메뉴 건너뛰기




Volumn 216, Issue , 2017, Pages S474-S483

Novel agents and drug targets to meet the challenges of resistant fungi

Author keywords

Chelator; Dihydroorotate dehydrogenase; E1210; Epigenetic; Glycosphingolipids; Glycosylphosphatidylinositol; Transcription factors

Indexed keywords

ANTIFUNGAL AGENT;

EID: 85029713770     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jix130     Document Type: Article
Times cited : (135)

References (136)
  • 2
    • 84926058258 scopus 로고    scopus 로고
    • Infectious disease. How to bolster the antifungal pipeline
    • Denning DW, Bromley MJ. Infectious disease. How to bolster the antifungal pipeline. Science 2015; 347:1414–6.
    • (2015) Science , vol.347 , pp. 1414-1416
    • Denning, D.W.1    Bromley, M.J.2
  • 3
    • 84926387353 scopus 로고    scopus 로고
    • Treatment principles for the management of mold infections
    • pii:a019737
    • Kontoyiannis DP, Lewis RE. Treatment principles for the management of mold infections. Cold Spring Harb Perspect Med 2015; 5. pii:a019737.
    • (2015) Cold Spring Harb Perspect Med , vol.5
    • Kontoyiannis, D.P.1    Lewis, R.E.2
  • 5
    • 80051558724 scopus 로고    scopus 로고
    • How I treat mucormycosis
    • Kontoyiannis DP, Lewis RE. How I treat mucormycosis. Blood 2011; 118:1216–24.
    • (2011) Blood , vol.118 , pp. 1216-1224
    • Kontoyiannis, D.P.1    Lewis, R.E.2
  • 6
    • 85028063850 scopus 로고    scopus 로고
    • Emerging threats in antifungal-resistant fungal pathogens
    • Sanglard D. Emerging threats in antifungal-resistant fungal pathogens. Front Med (Lausanne) 2016; 3:11.
    • (2016) Front Med (Lausanne) , vol.3 , pp. 11
    • Sanglard, D.1
  • 7
    • 79955789192 scopus 로고    scopus 로고
    • Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease: Review of the literature
    • Mayr A, Lass-Flörl C. Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease: review of the literature. Eur J Med Res 2011; 16:153–7.
    • (2011) Eur J Med Res , vol.16 , pp. 153-157
    • Mayr, A.1    Lass-Flörl, C.2
  • 8
    • 85015953904 scopus 로고    scopus 로고
    • The anti-Aspergillus drug pipeline: Is the glass half full or empty?
    • Osherov N, Kontoyiannis DP. The anti-Aspergillus drug pipeline: is the glass half full or empty? Med Mycol 2017; 55:118–24.
    • (2017) Med Mycol , vol.55 , pp. 118-124
    • Osherov, N.1    Kontoyiannis, D.P.2
  • 9
    • 84875467898 scopus 로고    scopus 로고
    • Systems-level antimicrobial drug and drug synergy discovery
    • Roemer T, Boone C. Systems-level antimicrobial drug and drug synergy discovery. Nat Chem Biol 2013; 9:222–31.
    • (2013) Nat Chem Biol , vol.9 , pp. 222-231
    • Roemer, T.1    Boone, C.2
  • 11
    • 0038662549 scopus 로고    scopus 로고
    • Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly
    • Tsukahara K, Hata K, Nakamoto K, et al. Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly. Mol Microbiol 2003; 48:1029–42.
    • (2003) Mol Microbiol , vol.48 , pp. 1029-1042
    • Tsukahara, K.1    Hata, K.2    Nakamoto, K.3
  • 12
    • 0037593245 scopus 로고    scopus 로고
    • GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast
    • Umemura M, Okamoto M, Nakayama K, et al. GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast. J Biol Chem 2003; 278:23639–47.
    • (2003) J Biol Chem , vol.278 , pp. 23639-23647
    • Umemura, M.1    Okamoto, M.2    Nakayama, K.3
  • 13
    • 84856073587 scopus 로고    scopus 로고
    • E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis
    • Watanabe NA, Miyazaki M, Horii T, Sagane K, Tsukahara K, Hata K. E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis. Antimicrob Agents Chemother 2012; 56:960–71.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 960-971
    • Watanabe, N.A.1    Miyazaki, M.2    Horii, T.3    Sagane, K.4    Tsukahara, K.5    Hata, K.6
  • 14
    • 80052854203 scopus 로고    scopus 로고
    • In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds
    • Miyazaki M, Horii T, Hata K, et al. In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds. Antimicrob Agents Chemother 2011; 55:4652–8.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4652-4658
    • Miyazaki, M.1    Horii, T.2    Hata, K.3
  • 15
    • 80054695206 scopus 로고    scopus 로고
    • Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: Comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods
    • Pfaller MA, Watanabe N, Castanheira M, Messer SA, Jones RN. Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods. J Antimicrob Chemother 2011; 66:2581–4.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2581-2584
    • Pfaller, M.A.1    Watanabe, N.2    Castanheira, M.3    Messer, S.A.4    Jones, R.N.5
  • 16
    • 80052856780 scopus 로고    scopus 로고
    • Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis
    • Hata K, Horii T, Miyazaki M, et al. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. Antimicrob Agents Chemother 2011; 55:4543–51.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4543-4551
    • Hata, K.1    Horii, T.2    Miyazaki, M.3
  • 17
    • 84868159204 scopus 로고    scopus 로고
    • Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity
    • McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S. Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. ACS Chem Biol 2012; 7:1520–8.
    • (2012) ACS Chem Biol , vol.7 , pp. 1520-1528
    • McLellan, C.A.1    Whitesell, L.2    King, O.D.3    Lancaster, A.K.4    Mazitschek, R.5    Lindquist, S.6
  • 18
    • 84866953429 scopus 로고    scopus 로고
    • Antifungal drug discovery: Something old and something new
    • Butts A, Krysan DJ. Antifungal drug discovery: something old and something new. PLoS Pathog 2012; 8:e1002870.
    • (2012) PLoS Pathog , vol.8 , pp. e1002870
    • Butts, A.1    Krysan, D.J.2
  • 19
    • 0027439619 scopus 로고
    • Compounds active against cell walls of medically important fungi
    • Hector RF. Compounds active against cell walls of medically important fungi. Clin Microbiol Rev 1993; 6:1–21.
    • (1993) Clin Microbiol Rev , vol.6 , pp. 1-21
    • Hector, R.F.1
  • 20
    • 0030730483 scopus 로고    scopus 로고
    • Echinocandins and pneumocandins—a new antifungal class with a novel mode of action
    • Denning DW. Echinocandins and pneumocandins—a new antifungal class with a novel mode of action. J Antimicrob Chemother 1997; 40:611–4.
