    • 84946554642 scopus 로고    scopus 로고
    • A longitudinal study of BDNF promoter methylation and depression in breast cancer
    • Kang H-J, et al. A longitudinal study of BDNF promoter methylation and depression in breast cancer. Psychiatry Investig. 2015;12(4):523-31.
    • (2015) Psychiatry Investig , vol.12 , Issue.4 , pp. 523-531
    • Kang, H.-J.1
  • 51
    • 84930086282 scopus 로고    scopus 로고
    • BDNF serum levels and promoter methylation of BDNF exon I, IV and VI in depressed patients receiving electroconvulsive therapy
    • Kleimann A, et al. BDNF serum levels and promoter methylation of BDNF exon I, IV and VI in depressed patients receiving electroconvulsive therapy. J Neural Transm. 2014;122(6):925-8.
    • (2014) J Neural Transm , vol.122 , Issue.6 , pp. 925-928
    • Kleimann, A.1
  • 52
    • 84888339820 scopus 로고    scopus 로고
    • DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients
    • Ikegame T, et al. DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients. Neurosci Res. 2013;77(4):208-14.
    • (2013) Neurosci Res , vol.77 , Issue.4 , pp. 208-214
    • Ikegame, T.1
  • 53
    • 85027949017 scopus 로고    scopus 로고
    • DNA methylation and expression profiles of the brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in patients with schizophrenia
    • Kordi-Tamandani DM, et al. DNA methylation and expression profiles of the brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in patients with schizophrenia. Mol Biol Rep. 2012;39(12):10889-93.
    • (2012) Mol Biol Rep , vol.39 , Issue.12 , pp. 10889-10893
    • Kordi-Tamandani, D.M.1
  • 54
    • 84861190781 scopus 로고    scopus 로고
    • Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII
    • D'Addario C, et al. Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII. Neuropsychopharmacol. 2012;37(7):1647-55.
    • (2012) Neuropsychopharmacol , vol.37 , Issue.7 , pp. 1647-1655
    • D'Addario, C.1
  • 55
    • 84870906081 scopus 로고    scopus 로고
    • Epigenetic modulation of BDNF gene in patients with major depressive disorder
    • D'Addario C, et al. Epigenetic modulation of BDNF gene in patients with major depressive disorder. Biol Psychiatry. 2013;73(2):e6-7. doi: 10.1016/j.biopsych.2012.07.009.
    • (2013) Biol Psychiatry , vol.73 , Issue.2
    • D'Addario, C.1
  • 56
    • 84902578460 scopus 로고    scopus 로고
    • Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients
    • Dell'Osso B, et al. Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients. J Affect Disord. 2014;166:330-3.
    • (2014) J Affect Disord , vol.166 , pp. 330-333
    • Dell'Osso, B.1
  • 57
    • 84894558937 scopus 로고    scopus 로고
    • Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression
    • Tadić A, et al. Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression. Mol Psychiatry. 2014;19(3):281-3.
    • (2014) Mol Psychiatry , vol.19 , Issue.3 , pp. 281-283
    • Tadić, A.1
  • 58
    • 84880869360 scopus 로고    scopus 로고
    • Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene
    • Perroud N, et al. Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene. Transl Psychiatry. 2013;3:e207. doi: 10.1038/tp.2012.140.
    • (2013) Transl Psychiatry , vol.3
    • Perroud, N.1
  • 59
    • 84942423188 scopus 로고    scopus 로고
    • Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women
    • Unternaehrer E, et al. Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress. 2015;18(4):451-61.
    • (2015) Stress , vol.18 , Issue.4 , pp. 451-461
    • Unternaehrer, E.1
  • 60
    • 84902478625 scopus 로고    scopus 로고
    • Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder
    • Thaler L, et al. Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014;54:43-9.
    • (2014) Prog Neuropsychopharmacol Biol Psychiatry , vol.54 , pp. 43-49
    • Thaler, L.1
  • 61
    • 84923642506 scopus 로고    scopus 로고
    • DNA methylation biomarkers: cancer and beyond
    • Mikeska T, Craig JM. DNA methylation biomarkers: cancer and beyond. Genes. 2014;5(3):821-64.
    • (2014) Genes , vol.5 , Issue.3 , pp. 821-864
    • Mikeska, T.1    Craig, J.M.2
  • 62
    • 84923883762 scopus 로고    scopus 로고
    • BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues
    • Stenz L, et al. BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues. Neurosci Res. 2015;91:1-7.
    • (2015) Neurosci Res , vol.91 , pp. 1-7
    • Stenz, L.1
  • 63
    • 34247849498 scopus 로고    scopus 로고
    • Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation
    • Wojdacz TK, Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res. 2007;35(6):e41. doi: 10.1093/nar/gkm013.
    • (2007) Nucleic Acids Res , vol.35 , Issue.6
    • Wojdacz, T.K.1    Dobrovic, A.2
  • 65
    • 4544293301 scopus 로고    scopus 로고
    • Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates
    • Lewin J, et al. Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates. Bioinformatics. 2004;20(17):3005-12.
    • (2004) Bioinformatics , vol.20 , Issue.17 , pp. 3005-3012
    • Lewin, J.1
  • 66
    • 0036962761 scopus 로고    scopus 로고
    • Evaluation of a potential epigenetic biomarker by quantitative methyl-single nucleotide polymorphism analysis
    • Uhlmann K, et al. Evaluation of a potential epigenetic biomarker by quantitative methyl-single nucleotide polymorphism analysis. Electrophoresis. 2002;23(24):4072-9.
    • (2002) Electrophoresis , vol.23 , Issue.24 , pp. 4072-4079
    • Uhlmann, K.1
  • 67
    • 34047170360 scopus 로고    scopus 로고
    • Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes
    • Milutinovic S, et al. Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. Carcinogenesis. 2007;28(3):560-71.
    • (2007) Carcinogenesis , vol.28 , Issue.3 , pp. 560-571
    • Milutinovic, S.1
  • 68
    • 53449087663 scopus 로고    scopus 로고
    • Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice
    • Deltheil T, et al. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. 2008;55(6):1006-14.
    • (2008) Neuropharmacology , vol.55 , Issue.6 , pp. 1006-1014
    • Deltheil, T.1
  • 69
    • 32444451651 scopus 로고    scopus 로고
    • Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    • Berton O, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006;311(5762):864-8.
    • (2006) Science , vol.311 , Issue.5762 , pp. 864-868
    • Berton, O.1
  • 70
    • 84864359044 scopus 로고    scopus 로고
    • Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
    • Reinius LE, et al. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS ONE. 2012;7(7):e41361. doi: 10.1371/journal.pone.0041361.
    • (2012) PLoS ONE , vol.7 , Issue.7
    • Reinius, L.E.1
  • 71
    • 0026519357 scopus 로고
    • Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining
    • Maes M, et al. Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol Med. 1992;22(1):45-53.
    • (1992) Psychol Med , vol.22 , Issue.1 , pp. 45-53
    • Maes, M.1


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