Cell wall protection by the Candida albicans class I chitin synthases

Fungal Genetics and Biology

Volumn 82, Issue , 2015, Pages 264-276

  Preechasuth, Kanya ^a,c   Anderson, Jeffrey C ^b   Peck, Scott C ^b   Brown, Alistair J P ^a   Gow, Neil A R ^a   Lenardon, Megan D ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b University of Missouri   (United States)

^c CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

Candida albicans; Cell wall; Chitin synthase; Chs2; Chs8; Class I chitin synthase; Phosphorylation; Polarized growth

Indexed keywords

CHITIN SYNTHASE; CHITIN SYNTHASE 1; CHITIN SYNTHASE 2; CHITIN SYNTHASE 8; UNCLASSIFIED DRUG; HYBRID PROTEIN;

ARTICLE; CANDIDA ALBICANS; CELL BUDDING; CELL DEATH; CELL EXPANSION; CELL GROWTH; CELL POLARITY; CELL PROTECTION; CELL STRESS; CONTROLLED STUDY; CYTOLYSIS; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FUNGAL CELL; FUNGUS HYPHAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; CELL WALL; GENE EXPRESSION; GENETICS; METABOLISM; MUTATION; PHENOTYPE; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PROTEIN TRANSPORT; REPORTER GENE;

CANDIDA ALBICANS;

CANDIDA ALBICANS; CELL WALL; CHITIN SYNTHASE; GENE EXPRESSION; GENES, REPORTER; HYPHAE; MUTATION; PHENOTYPE; PHOSPHORYLATION; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; STRESS, PHYSIOLOGICAL;

EID: 84939445135     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2015.08.001     Document Type: Article

References (33)