    • (1997) J Antimicrob Chemother , vol.40 , pp. 611-614
    • Denning, D.W.1
  • 21
    • 0141863188 scopus 로고    scopus 로고
    • Echinocandin antifungal drugs
    • Denning DW. Echinocandin antifungal drugs. Lancet 2003; 362:1142–51.
    • (2003) Lancet , vol.362 , pp. 1142-1151
    • Denning, D.W.1
  • 22
    • 85010952095 scopus 로고    scopus 로고
    • Structure-activity relationships of a series of echinocandins and the discovery of CD101, a highly stable and soluble echinocandin with distinctive pharmacokinetic properties
    • James KD, Laudeman CP, Malkar NB, Krishnan R, Polowy K. Structure-activity relationships of a series of echinocandins and the discovery of CD101, a highly stable and soluble echinocandin with distinctive pharmacokinetic properties. Antimicrob Agents Chemother 2017; 61. pii:e01541-16.
    • (2017) Antimicrob Agents Chemother , vol.61 , pp. e01541-e01616
    • James, K.D.1    Laudeman, C.P.2    Malkar, N.B.3    Krishnan, R.4    Polowy, K.5
  • 23
    • 84994528732 scopus 로고    scopus 로고
    • Preclinical evaluation of the stability, safety, and efficacy of CD101, a novel echinocandin
    • Ong V, Hough G, Schlosser M, et al. Preclinical evaluation of the stability, safety, and efficacy of CD101, a novel echinocandin. Antimicrob Agents Chemother 2016; 60:6872–9.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 6872-6879
    • Ong, V.1    Hough, G.2    Schlosser, M.3
  • 24
    • 84994711538 scopus 로고    scopus 로고
    • Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- And azole-resistant isolates
    • Pfaller MA, Messer SA, Rhomberg PR, Jones RN, Castanheira M. Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates. J Antimicrob Chemother 2016; 71: 2868–73.
    • (2016) J Antimicrob Chemother , vol.71 , pp. 2868-2873
    • Pfaller, M.A.1    Messer, S.A.2    Rhomberg, P.R.3    Jones, R.N.4    Castanheira, M.5
  • 26
    • 85011103211 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of CD101 IV, a novel echinocandin, in healthy adults
    • Sandison T, Ong V, Lee J, Thye D. Safety and pharmacokinetics of CD101 IV, a novel echinocandin, in healthy adults. Antimicrob Agents Chemother 2017; 61. pii:e01627-16.
    • (2017) Antimicrob Agents Chemother , vol.61 , pp. e01627-e01716
    • Sandison, T.1    Ong, V.2    Lee, J.3    Thye, D.4
  • 27
    • 85020112406 scopus 로고    scopus 로고
    • In vitro activity of the novel echinocandin CD101 at pH 7 and 4 against Candida spp. Isolates from patients with vulvovaginal candidiasis
    • Boikov DA, Locke JB, James KD, Bartizal K, Sobel JD. In vitro activity of the novel echinocandin CD101 at pH 7 and 4 against Candida spp. isolates from patients with vulvovaginal candidiasis. J Antimicrob Chemother 2017. doi:10.1093/jac/ dkx008.
    • (2017) J Antimicrob Chemother
    • Boikov, D.A.1    Locke, J.B.2    James, K.D.3    Bartizal, K.4    Sobel, J.D.5
  • 28
    • 85011818132 scopus 로고    scopus 로고
    • New developments and directions in the clinical application of the echinocandins
    • Chang CC, Slavin MA, Chen SC. New developments and directions in the clinical application of the echinocandins. Arch Toxicol 2017. doi:10.1007/ s00204-016-1916-3.
    • (2017) Arch Toxicol
    • Chang, C.C.1    Slavin, M.A.2    Chen, S.C.3
  • 29
    • 84921820378 scopus 로고    scopus 로고
    • Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model
    • Lepak AJ, Marchillo K, Andes DR. Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Antimicrob Agents Chemother 2015; 59:1265–72.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 1265-1272
    • Lepak, A.J.1    Marchillo, K.2    Andes, D.R.3
  • 31
    • 84931287884 scopus 로고    scopus 로고
    • Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates
    • Lamoth F, Alexander BD. Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates. Antimicrob Agents Chemother 2015; 59:4308–11.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 4308-4311
    • Lamoth, F.1    Alexander, B.D.2
  • 32
    • 85017012850 scopus 로고    scopus 로고
    • SCY-078 a first in class orally active antifungal glucan synthesis inhibitor: Pre-clinical pharmacokinetics and pharmaco-dynamic target in murine models of disseminated candidiasis
    • pii:AAC.02068-16
    • Wring SA, Randolph R, Park S, et al. SCY-078 a first in class orally active antifungal glucan synthesis inhibitor: pre-clinical pharmacokinetics and pharmaco-dynamic target in murine models of disseminated candidiasis. Antimicrob Agents Chemother 2017. pii:AAC.02068-16.
    • (2017) Antimicrob Agents Chemother
    • Wring, S.A.1    Randolph, R.2    Park, S.3
  • 34
  • 36
    • 84866101261 scopus 로고    scopus 로고
    • Structural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis
    • Oberdorfer G, Binter A, Ginj C, Macheroux P, Gruber K. Structural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis. J Biol Chem 2012; 287:31427–36.
    • (2012) J Biol Chem , vol.287 , pp. 31427-31436
    • Oberdorfer, G.1    Binter, A.2    Ginj, C.3    Macheroux, P.4    Gruber, K.5
  • 37
    • 0030771531 scopus 로고    scopus 로고
    • Efficacy of nikkomycin Z against experimental pulmonary blastomycosis
    • Clemons KV, Stevens DA. Efficacy of nikkomycin Z against experimental pulmonary blastomycosis. Antimicrob Agents Chemother 1997; 41:2026–8.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 2026-2028
    • Clemons, K.V.1    Stevens, D.A.2
  • 38
    • 84901759593 scopus 로고    scopus 로고
    • Modeling nikkomycin Z dosing and pharmacology in murine pulmonary coccidioidomycosis preparatory to phase 2 clinical trials
    • Shubitz LF, Trinh HT, Perrill RH, et al. Modeling nikkomycin Z dosing and pharmacology in murine pulmonary coccidioidomycosis preparatory to phase 2 clinical trials. J Infect Dis 2014; 209:1949–54.
    • (2014) J Infect Dis , vol.209 , pp. 1949-1954
    • Shubitz, L.F.1    Trinh, H.T.2    Perrill, R.H.3
  • 39
    • 84899653514 scopus 로고    scopus 로고
    • Novel nikkomycin analogues generated by mutasynthesis in streptomyces ansochromogenes
    • Feng C, Ling H, Du D, Zhang J, Niu G, Tan H. Novel nikkomycin analogues generated by mutasynthesis in streptomyces ansochromogenes. Microb Cell Fact 2014; 13:59.
