메뉴 건너뛰기




Volumn 11, Issue 7, 2015, Pages

Exploiting Fungal Virulence-Regulating Transcription Factors As Novel Antifungal Drug Targets

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; BRG1 PROTEIN; CYTOSINE DEAMINASE; DNA BINDING PROTEIN; HISTONE DEACETYLASE; TRANSCRIPTION FACTOR;

EID: 84938768178     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004936     Document Type: Article
Times cited : (37)

References (34)
  • 2
    • 84878262645 scopus 로고    scopus 로고
    • Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes
    • Kong D, Lee MJ, Lin S, Kim ES, (2013) Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes. J Ind Microbiol Biotechnol 40: 529–543. doi: 10.1007/s10295-013-1258-6 23515854
    • (2013) J Ind Microbiol Biotechnol , vol.40 , pp. 529-543
    • Kong, D.1    Lee, M.J.2    Lin, S.3    Kim, E.S.4
  • 3
    • 84891357976 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of potent antifungal agents
    • Geronikaki A, Fesatidou M, Kartsev V, Macaev F, (2013) Synthesis and biological evaluation of potent antifungal agents. Curr Top Med Chem 13: 2684–2733. 24083791
    • (2013) Curr Top Med Chem , vol.13 , pp. 2684-2733
    • Geronikaki, A.1    Fesatidou, M.2    Kartsev, V.3    Macaev, F.4
  • 4
    • 49049111363 scopus 로고    scopus 로고
    • Echinocandins: a wealth of choice—how clinically different are they?
    • Zaas AK, (2008) Echinocandins: a wealth of choice—how clinically different are they? Curr Opin Infect Dis 21: 426–432. doi: 10.1097/QCO.0b013e328307c79c 18594297
    • (2008) Curr Opin Infect Dis , vol.21 , pp. 426-432
    • Zaas, A.K.1
  • 5
    • 0033869563 scopus 로고    scopus 로고
    • Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions
    • Vermes A, Guchelaar HJ, Dankert J, (2000) Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother 46: 171–179. 10933638
    • (2000) J Antimicrob Chemother , vol.46 , pp. 171-179
    • Vermes, A.1    Guchelaar, H.J.2    Dankert, J.3
  • 6
    • 33749234216 scopus 로고    scopus 로고
    • Drugs, their targets and the nature and number of drug targets
    • Imming P, Sinning C, Meyer A, (2006) Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 5: 821–834. 17016423
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 821-834
    • Imming, P.1    Sinning, C.2    Meyer, A.3
  • 7
    • 77952545553 scopus 로고    scopus 로고
    • A complex task? Direct modulation of transcription factors with small molecules
    • Koehler AN, (2010) A complex task? Direct modulation of transcription factors with small molecules. Curr Opin Chem Biol 14: 331–340. doi: 10.1016/j.cbpa.2010.03.022 20395165
    • (2010) Curr Opin Chem Biol , vol.14 , pp. 331-340
    • Koehler, A.N.1
  • 8
    • 50249186849 scopus 로고    scopus 로고
    • Inhibition of transcription factors with small organic molecules
    • Berg T, (2008) Inhibition of transcription factors with small organic molecules. Curr Opin Chem Biol 12: 464–471. doi: 10.1016/j.cbpa.2008.07.023 18706517
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 464-471
    • Berg, T.1
  • 9
    • 25144452721 scopus 로고    scopus 로고
    • Chemical approaches to transcriptional regulation
    • Majmudar CY, Mapp AK, (2005) Chemical approaches to transcriptional regulation. Curr Opin Chem Biol 9: 467–474. 16122970
    • (2005) Curr Opin Chem Biol , vol.9 , pp. 467-474
    • Majmudar, C.Y.1    Mapp, A.K.2
  • 11