1. Ali I., Khan F.G., Suri K.A., Gupta B.D., Satti N.K., Dutt P., Afrin F., Qazi G.N., Khan I.A. In vitro antifungal activity of hydroxychavicol isolated from Piper betle L. Ann. Clin. Microbiol. Antimicrob. 2010, 9:7.
2. Beltrao P., Trinidad J.C., Fiedler D., Roguev A., Lim W.A., Shokat K.M., Burlingame A.L., Krogan N.J. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol. 2009, 7:e1000134.
3. Bulawa C.E., Miller D.W., Henry L.K., Becker J.M. Attenuated virulence of chitin-deficient mutants of Candida albicans. Proc. Natl. Acad. Sci. USA 1995, 92:10570-10574.
4. Bulawa C.E., Slater M., Cabib E., Au-Young J., Sburlati A., Adair W.L., Robbins P.W. The S. cerevisiae structural gene for chitin synthase is not required for chitin synthesis in vivo. Cell 1986, 46:213-225.
5. Cabib E., Arroyo J. How carbohydrates sculpt cells: chemical control of morphogenesis in the yeast cell wall. Nat. Rev. Microbiol. 2013, 11:648-655.
6. Cabib E., Sburlati A., Bowers B., Silverman S.J. Chitin synthase 1, an auxiliary enzyme for chitin synthesis in Saccharomyces cerevisiae. J. Cell Biol. 1989, 108:1665-1672.
7. Fonzi W.A., Irwin M.Y. Isogenic strain construction and gene mapping in Candida albicans. Genetics 1993, 134:717-728.
8. Gerami-Nejad M., Berman J., Gale C.A. Cassettes for the PCR-mediated construction of green, yellow, and cyan fluorescent protein fusions in Candida albicans. Yeast 2001, 18:859-864.
9. Gooday G.W., Gow N.A.R. A model of the hyphal septum of Candida albicans. Exp. Mycol. 1983, 7:370-373.
10. Gow N.A.R., Gooday G.W., Newsam R.J., Gull K. Ultrastructure of the septum in Candida albicans. Curr. Microbiol. 1980, 4:357-359.
11. Gow N.A.R., Robbins P.W., Lester J.W., Brown A.J., Fonzi W.A., Chapman T., Kinsman O.S. A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans. Proc. Natl. Acad. Sci. USA 1994, 91:6216-6220.
12. Jones K.H., Senft J.A. An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide. J. Histochem. Cytochem. 1985, 33:77-79.
13. Kaloriti D., Tillmann A., Cook E., Jacobsen M., You T., Lenardon M.D., Ames L., Barahona M., Chandrasekaran K., Coghill G., Goodman D., Gow N.A.R., Grebogi C., Ho H.L., Ingram P., McDonagh A., Moura A.P., Pang W., Puttnam M., Radmaneshfar E., Romano M.C., Silk D., Stark J., Stumpf M., Thiel M., Thorne T., Usher J., Yin Z., Haynes K., Brown A.J.P. Combinatorial stresses kill pathogenic Candida species. Med. Mycol. 2012, 50:699-709.
14. Lenardon M.D., Milne S.A., Mora-Montes H.M., Kaffarnik F.A.R., Peck S.C., Brown A.J.P., Munro C.A., Gow N.A.R. Phosphorylation regulates polarisation of chitin synthesis in Candida albicans. J. Cell Sci. 2010, 123:2199-2206.
15. Lenardon M.D., Munro C.A., Gow N.A.R. Chitin synthesis and fungal pathogenesis. Curr. Opin. Microbiol. 2010, 13:416-423.
16. Lenardon M.D., Whitton R.K., Munro C.A., Marshall D., Gow N.A.R. Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall. Mol. Microbiol. 2007, 66:1164-1173.
17. Mascotti K., McCullough J., Burger S.R. HPC viability measurement: trypan blue versus acridine orange and propidium iodide. Transfusion 2000, 40:693-696.
18. Mio T., Yabe T., Sudoh M., Satoh Y., Nakajima T., Arisawa M., Yamada-Okabe H. Role of three chitin synthase genes in the growth of Candida albicans. J. Bacteriol. 1996, 178:2416-2419.
19. Motoyama T., Kojima N., Horiuchi H., Ohta A., Takagi M. Isolation of a chitin synthase gene (chsC) of Aspergillus nidulans. Biosci. Biotechnol. Biochem. 1994, 58:2254-2257.
20. Munro C.A., Schofield D.A., Gooday G.W., Gow N.A.R. Regulation of chitin synthesis during dimorphic growth of Candida albicans. Microbiology 1998, 144:391-401.
21. 2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans. Mol. Microbiol. 2007, 63:1399-1413.
22. Munro C.A., Whitton R.K., Hughes H.B., Rella M., Selvaggini S., Gow N.A.R. CHS8-a fourth chitin synthase gene of Candida albicans contributes to in vitro chitin synthase activity, but is dispensable for growth. Fungal Genet. Biol. 2003, 40:146-158.
23. Munro C.A., Winter K., Buchan A., Henry K., Becker J.M., Brown A.J., Bulawa C.E., Gow N.A.R. Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity. Mol. Microbiol. 2001, 39:1414-1426.
24. Noble S.M., Johnson A.D. Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Eukaryot. Cell 2005, 4:298-309.
25. Ramani R., Ramani A., Wong S.J. Rapid flow cytometric susceptibility testing of Candida albicans. J. Clin. Microbiol. 1997, 35:2320-2324.
26. Sudoh M., Yamazaki T., Masubuchi K., Taniguchi M., Shimma N., Arisawa M., Yamada-Okabe H. Identification of a novel inhibitor specific to the fungal chitin synthase. Inhibition of chitin synthase 1 arrests the cell growth, but inhibition of chitin synthase 1 and 2 is lethal in the pathogenic fungus Candida albicans. J. Biol. Chem. 2000, 275:32901-32905.
27. Veses V., Gow N.A.R. Vacuolar dynamics during the morphogenetic transition in Candida albicans. FEMS Yeast Res. 2008, 8:1339-1348.
28. Walker L.A., Lenardon M.D., Preechasuth K., Munro C.A., Gow N.A.R. Cell wall stress induces alternative fungal cytokinesis and septation strategies. J. Cell Sci. 2013, 126:2668-2677.
29. Walker L.A., Munro C.A., de Bruijn I., Lenardon M.D., McKinnon A., Gow N.A.R. Stimulation of chitin synthesis rescues Candida albicans from echinocandins. PLoS Pathog. 2008, 4:e1000040.
30. Wang Z., Zheng L., Liu H., Wang Q., Hauser M., Kauffman S., Becker J.M., Szaniszlo P.J. WdChs2p, a class I chitin synthase, together with WdChs3p (class III) contributes to virulence in Wangiella (Exophiala) dermatitidis. Infect. Immun. 2001, 69:7517-7526.
31. Wilson R.B., Davis D., Enloe B.M., Mitchell A.P. A recyclable Candida albicans URA3 cassette for PCR product-directed gene disruptions. Yeast 2000, 16:65-70.
32. Wilson R.B., Davis D., Mitchell A.P. Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J. Bacteriol. 1999, 181:1868-1874.
33. Wloka C., Bi E. Mechanisms of cytokinesis in budding yeast. Cytoskeleton 2012, 69:710-726.