    • (2014) Microb Cell Fact , vol.13 , pp. 59
    • Feng, C.1    Ling, H.2    Du, D.3    Zhang, J.4    Niu, G.5    Tan, H.6
  • 42
    • 0037077684 scopus 로고    scopus 로고
    • Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth
    • Levery SB, Momany M, Lindsey R, et al. Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth. FEBS Lett 2002; 525:59–64.
    • (2002) FEBS Lett , vol.525 , pp. 59-64
    • Levery, S.B.1    Momany, M.2    Lindsey, R.3
  • 43
    • 85053765884 scopus 로고    scopus 로고
    • Accessed 19 April 2017
    • American Society for Microbiology. Researchers identify new class of antifungal agents. https://www.asm.org/index.php/journal-press-releases/93560-researchers-identify-new-class-of-antifungal-agents. Accessed 19 April 2017.
    • Researchers Identify New Class of Antifungal Agents
  • 44
    • 84936980438 scopus 로고    scopus 로고
    • Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids
    • Mor V, Rella A, Farnoud AM, et al. Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids. MBio 2015; 6:e00647.
    • (2015) MBio , vol.6 , pp. e00647
    • Mor, V.1    Rella, A.2    Farnoud, A.M.3
  • 45
    • 0036777063 scopus 로고    scopus 로고
    • Life and death in a macrophage: Role of the glyoxylate cycle in virulence
    • Lorenz MC, Fink GR. Life and death in a macrophage: role of the glyoxylate cycle in virulence. Eukaryot Cell 2002; 1:657–62.
    • (2002) Eukaryot Cell , vol.1 , pp. 657-662
    • Lorenz, M.C.1    Fink, G.R.2
  • 46
    • 71049115075 scopus 로고    scopus 로고
    • Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis
    • Dunn MF, Ramírez-Trujillo JA, Hernández-Lucas I. Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis. Microbiology 2009; 155:3166–75.
    • (2009) Microbiology , vol.155 , pp. 3166-3175
    • Dunn, M.F.1    Ramírez-Trujillo, J.A.2    Hernández-Lucas, I.3
  • 47
    • 55549099259 scopus 로고    scopus 로고
    • The activity of the glyoxylate cycle in per-oxisomes of Candida albicans depends on a functional beta-oxidation pathway: Evidence for reduced metabolite transport across the peroxisomal membrane
    • Piekarska K, Hardy G, Mol E, et al. The activity of the glyoxylate cycle in per-oxisomes of Candida albicans depends on a functional beta-oxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane. Microbiology 2008; 154:3061–72.
    • (2008) Microbiology , vol.154 , pp. 3061-3072
    • Piekarska, K.1    Hardy, G.2    Mol, E.3
  • 48
    • 33646575320 scopus 로고    scopus 로고
    • Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development
    • Ebel F, Schwienbacher M, Beyer J, Heesemann J, Brakhage AA, Brock M. Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development. Fungal Genet Biol 2006; 43:476–89.
    • (2006) Fungal Genet Biol , vol.43 , pp. 476-489
    • Ebel, F.1    Schwienbacher, M.2    Beyer, J.3    Heesemann, J.4    Brakhage, A.A.5    Brock, M.6
  • 49
    • 59649114534 scopus 로고    scopus 로고
    • 5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp
    • Lee HS, Yoon KM, Han YR, et al. 5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp. Bioorg Med Chem Lett 2009; 19:1051–3.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 1051-1053
    • Lee, H.S.1    Yoon, K.M.2    Han, Y.R.3
  • 50
    • 84899731549 scopus 로고    scopus 로고
    • Inhibitors of the glyoxylate cycle enzyme ICL1 in Candida albicans for potential use as antifungal agents
    • Cheah HL, Lim V, Sandai D. Inhibitors of the glyoxylate cycle enzyme ICL1 in Candida albicans for potential use as antifungal agents. PLoS One 2014; 9: e95951.
    • (2014) PLoS One , vol.9 , pp. e95951
    • Cheah, H.L.1    Lim, V.2    Sandai, D.3
  • 51
    • 84922615549 scopus 로고    scopus 로고
    • Mohangamides A and B, new dilactone-tethered pseudo-dimeric peptides inhibiting Candida albicans isocitrate lyase
    • Bae M, Kim H, Moon K, et al. Mohangamides A and B, new dilactone-tethered pseudo-dimeric peptides inhibiting Candida albicans isocitrate lyase. Org Lett 2015; 17:712–5.
    • (2015) Org Lett , vol.17 , pp. 712-715
    • Bae, M.1    Kim, H.2    Moon, K.3
  • 52
    • 85053814565 scopus 로고    scopus 로고
    • F901318, a novel antifungal agent from the orotomide class: Discovery and mechanism of action
    • Poster 749
    • Oliver J, Law D, Sibley G, Kennedy A, Birch M. F901318, a novel antifungal agent from the orotomide class: discovery and mechanism of action. In: Advances Against Aspergillosis, 2016. Poster 749.
    • (2016) Advances Against Aspergillosis
    • Oliver, J.1    Law, D.2    Sibley, G.3    Kennedy, A.4    Birch, M.5
  • 53
    • 85015975133 scopus 로고    scopus 로고
    • The efficacy of F901318 a novel antifungal drug in an animal model of aspergillosis
    • American Society for Microbiology, Boston, MA
    • Law D. The efficacy of F901318 a novel antifungal drug in an animal model of aspergillosis. In: Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Boston, MA, 2016.
    • (2016) Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Law, D.1
  • 54
    • 0036890399 scopus 로고    scopus 로고
    • The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans
    • Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab 2002; 3:561–97.
    • (2002) Curr Drug Metab , vol.3 , pp. 561-597
    • Danielson, P.B.1
  • 55
    • 58149173952 scopus 로고    scopus 로고
    • How do azoles inhibit cytochrome P450 enzymes? A density functional study
    • Balding PR, Porro CS, McLean KJ, et al. How do azoles inhibit cytochrome P450 enzymes? A density functional study. J Phys Chem A 2008; 112:12911–8.