    • 20544456163 scopus 로고    scopus 로고
    • Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p
    • Nobile CJ, Mitchell AP, (2005) Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p. Curr Biol 15: 1150–1155. 15964282
    • (2005) Curr Biol , vol.15 , pp. 1150-1155
    • Nobile, C.J.1    Mitchell, A.P.2
  • 12
    • 74249093221 scopus 로고    scopus 로고
    • A phenotypic profile of the Candida albicans regulatory network
    • Homann OR, Dea J, Noble SM, Johnson AD, (2009) A phenotypic profile of the Candida albicans regulatory network. PLoS genetics 5: e1000783. doi: 10.1371/journal.pgen.1000783 20041210
    • (2009) PLoS genetics , vol.5 , pp. e1000783
    • Homann, O.R.1    Dea, J.2    Noble, S.M.3    Johnson, A.D.4
  • 13
    • 77954095162 scopus 로고    scopus 로고
    • Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    • Noble SM, French S, Kohn LA, Chen V, Johnson AD, (2010) Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat Genet 42: 590–598. doi: 10.1038/ng.605 20543849
    • (2010) Nat Genet , vol.42 , pp. 590-598
    • Noble, S.M.1    French, S.2    Kohn, L.A.3    Chen, V.4    Johnson, A.D.5
  • 14
    • 52949114243 scopus 로고    scopus 로고
    • Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans
    • Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, et al. (2008) Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell 135: 174–188. doi: 10.1016/j.cell.2008.07.046 18854164
    • (2008) Cell , vol.135 , pp. 174-188
    • Liu, O.W.1    Chun, C.D.2    Chow, E.D.3    Chen, C.4    Madhani, H.D.5
  • 15
    • 84926653962 scopus 로고    scopus 로고
    • Systematic functional profiling of transcription factor networks in Cryptococcus neoformans
    • Jung KW, Yang DH, Maeng S, Lee KT, So YS, et al. (2015) Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. Nat Comms 6: 6757.
    • (2015) Nat Comms , vol.6 , pp. 6757
    • Jung, K.W.1    Yang, D.H.2    Maeng, S.3    Lee, K.T.4    So, Y.S.5
  • 16
    • 84929657744 scopus 로고    scopus 로고
    • Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation
    • Maier EJ, Haynes BC, Gish SR, Wang ZA, Skowyra ML, et al. (2015) Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation. Genome Res. 25:690–700. doi: 10.1101/gr.184101.114 25644834
    • (2015) Genome Res , vol.25 , pp. 690-700
    • Maier, E.J.1    Haynes, B.C.2    Gish, S.R.3    Wang, Z.A.4    Skowyra, M.L.5
  • 17
    • 84901456605 scopus 로고    scopus 로고
    • Calcineurin-Crz1 signaling in lower eukaryotes
    • Thewes S, (2014) Calcineurin-Crz1 signaling in lower eukaryotes. Eukaryot Cell 13: 694–705. doi: 10.1128/EC.00038-14 24681686
    • (2014) Eukaryot Cell , vol.13 , pp. 694-705
    • Thewes, S.1
  • 18
    • 84874614624 scopus 로고    scopus 로고
    • Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses
    • O'Meara TR, Holmer SM, Selvig K, Dietrich F, Alspaugh JA, (2013) Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. mBio 4: e00522–00512. doi: 10.1128/mBio.00522-12 23322637
    • (2013) mBio , vol.4 , pp. 512-522
    • O'Meara, T.R.1    Holmer, S.M.2    Selvig, K.3    Dietrich, F.4    Alspaugh, J.A.5
  • 19
    • 33746267436 scopus 로고    scopus 로고
    • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans
    • Cramer KL, Gerrald QD, Nichols CB, Price MS, Alspaugh JA, (2006) Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. Eukaryot Cell 5: 1147–1156. 16835458
    • (2006) Eukaryot Cell , vol.5 , pp. 1147-1156
