Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth

FEBS Letters

Volumn 525, Issue 1-3, 2002, Pages 59-64

  Levery, Steven B ^a   Momany, Michelle ^b   Lindsey, Rebecca ^b   Toledo, Marcos S ^c   Shayman, James A ^d   Fuller, Matthew ^e   Brooks, Kelly ^e   Doong, Ron Lou ^e   Straus, Anita H ^c   Takahashi, Helio K ^c  

^a University of New Hampshire   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e University of Georgia   (United States)

Author keywords

Fungus; Glycolipid; Glycosyltransferase; PDMP; Sphingolipid; Synthase

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; DEXTRO THREO 1 PHENYL 2 PALMITOYL 3 PYRROLIDINOPROPANOL; DEXTRO THREO 3',4' ETHYLENEDIOXY DEXTRO THREO 1 PHENYL 2 PALMITOYL 3 PYRROLIDINOPROPANOL; FUNGAL PROTEIN; GALACTOSYLCERAMIDE; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIDULANS; BIOSYNTHESIS; CELL CYCLE; CONTROLLED STUDY; ENZYME SYNTHESIS; FUNGUS CULTURE; FUNGUS GROWTH; FUNGUS HYPHAE; GROWTH INHIBITION; MAMMAL; NONHUMAN; PRIORITY JOURNAL; SPORE GERMINATION;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIDULANS; CARBON ISOTOPES; CELL CYCLE; CELL DIVISION; CEREBROSIDES; ENZYME INHIBITORS; FUNGAL PROTEINS; GALACTOSYLCERAMIDES; GLUCOSYLCERAMIDES; GLUCOSYLTRANSFERASES; HYPHAE; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PYRROLIDINES; SPORES, FUNGAL;

ASPERGILLUS; ASPERGILLUS FUMIGATUS; EMERICELLA NIDULANS; FUNGI; MAMMALIA;

EID: 0037077684     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(02)03067-3     Document Type: Article

References (27)