    • (2008) J Phys Chem A , vol.112 , pp. 12911-12918
    • Balding, P.R.1    Porro, C.S.2    McLean, K.J.3
  • 58
    • 84954519328 scopus 로고    scopus 로고
    • Evaluation of VT-1161 for treatment of coccidioidomycosis in murine infection models
    • Shubitz LF, Trinh HT, Galgiani JN, et al. Evaluation of VT-1161 for treatment of coccidioidomycosis in murine infection models. Antimicrob Agents Chemother 2015; 59:7249–54.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 7249-7254
    • Shubitz, L.F.1    Trinh, H.T.2    Galgiani, J.N.3
  • 59
    • 84912083880 scopus 로고    scopus 로고
    • The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme
    • Warrilow AG, Hull CM, Parker JE, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother 2014; 58:7121–7.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 7121-7127
    • Warrilow, A.G.1    Hull, C.M.2    Parker, J.E.3
  • 60
    • 84957900380 scopus 로고    scopus 로고
    • In vitro activity of ASP2397 against Aspergillus isolates with or without acquired azole resistance mechanisms
    • Arendrup MC, Jensen RH, Cuenca-Estrella M. In vitro activity of ASP2397 against Aspergillus isolates with or without acquired azole resistance mechanisms. Antimicrob Agents Chemother 2016; 60:532–6.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 532-536
    • Arendrup, M.C.1    Jensen, R.H.2    Cuenca-Estrella, M.3
  • 61
    • 84868007836 scopus 로고    scopus 로고
    • T-2307 causes collapse of mitochondrial membrane potential in yeast
    • Shibata T, Takahashi T, Yamada E, et al. T-2307 causes collapse of mitochondrial membrane potential in yeast. Antimicrob Agents Chemother 2012; 56:5892–7.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 5892-5897
    • Shibata, T.1    Takahashi, T.2    Yamada, E.3
  • 62
    • 42049087374 scopus 로고    scopus 로고
    • In vitro and in vivo antifungal activities of T-2307, a novel arylamidine
    • Mitsuyama J, Nomura N, Hashimoto K, et al. In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. Antimicrob Agents Chemother 2008; 52:1318–24.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1318-1324
    • Mitsuyama, J.1    Nomura, N.2    Hashimoto, K.3
  • 63
    • 77956097960 scopus 로고    scopus 로고
    • T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena
    • Yamada E, Nishikawa H, Nomura N, Mitsuyama J. T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. Antimicrob Agents Chemother 2010; 54:3630–4.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3630-3634
    • Yamada, E.1    Nishikawa, H.2    Nomura, N.3    Mitsuyama, J.4
  • 64
    • 84960798992 scopus 로고    scopus 로고
    • The novel arylamidine T-2307 demonstrates in vitro and in vivo activity against echinocandin-resistant Candida glabrata
    • Wiederhold NP, Najvar LK, Fothergill AW, et al. The novel arylamidine T-2307 demonstrates in vitro and in vivo activity against echinocandin-resistant Candida glabrata. J Antimicrob Chemother 2016; 71:692–5.
    • (2016) J Antimicrob Chemother , vol.71 , pp. 692-695
    • Wiederhold, N.P.1    Najvar, L.K.2    Fothergill, A.W.3
  • 65
    • 84940908922 scopus 로고    scopus 로고
    • Identification and characterization of a novel family of selective antifungal compounds (CANBEFs) that interfere with fungal protein synthesis
    • Mircus G, Albert N, Ben-Yaakov D, et al. Identification and characterization of a novel family of selective antifungal compounds (CANBEFs) that interfere with fungal protein synthesis. Antimicrob Agents Chemother 2015; 59:5631–40.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 5631-5640
    • Mircus, G.1    Albert, N.2    Ben-Yaakov, D.3
  • 66
    • 84964319912 scopus 로고    scopus 로고
    • Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis
    • Ben Yaakov D, Rivkin A, Mircus G, et al. Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis. J Antimicrob Chemother 2016; 71:946–52.
    • (2016) J Antimicrob Chemother , vol.71 , pp. 946-952
    • Ben Yaakov, D.1    Rivkin, A.2    Mircus, G.3
  • 67
    • 80155136212 scopus 로고    scopus 로고
    • Sampangine inhibits heme biosynthesis in both yeast and human
    • Huang Z, Chen K, Xu T, et al. Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryot Cell 2011; 10:1536–44.
    • (2011) Eukaryot Cell , vol.10 , pp. 1536-1544
    • Huang, Z.1    Chen, K.2    Xu, T.3
  • 68
    • 84953340653 scopus 로고    scopus 로고
    • Sampangine (a copyrine alkaloid) exerts biological activities through cellular redox cycling of its quinone and semiquinone intermediates
    • Mahdi F, Morgan JB, Liu W, et al. Sampangine (a copyrine alkaloid) exerts biological activities through cellular redox cycling of its quinone and semiquinone intermediates. J Nat Prod 2015; 78:3018–23.
    • (2015) J Nat Prod , vol.78 , pp. 3018-3023
    • Mahdi, F.1    Morgan, J.B.2    Liu, W.3
  • 69
    • 84941902254 scopus 로고    scopus 로고
    • The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine
    • Jiang Z, Liu N, Hu D, et al. The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine. Chem Commun (Camb) 2015; 51:14648–51.
    • (2015) Chem Commun (Camb) , vol.51 , pp. 14648-14651
    • Jiang, Z.1    Liu, N.2    Hu, D.3
  • 70
    • 79961098039 scopus 로고    scopus 로고
    • Functional analyses of two acetyl coenzyme A synthe-tases in the ascomycete Gibberella zeae
    • Lee S, Son H, Lee J, et al. Functional analyses of two acetyl coenzyme A synthe-tases in the ascomycete Gibberella zeae. Eukaryot Cell 2011; 10:1043–52.
    • (2011) Eukaryot Cell , vol.10 , pp. 1043-1052
    • Lee, S.1    Son, H.2    Lee, J.3
  • 71
    • 85019538504 scopus 로고    scopus 로고
    • Antitumor/antifungal celecoxib derivative AR-12 is a non-nucleoside inhibitor of the ANL-family adenylating enzyme acetyl CoA synthetase
    • Koselny K, Green J, Favazzo L, et al. Antitumor/antifungal celecoxib derivative AR-12 is a non-nucleoside inhibitor of the ANL-family adenylating enzyme acetyl CoA synthetase. ACS Infect Dis 2016; 2:268–80.
    • (2016) ACS Infect Dis , vol.2 , pp. 268-280
    • Koselny, K.1    Green, J.2    Favazzo, L.3
  • 72
    • 84996599717 scopus 로고    scopus 로고
    • The celecoxib derivative AR-12 has broad-spectrum antifungal activity in vitro and improves the activity of fluconazole in a murine model of cryptococcosis
    • Koselny K, Green J, DiDone L, et al. The celecoxib derivative AR-12 has broad-spectrum antifungal activity in vitro and improves the activity of fluconazole in a murine model of cryptococcosis. Antimicrob Agents Chemother 2016; 60:7115–27.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 7115-7127
    • Koselny, K.1    Green, J.2    DiDone, L.3
  • 73
    • 3042562279 scopus 로고    scopus 로고
    • From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors
    • Zhu J, Huang JW, Tseng PH, et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res 2004; 64:4309–18.
    • (2004) Cancer Res , vol.64 , pp. 4309-4318
    • Zhu, J.1    Huang, J.W.2    Tseng, P.H.3
  • 74
    • 0034444677 scopus 로고    scopus 로고
    • Signal transduction cascades regulating fungal development and virulence
    • Lengeler KB, Davidson RC, D’souza C, et al. Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev 2000; 64:746–85.