    • Cramer, K.L.1    Gerrald, Q.D.2    Nichols, C.B.3    Price, M.S.4    Alspaugh, J.A.5
  • 20
    • 47049092533 scopus 로고    scopus 로고
    • Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions
    • Nobile CJ, Solis N, Myers CL, Fay AJ, Deneault JS, et al. (2008) Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions. Cell Microbiol 10: 2180–2196. doi: 10.1111/j.1462-5822.2008.01198.x 18627379
    • (2008) Cell Microbiol , vol.10 , pp. 2180-2196
    • Nobile, C.J.1    Solis, N.2    Myers, C.L.3    Fay, A.J.4    Deneault, J.S.5
  • 21
    • 2942677354 scopus 로고    scopus 로고
    • RBR1, a novel pH-regulated cell wall gene of Candida albicans, is repressed by RIM101 and activated by NRG1
    • Lotz H, Sohn K, Brunner H, Muhlschlegel FA, Rupp S, (2004) RBR1, a novel pH-regulated cell wall gene of Candida albicans, is repressed by RIM101 and activated by NRG1. Eukaryot Cell 3: 776–784. 15189998
    • (2004) Eukaryot Cell , vol.3 , pp. 776-784
    • Lotz, H.1    Sohn, K.2    Brunner, H.3    Muhlschlegel, F.A.4    Rupp, S.5
  • 22
    • 0033796715 scopus 로고    scopus 로고
    • Candida albicans RIM101 pH response pathway is required for host-pathogen interactions
    • Davis D, Edwards JE, Jr.Mitchell AP, Ibrahim AS, (2000) Candida albicans RIM101 pH response pathway is required for host-pathogen interactions. Infect Immun 68: 5953–5959. 10992507
    • (2000) Infect Immun , vol.68 , pp. 5953-5959
    • Davis, D.1    Edwards, J.E.2    Mitchell, A.P.3    Ibrahim, A.S.4
  • 23
    • 77649265932 scopus 로고    scopus 로고
    • Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule
    • O'Meara TR, Norton D, Price MS, Hay C, Clements MF, et al. (2010) Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. PLoS Pathog 6: e1000776. doi: 10.1371/journal.ppat.1000776 20174553
    • (2010) PLoS Pathog , vol.6 , pp. e1000776
    • O'Meara, T.R.1    Norton, D.2    Price, M.S.3    Hay, C.4    Clements, M.F.5
  • 24
    • 84859005247 scopus 로고    scopus 로고
    • Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway
    • Jung KW, Strain AK, Nielsen K, Jung KH, Bahn YS, (2012) Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway. Fungal Genet Biol 49: 332–345. doi: 10.1016/j.fgb.2012.02.001 22343280
    • (2012) Fungal Genet Biol , vol.49 , pp. 332-345
    • Jung, K.W.1    Strain, A.K.2    Nielsen, K.3    Jung, K.H.4    Bahn, Y.S.5
  • 25
    • 0037223751 scopus 로고    scopus 로고
    • The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae
    • Lamb TM, Mitchell AP, (2003) The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae. Mol Cell Biol 23: 677–686. 12509465
    • (2003) Mol Cell Biol , vol.23 , pp. 677-686
    • Lamb, T.M.1    Mitchell, A.P.2
  • 26
    • 80055118535 scopus 로고    scopus 로고
    • Zap1 control of cell-cell signaling in Candida albicans biofilms
    • Ganguly S, Bishop AC, Xu W, Ghosh S, Nickerson KW, et al. (2011) Zap1 control of cell-cell signaling in Candida albicans biofilms. Eukaryot Cell 10: 1448–1454. doi: 10.1128/EC.05196-11 21890817
    • (2011) Eukaryot Cell , vol.10 , pp. 1448-1454
    • Ganguly, S.1    Bishop, A.C.2    Xu, W.3    Ghosh, S.4    Nickerson, K.W.5
  • 27
    • 79952643476 scopus 로고    scopus 로고
    • A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans
    • Chun CD, Brown JC, Madhani HD, (2011) A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe 9: 243–251. doi: 10.1016/j.chom.2011.02.003 21402362