    • (2000) Microbiol Mol Biol Rev , vol.64 , pp. 746-785
    • Lengeler, K.B.1    Davidson, R.C.2    D’souza, C.3
  • 75
    • 68849099102 scopus 로고    scopus 로고
    • The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans
    • Román E, Alonso-Monge R, Gong Q, Li D, Calderone R, Pla J. The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans. FEMS Yeast Res 2009; 9:942–55.
    • (2009) FEMS Yeast Res , vol.9 , pp. 942-955
    • Román, E.1    Alonso-Monge, R.2    Gong, Q.3    Li, D.4    Calderone, R.5    Pla, J.6
  • 76
    • 84888214854 scopus 로고    scopus 로고
    • Stress signaling pathways for the pathogenicity of Cryptococcus
    • Bahn YS, Jung KW. Stress signaling pathways for the pathogenicity of Cryptococcus. Eukaryot Cell 2013; 12:1564–77.
    • (2013) Eukaryot Cell , vol.12 , pp. 1564-1577
    • Bahn, Y.S.1    Jung, K.W.2
  • 77
    • 84871363778 scopus 로고    scopus 로고
    • The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans
    • Herrero de Dios C, Román E, Diez C, Alonso-Monge R, Pla J. The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans. Fungal Genet Biol 2013; 50:21–32.
    • (2013) Fungal Genet Biol , vol.50 , pp. 21-32
    • Herrero De Dios, C.1    Román, E.2    Diez, C.3    Alonso-Monge, R.4    Pla, J.5
  • 78
    • 77958121046 scopus 로고    scopus 로고
    • PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90
    • LaFayette SL, Collins C, Zaas AK, et al. PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. PLoS Pathog 2010; 6:e1001069.
    • (2010) PLoS Pathog , vol.6 , pp. e1001069
    • LaFayette, S.L.1    Collins, C.2    Zaas, A.K.3
  • 79
    • 79951479272 scopus 로고    scopus 로고
    • Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3
    • Argimón S, Fanning S, Blankenship JR, Mitchell AP. Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3. Eukaryot Cell 2011; 10:272–5.
    • (2011) Eukaryot Cell , vol.10 , pp. 272-275
    • Argimón, S.1    Fanning, S.2    Blankenship, J.R.3    Mitchell, A.P.4
  • 80
    • 1842453025 scopus 로고    scopus 로고
    • Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: Regulating adaptation to citric acid stress
    • Lawrence CL, Botting CH, Antrobus R, Coote PJ. Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress. Mol Cell Biol 2004; 24:3307–23.
    • (2004) Mol Cell Biol , vol.24 , pp. 3307-3323
    • Lawrence, C.L.1    Botting, C.H.2    Antrobus, R.3    Coote, P.J.4
  • 81
    • 0036548318 scopus 로고    scopus 로고
    • Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress
    • Winkler A, Arkind C, Mattison CP, Burkholder A, Knoche K, Ota I. Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress. Eukaryot Cell 2002; 1:163–73.
    • (2002) Eukaryot Cell , vol.1 , pp. 163-173
    • Winkler, A.1    Arkind, C.2    Mattison, C.P.3    Burkholder, A.4    Knoche, K.5    Ota, I.6
  • 82
    • 0032908687 scopus 로고    scopus 로고
    • Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans
    • Alonso-Monge R, Navarro-García F, Molero G, et al. Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans. J Bacteriol 1999; 181:3058–68.
    • (1999) J Bacteriol , vol.181 , pp. 3058-3068
    • Alonso-Monge, R.1    Navarro-García, F.2    Molero, G.3
  • 83
    • 84940729003 scopus 로고    scopus 로고
    • Genomic profiling of fungal cell wall-interfering compounds: Identification of a common gene signature
    • García R, Botet J, Rodríguez-Peña JM, et al. Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature. BMC Genomics 2015; 16:683.
    • (2015) BMC Genomics , vol.16 , pp. 683
    • García, R.1    Botet, J.2    Rodríguez-Peña, J.M.3
  • 84
    • 84879507441 scopus 로고    scopus 로고
    • The HOG signal transduction pathway in the halophilic fungus Wallemia ichthyophaga: Identification and characterisation of MAP kinases WiHog1A and WiHog1B
    • Konte T, Plemenitas A. The HOG signal transduction pathway in the halophilic fungus Wallemia ichthyophaga: identification and characterisation of MAP kinases WiHog1A and WiHog1B. Extremophiles 2013; 17:623–36.
    • (2013) Extremophiles , vol.17 , pp. 623-636
    • Konte, T.1    Plemenitas, A.2
  • 85
    • 55849146632 scopus 로고    scopus 로고
    • Two-component signal transduction proteins as potential drug targets in medically important fungi
    • Chauhan N, Calderone R. Two-component signal transduction proteins as potential drug targets in medically important fungi. Infect Immun 2008; 76:4795–803.
    • (2008) Infect Immun , vol.76 , pp. 4795-4803
    • Chauhan, N.1    Calderone, R.2
  • 86
    • 79957788651 scopus 로고    scopus 로고
    • Design, synthesis, and characterization of a highly effective Hog1 inhibitor: A powerful tool for analyzing MAP kinase signaling in yeast
    • Dinér P, Veide Vilg J, Kjellén J, et al. Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast. PLoS One 2011; 6:e20012.
    • (2011) PLoS One , vol.6 , pp. e20012
    • Dinér, P.1    Veide Vilg, J.2    Kjellén, J.3
  • 87
    • 33645106541 scopus 로고    scopus 로고
    • Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans
    • Kojima K, Bahn YS, Heitman J. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 2006; 152:591–604.
    • (2006) Microbiology , vol.152 , pp. 591-604
    • Kojima, K.1    Bahn, Y.S.2    Heitman, J.3
  • 88
    • 0033763743 scopus 로고    scopus 로고
    • On the mechanism of action of the myxobacterial fungicide ambruticin
    • Knauth P, Reichenbach H. On the mechanism of action of the myxobacterial fungicide ambruticin. J Antibiot (Tokyo) 2000; 53:1182–90.
    • (2000) J Antibiot (Tokyo) , vol.53 , pp. 1182-1190
    • Knauth, P.1    Reichenbach, H.2
  • 89
    • 0017799529 scopus 로고
    • Therapeutic properties of oral ambruticin (W7783) in experimental pulmonary coccidioidomycosis of mice
    • Levine HB, Ringel SM, Cobb JM. Therapeutic properties of oral ambruticin (W7783) in experimental pulmonary coccidioidomycosis of mice. Chest 1978; 73:202–6.
    • (1978) Chest , vol.73 , pp. 202-206
    • Levine, H.B.1    Ringel, S.M.2    Cobb, J.M.3
  • 91
    • 79957449178 scopus 로고    scopus 로고
    • Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules
    • Baxter BK, DiDone L, Ogu D, Schor S, Krysan DJ. Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules. ACS Chem Biol 2011; 6:502–10.
    • (2011) ACS Chem Biol , vol.6 , pp. 502-510
    • Baxter, B.K.1    DiDone, L.2    Ogu, D.3    Schor, S.4    Krysan, D.J.5
  • 92
    • 84928382653 scopus 로고    scopus 로고
    • OSU-03012 and Viagra treatment inhibits the activity of multiple chaperone proteins and disrupts the blood-brain barrier: Implications for anti-cancer therapies
    • Booth L, Roberts JL, Tavallai M, et al. OSU-03012 and Viagra treatment inhibits the activity of multiple chaperone proteins and disrupts the blood-brain barrier: implications for anti-cancer therapies. J Cell Physiol 2015; 230:1982–98.
    • (2015) J Cell Physiol , vol.230 , pp. 1982-1998
    • Booth, L.1    Roberts, J.L.2    Tavallai, M.3
  • 93
    • 84865650458 scopus 로고    scopus 로고
    • Effect of CCH1 or MID1 gene disruption on drug tolerance and pathogenesis of Candida albicans
    • Wang H, Lu G, Yang B, et al. Effect of CCH1 or MID1 gene disruption on drug tolerance and pathogenesis of Candida albicans. Sheng Wu Gong Cheng Xue Bao 2012; 28:726–36.
    • (2012) Sheng Wu Gong Cheng Xue Bao , vol.28 , pp. 726-736
    • Wang, H.1    Lu, G.2    Yang, B.3
  • 94
    • 84921935064 scopus 로고    scopus 로고
    • The calcium channel blocker verapamil inhibits oxidative stress response in Candida albicans
    • Yu Q, Xiao C, Zhang K, et al. The calcium channel blocker verapamil inhibits oxidative stress response in Candida albicans. Mycopathologia 2014; 177: 167–77.
    • (2014) Mycopathologia , vol.177 , pp. 167-177
    • Yu, Q.1    Xiao, C.2    Zhang, K.3
  • 95
    • 44249084246 scopus 로고    scopus 로고
    • Systematic functional analysis of calcium-signalling proteins in the genome of the rice-blast fungus, Magnaporthe oryzae, using a high-throughput RNA-silencing system
    • Nguyen QB, Kadotani N, Kasahara S, Tosa Y, Mayama S, Nakayashiki H. Systematic functional analysis of calcium-signalling proteins in the genome of the rice-blast fungus, Magnaporthe oryzae, using a high-throughput RNA-silencing system. Mol Microbiol 2008; 68:1348–65.
    • (2008) Mol Microbiol , vol.68 , pp. 1348-1365
    • Nguyen, Q.B.1    Kadotani, N.2    Kasahara, S.3    Tosa, Y.4    Mayama, S.5    Nakayashiki, H.6
  • 96
    • 84901456605 scopus 로고    scopus 로고
    • Calcineurin-Crz1 signaling in lower eukaryotes
    • Thewes S. Calcineurin-Crz1 signaling in lower eukaryotes. Eukaryot Cell 2014; 13:694–705.
    • (2014) Eukaryot Cell , vol.13 , pp. 694-705
    • Thewes, S.1
  • 97
    • 34249069582 scopus 로고    scopus 로고
    • Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
    • Steinbach WJ, Reedy JL, Cramer RA Jr, Perfect JR, Heitman J. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat Rev Microbiol 2007; 5:418–30.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 418-430
    • Steinbach, W.J.1    Reedy, J.L.2    Jr, C.R.A.3    Perfect, J.R.4    Heitman, J.5
  • 98
    • 33746267436 scopus 로고    scopus 로고
    • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans
    • Cramer KL, Gerrald QD, Nichols CB, Price MS, Alspaugh JA. Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. Eukaryot Cell 2006; 5:1147–56.
    • (2006) Eukaryot Cell , vol.5 , pp. 1147-1156
    • Cramer, K.L.1    Gerrald, Q.D.2    Nichols, C.B.3    Price, M.S.4    Alspaugh, J.A.5
  • 99
    • 47049092533 scopus 로고    scopus 로고
    • Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions
    • Nobile CJ, Solis N, Myers CL, et al. Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions. Cell Microbiol 2008; 10:2180–96.
    • (2008) Cell Microbiol , vol.10 , pp. 2180-2196
    • Nobile, C.J.1    Solis, N.2    Myers, C.L.3
  • 100
    • 84942279828 scopus 로고    scopus 로고
    • Potential targets for antifungal drug discovery based on growth and virulence in Candida albicans
    • Li X, Hou Y, Yue L, Liu S, Du J, Sun S. Potential targets for antifungal drug discovery based on growth and virulence in Candida albicans. Antimicrob Agents Chemother 2015; 59:5885–91.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 5885-5891
    • Li, X.1    Hou, Y.2    Yue, L.3    Liu, S.4    Du, J.5    Sun, S.6
  • 101
    • 4344650084 scopus 로고    scopus 로고
    • Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine
    • Welsch CA, Roth LW, Goetschy JF, Movva NR. Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. J Biol Chem 2004; 279:36720–31.
    • (2004) J Biol Chem , vol.279 , pp. 36720-36731
    • Welsch, C.A.1    Roth, L.W.2    Goetschy, J.F.3    Movva, N.R.4
  • 102
    • 84891712223 scopus 로고    scopus 로고
    • Fingolimod (FTY720) stimulates Ca(2+)/ calcineurin signaling in fission yeast
    • Hagihara K, Kita A, Mizukura A, et al. Fingolimod (FTY720) stimulates Ca(2+)/ calcineurin signaling in fission yeast. PLoS One 2013; 8:e81907.
    • (2013) PLoS One , vol.8 , pp. e81907
    • Hagihara, K.1    Kita, A.2    Mizukura, A.3
  • 103
    • 80053172883 scopus 로고    scopus 로고
    • The Aspergillus giganteus antifungal protein AFPNN5353 activates the cell wall integrity pathway and perturbs calcium homeostasis
    • Binder U, Bencina M, Eigentler A, Meyer V, Marx F. The Aspergillus giganteus antifungal protein AFPNN5353 activates the cell wall integrity pathway and perturbs calcium homeostasis. BMC Microbiol 2011; 11:209.
    • (2011) BMC Microbiol , vol.11 , pp. 209
    • Binder, U.1    Bencina, M.2    Eigentler, A.3    Meyer, V.4    Marx, F.5
  • 104
    • 79954593822 scopus 로고    scopus 로고
    • Survival strategies of yeast and filamentous fungi against the antifungal protein AFP
    • Ouedraogo JP, Hagen S, Spielvogel A, Engelhardt S, Meyer V. Survival strategies of yeast and filamentous fungi against the antifungal protein AFP. J Biol Chem 2011; 286:13859–68.