    • (2011) Cell Host Microbe , vol.9 , pp. 243-251
    • Chun, C.D.1    Brown, J.C.2    Madhani, H.D.3
  • 28
    • 84861205961 scopus 로고    scopus 로고
    • A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans
    • Lu Y, Su C, Liu H, (2012) A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans. PLoS Pathog 8: e1002663. doi: 10.1371/journal.ppat.1002663 22536157
    • (2012) PLoS Pathog , vol.8 , pp. e1002663
    • Lu, Y.1    Su, C.2    Liu, H.3
  • 29
    • 84876838282 scopus 로고    scopus 로고
    • Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans
    • Lin CH, Kabrawala S, Fox EP, Nobile CJ, Johnson AD, et al. (2013) Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans. PLoS Pathog 9: e1003305. doi: 10.1371/journal.ppat.1003305 23637598
    • (2013) PLoS Pathog , vol.9 , pp. e1003305
    • Lin, C.H.1    Kabrawala, S.2    Fox, E.P.3    Nobile, C.J.4    Johnson, A.D.5
  • 30
    • 84864086156 scopus 로고    scopus 로고
    • BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence
    • Cleary IA, Lazzell AL, Monteagudo C, Thomas DP, Saville SP, (2012) BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence. Mol Microbiol 85: 557–573. doi: 10.1111/j.1365-2958.2012.08127.x 22757963
    • (2012) Mol Microbiol , vol.85 , pp. 557-573
    • Cleary, I.A.1    Lazzell, A.L.2    Monteagudo, C.3    Thomas, D.P.4    Saville, S.P.5
  • 31
    • 84855998530 scopus 로고    scopus 로고
    • Roles of Candida albicans Gat2, a GATA-type zinc finger transcription factor, in biofilm formation, filamentous growth and virulence
    • Du H, Guan G, Xie J, Sun Y, Tong Y, et al. (2012) Roles of Candida albicans Gat2, a GATA-type zinc finger transcription factor, in biofilm formation, filamentous growth and virulence. PLoS One 7: e29707. doi: 10.1371/journal.pone.0029707 22276126
    • (2012) PLoS One , vol.7 , pp. e29707
    • Du, H.1    Guan, G.2    Xie, J.3    Sun, Y.4    Tong, Y.5
  • 32
    • 0036801212 scopus 로고    scopus 로고
    • Co-regulation of pathogenesis with dimorphism and phenotypic switching in Candida albicans, a commensal and a pathogen
    • Liu H, (2002) Co-regulation of pathogenesis with dimorphism and phenotypic switching in Candida albicans, a commensal and a pathogen. Int J Med Microbiol 292: 299–311. 12452278
    • (2002) Int J Med Microbiol , vol.292 , pp. 299-311
    • Liu, H.1
  • 33
    • 80052309751 scopus 로고    scopus 로고
    • Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans
    • Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS, et al. (2011) Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathog 7: e1002177. doi: 10.1371/journal.ppat.1002177 21852949
    • (2011) PLoS Pathog , vol.7 , pp. e1002177
    • Cheon, S.A.1    Jung, K.W.2    Chen, Y.L.3    Heitman, J.4    Bahn, Y.S.5
  • 34
    • 77954496866 scopus 로고    scopus 로고
    • Morphogenic regulator EFG1 affects the drug susceptibilities of pathogenic Candida albicans
    • Prasad T, Hameed S, Manoharlal R, Biswas S, Mukhopadhyay CK, et al. (2010) Morphogenic regulator EFG1 affects the drug susceptibilities of pathogenic Candida albicans. FEMS Yeast Res 10: 587–596 doi: 10.1111/j.1567-1364.2010.00639.x 20491944
    • (2010) FEMS Yeast Res , vol.10 , pp. 587-596
    • Prasad, T.1    Hameed, S.2    Manoharlal, R.3    Biswas, S.4    Mukhopadhyay, C.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.