    • (2011) J Biol Chem , vol.286 , pp. 13859-13868
    • Ouedraogo, J.P.1    Hagen, S.2    Spielvogel, A.3    Engelhardt, S.4    Meyer, V.5
  • 105
    • 67650617262 scopus 로고    scopus 로고
    • A comparative genomic analysis of calcium and proton signaling/homeostasis in Aspergillus species
    • Bencina M, Bagar T, Lah L, Krasevec N. A comparative genomic analysis of calcium and proton signaling/homeostasis in Aspergillus species. Fungal Genet Biol 2009; 46:S93–104.
    • (2009) Fungal Genet Biol , vol.46 , pp. S93-S104
    • Bencina, M.1    Bagar, T.2    Lah, L.3    Krasevec, N.4
  • 106
    • 3843054526 scopus 로고    scopus 로고
    • A comparative genomic analysis of the calcium signaling machinery in Neurospora crassa, Magnaporthe grisea, and Saccharomyces cerevisiae
    • Zelter A, Bencina M, Bowman BJ, Yarden O, Read ND. A comparative genomic analysis of the calcium signaling machinery in Neurospora crassa, Magnaporthe grisea, and Saccharomyces cerevisiae. Fungal Genet Biol 2004; 41:827–41.
    • (2004) Fungal Genet Biol , vol.41 , pp. 827-841
    • Zelter, A.1    Bencina, M.2    Bowman, B.J.3    Yarden, O.4    Read, N.D.5
  • 107
    • 84938768178 scopus 로고    scopus 로고
    • Exploiting fungal virulence-regulating transcription factors as novel antifungal drug targets
    • Bahn YS. Exploiting fungal virulence-regulating transcription factors as novel antifungal drug targets. PLoS Pathog 2015; 11:e1004936.
    • (2015) PLoS Pathog , vol.11 , pp. e1004936
    • Bahn, Y.S.1
  • 108
    • 84880776876 scopus 로고    scopus 로고
    • Fungal-specific transcription factor AbPf2 activates pathogenicity in Alternaria brassicicola
    • Cho Y, Ohm RA, Grigoriev IV, Srivastava A. Fungal-specific transcription factor AbPf2 activates pathogenicity in Alternaria brassicicola. Plant J 2013; 75:498–514.
    • (2013) Plant J , vol.75 , pp. 498-514
    • Cho, Y.1    Ohm, R.A.2    Grigoriev, I.V.3    Srivastava, A.4
  • 109
    • 84856117019 scopus 로고    scopus 로고
    • A recently evolved transcriptional network controls biofilm development in Candida albicans
    • Nobile CJ, Fox EP, Nett JE, et al. A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 2012; 148:126–38.
    • (2012) Cell , vol.148 , pp. 126-138
    • Nobile, C.J.1    Fox, E.P.2    Nett, J.E.3
  • 110
    • 3843090057 scopus 로고    scopus 로고
    • Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence
    • Kamran M, Calcagno AM, Findon H, et al. Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell 2004; 3:546–52.
    • (2004) Eukaryot Cell , vol.3 , pp. 546-552
    • Kamran, M.1    Calcagno, A.M.2    Findon, H.3
  • 111
    • 33749234216 scopus 로고    scopus 로고
    • Drugs, their targets and the nature and number of drug targets
    • Imming P, Sinning C, Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 2006; 5:821–34.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 821-834
    • Imming, P.1    Sinning, C.2    Meyer, A.3
  • 112
    • 25144452721 scopus 로고    scopus 로고
    • Chemical approaches to transcriptional regulation
    • Majmudar CY, Mapp AK. Chemical approaches to transcriptional regulation. Curr Opin Chem Biol 2005; 9:467–74.
    • (2005) Curr Opin Chem Biol , vol.9 , pp. 467-474
    • Majmudar, C.Y.1    Mapp, A.K.2
  • 113
    • 77952545553 scopus 로고    scopus 로고
    • A complex task? Direct modulation of transcription factors with small molecules
    • Koehler AN. A complex task? Direct modulation of transcription factors with small molecules. Curr Opin Chem Biol 2010; 14:331–40.
    • (2010) Curr Opin Chem Biol , vol.14 , pp. 331-340
    • Koehler, A.N.1
  • 114
    • 77951233113 scopus 로고    scopus 로고
    • Transcriptional switches: Chemical approaches to gene regulation
    • Lee LW, Mapp AK. Transcriptional switches: chemical approaches to gene regulation. J Biol Chem 2010; 285:11033–8.
    • (2010) J Biol Chem , vol.285 , pp. 11033-11038
    • Lee, L.W.1    Mapp, A.K.2
  • 115
    • 84891528835 scopus 로고    scopus 로고
    • Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor
    • Gallo-Ebert C, Donigan M, Stroke IL, et al. Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor. Antimicrob Agents Chemother 2014; 58:258–66.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 258-266
    • Gallo-Ebert, C.1    Donigan, M.2    Stroke, I.L.3
  • 116
    • 18244396070 scopus 로고    scopus 로고
    • Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes
    • MacPherson S, Akache B, Weber S, De Deken X, Raymond M, Turcotte B. Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. Antimicrob Agents Chemother 2005; 49:1745–52.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1745-1752
    • MacPherson, S.1    Akache, B.2    Weber, S.3    De Deken, X.4    Raymond, M.5    Turcotte, B.6
  • 117
    • 84891604637 scopus 로고    scopus 로고
    • Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence
    • Lohberger A, Coste AT, Sanglard D. Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence. Eukaryot Cell 2014; 13:127–42.
    • (2014) Eukaryot Cell , vol.13 , pp. 127-142
    • Lohberger, A.1    Coste, A.T.2    Sanglard, D.3
  • 118
    • 84880065202 scopus 로고    scopus 로고
    • Regulatory role of glycerol in Candida albicans biofilm formation
    • Desai JV, Bruno VM, Ganguly S, et al. Regulatory role of glycerol in Candida albicans biofilm formation. MBio 2013; 4:e00637–12.
    • (2013) MBio , vol.4 , pp. e00637-e00712
    • Desai, J.V.1    Bruno, V.M.2    Ganguly, S.3
  • 120
    • 33746636085 scopus 로고    scopus 로고
    • Critical role of Bcr1-dependent adhesins in C. Albicans biofilm formation in vitro and in vivo
    • Nobile CJ, Andes DR, Nett JE, et al. Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog 2006; 2:e63.
    • (2006) PLoS Pathog , vol.2 , pp. e63
    • Nobile, C.J.1    Andes, D.R.2    Nett, J.E.3
  • 121
    • 77954095162 scopus 로고    scopus 로고
    • Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    • Noble SM, French S, Kohn LA, Chen V, Johnson AD. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat Genet 2010; 42:590–8.
    • (2010) Nat Genet , vol.42 , pp. 590-598
    • Noble, S.M.1    French, S.2    Kohn, L.A.3    Chen, V.4    Johnson, A.D.5
  • 122
    • 52949114243 scopus 로고    scopus 로고
    • Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans
    • Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell 2008; 135:174–88.
    • (2008) Cell , vol.135 , pp. 174-188
    • Liu, O.W.1    Chun, C.D.2    Chow, E.D.3    Chen, C.4    Madhani, H.D.5    Noble, S.M.6
  • 123
    • 84926653962 scopus 로고    scopus 로고
    • Systematic functional profiling of transcription factor networks in Cryptococcus neoformans
    • Jung KW, Yang DH, Maeng S, et al. Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. Nat Commun 2015; 6:6757.
    • (2015) Nat Commun , vol.6 , pp. 6757
    • Jung, K.W.1    Yang, D.H.2    Maeng, S.3
  • 124
    • 84929657744 scopus 로고    scopus 로고
    • Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation
    • Maier EJ, Haynes BC, Gish SR, et al. Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation. Genome Res 2015; 25:690–700.
    • (2015) Genome Res , vol.25 , pp. 690-700
    • Maier, E.J.1    Haynes, B.C.2    Gish, S.R.3
  • 125
    • 84892942381 scopus 로고    scopus 로고
    • New and emerging HDAC inhibitors for cancer treatment
    • West AC, Johnstone RW. New and emerging HDAC inhibitors for cancer treatment. J Clin Invest 2014; 124:30–9.
    • (2014) J Clin Invest , vol.124 , pp. 30-39
    • West, A.C.1    Johnstone, R.W.2
  • 126
    • 71549146873 scopus 로고    scopus 로고
    • Activity of MGCD290, a Hos2 histone deacetylase inhibitor, in combination with azole antifungals against opportunistic fungal pathogens
    • Pfaller MA, Messer SA, Georgopapadakou N, Martell LA, Besterman JM, Diekema DJ. Activity of MGCD290, a Hos2 histone deacetylase inhibitor, in combination with azole antifungals against opportunistic fungal pathogens. J Clin Microbiol 2009; 47:3797–804.
    • (2009) J Clin Microbiol , vol.47 , pp. 3797-3804
    • Pfaller, M.A.1    Messer, S.A.2    Georgopapadakou, N.3    Martell, L.A.4    Besterman, J.M.5    Diekema, D.J.6
  • 127
    • 77954139965 scopus 로고    scopus 로고
    • Small-molecule chromatin-modifying agents: Therapeutic applications
    • Mai A. Small-molecule chromatin-modifying agents: therapeutic applications. Epigenomics 2010; 2:307–24.
    • (2010) Epigenomics , vol.2 , pp. 307-324
    • Mai, A.1
  • 128
    • 84925041893 scopus 로고    scopus 로고
    • In vitro activity of a Hos2 deacetylase inhibitor, MGCD290, in combination with echinocandins against echinocandin-resistant Candida species
    • Pfaller MA, Rhomberg PR, Messer SA, Castanheira M. In vitro activity of a Hos2 deacetylase inhibitor, MGCD290, in combination with echinocandins against echinocandin-resistant Candida species. Diagn Microbiol Infect Dis 2015; 81:259–63.
    • (2015) Diagn Microbiol Infect Dis , vol.81 , pp. 259-263
    • Pfaller, M.A.1    Rhomberg, P.R.2    Messer, S.A.3    Castanheira, M.4
  • 129
    • 84927553790 scopus 로고    scopus 로고
    • Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis
    • Lamoth F, Juvvadi PR, Steinbach WJ. Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis. Front Microbiol 2015; 6:96.
    • (2015) Front Microbiol , vol.6 , pp. 96
    • Lamoth, F.1    Juvvadi, P.R.2    Steinbach, W.J.3
  • 130
    • 84978117016 scopus 로고    scopus 로고
    • Epidemiology of invasive fungal infections during induction therapy in adults with acute lymphoblastic leukemia: A GRAALL-2005 study
    • Mariette C, Tavernier E, Hocquet D, et al. Epidemiology of invasive fungal infections during induction therapy in adults with acute lymphoblastic leukemia: a GRAALL-2005 study. Leuk Lymphoma 2017; 58:586–93.
    • (2017) Leuk Lymphoma , vol.58 , pp. 586-593
    • Mariette, C.1    Tavernier, E.2    Hocquet, D.3
  • 131
    • 84941317313 scopus 로고    scopus 로고
    • International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus
    • Verweij PE, Ananda-Rajah M, Andes D, et al. International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus. Drug Resist Updat 2015; 21–22:30–40.
    • (2015) Drug Resist Updat , vol.21-22 , pp. 30-40
    • Verweij, P.E.1    Ananda-Rajah, M.2    Andes, D.3
  • 132
    • 84992472490 scopus 로고    scopus 로고
    • Triazole resistance in Aspergillus fumigatus isolates from patients with cystic fibrosis in Italy
    • Prigitano A, Esposto MC, Biffi A, et al. Triazole resistance in Aspergillus fumigatus isolates from patients with cystic fibrosis in Italy. J Cyst Fibros 2017; 16:64–9.
    • (2017) J Cyst Fibros , vol.16 , pp. 64-69
    • Prigitano, A.1    Esposto, M.C.2    Biffi, A.3
  • 133
    • 28844459420 scopus 로고    scopus 로고
    • Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation
    • Perruccio K, Tosti A, Burchielli E, et al. Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood 2005; 106:4397–406.
    • (2005) Blood , vol.106 , pp. 4397-4406
    • Perruccio, K.1    Tosti, A.2    Burchielli, E.3
  • 134
    • 84904632405 scopus 로고    scopus 로고
    • Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection
    • Kumaresan PR, Manuri PR, Albert ND, et al. Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection. Proc Natl Acad Sci U S A 2014; 111:10660–5.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 10660-10665
    • Kumaresan, P.R.1    Manuri, P.R.2    Albert, N.D.3
  • 135
    • 79951826116 scopus 로고    scopus 로고
    • Confronting the challenges of natural product-based antifungal discovery
    • Roemer T, Xu D, Singh SB, et al. Confronting the challenges of natural product-based antifungal discovery. Chem Biol 2011; 18:148–64.
    • (2011) Chem Biol , vol.18 , pp. 148-164
    • Roemer, T.1    Xu, D.2    Singh, S.B.3
  • 136
    • 84874238564 scopus 로고    scopus 로고
    • A comprehensive regulatory framework to address the unmet need for new antibacterial treatments
    • Rex JH, Eisenstein BI, Alder J, et al. A comprehensive regulatory framework to address the unmet need for new antibacterial treatments. Lancet Infect Dis 2013; 13:269–75.
    • (2013) Lancet Infect Dis , vol.13 , pp. 269-275
    • Rex, J.H.1    Eisenstein, B.I.2    Alder, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.